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Patent # Description
2016/0229839 Factor XIa Inhibitors
The present invention provides a compound of Formula (I) ##STR00001## and pharmaceutical compositions comprising one or more said compounds, and methods for...
2016/0229838 AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME
Disclosed are substituted pyridine compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure ...
2016/0229837 SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE
The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, managing, treating or...
2016/0229836 MULTIVALENT RAS BINDING COMPOUNDS
The present invention provides, inter alia, compounds that selectively bind a RAS protein at two or more sites and methods for their synthesis. Compositions...
2016/0229835 NOVEL PYRIDYLOXYACETYL TETRAHYDROISOQUINOLINE COMPOUNDS USEFUL AS NAMPT INHIBITORS
The present invention provides novel pyridyloxyacetyl tetrahydroisoquinoline compounds that inhibit NAMPT and may be useful in the treatment of cancer.
2016/0229834 QUINAZOLINE DERIVATIVES AND THEIR USE AS DNA METHYLTRANSFERASE INHIBITORS
The present invention relates to compounds of the following formula (I): and pharmaceutically acceptable salts and solvates thereof, their methods of...
2016/0229833 QUINAZOLINONES AND AZAQUINAZOLINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS
The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders,...
2016/0229832 POLYMER-FIXED DERIVATIVES OF DITHIOLANE OR DITHIANE
Derivatives of 1,3-dithianes and 1,3-dithiolanes of the general formula 1a ##STR00001## or salts thereof of the general formula 1b ##STR00002## where...
2016/0229831 SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS
The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and...
2016/0229830 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES
Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and...
2016/0229829 Method for Producing Asymmetric Conjugated Diyne Compound and Method for Producing Z,Z-Conjugated Diene...
Provided are a method for efficiently producing an asymmetric conjugated diyne from an inexpensive and safe alternative compound to hydroxylamine hydrochloride...
2016/0229828 R TYPE OF RESVERATROL DIMER, PREPARATION PROCESS THEREFOR AND PURPOSE THEREOF IN LOWERING BLOOD SUGAR LEVEL
The present invention relates to the field of natural pharmaceutical chemistry, and in particular, to a resveratrol dimer (7R,8R)-trans-.delta.-viniferin (I),...
2016/0229827 A PROCESS FOR THE PREPARATION OF ANTI-INFLAMMATORY AROYLBENZOFURAN COMPOUNDS
Disclosed herein an efficient process for synthesis of benzofuran analogues having anti-inflammatory activity which comprises, Ru-catalyzed branched and linear...
2016/0229826 SYNTHETIC PROCESS FOR PREPARING 2-((2-ETHOXY-2-OXOETHYL)(METHYL)AMINO)-2-OXOETHYL ...
Disclosed herein are processes for forming 2-((2-ethoxy-2-oxoethyl)(methyl)amino)-2-oxoethyl 5-tetradecyloxy)furan-2-carboxylate: ##STR00001##
2016/0229825 SYNTHETIC PROCESS FOR PREPARING 2-FUROIC ACID DERIVATIVES
Disclosed herein are processes for forming 2-furoic acid derivatives represented by Formula (I): ##STR00001##
2016/0229824 ASSAY FOR THE DETECTION OF THE PHENYLPIPERAZINE FAMILY
The current invention describes novel immunogens which are used in the production of novel antibodies with unique binding properties in that they cross-react...
2016/0229823 DEUTERATED COMPOUNDS USEFUL FOR TREATING NEURODEGENERATIVE DISEASES
The present application is related to deuterated compounds which are novel neurotrophin mimetics. The application also discloses the treatment of disorders...
2016/0229822 CRYSTAL MODIFICATIONS OF ELOBIXIBAT
The present invention relates to crystal modifications of N-{(2R)-2-[({[3,3-dibutyl-7-(methyl-thio)-1,1-dioxido-5-phenyl-2,3,4,5-te- ...
2016/0229821 ARYLPIPERAZINE DERIVATIVES AND METHODS OF UTILIZING SAME
The present invention provides arylpiperazine derivatives having Formula I as shown below, which can be advantageously used for treating schizophrenia and...
2016/0229820 PROCESS FOR PREPARING SUBSTITUTED ISATOIC ACID ANHYDRIDE COMPOUNDS AND DERIVATIVES THEREOF
The present invention relates to a process for preparing substituted isatoic acid anhydride compounds of the formula (I) ##STR00001## in which R.sup.1 is Cl,...
2016/0229819 FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE
Fumarate compounds, pharmaceutical compositions comprising the fumarate compounds, and methods of using fumarate compounds and pharmaceutical compositions for...
2016/0229818 Compounds for Nonsense Suppression, and Methods for Their Use
The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by...
2016/0229817 ANTIFUNGAL COMPOUNDS OF (ARYLALKYL) AZOLE DERIVATIVES IN THE STRUCTURE OF OXIME ESTER
This invention is related to the antifungal compounds having azole structure in Formula (1), and hydrates, solvates, pharmaceutically acceptable salts or...
2016/0229816 CYANOTRIAZOLE COMPOUNDS
This invention relates to a cyanotriazole compound represented by the formula (1): ##STR00001## wherein each symbols are defined in the specification, or a salt...
