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The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies that specifically recognize and bind...
METHOD OF INHIBITING COMPLEMENT ACTIVATION WITH HUMAN ANTI-FACTOR C3
ANTIBODIES AND USES THEREOF
A method of inhibiting complement activation mediated by C3b inhibitors in a subject includes administering a C3B inhibitor to the subject to inhibit at least...
METHOD TO PRODUCE A HIGHLY CONCENTRATED IMMUNOGLOBULIN PREPARATION FOR
The present invention relates to a new and improved method for preparing a highly concentrated immunoglobulin composition from pooled plasma for subcutaneous...
CROSS-REACTIVE STAPHYLOCOCCUS AUREUS ANTIBODY SEQUENCES
The invention refers to a cross-neutralizing antibody comprising at least one polyspecific binding site that binds to alpha-toxin (Hla) and at least one of the...
HUMAN MONOCLONAL ANTIBODIES
The present invention relates, in general, to HIV-1-reactive antibodies and, in at least certain specific embodiments, to broadly neutralizing antibodies...
RSV-SPECIFIC BINDING MOLECULES AND MEANS FOR PRODUCING THEM
The invention provides antibodies and functional equivalents thereof which are capable of specifically binding RSV, and means and methods for producing them.
USE OF ENDOSTATIN PEPTIDES FOR THE TREATMENT OF FIBROSIS
C-terminal endostatin polypeptides are disclosed herein. Polynucleotides encoding these polypeptide, host cells transformed with the polynucleotides, and...
PEPTIDE COMPOUNDS FOR SUPPRESSING INFLAMMATION
Provided herein are peptides that exhibit ApoE biological activity, as well as compositions and pharmaceutical formulations that include the peptides. The...
CELL CULTURE PROCESSES
Culturing heterologous protein-secreting mammalian cells, such as CHO or BHK cells, at 35.1-36.5.degree. C. and/or at pH 7.15-7.20 and/or at a dissolved...
VEGF ANTAGONIST FORMULATIONS SUITABLE FOR INTRAVITREAL ADMINISTRATION
Ophthalmic formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided suitable for intravitreal administration...
VEGF ANTAGONIST FORMULATIONS
Formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided including a pre-lyophilized formulation, a...
Novel Epitope for Switching to Th17 Cell and Use Thereof
The present invention relates to a novel epitope to convert T cell to type 17 helper T (T.sub.H17) cell. Specifically, the present invention relates to an...
POLYNUCLEOTIDES ENCODING IMMUNE MODULATING POLYPEPTIDES
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding at least one...
Polynucleotides Encoding Low Density Lipoprotein Receptor
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding low density...
NATRIURETIC POLYPEPTIDES WITH UNIQUE PHARMACOLOGIC PROFILES
This document provides natriuretic polypeptides. For example, this document provides polypeptides having a natriuretic activity. In some cases, a polypeptide...
SUPERKINES AND SYNTHEKINES: REPURPOSED CYTOKINES WITH NEW AND ENHANCED
Disclosed herein are IL-4 cytokine compositions with enhanced biological activity having increased selectivity for IL-4 cytokine receptors, and methods for...
TISSUE PROTECTIVE PEPTIDES AND USES THEREOF
The present invention is directed to novel tissue protective peptides. The tissue protective peptides of the invention may bind to a tissue protective receptor...
FGF21 MUTANTS AND USES THEREOF
The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21...
NOVEL PRONGF MUTANTS AND USES THEREOF IN THE PRODUCTION OF BETA-NGF
The present invention relates to a proNGF mutant and to uses thereof, in particular the use of a proNGF mutant for producing human beta-NGF. The present...
COLLAGEN-BINDING SYNTHETIC PEPTIDOGLYCANS, PREPARATION, AND METHODS OF USE
This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding...
STABILIZED POLYPEPTIDES AND USES THEREOF
The present invention provides inventive stabilized STAT polypeptides, pharmaceutical compositions thereof and methods of making and using inventive stabilized...
The invention concerns peptides useful as MAP kinase/ERK pathway-specific inhibitors relative to a given substrate in a given subcellular compartment.
HCBI SEQUENCES AS AN EARLY MARKER FOR THE FUTURE DEVELOPMENT OF CANCER AND
DISEASES OF THE CNS AND AS A TARGET...
The present invention relates to HCBI (Healthy Cattle Blood Isolate) nucleotide sequences as well as probes and primers comprising part of said nucleotide...
PEPTIDES AND COMPOSITIONS FOR TREATMENT OF JOINT DAMAGE
The present invention provides new protease resistant polypeptides, as well as compositions and methods for treating, ameliorating or preventing conditions...
Microorganism and Method for the Fermentative Production of an
The invention relates to a microorganism which produces and/or secretes an organic-chemical compound, wherein the microorganism has increased expression,...
PROTEINS AND NUCLEIC ACIDS FROM MENINGITIS/SEPSIS-ASSOCIATED ESCHERICHIA
Disclosed herein are various open reading frames from a strain of E. coli responsible for neonatal meningitis (MNEC), and a subset of these that is of...
CHOLERA TOXIN A-LIKE POLYPEPTIDE USEFUL AS ADJUVANT COMPONENT
A cholera toxin-like polypeptide useful as adjuvant is provided. Polynucleotide coding to the polypeptide and associated vectors, host cells and methods of...
