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MULTIMERIC IMMUNOGLOBULIN-BINDING DOMAIN
A multimeric immunoglobulin-binding protein having improved properties as an affinity ligand for affinity chromatography, and an insoluble support ...
DISSOCIATION CAPACITY-BOOSTED LIGAND FOR AFFINITY DISSOCIATION MATRIX
The present invention produces affinity ligands that make it possible to increase the purity of antibodies themselves, which is the main purpose of affinity...
PSEUDOMONAS EXOTOXIN A WITH LESS IMMUNOGENIC T CELL AND/OR B CELL EPITOPES
The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The...
Methods of Predicting Ancestral Virus Sequences and Uses Thereof
Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated...
SIMPLE VACCINES FROM DNA LAUNCHED SUICIDAL FLAVIVIRUSES
Immunogenic compositions relating to DNA launched suicidal flaviviruses and methods of administering the same are described herein.
CELL-PENETRATING COMPSTATIN ANALOGS AND USES THEREOF
In some aspects, the present invention cell-penetrating compstatin analog and compositions comprising cell-penetrating compstatin analog. In some aspects, the...
The present invention relates to a novel cyclohexapeptide, to a method for the preparation of said cyclohexapeptide and to the use of said cyclohexapeptide.
CELL-REACTIVE, LONG-ACTING, OR TARGETED COMPSTATIN ANALOGS AND RELATED
COMPOSITIONS AND METHODS
In some aspects, the present invention provides cell-reactive compstatin analogs and compositions comprising cell-reactive compstatin analogs. In some aspects,...
PEPTIDES CAPABLE OF REACTIVATING p53 MUTANTS
The invention provides peptides that can reactivate p53 mutants efficiently and specifically, as well as methods that allow the identification, selection and...
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OCULAR SURFACE
A pharmaceutical composition for preventing or treating an ocular surface disease is disclosed, wherein the pharmaceutical composition includes, as an active...
Brachiatin D and Process for Production Thereof
The present invention relates to a peptaibol having sequence AcAib-Asn-Aib-Leu-Aib-Pro-Aib-Asn-Leu-Pro-Ileuol, isolated from endophytic fungus Trichoderma...
SYNTHESIS OF PEPTIDE EPOXY KETONES
It is provided an improved process for preparing peptide epoxy ketones, including novel compounds that can be used as intermediates in the process for...
NOVEL METHOD FOR PREVENTING THE UNFOLDING OF A (POLY)PEPTIDE AND/OR
INDUCING THE (RE-)FOLDING OF A (POLY)PEPTIDE
The present invention relates to a method for preventing the unfolding of a (poly)peptide during drying and/or inducing the (re-)folding of a (poly)peptide...
Preparation and Uses of Obeticholic Acid
The present invention relates to obeticholic acid: ##STR00001## or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid...
Cytidine-5-Carboxamide Modified Nucleotide Compositions and Methods
Described herein are 5-position modified cytosine nucleotides and nucleosides as well as phosphoramidites and triphosphates derivatives thereof. Further...
AMPHOTERICIN B DERIVATIVES WITH IMPROVED THERAPEUTIC INDEX
Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are...
4--5-(PROPAN-2-YL)-1H-PYRAZOL-3-YL BETA-D GLUCOPYRANOSIDE ACETATE
The present invention provides a compound of Formula I or hydrate thereof, useful for the treatment of diabetes. ##STR00001##
METHOD FOR PURIFYING DOUBLE-STRANDED RIBONUCLEIC ACID
The present invention provides a method of recovering dsRNA, from which a surfactant and endotoxin have been removed simultaneously, which includes mixing the...
BIS-ORGANOMETALLIC 2-AMINO-3-HYDROXY-2-METHYLPROPANENITRILE DERIVATIVES
FOR USE AS ANTHELMINTICS
The invention comprises a compound characterized by a general formula (1). ##STR00001## wherein X is a group described by a general formula wherein is with l ...
VORICONAZOLE SODIUM PHOSPHATE HYDRATES AND POLYMORPHS THEREOF
The present invention relates to a voriconazole sodium phosphate hydrate, polymorphs thereof, a preparation method thereof, and use thereof, wherein the...
METHOD OF PRODUCING PYRAZINO[2,1-C][1,2,4]TRIAZINE COMPOUND
A method of producing 4-(((6S,9S)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylme- thyl)octahydro...
PEPTIDOMIMETIC INHIBITORS OF PSMA
Compounds of the formulae, (I), wherein each variable is as defined herein are provided which are useful in (i) diagnostic methods for detecting and/or...
SYNTHESIS AND FORMULATIONS OF SALTS OF ISOPHOSPHORAMIDE MUSTARD AND
Disclosed herein are formulations and methods of manufacture of compounds of formula (E): ##STR00001## wherein X and Y independently represent leaving groups;...
A NOVEL LIGAND COMPOUND, A PREPARATION METHOD THEREOF, A TRANSITION METAL
COMPOUND, AND A PREPARATION METHOD...
The present invention relates to a novel ligand compound, a preparation method thereof, a transition metal compound including the ligand compound, and a...
