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Patent # Description
2016/0237449 TRANSGENIC PLANTS FOR NITROGEN FIXATION
Provided are genetic material and nucleic acid sequences useful in increasing yield, biomass, growth rate, vigor, nitrogen use efficiency and/or abiotic stress...
2016/0237448 NOVEL ACYLTRANSERASES AND METHODS OF USING
Provided herein are novel acyltransferases and methods of using such novel acyltransferases in making medium-chain fatty acids.
2016/0237447 Transgenic Plants With Enhanced Traits
This disclosure provides transgenic plants having enhanced traits such as increased yield, increased nitrogen use efficiency and enhanced drought tolerance;...
2016/0237446 ZEA MAYS REGULATORY ELEMENTS AND USES THEREOF
Provided are constructs and methods for expressing a transgene in plant cells and/or plant tissues using Zea mays chlorophyll a/b binding gene regulatory...
2016/0237445 SOYBEAN PIP1 PROMOTER AND ITS USE IN CONSTITUTIVE EXPRESSION OF TRANSGENIC GENES IN PLANTS
The disclosure relates to gene expression regulatory sequences from soybean, specifically to recombinant DNA constructs comprising the promoter of a soybean...
2016/0237444 Engineering of Hydrocarbon Metabolism in Yeast
The present invention relates to the development of genetically engineered yeasts that can produce hydrocarbons in a controllable and economic fashion. More...
2016/0237443 METHODS AND SYSTEMS FOR PRODUCING FUNGAL SECONDARY METABOLITES
The present invention discloses methods and systems for producing fungal secondary metabolites. The invention also discloses genetically modified organisms and...
2016/0237442 MODIFIED GROUP I METHANOTROPHIC BACTERIA AND USES THEREOF
Described herein are methods and compositions relating to engineered methanotrophic bacterium and the production of carbon products from methane.
2016/0237441 Engineering of Acetyl-CoA Metabolism in Yeast
The invention relates to engineering of acetyl-CoA metabolism in yeast and in particular to production of acetyl-CoA in a non-ethanol producing yeast lacking...
2016/0237440 siRNA AND THEIR USE IN METHODS AND COMPOSITIONS FOR INHIBITING THE EXPRESSION OF THE PDK1 GENE
The invention relates to siRNA molecules and their use in methods and pharmaceutical compositions for inhibiting the expression of the PDK1 gene. The invention...
2016/0237439 MODULAR RNA REGULATORS AND METHODS
This disclosure describes modular miRNA regulator molecules and methods of using modular miRNA regulator molecules. Generally, the modular miRNA regulator...
2016/0237438 METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF COMPLEMENT COMPONENT 5(C5) BY DOUBLE-STRANDED RNA
This invention relates to compounds, compositions, and methods useful for reducing C5 target RNA and protein levels via use of dsRNAs, e.g., Dicer substrate...
2016/0237437 TOLL-LIKE RECEPTOR 9 ANTAGONIST AND METHODS OF USE THEREOF
The invention provides antagonist of TLR9 and methods of use thereof. These compounds inhibit or suppress TLR9-mediated signaling. The methods may have use in...
2016/0237436 APTAMERS BOUND HUMAN SERUM ALBUMIN AND GLYCATED HUMAN SERUM ALBUMIN
This invention is about the selection and development of aptamers that specifically bound HSA and GHSA. HSA and GHSA are associated with diabetes mellitus. The...
2016/0237435 Multiaptamer Target Detection
Described herein are compositions comprising a first aptamer, second aptamer and a target that are capable of forming a ternary complex, and wherein the first...
2016/0237434 MODULATION OF APOLIPOPROTEIN C-III EXPRESSION
Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to...
2016/0237433 METHOD FOR PROMOTING ANGIOGENESIS, VASCULARIZATION OR VESSEL REPAIR OR FOR INHIBITING TUMOR ANGIOGENESIS
The invention relates to a method for influencing the miR-92 expression in a cell, comprising the following steps: (a) providing a cell; and (b1) reducing the...
2016/0237432 METHODS FOR MODULATING EXPRESSION OF C9ORF72 ANTISENSE TRANSCRIPT
Disclosed herein are methods for reducing expression of C90RF72 antisense transcript in an animal with C90RF72 antisense transcript specific inhibitors. Such...
2016/0237431 INHIBITORS OF CACNA1A/ALPHA1A SUBUNIT INTERNAL RIBOSOMAL ENTRY SITE (IRES) AND METHODS OF TREATING...
The disclosure provides methods of treating polyglutamine diseases, e.g., spinocerebellar ataxia Type 6, in a subject, comprising administering to the subject...
2016/0237430 ALLELE-SPECIFIC RNA SILENCING FOR THE TREATMENT OF HYPERTROPHIC CARDIOMYOPATHY
Provided herein are methods and compositions useful for the treatment of hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM) and/or left...
2016/0237429 COMPOUNDS FOR INDUCING ANTI-TUMOR IMMUNITY AND METHODS THEREOF
Described herein is a previously unknown function of XBP1 in controlling anti-tumor immunity. It is shown that inhibiting XBP1 in tumor-associated dendritic...
2016/0237428 METHODS AND COMPOSITIONS TO INHIBIT METASTASIS AND TO TREAT FIBROSIS AND TO ENHANCE WOUND HEALING
Methods and compositions are provided for inhibiting or treating metastasis based on discoveries regarding Kif19 and Cep192. Methods and compositions are...
2016/0237427 Tau Antisense Oligomers and Uses Thereof
The present invention relates to oligomer compounds (oligomers), which target Tau mRNA in a cell, leading to reduced expression of Tau protein. Reduction of...
