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Patent # Description
2016/0229889 METHODS OF PRODUCING ANAMORELIN HYDROCHLORIDE HAVING CONTROLLED CHLORIDE CONTENT
The present invention relates to particulate forms of anamorelin monohydrochloride or a composition comprising anamorelin monohydrochloride having controlled...
2016/0229888 N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF
N-Substituted indenoisoquinoline compounds, and pharmaceutical formulations of N-substituted indenoisoquinoline compounds are described. Also described are...
2016/0229887 NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein -------, R.sup.1, R.sup.2, R.sup.5, A and...
2016/0229886 BILE ACID ANALOGS AS FXR/TGR5 AGONISTS AND METHODS OF USE THEREOF
The present invention provides compounds of Formula I: ##STR00001## pharmaceutical compositions comprising these compounds and methods of using these compounds...
2016/0229885 PROCESS FOR THE PREPARATION OF ESTETROL
The invention relates to a process for obtaining Estetrol or a salt or solvate thereof, the process comprising: a) reacting a compound of formula (IV) or a...
2016/0229884 METHODS AND DEVICES FOR DE NOVO OLIGONUCLEIC ACID ASSEMBLY
Methods and devices are provided herein for surfaces for de novo nucleic acid synthesis which provide for low error rates. In addition, methods and devices are...
2016/0229883 POTENT LNA OLIGONUCLEOTIDES FOR THE INHIBITION OF HIF-1A EXPRESSION
The present disclosure relates to an LNA oligonucleotide consisting of a sequence selected from the group consisting of ...
2016/0229882 NON-ENZYMATIC, SALT-MEDIATED SYNTHESIS OF POLYNUCLEIC ACIDS
Provided herein is a method for synthesizing polynucleic acids, comprising the steps of (a) providing an acidic solution substantially free of nucleic acid...
2016/0229881 METHODS FOR PREPARATION OF GLYCOSPHINGOLIPIDS AND USES THEREOF
Methods for synthesis and preparation of alpha-glycosphingolipids are provided. Methods for synthesis of .alpha.-galactosyl ceramide, and pharmaceutically...
2016/0229880 A METHOD FOR TREATING LIGNIN AND FOR PRODUCING A BINDER COMPOSITION
The invention relates to a method for treating lignin, wherein the method comprises the following steps: a) dissolving lignin into an aqueous composition,...
2016/0229879 Lignin Derivatives
The present invention provides lignin derivatives having a certain physical and/or chemical properties. In particular, the lignin derivatives of the invention...
2016/0229878 METAL-BASED THIOPHENE PHOTODYNAMIC COMPOUNDS AND THEIR USE
Compositions of the invention include tunable metal-based thiophene photodynamic compounds useful as therapeutic agents and as in vivo diagnostic agents for...
2016/0229877 METATHESIS CATALYSTS AND METHODS THEREOF
The present invention provides, among other things, novel compounds and methods for metathesis reactions. In some embodiments, a provided compound has the...
2016/0229876 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE
Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described here.
2016/0229875 FLUOROALKYLSILANES AND COATINGS THEREFROM
Novel fluoroalkysilanes of the following formula are described; R.sub.f--O--CHFCF.sub.2--O--(CH.sub.2).sub.n--Si(R).sub.xX.sub.3-x, wherein R.sub.f is a...
2016/0229874 Method for Preparation of Cyano Compounds of the 13th Group with a Lewis Acid
The invention discloses a method for preparation of cyano compounds of the 13th group of the periodic table with 1, 2, 3 or 4 cyano residues, represented by...
2016/0229873 TUNABLE ELECTRICAL CONDUCTIVITY IN METAL-ORGANIC FRAMEWORK THIN FILM DEVICES
A composition including a porous metal organic framework (MOF) including an open metal site and a guest species capable of charge transfer that can coordinate...
2016/0229872 ISOTHIAZOLOPYRIMIDINONES, PYRAZOLOPYRIMIDINONES, AND PYRROLOPYRIMIDINONES AS UBIQUITIN-SPECIFIC PROTEASE 7...
The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory...
2016/0229871 PYRIDAZINONE MACROCYCLES AS IRAK INHIBITORS AND USES THEREOF
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
2016/0229870 METHODS OF PRODUCING COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY
A process for preparing a compound represented by formula (Y1) or (Y2) ##STR00001## wherein R.sup.X is an optionally substituted carbocyclyl lower alkyl, or the...
2016/0229869 COMPOUNDS AND METHODS FOR PREVENTING OR TREATING SENSORY HAIR CELL DEATH
Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and...
2016/0229868 NOVEL FUSED PYRIMIDINE DERIVATIVES FOR INHIBITION OF TYROSINE KINASE ACTIVITY
A novel fused pyrimidine derivative has an inhibitory activity for tyrosine kinases. A pharmaceutical composition for preventing or treating cancers, tumors,...
2016/0229867 THIENO[2,3-e]INDOLE DERIVATIVES AS NEW ANTITUMOR AGENTS
The present invention relates to a novel class of alkylating agents comprising a thieno[2,3-e]indole moiety tethered to a DNA-binding moiety, which have...
