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Patent # Description
2016/0230189 NANOPARTICLE-MEDIATED GENE DELIVERY, GENOMIC EDITING AND LIGAND-TARGETED MODIFICATION IN VARIOUS CELL POPULATIONS
An improved nanoparticle for transfecting cells is provided. The nanoparticle includes a core polyplex and a silica coating on the core polyplex and,...
2016/0230188 METHOD OF DE-DIFFERENTIATING AND RE-DIFFERENTIATING SOMATIC CELLS USING RNA
RNA prepared by in vitro transcription using a polymerase chain reaction (PCR)-generated template can be introduced into a cell to modulate cell activity. This...
2016/0230187 COMPOSITIONS AND METHODS FOR IMPROVING INSECT RESISTANCE
Compositions and methods for improving the pest resistance of plants. Plants and plant parts identified, selected and/or produced using the compositions and...
2016/0230186 COMPOSITIONS AND METHODS FOR CONTROLLING DIABROTICA
The present invention provides methods for controlling invertebrate pest infestations, for instance in plants, and related compositions and polynucleotides...
2016/0230185 COMPOSITIONS AND METHODS FOR CONTROLLING DIABROTICA
The present invention provides methods for controlling invertebrate pest infestations, for instance in plants, and related compositions and polynucleotides...
2016/0230184 HERBICIDE-RESISTANT SUNFLOWER PLANTS, POLYNUCLEOTIDES ENCODING HERBICIDE-RESISTANT ACETOHYDROXYACID SYNTHASE...
Herbicide-resistant sunflower plants, isolated polynucleotides that encode herbicide-resistant and wild-type acetohydroxyacid synthase large subunit (AHASL)...
2016/0230183 TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS
This invention provides recombinant DNA constructs, transgenic plant nuclei and cells with such recombinant DNA construct for expression of proteins that are...
2016/0230182 POLYPEPTIDE REGULATING AND CONTROLLING THE FORMATION OF PLANT AGRONOMIC TRAIT OR YIELD TRAIT, AND USE OF...
The invention relates to a polypeptide for regulating agronomic characters and yield characters of plants and application thereof. The invention alters...
2016/0230181 TOBACCO NICOTINE DEMETHYLASE GENOMIC CLONE AND USES THEREOF
The present invention features tobacco nicotine demethylase nucleic acid and amino acid sequences, tobacco plants and plant components containing such...
2016/0230180 ENGINEERING THE PLANT ACTIN CYTOSKELETON TO MODULATE CELL WALL PROPERTIES
A method for controlling the mechanical properties of the cell wall and polarized growth in a cell that includes selectively manipulating the cell cytoskeleton...
2016/0230179 SHUTTLE PLASMID REPLICABLE IN BOTH CLOSTRIDIA AND ESCHERICHIA COLI
Disclosed is a shuttle plasmid replicable in both Clostridium and Escherichia coli comprising: a base sequence of a first replication origin replicable in...
2016/0230178 A BACTERIAL SURROGATE FOR TESTING OF ANTIMALARIALS: THYA KNOCKOUT, FOLA KNOCKOUT, FOLP KNOCKOUT, AND FOLK...
In this invention, cell lines are created for enzyme inhibitory testing of inhibitors against Plasmodium falciparum DHFR-TS and HPPK-DHPS. Provided the...
2016/0230177 E. COLI SEPARATOME-BASED PROTEIN EXPRESSION AND PURIFICATION PLATFORM
Provided is a separatome-based peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of...
2016/0230176 Recombinant Cells and Organisms Having Persistent Nonstandard Amino Acid Dependence and Methods of Making Them
Novel recombinant cells and recombinant organisms persistently expressing nonstandard amino acids (NSAAs) are provided. Methods of making novel recombinant...
2016/0230175 METHODS AND COMPOSITIONS FOR RAPID SEAMLESS DNA ASSEMBLY
Provided herein are methods for assembling DNA fragments employing at least three enzymatic activities: DNA polymerase, flap endonuclease, and DNA ligase....
2016/0230174 TOLEROGENIC DENDRITIC CELLS TO TREAT INFLAMMATORY BOWEL DISEASE
Methods are disclosed herein for treating or preventing an inflammatory bowel disease in a subject. These methods include administering to a subject an...
2016/0230173 METHODS FOR OVERCOMING GLUCOCORTICOID RESISTANCE AND FOR DETERMINING GLUCOCORTICOID RESISTANCE POTENTIAL IN CANCER
The invention provides methods for overcoming glucocorticoid resistance of cancers by inhibition of CASP1. Also disclosed are diagnostic methods for...
2016/0230172 COMPOSITIONS FOR MODULATING EXPRESSION OF C9ORF72 ANTISENSE TRANSCRIPT
Disclosed herein are compositions and methods for reducing expression of C90RF72 antisense transcript in an animal with C90RF72 antisense transcript specific...
2016/0230171 METHODS FOR INDUCING GLUCOSE UPTAKE
The present invention provides a method for inducing glucose uptake in a muscle cell by inhibiting Trim32 protein in the cell and to a method for inducing...
2016/0230170 SIRNA SEQUENCE-INDEPENDENT MODIFICATION FORMATS FOR REDUCING OFF-TARGET PHENOTYPIC EFFECTS IN RNAI, AND...
Modification formats having modified nucleotides are provided for siRNA. Short interfering RNA having modification formats and modified nucleotides provided...
2016/0230169 RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF
The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence that encodes poly-glutamine repeat diseases,...
2016/0230168 APPARATUS FOR SEPARATING PARTICLES UTILIZING ENGINEERED ACOUSTIC CONTRAST CAPTURE PARTICLES
An apparatus for separating particles from a medium includes a capillary defining a flow path therein that is in fluid communication with a medium source. The...
