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Patent # Description
2016/0237149 Manufacturing methods to control C-terminal lysine, galactose and sialic acid content in recombinant proteins
Provided herein is a method for producing an antibody, such as an anti-TNF.alpha. antibody (e.g., infliximab) having a C-terminal lysine content of about 20%...
2016/0237148 METHOD OF TREATING OSTEOARTHRITIS WITH AN ANTIBODY TO NGF
Methods are disclosed for treating osteoarthritis in a human subject in need thereof, comprising administering to the subject a therapeutically effective...
2016/0237147 Human Anti-NGF Neutralizing Antibodies As Selective NGF Pathway Inhibitors
This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also...
2016/0237146 Methods of Preventing or Reducing Photoreceptor Cell Death
The invention provides compositions and methods for preventing or reducing photoreceptor cell death. The invention further provides compositions and methods...
2016/0237145 BINDING MOIETIES FOR BIOFILM REMEDIATION
Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected...
2016/0237144 THERMUS THERMOPHILUS SLYD FKBP DOMAIN SPECIFIC ANTIBODIES
The present description relates to anti-Thermus thermophilus SlyD FKBP domain antibodies and methods of using the same.
2016/0237143 ANTI-HPV E7 ANTIBODIES
The present invention relates to monoclonal anti-HPV (human papillomavirus) E7 antibodies capable of specifically recognising an epitope of the C-terminal or...
2016/0237142 Synthetic Single Domain Antibody
The invention relates to the identification of a highly stable single domain antibody scaffold (hs2d Ab) and its use in generating synthetic single domain...
2016/0237141 METHODS OF TREATING ALZHEIMER'S DISEASE WITH APO A-1 MILANO
This invention relates to the treatment of Alzheimer's disease, the reduction of the progression of Alzheimer's disease, and the alleviation of symptoms of...
2016/0237140 CATION AND ANION EXCHANGE CHROMATOGRAPHY METHOD
Herein is reported a method for purifying a polypeptide comprising the steps of i) applying a solution comprising the polypeptide to an ion exchange...
2016/0237139 CHIMERIC ANTIGEN RECEPTOR
The present invention provides a chimeric antigen receptor (CAR) comprising: (i) a B cell maturation antigen (BCMA)-binding domain which comprises at least...
2016/0237138 Polypeptides and Methods For Modulating D1-D2 Dopamine Receptor Interaction and Function
The present invention provides for prevention and/or treatment of neurological or neuropsychiatric disorders involving abnormal D1-D2 dopamine receptor...
2016/0237137 Nanoparticle Based Artificial Antigen Presenting Cell Mediated Activation of NKT Cells
The present invention relates to, in part, artificial antigen presenting cells that are useful in treating disease (including cancers) and have uses, for...
2016/0237136 NOVEL CELL LINES EXPRESSING ENaC and METHODS USING THEM
Cell lines that stably express ENaC and methods for using those cell lines are disclosed herein. The invention includes cell lines that express various subunit...
2016/0237135 INTERLEUKIN-4 RECEPTOR-BINDING FUSION PROTEINS AND USES THEREOF
The present invention relates to interleukin-4 receptor-binding fusion proteins. More specifically, the invention provides, in part, fusion proteins that...
2016/0237134 ALTERNATIVE NUCLEIC ACID MOLECULES CONTAINING REDUCED URACIL CONTENT AND USES THEREOF
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides...
2016/0237133 CHIMERIC FIBROBLAST GROWTH FACTOR (FGF) 2/FGF1 PEPTIDES AND METHODS OF USE
The present disclosure provides chimeric proteins having an N-terminus coupled to a C-terminus, wherein the N-terminus comprises an N-terminal portion of...
2016/0237132 FUSION POLYPEPTIDES COMPRISING MUCIN-DOMAIN POLYPEPTIDE LINKERS
The invention provides fusion proteins having improved bioactivity comprising a first polypeptide fusion partner and a second polypeptide fusion partner...
2016/0237131 METHODS AND COMPOSITIONS OF HUMAN RECOMBINANT GROWTH AND DIFFERENTIATON FACTOR-5 (RHGDF-5) ISOLATED FROM...
Expression vector systems are provided for increased production of a recombinant GDF-5 (rhGDF-5) protein. Also provided are transformed host cells that were...
2016/0237130 Apelin Fusion Proteins and Uses Thereof
The invention provides a fusion protein or polypeptide comprising an apelin peptide fused to a multimerizing component. The invention also provides a fusion...
2016/0237129 MITOCHONDRIAL TARGETING AND THERAPEUTIC USE THEREOF
The present invention provides, among other things, compositions and methods for treatment of Friedrich's Ataxia based on effective targeting of a therapeutic...
2016/0237128 OPTICALLY TRANSPARENT SILK HYDROGELS
The present application relates to silk fibroin-based hydrogels, methods for making and using the same.
2016/0237127 RECOMBINANT PEPTIDE VACCINES AGAINST TICKS, AND NUCLEOTIDE SEQUENCES CODING FOR THE RECOMBINANT PEPTIDES
The present invention relates to the field of biotechnology and genetic engineering, and particularly to the expression of recombinant peptides. The...
2016/0237126 LIGHT-ACTIVATED CHIMERIC OPSINS AND METHODS OF USING THE SAME
Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively...
2016/0237125 PROTEINS WITH DIAGNOSTIC AND THERAPEUTIC USES
The present invention provides a recombinant protein capable of binding to complement factor H (CFH), and thereby inducing increased binding of C3d and C3b by...
2016/0237124 KIND OF MUTATED PROTEINS A WITH HIGH ALKALI RESISTANCE FEATURE AND APPLICATION THEREOF
A series of protein A mutants having high alkali resistance, and methods of using the protein A mutants are provided. The protein A mutants have a high binding...
