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Patent # Description
2016/0222142 Polypropylene for Reduced Plate Out in Polymer Article Production Processes
Polymer articles and processes of forming polymer articles are described herein. The processes generally include providing a propylene based polymer formed...
2016/0222141 Silica-Coated Alumina Activator-Supports For Metallocene Catalyst Compositions
Silica-coated alumina activator-supports, and catalyst compositions containing these activator-supports, are disclosed. Methods also are provided for preparing...
2016/0222140 POLYMERIZABLE MIXTURES CONTAINING IONIC GEMINI SURFACTANTS; AND LYOTROPIC LIQUID CRYSTALS, POLYMERS, AND...
Disclosed are polymerizable mixtures comprising a functionalized ionic gemini surfactant and a thiol-ene crosslinking agent. The polymerizable mixtures that...
2016/0222139 METHOD OF PREPARING POLYOLEFIN, AND POLYOLEFIN PREPARED THEREBY (As Amended)
A method of preparing a polyolefin, wherein the method is used to more effectively prepare a polyolefin which has a high molecular weight and multimodal...
2016/0222138 Low Vinyl Bond Modified Elastomeric Copolymers
The present invention relates to a modified elastomeric polymer obtained by reacting a living anionic elastomeric polymer and specific chain end modifying...
2016/0222137 COMPOSITIONS AND METHOD FOR ANTI-SICKLING OF RED BLOOD CELLS IN SICKLE CELL DISEASE
A nano-composition that includes nanoparticles, a method of forming the nano-composition, and a method of using the composition. The nanoparticles include a...
2016/0222136 A Method for Fractionating Dextrin
A method for fractionating dextrin, belonging to the technical field of food processing. In principle, the method for fractionating dextrin of the present...
2016/0222135 SYSTEM FOR AND METHOD OF SEPARATING PURE STARCH FROM GRAINS FOR ALCOHOL PRODUCTION USING A DRY MILL PROCESS
Methods of and systems for recovering starch before fermentation in a dry mill process and/or a wet mill process. The starch is able to be further purified....
2016/0222134 METHOD FOR PRODUCING HYDROGELS COUPLING HIGH ELASTIC MODULUS AND ABSORBANCE
The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated...
2016/0222133 A PROCESS FOR RECOVERING AN ESTERIFIED CELLULOSE ETHER FROM A REACTION PRODUCT MIXTURE
A process for recovering an esterified cellulose ether from a reaction product mixture obtained from a reaction of (a) a cellulose ether with (b) an aliphatic...
2016/0222132 CONSTANT CHAIN MODIFIED BISPECIFIC, PENTA- AND HEXAVALENT IG-M ANTIBODIES
The present invention concerns binding molecules having a penta- or hexameric ring structure, such as for example, isolated IgM antibodies with five or six...
2016/0222131 ATRX AS A COMPANION DIAGNOSTIC FOR CDK4 INHIBITORS
The present invention relates to the use of one or more biomarkers to evaluate the likelihood that a CDK4 inhibitor would produce an anti-cancer effect in a...
2016/0222130 NOVEL ANTI-HUMAN TIE-2 ANTIBODY
Provided is an anti-human Tie2 antibody for preventing or treating diabetic macular edema, diabetic retinopathy, and critical limb ischemia by binding to a...
2016/0222129 MULTI-SPECIFIC ANTIGEN-BINDING MOLECULE HAVING ALTERNATIVE FUNCTION TO FUNCTION OF BLOOD COAGULATION FACTOR VIII
Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X...
2016/0222128 COMPOSITIONS AND METHODS FOR TREATING TUMORS, FIBROSIS, AND PULMONARY ALVEOLAR PROTEINOSIS
The present disclosure provides pharmaceutical compositions and methods useful for modulating angiogenesis and for inhibiting metastasis, tumors, pulmonary...
2016/0222127 Anti-CD38 Antibody and Lenalidomide or Bortezomib for the Treatment of Multipe Myeloma and NHL
The present disclosure describes a pharmaceutical combination of an anti-CD38 antibody and lenalidomide and a pharmaceutical combination of an anti-CD38...
2016/0222126 MATERIAL AND METHODS FOR TREATING OR PREVENTING HER-3 ASSOCIATED DISEASES
Described herein are materials and methods for treating subjects having a HER-3 associated disease, by administering a first agent that binds to HER-3, in...
2016/0222125 ANTIBODIES SPECIFIC FOR CLAUDIN 6 (CLDN6)
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6),...
2016/0222124 ANTI-CD40 ANTIBODIES
The present invention relates to new humanized antagonistic anti-CD40 antibodies and therapeutic and diagnostic methods and compositions for using the same.
2016/0222123 METHOD TREATING NEURONAL TISSUE INFLAMMATION USING AN IL-31RA MONOCLONAL ANTIBODY
Use of antagonists to IL-31Ra and OSMRb are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing...
2016/0222122 INTEGRIN-MODULATING THERAPIES FOR TREATING FIBROTIC DISEASE
A method of treating scleroderma and other fibrotic conditions is disclosed. The method includes the step of administering to a subject having a fibrotic...
2016/0222121 METHODS FOR TREATING HEMATOLOGIC CANCERS
The present invention relates to methods of treating hematologic cancers using a combination of inhibitors of PD-1 or PD-L1 and TIM-3, LAG-3 or CTLA-4. In one...
