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Patent # Description
2016/0215027 MULTIMERIC IMMUNOGLOBULIN-BINDING DOMAIN
A multimeric immunoglobulin-binding protein having improved properties as an affinity ligand for affinity chromatography, and an insoluble support ...
2016/0215026 DISSOCIATION CAPACITY-BOOSTED LIGAND FOR AFFINITY DISSOCIATION MATRIX
The present invention produces affinity ligands that make it possible to increase the purity of antibodies themselves, which is the main purpose of affinity...
2016/0215025 PSEUDOMONAS EXOTOXIN A WITH LESS IMMUNOGENIC T CELL AND/OR B CELL EPITOPES
The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The...
2016/0215024 Methods of Predicting Ancestral Virus Sequences and Uses Thereof
Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated...
2016/0215023 SIMPLE VACCINES FROM DNA LAUNCHED SUICIDAL FLAVIVIRUSES
Immunogenic compositions relating to DNA launched suicidal flaviviruses and methods of administering the same are described herein.
2016/0215022 CELL-PENETRATING COMPSTATIN ANALOGS AND USES THEREOF
In some aspects, the present invention cell-penetrating compstatin analog and compositions comprising cell-penetrating compstatin analog. In some aspects, the...
2016/0215021 NOVEL CYCLOHEXAPEPTIDE
The present invention relates to a novel cyclohexapeptide, to a method for the preparation of said cyclohexapeptide and to the use of said cyclohexapeptide.
2016/0215020 CELL-REACTIVE, LONG-ACTING, OR TARGETED COMPSTATIN ANALOGS AND RELATED COMPOSITIONS AND METHODS
In some aspects, the present invention provides cell-reactive compstatin analogs and compositions comprising cell-reactive compstatin analogs. In some aspects,...
2016/0215019 PEPTIDES CAPABLE OF REACTIVATING p53 MUTANTS
The invention provides peptides that can reactivate p53 mutants efficiently and specifically, as well as methods that allow the identification, selection and...
2016/0215018 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OCULAR SURFACE DISEASE
A pharmaceutical composition for preventing or treating an ocular surface disease is disclosed, wherein the pharmaceutical composition includes, as an active...
2016/0215017 Brachiatin D and Process for Production Thereof
The present invention relates to a peptaibol having sequence AcAib-Asn-Aib-Leu-Aib-Pro-Aib-Asn-Leu-Pro-Ileuol, isolated from endophytic fungus Trichoderma...
2016/0215016 SYNTHESIS OF PEPTIDE EPOXY KETONES
It is provided an improved process for preparing peptide epoxy ketones, including novel compounds that can be used as intermediates in the process for...
2016/0215015 NOVEL METHOD FOR PREVENTING THE UNFOLDING OF A (POLY)PEPTIDE AND/OR INDUCING THE (RE-)FOLDING OF A (POLY)PEPTIDE
The present invention relates to a method for preventing the unfolding of a (poly)peptide during drying and/or inducing the (re-)folding of a (poly)peptide...
2016/0215014 Preparation and Uses of Obeticholic Acid
The present invention relates to obeticholic acid: ##STR00001## or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid...
2016/0215013 Cytidine-5-Carboxamide Modified Nucleotide Compositions and Methods Related Thereto
Described herein are 5-position modified cytosine nucleotides and nucleosides as well as phosphoramidites and triphosphates derivatives thereof. Further...
2016/0215012 AMPHOTERICIN B DERIVATIVES WITH IMPROVED THERAPEUTIC INDEX
Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are...
2016/0215011 4--5-(PROPAN-2-YL)-1H-PYRAZOL-3-YL BETA-D GLUCOPYRANOSIDE ACETATE
The present invention provides a compound of Formula I or hydrate thereof, useful for the treatment of diabetes. ##STR00001##
2016/0215010 METHOD FOR PURIFYING DOUBLE-STRANDED RIBONUCLEIC ACID
The present invention provides a method of recovering dsRNA, from which a surfactant and endotoxin have been removed simultaneously, which includes mixing the...
2016/0215009 BIS-ORGANOMETALLIC 2-AMINO-3-HYDROXY-2-METHYLPROPANENITRILE DERIVATIVES FOR USE AS ANTHELMINTICS
The invention comprises a compound characterized by a general formula (1). ##STR00001## wherein X is a group described by a general formula wherein is with l ...
2016/0215008 VORICONAZOLE SODIUM PHOSPHATE HYDRATES AND POLYMORPHS THEREOF
The present invention relates to a voriconazole sodium phosphate hydrate, polymorphs thereof, a preparation method thereof, and use thereof, wherein the...
2016/0215007 METHOD OF PRODUCING PYRAZINO[2,1-C][1,2,4]TRIAZINE COMPOUND
A method of producing 4-(((6S,9S)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylme- thyl)octahydro...
2016/0215006 PEPTIDOMIMETIC INHIBITORS OF PSMA
Compounds of the formulae, (I), wherein each variable is as defined herein are provided which are useful in (i) diagnostic methods for detecting and/or...
2016/0215005 SYNTHESIS AND FORMULATIONS OF SALTS OF ISOPHOSPHORAMIDE MUSTARD AND ANALOGS THEREOF
Disclosed herein are formulations and methods of manufacture of compounds of formula (E): ##STR00001## wherein X and Y independently represent leaving groups;...
2016/0215004 A NOVEL LIGAND COMPOUND, A PREPARATION METHOD THEREOF, A TRANSITION METAL COMPOUND, AND A PREPARATION METHOD...
The present invention relates to a novel ligand compound, a preparation method thereof, a transition metal compound including the ligand compound, and a...
