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NOVEL BENZIMIDAZOLE DERIVATIVES AS EP4 ANTAGONISTS
The present invention relates to novel benzimidazole derivatives of the general formula (I), processes for their preparation and their use for the production...
CRYSTALLINE AND AMORPHOUS FORMS OF PALONOSETRON HYDROCHLORIDE
Amorphous and polymorphic of palonosetron hydrochloride are disclosed that can be characterized by X-ray powder diffraction patterns, thermal properties,...
The invention relates to novel heteroaryl carboxamides, a process for their preparation, and pharmaceutical compositions containing them. These materials are...
A compound of formula I, (I), wherein A, Q, R.sup.1, and R.sup.2, are as defined in claim 1. Furthermore, the present invention relates to intermediates used...
STORE OVERLOAD-INDUCED CALCIUM RELEASE INHIBITORS AND METHODS FOR
PRODUCING AND USING THE SAME
The present invention provides compounds having store overload-induced Ca.sup.2+ release (SOICR) inhibitory activity and methods for producing and using the...
COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR
The present invention relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor. In particular, the present invention is...
Biaryl Acyl-Sulfonamide Compounds as Sodium Channel Inhibitors
The present invention provides compounds of Formula (Ia), and pharmaceutically acceptable salts thereof. The compounds are useful as inhibitors of...
Bis(difluoromethyl)pyrazoles as Fungicides
Bis(difluoromethyl)pyrazole derivatives of the formula (I) ##STR00001## in which the symbols R.sup.1, X and G are each as defined in the description, and...
SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION
Disclosed are new small molecules and the uses thereof for inhibiting superoxide dismutase (SOD) expression. Also disclosed are pharmaceutical compositions...
COMPOUNDS AS MODULATOR OF JAK-STAT PATHWAY, METHODS AND APPLICATIONS
The present disclosure relates to compound of structural Formula I and a method for preparing said compounds. The disclosure further relates to a method of...
ACTIVATOR OF ADIPONECTIN RECEPTOR
An AdipoR activator for activating both AdipoR1 and AdipoR2 is provided. A compound represented by the following formula (1), wherein A is a substituted or...
OXIME ESTER PHOTOINITIATORS
Disclosed are oxime ester compounds which have specific benzo (unsaturated 5-membered ring)-carbonyl group and their use as photoinitiators in...
OLIGOOXOPIPERAZINES AND METHODS OF MAKING AND USING THEM
The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed.
QUINAZOLINE DERIVATIVE AND PREPARATION METHOD THEREFOR
The present invention relates to a quinazoline derivative shown in formula (I) and a preparation method therefor, a pharmaceutical composition comprising the...
INHIBITORS OF BRUTON'S TYROSINE KINASE
The disclosure includes compounds of Formula (I) ##STR00001## wherein R.sub.0, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and L are defined herein. Also...
PROCESS FOR PREPARING AN N-METHYL-SUBSTITUTED TRIACETONAMINE COMPOUND
An N-methyl-substituted triacetonamine compound is prepared by reacting at least one triacetonamine compound (I) with formaldehyde under reductive conditions,...
NOVEL SALTS OF CRIZOTINIB AND THEIR PREPARATION
The present invention relates to novel pharmaceutically acceptable substituted aryl acrylic acid addition salts of Crizotinib (I) or its hydrate or solvate...
2-PYRIDYLOXY-4-ESTER OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to 2-pyridyloxy-4-ester compounds which are antagonists of orexin receptors. The present invention is also directed to uses...
METALLOENZYME INHIBITOR COMPOUNDS
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by...
COMPOUNDS AND USE FOR TREATING CANCER
The present invention relates to certain 2,4-disubstituted quinoline derivatives, to their therapy, as well as to pharmaceutical compositions comprising said...
SOLID FORMS OF
Solid forms comprising 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, compositions comprising the solid forms, methods of making the...
NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE
The invention relates to activators of soluble guanylate cyclase and their use in pharmaceutical compositions, primarily topically administered ophthalmic...
Carbon Monoxide Releasing Molecules and Associated Methods
The present disclosure relates to carbon monoxide releasing molecules ("CORMs"), and methods of synthesizing and applying the molecules. More specifically,...
ALPHA-TEA SALT FORMS: COMPOSITIONS AND USES FOR TREATING DISEASE
The present disclosure relates to salts of the compound (I), polymorphic forms thereof, methods for preparation and use thereof, and pharmaceutical...
PROCESS FOR THE PREPARATION OF DAPAGLIFLOZIN
The present invention provides an improved process for the preparation of dapagliflozin.of Formula (II) wherein the process comprises the step of hydrolyzing...
IMPROVED PROCESS FOR MANUFACTURE OF TETRAHYDROFURAN
The disclosed process relates to an improved process for manufacturing THF from a reaction mixture comprising BDO in the presence of an acid catalyst in a...