HALOGEN FREE SYNTHESES OF AMINOSILANES BY CATALYTIC DEHYDROGENATIVE
Compounds and method of preparation of Si--X and Ge--X compounds (X.dbd.N, P, As and Sb) via dehydrogenative coupling between the corresponding unsubstituted...
COMPOSITIONS AND METHODS FOR TREATING CANCER WITH ABERRANT LIPOGENIC
The technology described herein relates to pinacolyl boronate substituted stilbenes for the treatment of cancers, e.g. cancers expressing abnormally high...
METALLACROWN COMPLEXES AND METHODS OF MAKING THE SAME
A metallacrown complex has the formula: Ln(III)[12-MC-4]2[24-MC-8], wherein MC is a metallacrown macrocycle with a repeating sub-unit consisting of a...
Production And Use Of Zinc Amides
Compounds, methods of making the compounds and methods of using the compounds are generally described herein. The compounds are generally of formula...
FLUORINE-CONTAINING COMPLEX COMPOUND, AND PRODUCTION METHOD FOR
FLUORINE-CONTAINING ORGANIC COMPOUND EMPLOYING SAME
An object of the present invention is to enable the synthesis of various fluorine-containing compounds having an organic group at both terminals of their...
NOVEL COMPOSITIONS USEFUL FOR INHIBITING HIV-1 INFECTION AND METHODS USING
The present invention includes novel compounds, and compositions comprising same, useful for preventing or treating an HIV-1 infection in a subject in need...
2,2-DIFLUORODIOXOLO A2A RECEPTOR ANTAGONISTS
The present invention is directed to 2,2-difluorodioxolo compounds that are antagonists of A.sub.2A receptor. The present invention is also directed to uses of...
MACROCYCLIC COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
The compounds and salts of the present invention inhibit kinases, especially the anaplastic lymphoma kinase (ALK) and the HGF receptor tyrosine kinase (RTK)...
The present invention in one embodiment provides a compound of Formula I: (I), or a pharmaceutically acceptable salt thereof, wherein Y.sup.1, Y.sup.2 and...
FUSED PYRIMIDINE COMPOUND, INTERMEDIATE, PREPARATION METHOD THEREFOR, AND
COMPOSITION AND APPLICATION THEREOF
Disclosed are a fused pyrimidine compound, an intermediate, a preparation method therefor, and a composition and an application thereof. The present invention...
NOVEL GLP-1 RECEPTOR MODULATORS
Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic...
INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS
Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.
METHOD FOR PRODUCING PYROMELLITIC DIANHYDRIDE, PYROMELLITIC DIANHYDRIDE
PRODUCED BY THE METHOD, AND APPARATUS...
A method for producing a highly pure PMDA comprises at least the following steps: (1) a step of preparing a raw material solution by dissolving a raw material...
OLIGOMER-OPIOID AGONIST CONJUGATES
The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when ...
Compositions and Methods for Enhancing Proteasome Activity
Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates....
Antimicrobial Compounds and Methods of Making and Using the Same
The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for...
METHOD FOR PREPARING AN INTERMEDIATE FOR PRODUCING HIGH-PURITY PEMETREXED
AND METHOD FOR PRODUCING HIGH-PURITY...
Disclosed are a method for preparing an intermediate for producing high-purity pemetrexed and a method for producing high-purity pemetrexed using the...
NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT
OF INFLAMMATORY DISORDERS
The present invention discloses compounds according to Formula I: ##STR00001## Wherein R.sup.1a, R.sup.1b, R.sup.2, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8,...
PRMT5 INHIBITORS AND USES THEREOF
Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
INHIBITOR OF BREAST CANCER RESISTANCE PROTEIN (BCRP)
Disclosed are compounds that inhibit breast cancer resistance protein (BCRP), of which compound (I-1), ((3S, 6S, 12aS)-6-isobutyl-9-methoxy-3-methyl-2,3,6,7,...
3,7-DIAZABICYCLO[3.3.1]NONANE CARBOXAMIDES AS ANTITHROMBOTIC AGENTS
The present invention relates to the 3,7-diazabicyclo[3.3.1]nonane carboxamides and process for preparation thereof. The present invention further relates to...
Radiosynthesis of Tau Radiopharmaceuticals
This disclosure relates to a one-step method for preparing the tau radiopharmaceutical, [18F]T807, using an unprotected or protected precursor (e.g.,...
The present invention relates to fluoro-9-methyl-.beta.-carbolines, their preparation as well as their medical use and pharmaceutical compositions containing...
SELECTIVE INHIBITOR OF PHOSPHATIDYLINOSITOL 3-KINASE-GAMMA
The present invention relates to a compound useful as a selective inhibitor of PI3K.gamma.. The invention also provides pharmaceutically acceptable...
MONO-PHOSPHATE SALT OF
The present invention relates to crystalline and amorphous forms of 6-fluoro-2-[4-(pyridin-2-yl)but-3-yn-1-yl]imidazo[1,2-a]pyridine mono-phosphate salt and...
SUBSTITUTED PYRIMIDINE BMI-1 INHIBITORS
Amine substituted pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus...