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Imaging Beta-Amyloid Peptides Aggregation
The present invention is in the field of pharmaceuticals and chemical industries. In particular, one aspect of the present invention relates to methods for...
PEGYLATED NANOPARTICLE COMPOSITIONS
An embodiment of the invention is directed to a composition comprising a noble metal nanoparticle, wherein the surface of the noble metal nanoparticle is...
ENZYME-ENCAPSULATED NANOPARTICLE PLATFORM
Disclosed are methods, systems, and devices for implementing nanoparticles to encapsulate biomolecules such as enzymes. In one aspect, a nanoparticle device...
DEVICES, COMPOSITIONS AND METHODS FOR IMAGING WITH RAMAN SCATTERING
Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are...
Treatment of neurological diseases using adeno-associated virus (AAV)
comprising AAV-5 capsid proteins
The present invention relates to methods for treating disorders affecting motor function, such as motor function affected by disease, injury to the brain...
POLYNUCLEOTIDE COMPOSITIONS CONTAINING AMINO ACIDS
The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides formulations containing amino...
LONG POLY(A) PLASMIDS AND METHODS FOR INTRODUCTION OF LONG POLY(A)
SEQUENCES INTO THE PLASMID
Disclosed herein are polynucleotides having a plurality of thymine nucleotides and an endonuclease recognition site inserted therein, methods of engineering...
MUCUS PENETRATING GENE CARRIERS
Nanoparticles gene carriers, particularly nanoparticle gene carriers which exhibit increased rates of diffusion through cystic fibrosis (CF) mucus, as well as...
NUCLEIC ACID-LIPOPOLYMER COMPOSITIONS
Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may...
COMPOSITIONS AND METHODS FOR THE MANUFACTURE OF LIPID NANOPARTICLES
The invention relates to methods, processes and apparatuses for the manufacture of lipid nanoparticles having a therapeutic payload.
Theranostic Nanoprobes for Overcoming Cancer Multidrug Resistance and
Theranostic nanoprobes are provided for overcoming cancer multidrug resistance, and methods for treating biological tissue, including cancerous tissue. The...
TOLEROGENIC SYNTHETIC NANOCARRIERS
This invention relates, at least in part, to compositions comprising synthetic nanocarriers and immunosuppressants that result in immune suppressive effects....
COMPOUNDS CONTAINING A VASCULAR DISRUPTING AGENT
The present invention relates to compounds, and pharmaceutically acceptable salts thereof, comprising a vascular disrupting agent (VDA) associated and a MMP...
ARTIFICIAL TRANSCRIPTION FACTORS COMPRISING A SLIDING DOMAIN AND USES
The present invention relates to compositions which may comprise a non-naturally occurring or engineered artificial transcription factor, wherein the...
TREATING INFLAMMATION USING LLP2A-BISPHOSPHONATE CONJUGATES AND
MESENCHYMAL STEM CELLS
The present invention provides methods of treating a subject having a primary inflammatory disease or disorder comprising administering to the subject a...
HCV PROTEASE INHIBITORS AND USES THEREOF
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
Glycotargeting therapeutics are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic...
METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL
The present application provides bifunctional compounds which act as protein degradation inducing moieties. The present application also relates to methods for...
HYALURONIC ACID-NUCLEIC ACID CONJUGATE AND COMPOSITION FOR NUCLEIC ACID
DELIVERY CONTAINING THE SAME
The present invention relates to a hyaluronic acid-nucleic acid conjugate for the development of in vivo nucleic acid delivery system, and the development of...
Methods and Compositions for Enhancing Intranasal Delivery of Therapeutic
A method for treating a patient suffering from a condition with an active compound comprising the steps of (a) treating the patient intranasally with an...
METHOD AND SYSTEM FOR ALLEVIATING JOINT PAIN
A system for providing a drug-eluting resorbable hydrogel for treating chronic pain, the system including carboxymethyl chitosan and oxidized carboxymethyl...
ANTIPARASITIC AND/OR ANTIFUNGAL COMPOSITION COMPRISING HYDROPHOBISED
A composition including hydrophobised chitosan can be used as an antiparasitic and/or antifungal agent or in the treatment of parasitic and/or fungal...
HFSH AQUEOUS FORMULATION
Provided is an aqueous formulation of a human follicle stimulating hormone (hFSH) which is stabilized to maintain the activity of hFSH for a prolonged period...
The present invention provides a solution formulation for inhalation comprising: a liquid phase; an active ingredient containing a carboxylic ester in which...
PREPARATION IN THE FORM OF A POWDER CONTAINING AT LEAST ONE CAROTENOID, AT
LEAST ONE MODIFIED STARCH, AND SUCROSE
A preparation in the form of a powder containing: (a) at least one carotenoid, (b) at least one modified starch, and (c) sucrose; wherein the at least one...
