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Patent # Description
2016/0214977 NOVEL BENZIMIDAZOLE DERIVATIVES AS EP4 ANTAGONISTS
The present invention relates to novel benzimidazole derivatives of the general formula (I), processes for their preparation and their use for the production...
2016/0214976 CRYSTALLINE AND AMORPHOUS FORMS OF PALONOSETRON HYDROCHLORIDE
Amorphous and polymorphic of palonosetron hydrochloride are disclosed that can be characterized by X-ray powder diffraction patterns, thermal properties,...
2016/0214975 HETEROARYL CARBOXAMIDES
The invention relates to novel heteroaryl carboxamides, a process for their preparation, and pharmaceutical compositions containing them. These materials are...
2016/0214974 INSECTICIDAL COMPOUNDS
A compound of formula I, (I), wherein A, Q, R.sup.1, and R.sup.2, are as defined in claim 1. Furthermore, the present invention relates to intermediates used...
2016/0214973 STORE OVERLOAD-INDUCED CALCIUM RELEASE INHIBITORS AND METHODS FOR PRODUCING AND USING THE SAME
The present invention provides compounds having store overload-induced Ca.sup.2+ release (SOICR) inhibitory activity and methods for producing and using the...
2016/0214972 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR
The present invention relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor. In particular, the present invention is...
2016/0214971 Biaryl Acyl-Sulfonamide Compounds as Sodium Channel Inhibitors
The present invention provides compounds of Formula (Ia), and pharmaceutically acceptable salts thereof. The compounds are useful as inhibitors of...
2016/0214970 Bis(difluoromethyl)pyrazoles as Fungicides
Bis(difluoromethyl)pyrazole derivatives of the formula (I) ##STR00001## in which the symbols R.sup.1, X and G are each as defined in the description, and...
2016/0214969 SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION
Disclosed are new small molecules and the uses thereof for inhibiting superoxide dismutase (SOD) expression. Also disclosed are pharmaceutical compositions...
2016/0214968 COMPOUNDS AS MODULATOR OF JAK-STAT PATHWAY, METHODS AND APPLICATIONS THEREOF
The present disclosure relates to compound of structural Formula I and a method for preparing said compounds. The disclosure further relates to a method of...
2016/0214967 ACTIVATOR OF ADIPONECTIN RECEPTOR
An AdipoR activator for activating both AdipoR1 and AdipoR2 is provided. A compound represented by the following formula (1), wherein A is a substituted or...
2016/0214966 OXIME ESTER PHOTOINITIATORS
Disclosed are oxime ester compounds which have specific benzo (unsaturated 5-membered ring)-carbonyl group and their use as photoinitiators in...
2016/0214965 OLIGOOXOPIPERAZINES AND METHODS OF MAKING AND USING THEM
The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed.
2016/0214964 QUINAZOLINE DERIVATIVE AND PREPARATION METHOD THEREFOR
The present invention relates to a quinazoline derivative shown in formula (I) and a preparation method therefor, a pharmaceutical composition comprising the...
2016/0214963 INHIBITORS OF BRUTON'S TYROSINE KINASE
The disclosure includes compounds of Formula (I) ##STR00001## wherein R.sub.0, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and L are defined herein. Also...
2016/0214962 PROCESS FOR PREPARING AN N-METHYL-SUBSTITUTED TRIACETONAMINE COMPOUND
An N-methyl-substituted triacetonamine compound is prepared by reacting at least one triacetonamine compound (I) with formaldehyde under reductive conditions,...
2016/0214961 NOVEL SALTS OF CRIZOTINIB AND THEIR PREPARATION
The present invention relates to novel pharmaceutically acceptable substituted aryl acrylic acid addition salts of Crizotinib (I) or its hydrate or solvate...
2016/0214960 2-PYRIDYLOXY-4-ESTER OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to 2-pyridyloxy-4-ester compounds which are antagonists of orexin receptors. The present invention is also directed to uses...
2016/0214959 METALLOENZYME INHIBITOR COMPOUNDS
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by...
2016/0214958 COMPOUNDS AND USE FOR TREATING CANCER
The present invention relates to certain 2,4-disubstituted quinoline derivatives, to their therapy, as well as to pharmaceutical compositions comprising said...
2016/0214957 SOLID FORMS OF 3-(5-AMINO-2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE, AND THEIR...
Solid forms comprising 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, compositions comprising the solid forms, methods of making the...
2016/0214956 NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE
The invention relates to activators of soluble guanylate cyclase and their use in pharmaceutical compositions, primarily topically administered ophthalmic...
2016/0214955 Carbon Monoxide Releasing Molecules and Associated Methods
The present disclosure relates to carbon monoxide releasing molecules ("CORMs"), and methods of synthesizing and applying the molecules. More specifically,...
2016/0214954 ALPHA-TEA SALT FORMS: COMPOSITIONS AND USES FOR TREATING DISEASE
The present disclosure relates to salts of the compound (I), polymorphic forms thereof, methods for preparation and use thereof, and pharmaceutical...
2016/0214953 PROCESS FOR THE PREPARATION OF DAPAGLIFLOZIN
The present invention provides an improved process for the preparation of dapagliflozin.of Formula (II) wherein the process comprises the step of hydrolyzing...
2016/0214952 IMPROVED PROCESS FOR MANUFACTURE OF TETRAHYDROFURAN
The disclosed process relates to an improved process for manufacturing THF from a reaction mixture comprising BDO in the presence of an acid catalyst in a...