2016/0230167 Method and Apparatus for Reprogramming Living Cells
A method and an apparatus for reprogramming living cells without using viruses. In that method a cocktail comprising at least two transcription factors and a...
2016/0230166 POLYNUCLEOTIDE ENCODING ACYL-COA SYNTHETASE HOMOLOG AND USE THEREOF
The present invention relates to an acyl-CoA synthetase homolog protein from microorganisms of the genus Mortierella, a polynucleotide encoding the protein,...
2016/0230165 POLYNUCLEOTIDE ENCODING ACYL-COA SYNTHETASE HOMOLOG AND USE THEREOF
The present invention relates to an acyl-CoA synthetase homolog protein from microorganisms of the genus Mortierella, a polynucleotide encoding the protein,...
2016/0230164 IMPROVED ACETYL-COA CARBOXYLASE VARIANTS
The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including...
2016/0230163 COMPOSITIONS AND METHODS COMPRISING ASPARTYL-TRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
Isolated aspartyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods...
2016/0230162 XYLOSE ISOMERASE GENES AND THEIR USE IN FERMENTATION OF PENTOSE SUGARS
The present invention relates to eukaryotic cells which have the ability to isomerise xylose directly into xylulose. The cells have acquired this ability by...
2016/0230161 PURIFIED LYSIN PROTEIN
The invention discloses a purified lysin protein for lysing Acinetobacter baumannii cells without pretreatment process using chloroform or EDTA. The purified...
2016/0230160 MODIFIED BETA-LACTAMASES AND METHODS AND USES RELATED THERETO
The present invention relates to pharmaceuticals and modified beta-lactamases. Specifically, the invention relates to novel recombinant beta-lactamases and...
2016/0230159 Multiprotease Therapeutics for Chronic Pain
The invention includes Clostridial neurotoxin derivatives containing at least two light chain endopeptidase domains, and nucleic acids encoding such...
2016/0230158 Polypeptides Having Cellulolytic Enhancing Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The...
2016/0230157 GLUCOAMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the...
2016/0230156 RECOMBINANT FUSION PROTEIN POSSESSING NUCLEASE AND PHOSPHATASE ACTIVITY
Disclosed herein is a fusion protein possessing both nuclease and phosphatase activities. The described fusion protein simplifies the processing of amplified...
2016/0230155 MODIFIED SULFAMIDASE AND PRODUCTION THEREOF
Disclosed herein are a modified sulfamidase, a composition comprising a modified sulfamidase, as well as methods for preparing a modified sulfamidase and...
2016/0230154 DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are...
2016/0230153 DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are...
2016/0230152 DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are...
2016/0230151 MICROORGANISM WITH ENHANCED L-LYSINE PRODUCTIVITY AND METHOD FOR PRODUCING L-LYSINE BY USING SAME
Provided are a beta prime subunit mutant of RNA polymerase, a microorganism of the Corynebacterium genus including a polynucleotide coding the same, and a...
2016/0230150 HETERO-TRANSGLYCOSYLASE AND USES THEREOF
The present invention relates to a hetero-transglycosylase protein having cellulose:xyloglucan endotransglucosylase (CXE) activity in addition to mixed-linkage...
2016/0230149 PRODUCT AND PROCESS FOR MUCUS VISCOSITY NORMALIZATION
Disclosed are compositions and methods for decreasing the viscosity and/or cohesiveness of and/or increasing the liquefaction of excessively or abnormally...
2016/0230148 PRODUCTION OF VIRUS OCCLUSION BODIES THAT OCCLUDE VIRIONS COMPRISING GENOMES OF DIFFERENT SPECIES OF...
Production of virus occlusion bodies that occlude virions comprising genomes of different species of baculoviruses that can be used to combat insect pests. A...
2016/0230147 METHOD FOR PRODUCING ENVELOPED VIRUSES
The invention relates to a process for producing enveloped viruses in a mildly acid medium. The processes of the invention are useful for producing and...
2016/0230146 METHOD FOR PRODUCING INDUCED PLURIPOTENT STEM CELL FROM MESENCHYMAL STEM CELL AND INDUCED PLURIPOTENT STEM CELL...
The present invention relates to a medium composition containing an Ecklonia cava extract for dediffentiating an induced pluripotent stem cell. Also, the...
2016/0230145 DEVICE AND SURGICAL SYSTEM FOR RAPID ASEPTIC ISOLATION AND CONCENTRATION OF AUTOLOGOUS FAT DERIVED STEM CELLS
The present disclosure provides an apparatus for harvesting stem cells from fat tissue. The apparatus may include a first transducer coupled to a first end of...
2016/0230144 Generation of Lineage-Restricted Progenitor Cells from Differentiated Cells
Method for reprogramming differentiated cells into lineage restricted progenitor cells is provided. The method may include contacting differentiated cells with...
2016/0230143 CHEMICALLY DEFINED CULTURE MEDIUM FOR STEM CELL MAINTENANCE AND DIFFERENTIATION
The present invention is directed to a low protein medium for the culture of pluripotent stem cells comprising one or more polysaccharides. The medium of the...
2016/0230142 CORNEAL STROMAL KERATOCYTE CULTURE
The present invention relates to corneal stromal keratocytes (CSKs) culture. In particular the present invention relates to a method for culturing corneal...
2016/0230141 PROCESS FOR INCREASED YEAST BIOMASS
The present invention relates to a process for enhancing the growth and increasing the biomass of yeast cultures. The addition of ethanol during log growth...
2016/0230140 ASPERGILLUS MUTANT STRAIN AND TRANSFORMANT THEREOF
Provided are an Aspergillus mutant strain which can dramatically enhance production of a heterologous enzyme when a saccharifying enzyme gene is transferred...
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