2016/0237426 PEPTIDE OLIGONUCLEOTIDE CONJUGATES
Oligonucleotide analogues conjugated to carrier peptides are provided. The disclosed compounds are useful for the treatment of various diseases, for example...
2016/0237425 Pri-mirna libraries and methods for making and using pri-mirna libraries
Provided are methods for the design, preparation, and use of non-native pri-microRNAs (pri-miRNAs), pri-microRNA (pri-miRNA) scaffolds, and libraries of...
2016/0237424 HIGH THROUGHPUT GENERATION AND AFFINITY MATURATION OF HUMANIZED ANTIBODY
Compositions, methods, and kits are provided for efficiently generating and screening humanized antibody with high affinity against a specific antigen. The...
2016/0237423 METHODS FOR THE SELECTION OF BINDING PROTEINS
This application provides an improved screening method for the selection of target-binding proteins having desirable biophysical properties. The method...
2016/0237422 NUCLEIC ACID EXTRACTION FROM HETEROGENEOUS BIOLOGICAL MATERIALS
Methods for extracting high quality nucleic acids from a heterogenous collection of nucleic acid-containing materials from a biological sample are disclosed....
2016/0237421 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS
Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional...
2016/0237420 LYOPHILIZED FORMULATIONS FOR FACTOR XA ANTIDOTE
The present disclosure relates to solutions and methods of preparing lyophilized formulations of factor Xa (fXa) antidotes. A suitable aqueous formulation...
2016/0237419 HUMAN TRYPSINOGEN WITH REDUCED AUTOACTIVATION AND ITS USE IN AN IMMUNOASSAY
The present invention relates to a polypeptide consisting of or comprising a variant of human trypsinogen-1, comprising the substitutions: amino acid residue...
2016/0237418 PROTEASE VARIANTS WITH INCREASED STABILITY
The invention relates to proteases comprising an amino acid sequence which has an at least 70% sequence identity with the amino acid sequence set forth in SEQ...
2016/0237417 Polypeptides Having Xylanase Activity And Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also...
2016/0237416 Polypeptides Having Cellobiohydrolase Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also...
2016/0237415 MUTANT STAPHYLOCOCCUS BETA-GLUCURONIDASE ENZYMES WITH ENHANCED ENZYMATIC ACTIVITY
Mutated Staphylococcus sp. RLH1 .beta.-glucuronidase enzymes with enhanced enzymatic activity and thermostability as compared to wild type enzyme are provided....
2016/0237414 LYSOSOMAL PROTEIN TARGETING SEQUENCE AND THERAPEUTIC APPLICATIONS OF SAME
The present disclosure relates to methods of treating diseases states such as lysosomal storage diseases and/or neurodegenerative diseases. Also disclosed are...
2016/0237413 VULCANISAETAL PHOSPHOTRIESTERASE-LIKE LACTONASES (PLL) HAVING ENHANCED PROPERTIES AND THE USES THEREOF
Provided is a mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus...
2016/0237412 RECOMBINANT POLYMERASES WITH INCREASED PHOTOTOLERANCE
Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that...
2016/0237411 LACCASES FOR BIO-BLEACHING
Provided herein are isolated laccase enzymes and nucleic acids encoding them. Also provided are mediators for laccase reactions. Also provided herein are...
2016/0237410 ALCOHOL DEHYDROGENASE VARIANTS
Described herein are non-natural NAD+-dependent alcohol dehydrogenases (ADHs) capable of at least two fold greater conversion of methanol or ethanol to...
2016/0237409 Renal Progenitor Cells
A method is provided for simultaneously producing both nephron progenitor cells and ureteric epithelial progenitor cells including the step of contacting...
2016/0237408 ADIPOSE DERIVED ADULT STEM CELLS IN HEPATIC REGENERATION
The present invention provides a method to derive hepatic stem cells from stem cells derived from non-liver tissue. In one embodiment of the invention, hepatic...
2016/0237407 UNIVERSAL DONOR CHIMERIC ANTIGEN RECEPTOR CELLS
Disclosed are allogeneic cells useful for the treatment of cancer in a universal donor, off the shelf, manner. In one embodiment of the invention cord blood...
2016/0237406 SEBOCYTES, SEBOCYTE CELL LINES AND APPLICATIONS THEREOF
Adipose cells (sebocytes) are described, The invention especially relates to sebaceous gland cells and to a sebaceous gland cell line with the property of...
2016/0237405 DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS TO MULTIPOTENT NEURAL CREST CELLS
The present invention relates to the differentiation of human pluripotent cells, including human pluripotent stems cells to produce a self-renewing multipotent...
2016/0237404 DIRECTED DIFFERENTIATION OF ASTROCYTES FROM HUMAN PLURIPOTENT STEM CELLS FOR USE IN DRUG SCREENING AND THE...
The present invention discloses a method of identifying agents that affect human astrocytes functionality using ex-vivo differentiated pluripotent stem cells...
2016/0237403 METHOD OF PRODUCING RETINAL PIGMENT EPITHELIAL CELL
Provided are a production method of retinal pigment epithelial (RPE) cells that improves differentiation induction efficiency of pluripotent stem cells into...
2016/0237402 Methods and Compositions for Ex Vivo Generation of Developmentally Competent Eggs from Germ Line Cells Using...
The present technology provides for methods for the directed differentiation of multi-potent cells, female germ line stem cells, or oogonial stem cells into...
2016/0237401 In Vitro Production of Foregut Stem Cells
This invention relates to the differentiation of pluripotent cells (PSCs) into foregut stem cells (FSCs) using a definitive endoderm induction medium...
2016/0237400 ISOLATION OF NON-EMBRYONIC STEM CELLS AND USES THEREOF
The invention described herein relates to methods of isolating non-embryonic stem cell, e.g., adult stem cell, from a non-embryonic tissue, e.g., an adult...
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