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Patent # Description
2016/0222392 METHODS TO IMPROVE VECTOR EXPRESSION AND GENETIC STABILITY
The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen...
2016/0222391 COMPOSITIONS AND METHODS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS
Methods for modulating expression of SMN1 and/or SMN2 in cells obtained from subjects having ALS or in subjects having ALS using single stranded ...
2016/0222390 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS
The present invention relates to a method and compositions for the treatment of cystic fibrosis.
2016/0222389 MODULATORS OF COMPLEMENT FACTOR B
The present embodiments provide methods, compounds, and compositions for treating, preventing, or ameliorating a disease associated with dysregulation of the...
2016/0222388 CHEMICAL INHIBITION OF FERROCHELATASE AS AN ANTIANGIOGENIC THERAPY
Methods for treating angiogenesis-mediated diseases are disclosed. More particularly, the present disclosure relates to methods of inhibiting ferrochelatase as...
2016/0222387 ANTI-TUMOR THERAPY
Panels, compositions, and methods for treating cancer in a subject in need thereof are disclosed involving one or more genes the suppression of which renders...
2016/0222386 NUCLEIC ACID MOLECULE FOR INHIBITING ACTIVITY OF RNAI MOLECULE
The purpose of the present invention is to develop and provide a nucleic acid molecule that can specifically and efficiently inhibit the activity of a target...
2016/0222385 COMPOSITIONS AND METHODS RELATED TO MIRNA MODULATION OF NEOVASCULARIZATION OR ANGIOGENESIS
The present invention concerns methods and compositions for diagnosing and/or treating vascular diseases including cancer, cardiac diseases, vascular diseases...
2016/0222384 Compositions for Targeted Delivery of siRNA
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi...
2016/0222383 ANTISENSE COMPOSITIONS AND METHODS OF MAKING AND USING SAME
The present invention provides pharmaceutical formulations for oral administration of antisense oligonucleotides, such as antisense oligonucleotides against...
2016/0222382 GENE EXPRESSION AND PAIN
The present invention relates to double-stranded oligonucleotides, pharmaceutical compositions thereof, and use of such double-stranded oligonucleotides and...
2016/0222381 SINGLE-STRANDED RNAI AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER
Single-stranded RNA molecules comprise one or more internal, non-nucleotide spacers, covalently linked with nucleotide portions of the molecule are provided....
2016/0222380 METHOD OF PREPARING NUCLEIC ACID MOLECULES
Disclosed is a method of preparing nucleic acid molecules, including: providing a pool of oligonucleotides, each containing restriction enzyme digestion...
2016/0222379 USE OF MULTIPLE RECOMBINATION SITES WITH UNIQUE SPECIFICITY IN COMBINATIONAL CLONING
The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites with...
2016/0222378 DIGITAL COUNTING OF INDIVIDUAL MOLECULES BY STOCHASTIC ATTACHMENT OF DIVERSE LABELS
Compositions, methods and kits are disclosed for high-sensitivity single molecule digital counting by the stochastic labeling of a collection of identical...
2016/0222377 METHOD FOR GENERATING ULTRA HIGH AFFINITY PEPTIDE LIGANDS
The present disclosure describes a method enabling the engineering of ligands with sub-nanomolar dissociation constants via a process of selection and...
2016/0222376 METHOD AND KIT FOR GENERATING HIGH AFFINITY BINDING AGENTS
A combined ribosome-display and phage-display method and kit for carrying out the method are provided. The method includes screening a ribosome-display library...
2016/0222375 METHOD, APPARATUS AND KIT FOR HUMAN IDENTIFICATION USING POLYMER FILTER MEANS FOR SEPARATION OF SPERM CELLS...
A method for processing forensic samples that include sperm cells from a perpetrator of sexual assault and epithelial cells that are primarily contributed by...
2016/0222374 METHODS FOR MODULATING THE ACTIVITY OF INSECTICIDAL PROTEINS
Compositions and methods for controlling pests are disclosed. In particular, methods for modulating the activity of Cry1Ba proteins against lepidopteran or...
2016/0222373 UNIVERSAL COLUMN
A universal column is provided which allows purification methods utilizing centrifugation, syringe coupling and/or use of a vacuum source. Methods for using...
2016/0222372 Enzyme/Protein Packaged Bacterial Vesicles for Therapeutic Delivery
A method of producing a protein includes providing a bacterial cell expressing both (a) a protein of interest fused to one of the SpyTag/SpyCatcher pair and...
2016/0222371 CARBONIC ANHYDRASE WITH STABILITY AT HIGH TEMPERATURE AND CAPTURRING AGENT FOR CARBON DIOXIDE COMPRISING THE SAME
The present invention relates to a carbonic anhydrase, a nucleic acid molecule encoding the carbonic anhydrase, a recombinant vector including the nucleic acid...
2016/0222370 Recombinant Yeast Host Cell With Fe-S Cluster Proteins And Methods Of Using Thereof
Yeast strains were engineered that have increased activity of heterologous proteins that require binding of an Fe--S cluster for their activity. The yeast...
2016/0222369 Human Cystathionine Beta-Synthase Variants and Methods of Production Thereof
Human cystathionine .beta.-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine .beta.-synthase and variants...
2016/0222368 Compositions and Methods Comprising LG12-CLADE Protease Variants
The present invention provides serine protease enzymes produced from LG12-clade enzymes. In addition, the present invention provides compositions comprising...
2016/0222367 ENZYME COMPOSITION AND PROCESS OF PREPARATION THEREOF
The present disclosure provides an enzyme composition comprising CMCase, xylanase, acid phosphatase, amylase, phytase, .beta.-glucosidase, pectinase and...