METHODS OF DETECTION AND REMOVAL OF RHABDOVIRUSES FROM CELL LINES
The present disclosure relates to compositions, methods, mixtures, and kits for detecting the presence of and for removing, a virus from a product produced in...
AB Modulating Peptides
The present invention relates to an A.beta. modulating peptide comprising a peptide selected from the list of peptides comprising: (i) ...
NMDA RECEPTOR MODULATORS AND PRODRUGS, SALTS, AND USES THEREOF
Disclosed are compounds having enhanced potency in the modulation of NMD A receptor activity. Such compounds are contemplated for use in the treatment of...
The present invention relates to tripeptide compounds according to the general formula (1) and their use as a medicament, in particular as anti-inflammatory...
PROCESS FOR PRODUCING POROUS CELLULOSE BEADS USING ALKALI AQUEOUS
SOLUTION, CARRIER FOR LIGAND IMMOBILIZATION,...
A process for producing porous cellulose beads of the present invention is characterized by comprising the steps of a) mixing an alkali aqueous solution and...
Method of Extracting Protein
The present disclosure provides a method for extracting a soluble protein from a population of microorganisms, the method comprising contacting the population...
METHOD FOR CROSS-LINKING PEPTIDES
The present invention relates to a method for cross-linking peptides using an activated furan-moiety. In particular, the present invention provides a method...
ENRICHMENT OF TRITERPINE ESTERS
A new process for enriching triterpene esters comprising: providing a mixture comprising a non-distilled vegetable oil and/or a non-distilled vegetable fat,...
SELECTIVE INHIBITORS OF ALPHA2 ISOFORM OF Na,K-ATPase AND USE FOR
REDUCTION OF INTRA-OCULAR PRESSURE
The present invention relates to digoxin and digitoxin derivatives that are selective inhibitors of the .alpha.2 isoform of Na,K-ATPase, and that reduce...
METHOD FOR PREPARING 6-ALKYLATED STEROIDAL DERIVATIVES AND CORRESPONDING
The present invention concerns a method for preparing certain steroidal derivatives alkylated in position 6, comprising a step of alkylating the corresponding...
METHOD FOR SOLUTION PHASE DETRITYLATION OF OLIGOMERIC COMPOUNDS
Provided herein are methods for the synthesis of oligomeric compounds wherein removal of the 5'-terminal trityl group is performed at reduced temperature and...
ANTI-VIRAL PYRIMIDINE NUCLEOSIDE ANALOGUES
A compound of formula (I) wherein Ar can be one six-membered or two fused six-membered aromatic rings; R.sub.8 and R.sub.9 can be hydrogen, alkyl, cycloalkyl,...
SUBSTITUTED NUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER AGENTS
Compounds of the general formula (I): ##STR00001## processes for the preparation of these compounds, compositions containing these compounds, and the uses of...
PROCESS OF MAKING REGADENOSON AND NOVEL POLYMORPH THEREOF
Novel processes for making the N-pyrrazole substituted 2-adenosine derivative regadenoson and a novel polymorph thereof. The novel polymorph of regadenoson...
2', 5' -DIDEOXY-5-FLUOROURIDINE DERIVATIVES HAVING CYTOTOXIC ACTIVITY, A
PROCESS FOR THE MANUFACTURE THEREOF...
The subject matter of the invention is novel 2',5'-dideoxy-5-fluorouridine derivatives of general formula 1. ##STR00001## wherein R.sub.1 denotes cinchona...
CRYSTALLINE FORMS OF A MACROLIDE, AND USES THEREFOR
New crystalline forms of macrolide compounds, and pharmaceutical compositions thereof, are described herein. In addition, processes for preparing the...
PHENOXYCYCLOTRIPHOSPHAZENE ACTIVE ESTER, HALOGEN-FREE RESIN COMPOSITION
AND USES THEREOF
The present invention discloses a phenoxycyclotriphosphazene active ester, a halogen-free resin composition and uses thereof. The phenoxycyclotriphosphazene...
ANTIOXIDANT COMPOUND HAVING ANTI ATHEROSCLEROTIC EFFECT AND PREPARATION
The present invention relates to an antioxidant compound having anti atherosclerotic effect and preparation thereof. The present invention more particularly...
Compounds for Inhibiting Cell Proliferation in EGFR-Driven Cancers
The invention features compounds, pharmaceutical compositions and methods for treating patients who have an EGFR-driven cancer of Formula I: ##STR00001## wherein...
Method For Preparing A Halosilane
A method for preparing a reaction product includes: steps (1) and (2). Step (1) is contacting, at a temperature from 200.degree. C. to 1400.degree. C., a first...
AMINO-SILOXANE COMPOSITION AND METHODS OF USING THE SAME
An amino-siloxane composition is presented. The amino-siloxane composition includes structure (I): ##STR00001## wherein R.sup.l is independently at each...
PROCESS FOR THE TRANS-SELECTIVE HYDROBORATION OF INTERNAL ALKYNES
The present invention refers to a process for the trans-selective hydroboration of internal alkynes and the so-obtained products. The inventive process makes...
SELECTIVE BACE1 INHIBITORS
The present invention provides a compound of Formula II: ##STR00001## or a pharmaceutically acceptable salt thereof.