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Patent # Description
2016/0220692 TARGETING THE M2-TUMOR ASSOCIATED MACROPHAGE FOR CANCER THERAPY
The present invention features methods of directly targeting specific cell surface receptors on the M2 macrophage for antibody or nanoparticle directed therapy.
2016/0220691 NOVEL SELF-ASSEMBLING DRUG AMPHIPHILES AND METHODS FOR SYNTHESIS AND USE
The present invention provides herein the design of monodisperse, amphiphilic anticancer drugs--which are now termed "drug amphiphiles" (DAs)--that can...
2016/0220690 ADVERSE SIDE-EFFECTS ASSOCIATED WITH ADMINISTRATION OF AN ANTI-HYALURONAN AGENT AND METHODS FOR AMELIORATING OR...
Provided herein are methods for ameliorating an adverse effect of systemic administration of a PEG hyaluronan degrading enzyme to a subject. The methods...
2016/0220689 MACROMOLECULES OF DENDRIMER-PLATINUM CONJUGATES
A macromolecule comprising a dendrimer having surface amino groups to which at least one platinum-containing moiety is attached is provided. The macromolecule...
2016/0220688 SYNTHESIS OF NOVEL ASYMMETRIC BOW-TIE PAMAM DENDRIMER-BASED CONJUGATES FOR TUMOR-TARGETING DRUG DELIVERY
The present disclosure relates to a dendrimer-based conjugate of the formula V.sub.m-D-C-D'-(T-F).sub.n, which is useful for tumor targeting drug delivery. The...
2016/0220687 METALLOPROTEINASE-CLEAVABLE ALPHA-AMANITIN-DENDRIMER CONJUGATES AND METHOD OF TREATING CANCER
A conjugate comprising a dendritic polymer or other scaffold, a metalloproteinase-cleavable linker and alpha-amanitin. Methods of using this conjugate for safe...
2016/0220686 REFILLABLE DRUG DELIVERY DEVICES AND METHODS OF USE THEREOF
The present invention provides refillable drug delivery systems, as well as methods of refilling the systems, and methods of using them to treat diseases.
2016/0220685 THERMOSENSITIVE HYALURONIC ACID CONJUGATES AND METHODS FOR THE PREPARATION THEREOF
The present invention provides for a method for preparing a thermosensitive hyaluronic acid conjugate comprising the steps of contacting, in any order, a. a...
2016/0220684 COMPOSITION AND METHOD FOR RELIEVING PAIN AND INFLAMMATION, TREATMENT OF ERECTILE DYSFUNCTION, AND TREATMENT OF...
Transdermal compositions including chitosan, glycated chitosan, or a combination thereof are provided for use in treatment methods wherein the compositions are...
2016/0220683 SEMI-SOLID DELIVERY SYSTEMS
The invention provides semi-solid systems for delivering biologically active materials that include a polymer comprising 1) one or more polycaprolactone (PCL)...
2016/0220682 NOVEL SUSTAINED RELEASE POLYMER
A polymer and a method for its preparation are provided. The polymer comprises poly(lactide), poly(lactide/glycolide) or poly(lactic acid/glycolic acid)...
2016/0220681 LIPOCATIONIC POLYMERS AND USES THEREOF
Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a...
2016/0220680 AQUEOUS SOLUTION FORMULATION AND METHOD FOR MANUFACTURING SAME
An aqueous solution formulation containing Compound (I) can be manufactured by performing a first step of preparing a dissolution liquid obtained by dissolving...
2016/0220679 COMPOSITIONS COMPRISING LECITHIN OILS AND NSAIDS FOR PROTECTING THE GASTROINTESTINAL TRACT AND PROVIDING...
A novel pharmaceutical composition is provided by which nonsteroidal anti-inflammatory drugs (NSAIDs) are added directly to phospholipid-containing oil such as...
2016/0220678 PHARMACEUTICAL FORMULATIONS CONTAINING LIPOIC ACID DERIVATIVES
Pharmaceutical formulations containing lipoic acid derivatives and ion pairs thereof are described. The pharmaceutical formulations are useful in the treatment...