2016/0229815 HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK
Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting...
2016/0229814 HETEROCYCLIC COMPOUND
The present invention provides a heterocyclic compound having an ROR.gamma.t inhibitory action. The present invention relates to a compound represented by the...
2016/0229813 ARYL METHYL BENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
The present invention is directed to benzoquinazilinone compounds of formula (I) ##STR00001## which are M1 receptor positive allosteric modulators and that are...
2016/0229812 SALT OF NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR CRYSTAL THEREOF, PHARMACEUTICAL COMPOSITION, AND FLT3...
An object of the present invention is to provide a compound and pharmaceutical composition showing superior stability and/or solubility, etc. and having...
2016/0229811 TETRA-ARYL CYCLOBUTANE INHIBITORS OF ANDROGEN RECEPTOR ACTION FOR THE TREATMENT OF HORMONE REFRACTORY CANCER
The present disclosure provides tetra-substituted cyclobutane inhibitors of Androgen Receptor Action, and methods of using such inhibitors, for the treatment...
2016/0229810 Selective Inhibition of Bacterial Topoisomerase I
The present invention provides novel bisbenzimidazole compounds and methods of using the compounds as antibacterial agents.
2016/0229809 HETEROCYCLIC VINYL AUTOTAXIN INHIBITOR COMPOUNDS
Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such...
2016/0229808 PROCEDURE FOR THE SYNTHESIS OF N-BENZYL-N-CYCLOPROPYL-1H-PYRAZOLE-4-CARBOXAMIDE DERIVATIVES
A new one-step process for the preparation of pyrazole carboxamide derivatives of the general formula (I) ##STR00001## by reaction of ...
2016/0229807 NEW PHENYL-DIHYDROPYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, ...
2016/0229806 SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE- -3-CARBOXAMIDE
The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline- -3-carboxamide (Compound 1),...
2016/0229805 Process for Preparing Quinoline Derivatives
A process for preparing a compound of Formula I is disclosed, comprising the steps: ##STR00001## wherein: R.sup.1 is halo; R.sup.2 is halo; R.sup.3 is ...
2016/0229804 TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
The present invention is directed to benzyl urea compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and...
2016/0229803 ELECTROCHROMIC COMPOUNDS WITH IMPROVED COLOR STABILITY IN THEIR RADICAL STATES
The invention relates to an electrochromic device and uses thereof, wherein the electrochromic device includes an electrochromic compound with reduced...
2016/0229802 C5AR ANTAGONISTS
Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions,...
2016/0229801 ONIUM SALT AND COMPOSITION COMPRISING THE SAME
The onium salt of the present invention contains predetermined compound A represented by the general formula (1). The composition of the present invention...
2016/0229800 ALLYL DISULFIDE-CONTAINING ADDITION-FRAGMENTATION OLIGOMERS
A Addition-fragmentation oligomers containing allylic disulfide groups are described. The oligomers may be added to polymerizable compositions to provide...
2016/0229799 PROCESS FOR OBTAINING METHIONINE
The invention relates to a method for crystallizing D,L-methionine from aqueous solutions and/or suspensions containing D,L-methionine and D,L-methionine...
2016/0229798 POLYTHIOL COMPOUND AND METHOD FOR PRODUCING SAME
According to the present invention, a polythiol compound having a total nitrogen content of 50 to 600 ppm inclusive can be provided. According to the present...
2016/0229797 LOW PH METAL-FREE PREPARATION OF AMINATED ORGANIC ACID
The invention provides a process for making compounds according to Formula I: ##STR00001## where R.sup.1, R.sup.1a, R.sup.2, R.sup.2a, R.sup.3 and R.sup.3a are ...
2016/0229796 METFORMIN SALTS TO TREAT TYPE2 DIABETES
Metformin salts of 2,4-thiazolidinediones are described for the treatment of diabetes mellitus Type2, gestational diabetes, polycystic ovary syndrome,...
2016/0229795 COMPOUNDS AND MESOGENIC MEDIA
Disclosed are compounds of formula I ##STR00001## the use of compounds of formula I in liquid crystal media and in particular to flexoelectric liquid crystal...
2016/0229794 PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF
The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide...
2016/0229793 METHOD OF PROCESSING PHOSPHOLIPID BASED LIPID MATERIALS
The present invention provides methods of processing lipid materials such as soapstock, wet gums and dry gums. Enzymes are utilized to catalyze hydrolysis of...
2016/0229792 METHOD FOR PRODUCING BIS (AMINOMETHYL) CYCLOHEXANE
A method for producing a bis(aminomethyl)cyclohexane having an isomerization step of isomerizing a cis-isomer of 1,4-bis(aminomethyl)cyclohexane and/or a...
2016/0229791 Malic Acid Esters Of Resveratrol And Cosmetic Compositions
Malic acid esters of resveratrol and topical compositions containing the esters.
2016/0229790 POLYOL ESTOLIDES AND METHODS OF MAKING AND USING THE SAME
Provided herein are polyol estolide compounds. Polyol estolides may be prepared by contacting a polyol with an estolide compound. Also provided are...
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