2016/0222366 SOLUBILIZED ENZYME AND USES THEREOF
The present invention relates to mixtures comprising a polypeptide or a plurality of polypeptides having biomass-degrading activity that is solubilized from an...
2016/0222365 ALPHA-AMYLASE MUTANTS
The invention relates to a variant of a parent Termamyl-like .alpha.-amylase, which exhibits an alteration in at least one of the following properties relative...
2016/0222364 MODIFIED ZINC FINGER BINDING PROTEINS
Disclosed herein are compositions and method comprising non-canonical (e.g., non-C2H2) zinc finger proteins.
2016/0222363 POLYMERASE VARIANTS
Described herein is a variant pol6 polymerase having at least one mutation selected from H223, N224, Y225, H227, I295, Y342, T343, I357, S360, L361, I363,...
2016/0222362 Target-Specific Double-Mutant Fusion Protein and Preparation Process Therefor
Disclosed are a fusion protein of a human gonadotrophin-releasing hormone mutant (mGnRH) and a pseudomonas aeruginosa exotoxin A mutant (PE38m4a), and a...
2016/0222361 MYRMECIA INCISA REISIGL DIACYLGLYCEROL ACYLTRANSFERASE GENE SEQUENCE AND USE THEREOF
Disclosed are an amino acid sequence of myrmecia incise reisigl diacylgycerol acyltransferase, an encoding gene sequence and application thereof. Specifically,...
2016/0222360 NOVEL HYDROXYPHENYLPYRUVATE DIOXYGENASE POLYPEPTIDES AND METHODS OF USE
Novel hydroxyphenyl pyruvate dioxygenase (HPPD) polypeptides, variants and fragments thereof, as as well as polynucleotides encoding the same, capable of...
2016/0222359 Modified Leucine Dehydrogenase
The present invention provides a means and method useful for measurement of a total branched-chain amino acid concentration. Specifically, the present...
2016/0222358 PLANTS WITH INCREASED GROWTH OVER EXPRESSING A MITOCHONDRIAL GLYCINE DECARBOXYLASE COMPLEX SUBUNIT
The present invention relates to the field of plant molecular biology and concerns methods for enhancing photorespiration, photosynthesis, growth or yield in...
2016/0222357 Purification method for Embryo - derived Infectious Bronchitis Virus (lBV)
The invention discloses an avian infectious bronchitis virus purification method. The method uses ordinary avian embryo which was affected by avian bronchitis...
2016/0222356 High Titer Recombinant AAV Vector Production in Adherent and Suspension Cells
Disclosed are an in vitro method of producing a recombinant AAV virion in a mammalian host cell that comprises a functional adenoviral E1A gene (e.g., a HEK...
2016/0222355 SYSTEMS AND METHODS FOR PRODUCING STEM CELLS DIFFERENTIATED CELLS, AND GENETICALLY EDITED CELLS
The present invention provides systems and methods for obtaining, generating, culturing, and handling cells, such as stem cells (including induced pluripotent...
2016/0222354 Medium for culturing the Marc-145 cell and the preparation method thereof
The present invention relates to a medium for culturing the M-arc-145 cell, which consists of the following components: the Dulbecco Modified Eagle Medium...
2016/0222353 METHOD FOR CULTURING MESENCHYMAL STEM CELLS ACCORDING TO CELL SIZE
A method for culturing mesenchymal stem cells. The method includes isolating mesenchymal stem cells having a size of 8 .mu.m or less and culturing the...
2016/0222352 USE OF CARDIOTROPHIN TO MODULATE STEM CELL PROLIFERATION
Methods of promoting stem cell proliferation by contacting the cells with cardiotrophin-1 (CT-1) are provided. The methods may further include contacting the...
2016/0222351 Method and Device for Activating Stem Cells
Invention embodiments described herein include methods and devices for stimulating mesenchymal stem cells in a stem cell source to differentiate into...
2016/0222350 Method For Enucleating Nucleated Erythrocyte, And Enucleation Inducer
Provided is a factor capable of inducing enucleation, which is a final stage of erythrocyte differentiation, within a short time. More particularly, provided...
2016/0222349 DIFFERENTIATION OF RPE PROGENITORS INTO NEURON-LIKE CELLS
A method of permanently culturing RPE cells under hypoxia, and differentiating the RPE cells into neuronal like cells.
2016/0222348 HUMAN IPSC-DERIVED VASCULAR-RELATED AND HEMATOPOETIC CELLS FOR THERAPIES AND TOXICOLOGY/DRUG SCREENINGS
Described herein are cells, cell culture methods, and cell culture media compositions useful for producing and maintaining iPSC-derived cell lines that are of...
2016/0222347 METHOD FOR INDUCING DIFFERENTIATION OF INDUCED PLURIPOTENT STEM CELLS AND METHOD FOR SELECTING THE SAME
It is an object of the present invention to provide a method for highly efficiently inducing differentiation of iPS cells into cells having functions of...
2016/0222346 METHODS AND COMPOSITIONS FOR FEEDER-FREE PLURIPOTENT STEM CELL MEDIA CONTAINING HUMAN SERUM
The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention...
2016/0222345 Biomimetic Cell Culture Substrates
Embodiments of the presently disclosed subject matter provide biomimetic cell culture substrates comprising highly tunable patterned polymer nanofiber matrices...
2016/0222344 A CHEMICALLY DEFINED MEDIUM FOR THE INDUSTRIAL SCALE CULTURE OF A SPECIES OF BORDETELLA
Chemically defined media for the industrial-scale culture of Bordetella species.
2016/0222343 Compositions Containing Amino Acids, Phosphate and Manganese and Their Uses
The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the...
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