Provided herein are small molecule Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) modulator compounds, compositions comprising the compounds,...
VORTIOXETINE SALT AND CRYSTAL THEREOF, THEIR PREPARATION METHOD,
PHARMACEUTICAL COMPOSITIONS AND USAGE
The present invention relates to the novel vortioxetine salts, solvates and crystalline forms thereof, specifically, vortioxetine hemihydrobromide and a...
AN AMORPHOUS VORTIOXETINE AND SALTS THEREOF
The present invention relates to an amorphous vortioxetine and salts thereof. In particular, the invention relates to a process for the preparation of an...
PRODRUGS OF MONOMETHYL FUMARATE (MMF)
The present invention relates to novel compounds for use as a medicament. In particular, the present invention relates to a medicament, preferably in the...
Described herein are certain processes for the synthesis of compounds of Formula (I): ##STR00001##
CATALYSED LIGATION OF AZIDES AND ACETYLENES
A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles....
The present invention relates to compounds which are of use in the field of agriculture as herbicides. The invention also relates to compositions comprising...
JAK2 AND ALK2 INHIBITORS AND METHODS FOR THEIR USE
Compounds having activity as inhibitors of ALK2 kinase and/or JAK2 kinase are disclosed. The compounds have the following structure (I): [FORMULA SHOULD BE...
Liver X Receptor (LXR) Modulators
Described herein are liver X receptor (LXR) modulators and methods of utilizing LXR modulators in the treatment of dermal diseases, disorders or conditions....
TRIARYLAMINE-SUBSTITUTED BENZO[H]QUINOLINE-DERIVATIVES AS MATERIALS FOR
The invention relates to a heteroaryl compound according to formula (I) and to the use thereof in electronic devices.
Compounds for lnhibition of Unregulated Cell Growth
Compounds For Inhibition Of Unregulated Cell Growth The present invention relates to compounds of Formula I for inhibition or eradication of unregulated cell...
NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2
Described are negative allosteric modulators of metabotropic glutamate receptor 2 (mGlu.sub.2), pharmaceutical compositions including the compounds, and...
SOLID FORMS OF 2-(5-(3-FLUOROPHENYL)-3-HYDROXYPICOLINAMIDO)ACETIC ACID,
COMPOSITIONS, AND USES THEREOF
Provided herein are solid forms comprising 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, methods of making the solid forms, methods of their use for...
METALLOTRIANGLE-BASED NANOMOLECULES AND METHODS OF MAKING THE SAME
Metallotriangle-based nanomolecules are formed by a one-step self-assembly of specifically chosen shaped poly-ligand monomers, the poly-ligand monomers...
SYNTHESIS OF TRIACETONEDIAMINE COMPOUNDS BY REDUCTIVE AMINATION PROCEEDING
FROM TRIACETONEDIAMINE AND...
An N-substituted triacetonediamine compound is prepared by reacting 4-amino-2,2,6,6-tetramethylpiperidine or a derivative thereof with a carbonyl compound in a...
CARBAZOLE COMPOUNDS FOR IN VIVO IMAGING
The present invention concerns in vivo imaging and in particular in vivo imaging of translocator protein (TSPO, formerly known as the peripheral benzodiazepine...
AUTOTAXIN INHIBITOR COMPOUNDS
Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such...
SUBSTITUTED INDOLE MCL-1 INHIBITORS
The present application, among other things, provides compounds that are capable of inhibiting the activity of anti-apoptotic Bcl-2 family proteins, for...
Amine Mining Collectors
A family of amine mining collectors that uses alkoxylates allows for the easy adjustment of solubility and molecular weight useful because anionic and cationic...
ALKYL PHENYL SULFIDE DERIVATIVE AND PEST CONTROL AGENT
An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the...
Zinc or Copper (II) Salt and Use Thereof as a Biocide
There is provided as a biocide zinc or copper (II) salt having the general formula CH.sub.2.dbd.C(R.sup.1)COO-M-OCOC.sub.6H.sub.3R.sup.2R.sup.4, wherein M ...
The present invention relates to novel compounds of polyfunctionalized polyethylene and polypropylene glycols, their synthesis and their use, in particular as...
PROCESS FOR PREPARING 4[[(BENZOYL)AMINO]SULPHONYL]BENZOYL CHLORIDES AND
PREPARATION OF ACYLSULPHAMOYLBENZAMIDES
Process for preparing 4-[[(benzoyl)amino]sulphonyl]benzoyl chlorides of the formula (II). ##STR00001##
Improvements in or Relating to Organic Compounds
A stock solution comprising a compound of formula (I) ##STR00001## Wherein R.sub.1 together with the carbonyl group to which it is attached is a residue of a...