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Patent # Description
2016/0235749 MICRO-PARTICULATED NANOCAPSULES CONTAINING LOPINAVIR WITH ENHANCED ORAL BIOAVAILABILITY AND EFFICACY
The present disclosure provides controlled-release delivery systems for oral delivery of active agents, e.g. lopinavir, comprising micro-particulated with...
2016/0235748 PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS
The invention provides compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections. The compounds and...
2016/0235747 FBXO3 INHIBITORS
A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: ##STR00001## wherein X is a divalent linking moiety; and ...
2016/0235746 Novel Amino Pyrimidine Derivatives
The present invention describes new amino pyrimidine derivatives and pharmaceutically acceptable salts thereof which appear to interact with Bruton's tyrosine...
2016/0235745 METHODS OF TREATING DIABETES OR OBESITY USING BILE ACIDS, BILE SALTS, AND MIMICS THEREOF
Provided herein are methods and compositions for treating metabolic diseases and conditions associated with metabolic diseases.
2016/0235744 SUBSTITUTED PYRIDO[2,3-b]PYRAZINES AS FGFR KINASE INHIBITORS
The invention relates to new pyridopyrazine derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of...
2016/0235743 NON-PLATINUM-BASED ANTI-CANCER COMPOUNDS FOR USE IN TARGETED CHEMOTHERAPY
Disclosed herein are non-platinum-based (NPB) anti-cancer compounds useful for targeted chemotherapy, e.g., to generate anti-cancer effects for the treatment...
2016/0235742 SPRAY DRY FORMULATIONS
Disclosed herein are compounds, compositions, and methods for preventing and treating proliferative diseases associated with aberrant receptor tyrosine kinase...
2016/0235741 METHOD FOR TREATING HYPERTENSION
Dextromethorphan is used to lower blood pressure in a subject suffering from hypertension, alone or in combination with another anti-hypertensive agent. In...
2016/0235740 Compositions of (-)-17-(Cyclobutylmethyl)Morphinan-3,14,-Diol
The present invention is directed to oral, therapeutically effective modified release pharmaceutical compositions of ...
2016/0235739 BUPRENORPHINE WAFER FOR DRUG SUBSTITUTION THERAPY
The present invention relates to oral pharmaceutical dosage forms comprising buprenorphine with the dosage form releasing buprenorphine instantly upon oral,...
2016/0235738 Buprenorphine-wafer for drug substitution therapy
The present invention relates to oral pharmaceutical dosage forms comprising buprenorphine with the dosage form releasing buprenorphine instantly upon oral,...
2016/0235737 MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS
Inhibitors of HCV replication of formula (I) ##STR00001## and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double...
2016/0235736 ANTIMICROBIAL COMPOSITIONS
The present invention relates to antimicrobial compositions and more specifically compositions of quinolone carboxylic acid derivatives. These compositions...
2016/0235735 TREATMENT OF MULTIPLE SCLEROSIS WITH COMBINATION OF LAQUINIMOD AND FAMPRIDINE
This invention provides a method of treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome comprising administering...
2016/0235734 COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY
Compounds of formula I, defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for treating...
2016/0235733 FORMULATIONS and PHARMACOKINETICS OF DEUTERATED BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2
The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2...
2016/0235732 METHODS AND COMPOSITIONS FOR REDUCTION OF SIDE EFFECTS OF THERAPEUTIC TREATMENTS
The invention provides compositions and methods utilizing a nicotinic receptor modulator, e.g., to reduce or eliminate a side effect associated with...
2016/0235731 METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES
The present application provides bifunctional compounds which act as protein degradation inducing moieties. The present application also relates to methods for...
2016/0235730 METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES
The present application provides bifunctional compounds which act as protein degradation inducing moieties. The present application also relates to methods for...
2016/0235729 2,4-THIAZOLIDINEDIONE DERIVATIVES IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS
The present invention provides 5-(4-(2-(5-(1-hydroxyethyl)pyridine-2-yl)ethoxy) benzyl)thiazolidine-2,4-dione and novel stereoisomers of said compound for...
2016/0235728 APOPTOSIS SIGNAL-REGULATING KINASE INHIBITOR
The present invention relates to a compound of formula (I): ##STR00001## The compound has apoptosis signal-regulating kinase ("ASK1") inhibitory activity, and is...
2016/0235727 NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS
The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of us ing the same in the treatment or prevention of...
2016/0235726 Controlled Delivery System
The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are...
2016/0235725 TREATMENT FOR CHEMOTHERAPY-INDUCED COGNITIVE IMPAIRMENT
The present invention provides methods and compositions for treating chemotherapy-induced cognitive impairment. One embodiment of the present invention is...
2016/0235724 TETRAHYDROPYRIDOETHERS FOR THE TREATMENT OF STARGARDT'S DISEASE
A pharmaceutical composition comprising tetrahydropyridoethers for use in the treatment of Stargardt's disease.