2016/0214951 EBI2 MODULATORS
Provided herein are small molecule Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) modulator compounds, compositions comprising the compounds,...
2016/0214950 VORTIOXETINE SALT AND CRYSTAL THEREOF, THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND USAGE
The present invention relates to the novel vortioxetine salts, solvates and crystalline forms thereof, specifically, vortioxetine hemihydrobromide and a...
2016/0214949 AN AMORPHOUS VORTIOXETINE AND SALTS THEREOF
The present invention relates to an amorphous vortioxetine and salts thereof. In particular, the invention relates to a process for the preparation of an...
2016/0214948 PRODRUGS OF MONOMETHYL FUMARATE (MMF)
The present invention relates to novel compounds for use as a medicament. In particular, the present invention relates to a medicament, preferably in the...
2016/0214947 MANUFACTURE OF 2-(5-BROMO-4-(4-CYCLOPROPYLNAPHTHALEN-1-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO)ACE- TIC ACID
Described herein are certain processes for the synthesis of compounds of Formula (I): ##STR00001##
2016/0214946 CATALYSED LIGATION OF AZIDES AND ACETYLENES
A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles....
2016/0214945 AGRICULTURAL CHEMICALS
The present invention relates to compounds which are of use in the field of agriculture as herbicides. The invention also relates to compositions comprising...
2016/0214944 JAK2 AND ALK2 INHIBITORS AND METHODS FOR THEIR USE
Compounds having activity as inhibitors of ALK2 kinase and/or JAK2 kinase are disclosed. The compounds have the following structure (I): [FORMULA SHOULD BE...
2016/0214943 Liver X Receptor (LXR) Modulators
Described herein are liver X receptor (LXR) modulators and methods of utilizing LXR modulators in the treatment of dermal diseases, disorders or conditions....
2016/0214942 TRIARYLAMINE-SUBSTITUTED BENZO[H]QUINOLINE-DERIVATIVES AS MATERIALS FOR ELECTRONIC DEVICES
The invention relates to a heteroaryl compound according to formula (I) and to the use thereof in electronic devices.
2016/0214941 Compounds for lnhibition of Unregulated Cell Growth
Compounds For Inhibition Of Unregulated Cell Growth The present invention relates to compounds of Formula I for inhibition or eradication of unregulated cell...
2016/0214940 NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2
Described are negative allosteric modulators of metabotropic glutamate receptor 2 (mGlu.sub.2), pharmaceutical compositions including the compounds, and...
2016/0214939 SOLID FORMS OF 2-(5-(3-FLUOROPHENYL)-3-HYDROXYPICOLINAMIDO)ACETIC ACID, COMPOSITIONS, AND USES THEREOF
Provided herein are solid forms comprising 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, methods of making the solid forms, methods of their use for...
2016/0214938 METALLOTRIANGLE-BASED NANOMOLECULES AND METHODS OF MAKING THE SAME
Metallotriangle-based nanomolecules are formed by a one-step self-assembly of specifically chosen shaped poly-ligand monomers, the poly-ligand monomers...
2016/0214937 SYNTHESIS OF TRIACETONEDIAMINE COMPOUNDS BY REDUCTIVE AMINATION PROCEEDING FROM TRIACETONEDIAMINE AND...
An N-substituted triacetonediamine compound is prepared by reacting 4-amino-2,2,6,6-tetramethylpiperidine or a derivative thereof with a carbonyl compound in a...
2016/0214936 CARBAZOLE COMPOUNDS FOR IN VIVO IMAGING
The present invention concerns in vivo imaging and in particular in vivo imaging of translocator protein (TSPO, formerly known as the peripheral benzodiazepine...
2016/0214935 AUTOTAXIN INHIBITOR COMPOUNDS
Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such...
2016/0214934 SUBSTITUTED INDOLE MCL-1 INHIBITORS
The present application, among other things, provides compounds that are capable of inhibiting the activity of anti-apoptotic Bcl-2 family proteins, for...
2016/0214933 Amine Mining Collectors
A family of amine mining collectors that uses alkoxylates allows for the easy adjustment of solubility and molecular weight useful because anionic and cationic...
2016/0214932 ALKYL PHENYL SULFIDE DERIVATIVE AND PEST CONTROL AGENT
An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the...
2016/0214931 Zinc or Copper (II) Salt and Use Thereof as a Biocide
There is provided as a biocide zinc or copper (II) salt having the general formula CH.sub.2.dbd.C(R.sup.1)COO-M-OCOC.sub.6H.sub.3R.sup.2R.sup.4, wherein M ...
2016/0214930 CHEMICAL COMPOUNDS
The present invention relates to novel compounds of polyfunctionalized polyethylene and polypropylene glycols, their synthesis and their use, in particular as...
2016/0214929 PROCESS FOR PREPARING 4[[(BENZOYL)AMINO]SULPHONYL]BENZOYL CHLORIDES AND PREPARATION OF ACYLSULPHAMOYLBENZAMIDES
Process for preparing 4-[[(benzoyl)amino]sulphonyl]benzoyl chlorides of the formula (II). ##STR00001##
2016/0214928 Improvements in or Relating to Organic Compounds
A stock solution comprising a compound of formula (I) ##STR00001## Wherein R.sub.1 together with the carbonyl group to which it is attached is a residue of a...
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