2016/0220677 STABLE AQUEOUS COMPOSITIONS OF PROSTGLANDIN AGONIST PRODRUGS AND METHODS FOR USE THEREOF
The present invention is based on the discovery that a marked increase in aqueous stability (and thereby shelf life) of prostanoid agonist prodrug compositions...
2016/0220676 VASOPRESSIN FORMULATIONS FOR USE IN TREATMENT OF HYPOTENSION
Provided herein are peptide formulations comprising polymers as stabilizing agents. The peptide formulations can be more stable for prolonged periods of time...
2016/0220675 HYPERTONIC ANTIMICROBIAL THERAPEUTIC COMPOSITIONS
Therapeutic compositions, primarily for topical application, and methods of making and using the composition. Pharmaceutical compositions formulated for...
2016/0220674 METHOD OF TREATING ONYCHOMYCOSIS
This application is directed to a method of treating onychomycosis by applying a phototherapeutic agent to a nail structure, waiting for a period of at least...
2016/0220673 LIGHT-ACTIVATABLE POLYMERIC NANOPARTICLES
The present subject matter relates to light-activatable polymeric nanoparticles (NPs) for the transportation and release of an active substance, methods for...
2016/0220672 Sonogenic Stimulation of Cells
The invention provides compositions featuring TRP-4 polypeptides and polynucleotides, methods for expressing such polypeptides and polynucleotides in a cell...
2016/0220671 Method Of Administration To A Patient Suffering From Disturbances In Vascular Tone
The method of treatment for diseases accompanied by disturbances of the vascular tone utilizes the use of ultra low doses of antibodies to a protein or a...
2016/0220670 BOOSTING THE EFFICACY OF DNA-BASED VACCINES WITH NON-THERMAL DBD PLASMA
The efficacy of a DNA-based vaccine in terms of eliciting a desired immune response is enhanced by directing a non-thermal plasma generated by a non-thermal...
2016/0220669 COMBINATION THERAPY OF ANTIBODIES AGAINST HUMAN CSF-1R AND TLR9 AGONIST
The present invention relates to the combination therapy of antibodies against human CSF-1R with a TLR9 agonist.
2016/0220668 Continuous Cell Programming Devices
The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate...
2016/0220667 CONTINUOUS CELL PROGRAMMING DEVICES
The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate...
2016/0220666 COMPOSITIONS OF VACCINES AND ADJUVANTS AND METHODS FOR THE TREATMENT OF URINARY TRACT INFECTIONS
This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about...
2016/0220665 TARGETING MOIETY PEPTIDE EPITOPE COMPLEXES HAVING A PLURALITY OF T-CELL EPITOPES
A variety of targeting moiety peptide epitope complexes (TPECs) are described in different embodiments. In each of the embodiments, however, a targeting moiety...
2016/0220664 ANTIGEN AND METHOD FOR PRODUCTION THEREOF
The invention refers to a method for producing an antigen comprising at least one hydrophobic or partially hydrophobic antigen molecule from a virus, a...
2016/0220663 HIV-1 VACCINE
A method for inducing an immune response against HIV in a subject includes the step of preparing an HIV-1 gp120 envelope protein coding sequence particle...
2016/0220662 IMMUNOGENIC FORMULATION CONTAINING RECOMBINANT LIVE BCG THAT EXPRESS ANTIGENS OF METAPNEUMOVIRUS (HMPV), IN A...
The present invention relates to an immunogenic formulation to be used in mammals against human Metapneumovirus (hMPV), consisting of a lyophilisate of...
2016/0220661 Broad Spectrum Influenza A Neutralizing Vaccines and D-Peptidic Compounds, and Methods for Making and Using the...
GB1 peptidic compounds that specifically bind to a hemagglutinin target protein, and libraries that include the same, as well as methods of making and using...
2016/0220660 Flagellin Fusion Proteins
Methods of making a protein that stimulates a protective immune response in a subject include separating a portion of a protein from a naturally occurring...