2016/0235723 BREAST CANCER CELL GROWTH-INHIBITING ENZYME INHIBITORS, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF
Novel enzyme inhibitors for treatment of breast cancer combine the inhibition of enzymes that combat aggressive breast cell growth both synergistically and...
2016/0235722 Stable Solid Immunosuppressor Composition
Provided herein is a stable solid pharmaceutical composition including 1) one or more immunosuppressant agents and/or pharmaceutically acceptable salts...
2016/0235721 BENZOHETEROCYCLIC COMPOUNDS AND USE THEREOF
Disclosed are compound of formula (I) and pharmaceutically accepted salts and prodrugs thereof, wherein each of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5,...
2016/0235720 Long-Acting Spiro-Isoxazoline Formulations
The invention describes a long-acting injectable veterinary composition comprising a spirocyclic isoxazoline, at least one biopolymer, and optionally, at least...
2016/0235719 METHOD FOR TREATING DEMENTIA
Methods are disclosed for treating dementia, including mild cognitive impairment, via administration of D-cycloserine, or a prodrug thereof, on a...
2016/0235718 COMPOUNDS AND METHODS FOR TREATING AN EPILEPTIC DISORDER
Provided, inter alia, are methods for treating an epilepsy disorder using clemizole, a clemizole analog, or pharmaceutical salts thereof.
2016/0235717 BENDAMUSTINE PHARMACEUTICAL COMPOSITIONS
Pharmaceutical formulations of bendamustine for pharmaceutical use and methods related thereto. The formulations and methods described herein utilize a polar...
2016/0235716 SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE
Compounds having a structure of Formula (IX): ##STR00001## or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2a,...
2016/0235715 Pasty Bio-Adhesive Sustained Release Compositions
The present invention provides pasty or liquid compositions for applications on mucous membranes of cavities easily reached by hand, having a bio-adhesive...
2016/0235714 ENZALUTAMIDE IN COMBINATION WITH AFURESERTIB FOR THE TREATMENT OF CANCER
A novel combination comprising an androgen receptor inhibitor, for example: 4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-th- ...
2016/0235713 AUTOTAXIN INHIBITOR COMPOUNDS
Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such...
2016/0235712 CANCER TREATMENT METHOD
Invented is a method of treating cancer or a pre-cancerous syndrome in a mammal, including a human, in need thereof which comprises the administration of an...
2016/0235711 AMIDE DERIVATIVES OF N-UREA SUBSTITUTED AMINO ACIDS AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS
The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions...
2016/0235710 COMPOSITION FOR TREATING OR PREVENTING ERECTILE DYSFUNCTION COMPRISING LDD175 AS ACTIVE INGREDIENT
The present invention relates to a pharmaceutical composition for treating or preventing erectile dysfunction, containing LDD175 as an active ingredient....
2016/0235709 LIMITED RELEASE LINGUAL THIOCTIC ACID DELIVERY SYSTEMS
A diffusion rate limiting matrix is utilized to buccally, lingually and/or sublingually deliver thioctic acid. This limited release matrix is intended for...
2016/0235708 TOPICAL PIGMENTORY COMPOSITION
A composition is provided for topical photochemotherapy for skin diseases, more specifically it comprises of a topical composition comprising of at least one...
2016/0235707 DISUBSTITUTED BETA-LACTONES AS INHIBITORS OF N-ACYLETHANOLAMINE ACID AMIDASE (NAAA)
The present invention provides compounds and pharmaceutical compositions for inhibiting N-acylethanolamine acid amidase (NAAA). Inhibition of NAAA is...
2016/0235706 INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS
The present invention relates to compounds of general formula I, ##STR00001## wherein the groups (Het)Ar and R.sup.1 are defined as in claim 1, which have...
2016/0235705 MULTI-ARM POLYMERIC PRODRUG CONJUGATES OF TAXANE-BASED COMPOUNDS
Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of taxane-based compounds and/or fluorinated forms thereof. Methods of...
2016/0235704 ANTIMICROBIAL TITANIUM DIOXIDE NANOPARTICLES FUNCTIONALIZED WITH CATIONIC SILVER IONS
The present invention generally relates to Titanium dioxide derivatives of formula TiO.sub.2-[L]-Ag+, functionalized with silver cations by a bifunctional...
2016/0235703 Novel Uses of Neuraminidase Inhibitors in Infectious Diseases
The present invention relates to methods of decreasing the infectivity, morbidity and rate of mortality, in treating diseases associated with a variety of...
2016/0235702 METHODS FOR IMPROVING JOINT FUNCTION
The present technology provides methods for improving joint function in a subject in need thereof. The methods include administering to the subject an...
2016/0235701 Composition and Methods for Treating Intestinal Hyperpermeability
The present invention provides methods, compositions, and kits for treating intestinal hyperpermeability in a subject in need thereof, including conditions...
2016/0235700 GRANULAR FEED SUPPLEMENT
A ruminant feed composition, having a granulated core having at least one active substance and at least one layer of a coating material surrounding the core,...
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