2016/0222120 Anti-B7-H1 Antibodies for Treating Tumors
Provided herein are methods of treating B7-H1-expressing tumors comprising administering an effective amount of MEDI4736 or an antigen-binding fragment thereof.
2016/0222119 ISOLATED B7-H4 SPECIFIC COMPOSITIONS AND METHODS OF USE THEREOF
The present invention relates to B7-H4-specific compositions and methods of use thereof.
2016/0222118 BIOMARKERS AND METHODS OF TREATING PD-1 AND PD-L1 RELATED CONDITIONS
Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-1/PD-L1 pathway antagonists. In particular,...
2016/0222117 NUCLEIC ACID ENCODING ANTI-PD-L1 ANTIBODIES
The present application relates to nucleic acid encoding anti-PD-L1 antibodies, which have therapeutic use to enhance T-cell function to upregulate...
2016/0222116 COMBINATION OF ANTI-LAG-3 ANTIBODIES AND ANTI-PD-1 ANTIBODIES TO TREAT TUMORS
Provided are methods for clinical treatment of tumors (e.g., advanced solid tumors) using an anti-LAG-3 antibody in combination with an anti-PD-1 antibody.
2016/0222115 MONOVALENT ANTIBODY FRAGMENTS USEFUL AS THERAPEUTICS
The invention provides methods and compositions comprising a novel stabilized monovalent antibody fragment.
2016/0222114 FULLY HUMAN ANTIBODIES TO BTLA
The present invention relates to binding compounds specific for BTLA and uses thereof. More specifically, the invention relates to fully human antibodies that...
2016/0222113 Antibodies Against PD-1 and Uses Thereof
The present invention provides antibodies and antigen-binding fragments that specifically bind PD-1 (Programmed Death 1), thereby modulating immune responses...
2016/0222112 FC RECEPTOR BINDING PROTEINS
This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding...
2016/0222111 FC RECEPTOR BINDING PROTEINS
This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding...
2016/0222110 FC RECEPTOR BINDING PROTEINS
This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding...
2016/0222109 FC RECEPTOR BINDING PROTEINS
This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding...
2016/0222108 FC RECEPTOR BINDING PROTEINS
This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding...
2016/0222107 METHODS OF TREATING PAIN USING FUNCTION MODIFYING NAv1.7 ANTIBODIES
A Na.sub.v1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Na.sub.v1.7 antibody or binding...
2016/0222106 Anti-CD38 Antibodies for Treatment of Acute Myeloid Leukemia
The present invention relates to methods of treatment of acute myeloid leukemia with anti-CD38 antibodies.
2016/0222105 Bi-Specific Monovalent Diabodies That are Capable of Binding to gpA33 and CD3, and Uses Thereof
The present invention is directed to bi-specific monovalent diabodies that comprise two polypeptide chains and which possess at least one binding site specific...
2016/0222104 Anti-IL-6 Antibodies, Compositions, Methods and Uses
A pen-injector device comprising an anti-IL-6 antibody with a liquid formulation have applications in diagnostic and/or therapeutic compositions, methods and...
2016/0222103 USE OF AN IL-31 MONOCLONAL ANTIBODY FOR ANTAGONIZING SIGNAL TRANSDUCTION IN SPINAL CORD CELLS
Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in...
2016/0222102 METHODS OF TREATING INFLAMMATORY DISEASES
This invention generally relates to methods for the treatment of IL-23 related diseases, in particular inflammatory diseases, such as psoriasis, psoriatic...
2016/0222101 PROTEIN FORMULATIONS AND METHODS OF MAKING SAME
The invention provides an aqueous formulation comprising water and a protein, and methods of making the same. The aqueous formulation of the invention may be a...
2016/0222100 Method of Treating Glioma
Methods of treating glioma are provided. Aspects of the invention include administering a therapeutically-effective amount of an agent that inhibits the...
2016/0222099 Methods Of Treatment With Angiopoietin-2 Antibodies
The disclosure is directed to methods and uses of antibodies or antigen-binding fragments thereof against Angiopoietin-2 (Ang-2). Specifically, the disclosure...
2016/0222098 NUCLEOTIDE AND AMINO ACID SEQUENCES RELATING TO RESPIRATORY DISEASES AND OBESITY
This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also...
2016/0222097 PREVENTION OF TISSUE ISCHEMIA AND RELATED METHODS
Provided herein are compositions for preventing, ameliorating, and/or reducing tissue ischemia and/or tissue damage due to ischemia, increasing blood vessel...
2016/0222096 GRAM-POSITIVE BACTERIA SPECIFIC BINDING COMPOUNDS
The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully...
2016/0222095 METHOD OF ADMINISTRATING IgC COMPOSITIONS TO PROVIDE SUSTAINED LEVELS OF AMINO ACIDS
The present invention provides methods for providing peak plasma amino acid concentrations through administration of an oral dose of at least 20 g of...
2016/0222094 Inducible Eukaryotic Expression System
Compositions and methods for the inducible expression of genes in eukaryotic cells are provided. Expression of a nucleotide sequence of interest encoding a...
2016/0222093 NON-HUMAN MAMMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES
The invention provides knock-in non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing knock-in cells and mammals....
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