2016/0237123 COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
The invention provides compositions, kits and methods utilizing polypeptides having a viral alpha-helix heptad repeat domain in a stabilized .alpha.-helical...
2016/0237122 FUSION PROTEIN FOR HIV-1 GP120 ANTIGEN DETECTION
The present disclosure relates to novel fusion proteins that bind to the HIV-1 gp120 antigen. The present disclosure also relates to nucleic acids, plasmids...
2016/0237121 COMPOUNDS THAT BIND TO HUMAN IMMUNODEFICIENCY VIRUS REV RESPONSE ELEMENT
Disclosed herein are compounds (such as peptides or peptide mimetics) that bind to HIV RRE RNA. In some examples, the compounds inhibit (for example, decrease)...
2016/0237120 POLYOMAVIRUS PEPTIDE SEQUENCES
The current invention concerns the identification of B-cell epitopes (as linear peptides) from human polyoma virus proteins and their use in an immune...
2016/0237119 C-Met Protein Agonist
Object of the present invention is to provide a peptide functioning as a c-Met agonist. The present invention provides a peptide complex comprising two or more...
2016/0237118 LEUKEMIA STEM CELL TARGETING LIGANDS AND METHODS OF USE
The present invention is directed to C-type lectin-like molecule-1 (CLL1) specific ligand peptides, comprising the amino acid motif LR(S/T), and methods of...
2016/0237117 CONNECTIVE TISSUE STIMULATING PEPTIDES
Novel peptides are described which comprise an amino acid motif selected from the group consisting of "PG", "GP", "PI" and "IG" and having up to 10 amino acids...
2016/0237116 SITE-SPECIFIC CHEMOENZYMATIC PROTEIN MODIFICATIONS
The present invention relates to methods and reagents for use in site-selective modification of proteins having lysine residues with functionalized peptides...
2016/0237115 METHODS OF PRODUCING ANAMORELIN HYDROCHLORIDE HAVING CONTROLLED CHLORIDE CONTENT
The present invention relates to particulate forms of anamorelin monohydrochloride or a composition comprising anamorelin monohydrochloride having controlled...
2016/0237114 PROTEIN AFFINITY PURIFICATION RESINS WITH TAGGED PROTEIN
Disclosed herein are protein enrichment substrates and methods for making the same that can be used to enrich proteins of interest. Also disclosed herein are...
2016/0237113 NOVEL ANTIBODY PURIFICATION METHOD, ANTIBODY OBTAINED THEREFROM, NOVEL ANTIBODY PURIFICATION METHOD USING...
The first embodiment of the present invention is a method for purifying an antibody or a substance derive from an antibody, wherein a carrier 1 having an...
2016/0237112 PURIFICATION OF ORGANIC COMPOUNDS BY SURFACTANT MEDIATED PREPARATIVE HPLC
A sample is provided that can be purified by preparative reversed phase high performance liquid chromatography (Prep-RP-HPLC) in a single run in spite of...
2016/0237111 DOWNSTREAM BIOPROCESSING DEVICE
Large-scale downstream processing of secreted recombinant proteins is provided in a single device, wherein the contents of a plurality of bioreactors are...
2016/0237110 ACOUSTIC MICROREACTOR AND METHODS OF USE THEREOF
Described herein are microreactors and methods of modifying support particles using acoustic standing waves. A liquid medium containing suspended support...
2016/0237109 Method for Preparing Abiraterone Acetate
A method for preparing abiraterone acetate. The steps are: dehydroepiandrosterone acetate and trifluoromethanesulphonic anhydride undergo a sulfonylation...
2016/0237108 POLYNUCLEOTIDE MOLECULES AND USES THEREOF
The present disclosure provides alternative sugar moieties and polynucleotides comprising such sugar moieties, and methods of use thereof.
2016/0237107 Synthetic Route to 2'-Deoxy-2',2'-Difluorotetrahydrouridines
The present invention relates to methods and intermediates for synthesizing 2'-deoxy-2',2'-difluorotetrahydrouridine compounds.
2016/0237106 4'-AZIDO SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF EBOLA VIRUS RNA REPLICATION
The application discloses compounds of Formula I ##STR00001## wherein the variable substituents are as defined herein. The compounds of Formula I and...
2016/0237105 RUTHENIUM CARBON MONOXIDE RELEASING MOLECULES AND USES THEREOF
The present invention provides novel ruthenium compounds of Formula (I): ##STR00001## or salts, isomers, hydrates, or solvates thereof, or combinations thereof;...
2016/0237104 PROCESS FOR PURIFICATION OF NEUTRAL HUMAN MILK OLIGOSACCHARIDE USING SIMULATED MOVING BED CHROMATOGRAPHY
The present application discloses a process for the purification of a neutral human milk oligosaccharide (neutral HMO). The process uses simulated moving bed...
2016/0237103 PROCESSING BIOMASS
Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example,...
2016/0237102 PROCESSES AND APPARATUS FOR LIGNIN SEPARATION IN BIOREFINERIES
The present invention generally provides methods of improving lignin separation during biomass fractionation with an acid to release sugars and a solvent for...
2016/0237101 IMIDAZOLIDINE-BASED METAL CARBENE METATHESIS CATALYSTS
The present invention relates to novel metathesis catalysts with an imidazolidine-based ligand and to methods for making and using the same. The inventive...
2016/0237100 BISAMINOALKOXYSILANE COMPOUNDS AND METHODS FOR USING SAME TO DEPOSIT SILICON-CONTAINING FILMS
Bisaminoalkoxysilanes of Formula I, and methods using same, are described herein: R.sup.1Si(NR.sup.2R.sup.3)(NR.sup.4R.sup.5)OR.sup.6 I where R.sup.1 is...
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