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Patent # Description
2016/0222042 NOVEL PHOSPHINES, SYNTHESIS THEREOF AND THEIR USE IN CATALYSIS
The present invention relates to a novel class of benzimidazolyl/imidazolyl phosphine ligands, methods of preparing such ligands via a simple one-pot protocol,...
2016/0222041 BIARYL LIGANDS
Embodiments of the present disclosure provide for biaryl ligands (also referred to herein as "biaryl compound"), biaryl complexes, methods of making biaryl...
2016/0222040 PROCESS FOR STABILIZING HYDROCYANATION CATALYST
The invention provides a method of forming a phosphonate diester compound from a ligand hydrolysis product (LHP) of a phosphite ligand used in a ...
2016/0222039 SPINTRONIC MATERIALS AND SPINTRONIC DEVICES INCLUDING THE SPINTRONIC MATERIALS
The invention relates to spintronic materials, and in particular, to spintronic materials comprised of halide perovskite compounds. In various embodiments, the...
2016/0222038 NOVEL, EASILY SYNTHESIZABLE, SPONTANEOUSLY WATER-SOLUBLE, ESSENTIALLY VOC-FREE, ENVIRONMENTALLY FRIENDLY...
The invention relates to a composition and to a process for producing the composition comprising essentially water-soluble (meth)acrylamido-functional...
2016/0222037 USE OF CYCLOHEXA-2,5-DIEN-1-YL-SILANES AS PRECURSORS FOR GASEOUS HYDROSILANES
A method of making hydrosilanes having a formula R.sup.1R.sup.2R.sup.3SiH by reacting a compound having formula I: ##STR00001## in solution using a strong Lewis...
2016/0222036 TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES AND METHODS OF USE THEREOF
A method of imaging a region in a subject includes administering to the subject a complex of a metal chelated to a compound, and obtaining an image of the...
2016/0222035 PRECISE THREE-DIMENSIONAL SUPRAMACROMOLECULE INTERCONVERSIONS
A process is provided for precise self-assembly and re-arrangement of a three-dimensional terpyridine-based coordination complex. A plurality of ...
2016/0222034 HEPATITIS C VIRUS INHIBITORS
The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: ##STR00001## which inhibit...
2016/0222033 THIAZOLOPYRIMIDINONES AND METHODS OF USE THEREOF
The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using...
2016/0222032 C5-SPIRO IMINOTHIAZINE DIOXIDES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
In its many embodiments, the present invention provides certain C5-spiro iminothiadiazine dioxide compounds, including compounds Formula (I): or a tautomers...
2016/0222031 EPIDITHIODIOXOPIPERAZINE COMPOUND OR ITS DERIVATIVES, AND THE USE THEREOF
The present invention relates to an epidithiodioxopiperazine derivative represented by the following Chemical Formula 1 or its reduced derivative; a method for...
2016/0222030 Cyclopentylbenzamide Derivatives and their Use for the Treatment of Psychotic and Cognitive Disorders
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein n, L, X, R.sup.a, R.sup.b, R.sup.1, R.sup.2 and...
2016/0222029 A PROCESS FOR THE PREPARATION OF INTERMEDIATE FOR THE PREPARATION OF OSELTAMIVIR PHOSPHATE
The present invention discloses an economic, simple, azide and aziridine complexity free process for the synthesis of osletamivir phosphate (Tamiflu) by...
2016/0222028 3-ALKYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an...
2016/0222027 POLYMORPHS OF 2-(4-(2-(1-ISOPROPYL-3-METHYL-1H-1,2,4-TRIAZOL-5-YL)-5,6-DIHYDROBENZO[F]I- ...
The present invention relates to crystalline polymorphs of (2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]- ...
2016/0222026 Dibenzo[B,F][1,4]oxazepin-11-yl-N-Hydroxybenzamides as HDAC Inhibitors
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) ...
2016/0222025 SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH
The present invention relates to compounds which are inhibitors of non-apoptotic regulated cell death, and to pharmaceutical compositions containing such...
2016/0222024 S-ENANTIOMER OF TETRACYCLIC INDOLE DERIVATIVE AS PBR LIGANDS
The present invention concerns in vivo imaging and in particular in vivo imaging of translocator protein (TSPO, formerly known as the peripheral benzodiazepine...
2016/0222023 NOVEL MONOTHIOL MUCOLYTIC AGENTS
Provided are mucolytic agents represented by formula (Ia)-(Id): ##STR00001## where the structural variables R.sub.1, R.sub.2, R.sub.5 and R.sub.6 are as defined...
2016/0222022 3-ARYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an...
2016/0222021 ARYL ETHER-BASE KINASE INHIBITORS
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and...
2016/0222020 NOVEL TRICYCLIC COMPOUNDS
The invention provides compounds of Formula (I) and Formula (II) ##STR00001## pharmaceutically acceptable salts, pro-drugs, biologically active metabolites,...
