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Patent # Description
2016/0228439 Method and Pharmaceutical Composition for use in the Treatment of Epilepsy
The present invention relates to a compound which is an antagonist of the GluK2/GluK5 receptor or an inhibitor of the GluK2/GluK5 receptor expression for use...
2016/0228438 AZA-PYRIDONE COMPOUNDS AND USES THEREOF
Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same....
2016/0228437 MIXED LINEAGE KINASE INHIBITORS AND METHOD OF TREATMENTS
Provided herein are imidazopyridine compounds having an inhibitory effect on mixed lineage kinases (MLKs), methods of their synthesis, and methods of their...
2016/0228436 USE OF TYROSINE KINASE INHIBITOR IN CANCER TREATMENT
The present invention provides methods for reducing apoptosis of non-cancerous cells during a cancer treatment and beneficial effects associated with reducing...
2016/0228435 Arylamide compounds and compositions and uses thereof
The present invention discloses ophthalmic and otic compositions of facially amphiphilic antimicrobial polymers and oligomers and their uses, including their...
2016/0228434 TREATMENT OF DISEASES CAUSED BY ABNORMAL LYMPHOCYTE FUNCTION WITH AN HDAC6 INHIBITOR
An HDAC6 inhibitor (a compound of Formula I) is shown to reduce the pathogenesis associated with the B cell mediated autoimmune disease, systemic lupus...
2016/0228433 INTRANASAL DHE FOR THE TREATMENT OF HEADACHE
Presented herein are powder formulations comprising dihydroergotamine (DHE), or a pharmaceutically acceptable salt thereof. In addition to such formulations,...
2016/0228432 HETEROARYL PYRIDONE AND AZA-PYRODINE COMPOUNDS
Heteroaryl pyridone and aza-pyridone compounds are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for...
2016/0228431 METHODS FOR TREATING CANCER WITH TRKA RECEPTOR TYROSINE KINASE ANTAGONISTS
The present disclosure relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same, said compounds being...
2016/0228430 Therapeutic Uses of Compounds Having Combined SERT, 5-HT3 and 5-HT1A Activity
New pharmaceutical uses of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine and pharmaceutically acceptable salts thereof are provided.
2016/0228429 CONTROLLED RELEASE HYDROCODONE FORMULATIONS
A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a...
2016/0228428 METHODS FOR TREATING PANCREATIC CANCER USING COMBINATION THERAPIES COMPRISING LIPOSOMAL IRINOTECAN
Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional...
2016/0228427 NOVEL PIPERIDINE COMPOUND OR SALT THEREOF
A novel compound which has an excellent aurora A-selective inhibitory action and is useful as an orally administrable anticancer agent is provided. Also, a...
2016/0228426 METHODS OF TREATING PRURITIC CONDITIONS MEDIATED THROUGH NON-HISTAMINERGIC MECHANISMS IN DIABETIC PATIENTS
Described herein are methods of treating a mammal in need of treatment for non-histaminic pruritus by administering to the mammal in need thereof a...
2016/0228425 COMPOSITIONS AND METHODS FOR TREATMENT OF GULF WAR ILLNESS
Pharmaceutical compositions and methods for the treatment of Gulf War Illness in human patients comprising administering a central nervous system (CNS)...
2016/0228424 SEMI-SOLID TOPICAL COMPOSITION CONTAINING PIRFENIDONE AND MODIFIED DIALLYL DISULFIDE OXIDE (M-DDO) FOR...
The instant invention relates to a semi-solid topical composition containing Pirfenidone and an antimicrobial/antiseptic agent such as Modified Diallyl...
2016/0228423 Methods of Administering Pirfenidone Therapy
The disclosure relates to improved methods of administering pirfenidone therapy when ciprofloxacin is administered concomitantly.
2016/0228422 TARGETED PHARMACOLOGICAL CHAPERONES
The present invention relates to the preparation and use of therapeutic compounds for the treatment of diseases at specific subcellular target areas such as...
2016/0228421 COMPOSITION FOR TREATING OR PREVENTING GLAUCOMA COMPRISING A SULFONAMIDE COMPOUND AND ANOTHER DRUG
A composition for preventing or treating glaucoma or ocular hypertension including a combination of isopropyl ...
2016/0228420 POLYETHYLENE GLYCOL-CONTAINING COMPOSITION
The present invention relates to a pharmaceutical composition comprising a compound represented by the formula (1) or a salt thereof and polyethylene glycol.
2016/0228419 SUBSTITUTED QUINOLIZINE DERIVATIVES USEFUL AS HIV INTEGRASE INHIBITORS
The present invention relates to Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y,...
2016/0228418 METHODS OF INCREASING TONIC INHIBITION AND TREATING SECONDARY INSOMNIA
Methods of increasing tonic inhibition in a subject in need thereof, for example a subject with Fragile X syndrome or Angelman syndrome are disclosed. Methods...
2016/0228417 COMBINATION THERAPY USING AZABICYCLO COMPOUND FOR CANCER
Provided is a novel method for treating cancer using an HSP90 inhibitor which exhibits a markedly superior antitumor effect and has a reduced side effect. An...
2016/0228416 METHODS FOR TREATING SEIZURE DISORDERS AND PAIN
The present invention provides methods for treating seizure disorders. The method includes administering to a subject in need thereof ...
2016/0228415 COMPOUNDS AND METHODS FOR TREATING INFLUENZA
This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds...
2016/0228414 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including CF Transmembrane Regulator ("CFTR"),...