2016/0229866 HEPATITIS C VIRUS INHIBITORS
Provided herein are hepatitis C virus inhibitor compounds, for example, of any of Formulae I to XIV, Ilia to XlVa, Illb to XlVb, IIIc to XIVc, Hid to XlVd,...
2016/0229865 COMPOUND INHIBITING ACTIVITIES OF BTK AND/OR JAK3 KINASES
The present invention relates to a compound inhibiting the activities of Bruton's tyrosine kinase (BTK) and/or Janus kinase 3 (JAK3), a pharmaceutical...
2016/0229864 THIENOPYRIMIDINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS
The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory...
2016/0229863 ISOSORBIDE-BASED POLYMETHACRYLATES
A monomer comprises the structure ##STR00001## wherein R.sup.1 comprises H or a substituted hydrocarbyl or unsubstituted hydrocarbyl, and wherein R.sup.2...
2016/0229862 NOVEL 20(S)-SULFONYLAMIDINE DERIVATIVES OF CAMPTOTHECIN AND THE USE THEREOF AS A POTENT ANTITUMOR AGENT
The present invention is related to novel 20-sulfonylamidine derivatives of camptothecin (1), method of synthesizing the same, and use thereof as an antitumor...
2016/0229861 SMALL MOLECULE SECURININE AND NORSECURININE ANALOGS AND THEIR USE IN CANCERS, INFLAMMATORY DISEASES AND INFECTIONS
The present invention relates to novel securinine and norsecurine analogs and their applicapility in treating cellular proliferative disorders.
2016/0229860 BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF
The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazpyrimidine compounds) that act as...
2016/0229859 METHOD FOR PREPARING INTERMEDIATE COMPOUND OF SITAGLIPTIN
The present invention provides a method for preparing an intermediate compound of sitagliptin represented by formula I. The preparation method comprises:...
2016/0229858 SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HEMATOLOGICAL DISEASES
The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis...
2016/0229857 SUBSTITUTED PYRROLO[2,3-D]DIPYRIMIDINES FOR SELECTIVELY TARGETING TUMOR CELLS WITH FR-ALPHA AND FR-BETA TYPE...
Pyrrolo[2,3-d]pyrimidine derivatives, and pharmaceutical acceptable salts thereof, useful in therapeutically treating patients with cancer are disclosed. These...
2016/0229856 Macrocyclic Compounds as IRAK1/4 Inhibitors and Uses Thereof
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
2016/0229855 NOVEL COMPOSITIONS, USES AND METHODS FOR THEIR PREPARATION
The present invention relates to novel compounds and pharmaceutical compositions thereof which may be useful in the treatment and/or prevention of various...
2016/0229854 PROCESS FOR THE PREPARATION OF N,N-DICYCLOPROPYL-4-(1,5-DIMETHYL-1H-PYRAZOL-3-YLAMINO)-6-ETHYL-1-METHYL-- ...
The invention relates to an improved process for synthesizing N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-- ...
2016/0229853 NOVEL AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION
The invention provides novel compounds having the general formula: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, W and X are as described herein,...
2016/0229852 KINASE INHIBITORS
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR00001## wherein R.sup.2, W, A, Y and R.sup.1 are as defined in the specification, ...
2016/0229851 NEW 3-(1H-PYRAZOL-4-YL)-1H-PYRROLO[2,3-c]PYRIDINE DERIVATIVES AS NIK INHIBITORS
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of ...
2016/0229850 TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
The present invention is directed to benzyl urea compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and...
2016/0229849 QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS
Compounds that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are...
2016/0229848 Benzazepine Ketone Compounds as Glycogen Phosphorylase Inhibitor, Preparation Method therefor, and Medical Uses
The present invention relates to the field of pharmaceutical chemistry, and particularly to a novel class of benzazepine ketone derivatives (I), their...
2016/0229847 NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS
Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula II as defined in the...
2016/0229846 COMPOSITION AND METHODS FOR THE TREATMENT OF CAMKK2-MEDIATED DISORDERS
The present disclosure provides compositions and methods for treating ocular disorders in mammals especially in and not limited to humans and mice. The present...
2016/0229845 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels....
2016/0229844 RORgamma MODULATORS
Described are ROR.gamma. modulators of the formula (I), or pharmaceutically acceptable salts thereof, wherein all substituents are defined herein. The...
2016/0229843 AZA-HETEROARYL COMPOUNDS AS PI3K-GAMMA INHIBITORS
The present invention provides aza-heteroaryl derivatives of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof, wherein X, Y, Z, A, W, ...
2016/0229842 Process for the Preparation of Voriconazole and Analogues Thereof
The present invention provides a process for preparing a compound of formula: (Formula XI and XII) (XI) (XII) wherein X, Y, Z, A, B and E are as defined...
2016/0229841 NOVEL BETA LACTAMS AS MODULATORS OF GLUTAMATE UPTAKE AND METHODS FOR USE THEREOF
Pharmaceutical compositions of the invention comprise compounds, compositions, methods useful for the treatment of drug addiction, drug withdrawal, and...
2016/0229840 ACTIVATABLE FLUOROGENIC COMPOUNDS AND USES THEREOF AS NEAR INFRARED PROBES
Novel fluorogenic compounds designed such that upon a chemical event, compounds capable of emitting NIR light are generated, are disclosed. The compounds...
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