2016/0220659 FMDV RECOMBINANT VACCINES AND USES THEREOF
The present invention encompasses FMDV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FMDV antigens. The...
2016/0220658 PCV2B DIVERGENT VACCINE COMPOSITION AND METHODS OF USE
This invention provides a vaccine composition for protecting pigs against PCV2, including a highly virulent porcine circovirus type 2b (PCV2b) divergent...
2016/0220657 RECOMBINANT MAREK'S DISEASE VIRUSES AND USES THEREOF
The present invention relates recombinant viruses and the uses thereof. More particularly, the invention relates to novel recombinant Marek's disease viruses...
2016/0220656 Mycobacterium Antigenic Composition
Immunogenic compositions comprising an Rv1196 related antigen, wherein the conductivity of the composition is 13 mS/cm or lower, or the concentration of salts...
2016/0220655 Use of the Salmonella SPP Type III Secretion Proteins as a Protective Vaccination
Antigenic molecules and compositions described herein protect against infection by typhoidal and non-typhoidal Salmonella serovars. Methods of immunization...
2016/0220654 Vaccine
A mutant of an E coli heat-stable toxin (ST) having the following wild-type sequence: NSSNYCCELCCNPACTGCY wherein the mutant comprises a mutation selected from...
2016/0220653 LYME DISEASE VACCINES
The present invention relates to Lyme disease vaccines, in particular to vaccines including one or more isolated polypeptides of Borrelia burgdorferi ss,...
2016/0220652 METHODS OF USING RECOMBINANT LISTERIA VACCINE STRAINS IN DISEASE IMMUNOTHERAPY
The present disclosure provides methods of treating, protecting against, enhancing and inducing an immune response against a tumor or cancer, comprising the...
2016/0220651 IMMUNOGENIC TUMOR ASSOCIATED STROMAL CELL ANTIGEN PEPTIDES AND METHODS OF THEIR USE
Immunogenic peptides from tumor associated stromal cell antigens, including combinations of such peptides, are disclosed herein. In some examples the peptides...
2016/0220650 CYTOMEGALOVIRUS-BASED IMMUNOGENIC PREPARATIONS
Methods of using recombinant replication-deficient cytomegalovirus (CMV) to generate a long-term, repeatedly stimulated immune response in a subject, for...
2016/0220649 COMBINATIONS OF AGGREGATING PROTEINS AND MOLECULAR CHAPERONE PROTEINS FOR THE TREATMENT OF PROTEINOPATHIES OR...
HSPs (chaperones or heat-shock proteins) have two very valuable characteristics that can be productively exploited in a specific manner in order to...
2016/0220648 PHARMACEUTICAL COMPOSITIONS AND METHODS TO VACCINATE AGAINST DISSEMINATED CANDIDIASIS AND OTHER INFECTIOUS AGENTS
The invention provides a vaccine including an isolated Als protein family member having cell adhesion activity, or an immunogenic fragment thereof, with an...
2016/0220647 PROTEINS FOR TARGETING NEURONAL NITRIC OXIDE SYNTHASE TO MUSCLE SARCOLEMMA AND RELATED METHODS OF USE
It is demonstrated herein that nNOS-.mu. is an important modulator of muscle function, and that the loss of nNOS-.mu. contributes to pathogenesis in...
2016/0220646 METHODS FOR INHIBITING TUMOR GROWTH
Methods of inhibiting or reducing tumor metabolism and growth are disclosed. A composition containing oxygen scavenging membrane fragments is administered...
2016/0220645 COMPOSITION FOR TISSUE/CELL REPAIR
The composition for tissue/cell repair facilitates healing of damaged tissues, promoting tissue and cell growth, protecting cells and tissues, and reducing...
2016/0220644 METHOD OF TREATING HAEMOPHILIA BY INDUCING TOLERANCE TO BLOOD FACTORS
The present invention relates to the treatment of haemophilia. More specifically, the invention relates to a new method of inducing an immune tolerance against...
2016/0220643 EXENDIN-4 DERIVATIVES AS DUAL GLP1/GLUCAGON AGONISTS
The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including...
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