2016/0228413 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY
The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups...
2016/0228412 NOVEL PYRAZOLE DERIVATIVE
Provided is a novel therapeutic means for Alzheimer's disease. In particular, provided is a compound represented by the following general formula (I): ...
2016/0228411 KCNQ CHANNELS AS THERAPEUTIC TARGETS
The present disclosure relates to methods and compositions for modulating the activity of KCNQ channels as a means for reducing the effects of aberrant KCNQ...
2016/0228410 AN ANTI-LEUKEMIC AGENT USEFUL FOR INDUCING DIFFERENTIATION IN MYELOID LEUKEMIA CELLS
The present invention provides the compound Ormeloxifene [3,4-trans-2,2-dimethyl-3-phenyl-4-p-(beta-pyrrolidinoethoxy)phenyl-7-met- hoxy chroman] as useful in...
2016/0228409 Compositions and Methods for Pain Relief
The invention provides pharmaceutical compositions having improved effects and synergistic efficacy against pain, and provides methods for their use to treat...
2016/0228408 Inhibitors of CD40-TRAF6 Interaction
The present invention relates to compounds acting as selective inhibitors of CD40-TRAF6 interaction, their use as medicaments and their use in the treatment of...
2016/0228407 NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS
The present invention relates to novel bis-sulfonamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as...
2016/0228406 THERAPEUTIC AGENT FOR DISEASE BASED ON INHIBITORY EFFECT OF MACROPHAGE MIGRATION INHIBITORY FACTOR
A method for inhibiting macrophage migration and a method for treating neuropathic pain, by administering a benzopyran derivative of the following formula, or...
2016/0228405 ORAL CANNABINOID FORMULATIONS
Oral cannabinoid formulations, including an aqueous-based oral dronabinol solution, that are stable at room or refrigerated temperatures and may possess...
2016/0228404 THERAPEUTIC AGENT FOR DISEASE BASED ON INHIBITORY EFFECT OF MACROPHAGE MIGRATION INHIBITORY FACTOR
A method for treating the relapsing-remitting or secondary progressive multiple sclerosis at the time of relapse, by administering a benzopyran derivative of...
2016/0228403 AGENT FOR PREVENTING OR AMELIORATING RENAL DYSFUNCTION
An object of the present invention is to provide an agent for preventing or ameliorating renal dysfunction, excellent in the inhibitory action on the advance...
2016/0228402 COMPOSITION CONTAINING LIGNAN COMPOUND AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER
The present invention relates to a pharmaceutical composition for preventing, ameliorating, or treating cancer. More specifically, the present invention...
2016/0228401 METHODS OF TREATING MELANOMA
Provided herein are methods for the treatment of melanoma comprising administration of a composition comprising nanoparticles comprising taxane and a carrier...
2016/0228400 COMPOSITIONS CAPABLE OF ENHANCING THERMOGENESIS AND USES THEREOF
The present invention refers to novel compositions and to methods of using the compositions to treat and/or prevent obesity, obesity-related diseases or...
2016/0228399 PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF CANCER
The present invention relates to pharmaceutical combinations comprising aminoacetonitrile derivatives and anticancer compounds. Further, the present invention...
2016/0228398 OMEGA-3 FATTY ACID ESTER COMPOSITIONS
Compositions including at least one Omega-3 fatty acid ester and at least one surface active agent are provided; wherein the compositions form micelles when in...
2016/0228397 OMEGA-3 FATTY ACID ESTER COMPOSITIONS
Compositions including at least one Omega-3 fatty acid ester and at least one surface active agent are provided; wherein the compositions form micelles when in...
2016/0228396 TOPICAL APPLICATION OF INGENOL MEBUTATE WITH OCCLUSION
The present invention relates to formulations of ingenol mebutate and methods of preparation and use thereof. More specifically, the invention relates to...
2016/0228395 (2S,4R)-5-(5'-CHLORO-2'-FLUOROBIPHENYL-4-YL)-4-(ETHOXYOXALYLAMINO)-2-HYDRO- XYMETHYL-2-METHYLPENTANOIC ACID
In one aspect, the invention relates to a compound of the structure: ##STR00001## or a pharmaceutically acceptable salt thereof, and a crystalline form of this...
2016/0228394 Compositions Comprising A Conjugate of Quinic Acid Wth Caffeic Acid, Cosmetic And Therapeutic Uses
Use of a composition for the for the prevention, amelioration and/or treatment of disorders and diseases involving cell, tissue or organ senescence, or for the...
2016/0228393 HYPERTENSION REDUCING COMPOSITION
A composition effective to relax smooth muscles in an individual in an altered state is described. The composition includes a dosage of GABA or GABA-a...
2016/0228392 TREATMENT OF PAIN WITH TOPICAL DICLOFENAC
The field involves compositions useful for pain relief, including diclofenac solution and gel formulations, in particular methods of use thereof, articles of...
2016/0228391 MATRIX AND LAYER COMPOSITIONS FOR PROTECTION OF BIOACTIVES
The invention relates to matrix and layer compositions comprising a first polymer. The matrix and layer compositions are useful in the delivery of bioactives....
2016/0228390 COMPOSITIONS AND METHODS FOR INCREASING THE METABOLIC LIFETIME OF DEXTROMETHORPHAN AND RELATED PHARMACODYNAMIC...
This disclosure relates to methods of increasing dextromethorphan plasma levels comprising co-administering hydroxybupropion, or a prodrug thereof, and...
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