2016/0215003 HALOGEN FREE SYNTHESES OF AMINOSILANES BY CATALYTIC DEHYDROGENATIVE COUPLING
Compounds and method of preparation of Si--X and Ge--X compounds (X.dbd.N, P, As and Sb) via dehydrogenative coupling between the corresponding unsubstituted...
2016/0215002 COMPOSITIONS AND METHODS FOR TREATING CANCER WITH ABERRANT LIPOGENIC SIGNALING
The technology described herein relates to pinacolyl boronate substituted stilbenes for the treatment of cancers, e.g. cancers expressing abnormally high...
2016/0215001 METALLACROWN COMPLEXES AND METHODS OF MAKING THE SAME
A metallacrown complex has the formula: Ln(III)[12-MC-4]2[24-MC-8], wherein MC is a metallacrown macrocycle with a repeating sub-unit consisting of a...
2016/0215000 Production And Use Of Zinc Amides
Compounds, methods of making the compounds and methods of using the compounds are generally described herein. The compounds are generally of formula...
2016/0214999 FLUORINE-CONTAINING COMPLEX COMPOUND, AND PRODUCTION METHOD FOR FLUORINE-CONTAINING ORGANIC COMPOUND EMPLOYING SAME
An object of the present invention is to enable the synthesis of various fluorine-containing compounds having an organic group at both terminals of their...
2016/0214998 NOVEL COMPOSITIONS USEFUL FOR INHIBITING HIV-1 INFECTION AND METHODS USING SAME
The present invention includes novel compounds, and compositions comprising same, useful for preventing or treating an HIV-1 infection in a subject in need...
2016/0214997 2,2-DIFLUORODIOXOLO A2A RECEPTOR ANTAGONISTS
The present invention is directed to 2,2-difluorodioxolo compounds that are antagonists of A.sub.2A receptor. The present invention is also directed to uses of...
2016/0214996 MACROCYCLIC COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
The compounds and salts of the present invention inhibit kinases, especially the anaplastic lymphoma kinase (ALK) and the HGF receptor tyrosine kinase (RTK)...
2016/0214995 SUBSTITUTED THIENOTRIAZOLODIAZAPINES
The present invention in one embodiment provides a compound of Formula I: (I), or a pharmaceutically acceptable salt thereof, wherein Y.sup.1, Y.sup.2 and...
2016/0214994 FUSED PYRIMIDINE COMPOUND, INTERMEDIATE, PREPARATION METHOD THEREFOR, AND COMPOSITION AND APPLICATION THEREOF
Disclosed are a fused pyrimidine compound, an intermediate, a preparation method therefor, and a composition and an application thereof. The present invention...
2016/0214993 NOVEL GLP-1 RECEPTOR MODULATORS
Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic...
2016/0214992 INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS
Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.
2016/0214991 METHOD FOR PRODUCING PYROMELLITIC DIANHYDRIDE, PYROMELLITIC DIANHYDRIDE PRODUCED BY THE METHOD, AND APPARATUS...
A method for producing a highly pure PMDA comprises at least the following steps: (1) a step of preparing a raw material solution by dissolving a raw material...
2016/0214990 OLIGOMER-OPIOID AGONIST CONJUGATES
The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when ...
2016/0214989 Compositions and Methods for Enhancing Proteasome Activity
Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates....
2016/0214988 Antimicrobial Compounds and Methods of Making and Using the Same
The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for...
2016/0214987 METHOD FOR PREPARING AN INTERMEDIATE FOR PRODUCING HIGH-PURITY PEMETREXED AND METHOD FOR PRODUCING HIGH-PURITY...
Disclosed are a method for preparing an intermediate for producing high-purity pemetrexed and a method for producing high-purity pemetrexed using the...
2016/0214986 NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS
The present invention discloses compounds according to Formula I: ##STR00001## Wherein R.sup.1a, R.sup.1b, R.sup.2, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8,...
2016/0214985 PRMT5 INHIBITORS AND USES THEREOF
Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
2016/0214984 INHIBITOR OF BREAST CANCER RESISTANCE PROTEIN (BCRP)
Disclosed are compounds that inhibit breast cancer resistance protein (BCRP), of which compound (I-1), ((3S, 6S, 12aS)-6-isobutyl-9-methoxy-3-methyl-2,3,6,7,...
2016/0214983 3,7-DIAZABICYCLO[3.3.1]NONANE CARBOXAMIDES AS ANTITHROMBOTIC AGENTS
The present invention relates to the 3,7-diazabicyclo[3.3.1]nonane carboxamides and process for preparation thereof. The present invention further relates to...
2016/0214982 Radiosynthesis of Tau Radiopharmaceuticals
This disclosure relates to a one-step method for preparing the tau radiopharmaceutical, [18F]T807, using an unprotected or protected precursor (e.g.,...
2016/0214981 FLUORO-9-METHYL-BETA-CARBOLINES
The present invention relates to fluoro-9-methyl-.beta.-carbolines, their preparation as well as their medical use and pharmaceutical compositions containing...
2016/0214980 SELECTIVE INHIBITOR OF PHOSPHATIDYLINOSITOL 3-KINASE-GAMMA
The present invention relates to a compound useful as a selective inhibitor of PI3K.gamma.. The invention also provides pharmaceutically acceptable...
2016/0214979 MONO-PHOSPHATE SALT OF 6-FLUORO-2-[4-(PYRIDIN-2-YL)BUT-3-YN-1-YL]IMIDAZO[1,2A]PYRIDINE AND POLYMORPHS...
The present invention relates to crystalline and amorphous forms of 6-fluoro-2-[4-(pyridin-2-yl)but-3-yn-1-yl]imidazo[1,2-a]pyridine mono-phosphate salt and...
2016/0214978 SUBSTITUTED PYRIMIDINE BMI-1 INHIBITORS
Amine substituted pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus...
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