2016/0222019 QUINAZOLIN-4 (3H)- ONE DERIVATIVES USED AS P13 KINASE INHIBITORS
The present invention relates to the compound of formula (I) ##STR00001## and to compositions comprising the same and to the use of the compound and to...
2016/0222018 SYNTHESIS OF IMIDAZO[1,2-a]PYRAZIN-4-IUM SALTS FOR THE SYNTHESIS OF 1,4,7-TRIAZACYCLONONANE (TACN) AND N-...
A compound with formula (V') ##STR00001## the synthesis method for compound (V'), and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N- and/or...
2016/0222017 PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS
Pyrimido[4,5-b]indole derivatives are provided. These compounds are useful to expand hematopoietic stem cell populations, particularly, human hematopoietic...
2016/0222016 HETEROCYCLIC COMPOUNDS AND USES THEREOF
Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods...
2016/0222015 TRICYCLIC GYRASE INHIBITORS
Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as...
2016/0222014 COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS
The present application provides novel optionally substituted fused pyridine and pyrimidine bicyclic compounds and pharmaceutically acceptable salts thereof....
2016/0222013 NOVEL BENZODIAZEPINE DERIVATIVES
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and...
2016/0222012 Heterocyclic compounds as inhibitors of class I PI3KS
The present application discloses a novel class of heterocycles as class I PI3Ks inhibitors. The compounds claimed herein could be used alone or in combination...
2016/0222011 COMT Inhibiting Methods and Compositions
The present inventions include a method of inhibiting COMT enzyme in a subject as well as compounds of formula I, or a pharmaceutically acceptable salt...
2016/0222010 4-AMINO-IMIDAZOQUINOLINE COMPOUNDS
This invention relates to novel 4-amino-imidazoquinoline compounds of the formula ##STR00001## wherein R.sup.1 to R.sup.4 are as defined in the ...
2016/0222009 INHIBITOR COMPOUNDS
The present invention relates to compounds of formula I ##STR00001## wherein R.sub.1, R.sub.4, Ar, W, X and Z are all as defined herein. The compounds of the...
2016/0222008 FORMULATIONS PHARMACOKINETICS OF DEUTERATED BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2
The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2...
2016/0222007 Novel Cyclopropabenzofuranyl Pyridopyrazinediones
Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I ##STR00001## wherein X,...
2016/0222006 3-(4-Ethylnylphenyl) Pyridopyrimidinone Compounds and Process for Preparation Thereof Useful As Potential...
The present invention provides 3-(4-ethynylphenyl)pyridopyrimidinone compounds of formula A as potential anticancer agents. ...
2016/0222005 2-(HETERO)ARYL-BENZIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES AS INHIBITORS OF ASPARAGIME EMETHYL TRANSFERASE
Substituted benzimidazole and 3H-imidazo[4,5-b]pyridines or formula I: where X and Y respectively are selected from: (i) N and N; and (ii) N and CR.sup.4;...
2016/0222004 THIAZOLE AND OXAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS
Compounds of the formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein, R.sup.1 is a group of formula A or formula B, ##STR00002## ...
2016/0222003 Novel Phtalazinone Derivatives and Manufacturing Process Thereof
The present invention relates to phthalazinone derivatives, including pharmaceutical compositions and for the preparation of phthalazinone derivatives. And...
2016/0222002 TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF
The disclosure relates to Compounds of Formula (I) ##STR00001## and pharmaceutically acceptable derivatives thereof, where R.sub.1, R.sub.4, R.sub.8, R.sub.9,...
2016/0222001 COMT Inhibiting Methods and Compositions
The present inventions include a method of inhibiting COMT enzyme in a subject as well as compounds of formula I, or a pharmaceutically acceptable salt...
2016/0222000 VINYL AUTOTAXIN INHIBITOR COMPOUNDS
Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such...
2016/0221999 COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC DISORDERS
The present invention relates to treatment and/or prevention of one or more metabolic disorders utilizing fatostatin A and/or a derivative and/or analog...
2016/0221998 HETEROCYCLIC AMIDE COMPOUND AND HERBICIDE
Provided are: a heterocyclic amide compound represented by formula (1); and a herbicide containing the heterocyclic amide compound. In the formula, G...
2016/0221997 BICYCLIC [4,6,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with...
2016/0221996 PROCESS FOR THE SYNTHESIS OF AN INDOLEAMINE 2,3-DIOXYGENASE INHIBITOR
The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl- ...
2016/0221995 SOLID FORMS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)CYCLOPROPANECARBOXAMIDO)-3-- ...
The present invention relates to a substantially crystalline and free solid state form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) ...
2016/0221994 Substituted 2,3-Dihydrobenzofuranyl Compounds And Uses Thereof
The invention generally relates to substituted 2,3-dihydrobenzofuranyl compounds, and more particularly to a compound represented by Structural Formula (I), or...
2016/0221993 DEOXYNOJIRIMYCIN DERIVATIVES AND METHODS OF THEIR USING
The present application provide novel iminosugars and their use in treatment of viral infections, such as Dengue infection and Influenza A infection. The...
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