PHARMACEUTICAL GELS AND METHODS FOR DELIVERING THERAPEUTIC AGENTS TO A
SITE BENEATH THE SKIN
Pharmaceutical gels and methods for delivering a therapeutic agent to a target tissue site beneath the skin of a patient are provided, the gel being capable of...
Compositions for Dermatological Use
The invention concerns novel compositions, and their use in the management of conditions associated with a defective or disrupted skin barrier in humans and...
EMULSIONS OF PERFLUOROCARBONS
The subject application provides for an emulsion comprising an amount of a perfluorocarbon liquid dispersed as particles within, a continuous liquid phase,...
HCD FORMULATION FOR CANCER TREATMENT
The present invention provides a novel formulation for cancer treatment and a method for enhancing the HCD's efficacy in cancer treatment. Specifically, the...
METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS USING
PLASMONICS ENHANCED PHOTOSPECTRAL THERAPY...
The use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation...
ULTRASOUND MEDIATED DELIVERY OF DRUGS
Disclosed is an ultrasound (US) mediated delivery of therapeutic agents, such as the delivery of a drug, gene, nanoparticle or radioisotope, using a bi-phasic...
MANAGEMENT OF TRACTIONAL MEMBRANES
Methods and compositions are provided here to manage tractional membranes, as well as other diseases and disorders of the eye. Compositions comprising...
PROSTATE CANCER TREATMENT
The present invention relates to a combination of botulinum toxin and hyaluronic acid for use in the radiation treatment of cancer. The present invention also...
The disclosure herein relates generally to immunotherapy and, more specifically, to the use of immunotherapy for treating tumors and pathogen infected tissues....
TARGETING IMMUNOTHERAPY FOR AMYLOIDOSIS
Disclosed are methods and compositions for targeting antibodies to amyloid deposits. For example, amyloid-reactive peptides that bind amyloid deposits are...
ADENOASSOCIATED VIRAL MEDIATED PERSISTANT ANTI-VEGF THERAPY FOR OVARIAN
The invention provides a method of treating ovarian cancer in a patient by administering to the patient an adeno-associated virus (AAV) vector encoding an...
METHODS, COMPOSITIONS, AND KITS FOR TREATMENT OF CANCER
Provided herein are the use of FGFR3 inhibitors and PD1 inhibitors to treat solid and hematologic cancers and compositions and kits comprising an FGFR3...
ANTI-ANGIOGENESIS THERAPY FOR THE TREATMENT OF BREAST CANCER
This invention concerns in general treatment of diseases and pathological conditions with anti-VEGF antibodies. More specifically, the invention concerns the...
Combination Therapy With Anti-CD74 and Anti-CD20 Antibodies Provides
Enhanced Toxicity to B-Cell Diseases
Disclosed are compositions and methods comprising combinations of anti-CD74 and anti-CD20 antibodies or antigen-binding fragments thereof. The antibody...
METHODS AND COMPOSITIONS COMPRISING A COMBINATION OF A VEGF ANTAGONIST AND
AN ANTI-CTLA-4 ANTIBODY
The present invention provides pharmaceutical compositions comprising a VEGF antagonist and an anti-CTLA-4 antibody, and methods of use thereof. The...
TWEAK ANTAGONISTS FOR TREATING LUPUS NEPHRITIS AND MUSCLE ATROPHY
Methods and compositions for treating lupus nephritis and muscle atrophy with anti-TWEAK antibodies are provided. Methods that include administering...
METHODS FOR TREATING CANCERS COMPRISING K-RAS MUTATIONS
Methods of inhibiting tumor growth, methods of treating cancer, and methods of reducing the frequency of cancer stem cells in a tumor are described....
NOVEL COMPOSITIONS AND ADJUVANTS
The present invention is directed toward adjuvants that effect an innate and/or a specific immune response. The adjuvants contain at least one lipoprotein,...
COMPOSITIONS AND METHODS FOR TOLERIZING CELLULAR SYSTEMS
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of molecules for tolerizing cellular systems.
COMPOSITIONS AND METHODS FOR REDUCING ANTIGEN-SPECIFIC IMMUNOGENICITY
Provided are method for inducing immune tolerance to antigens including therapeutic antigens. The method comprises administering to an individual OPLS or other...
VACCINE COMPRISING STREPTOCOCCUS PNEUMONIAE CAPSULAR POLYSACCHARIDE
The present invention discloses an immunogenic composition comprising S. pneumoniae capsular saccharide conjugates from serotypes 19A and 19F wherein 19A is...
INHIBITION OF NONSENSE MEDIATED DECAY PATHWAYS
Compositions for inducing or enhancing antigenicity of a target cell by modulating the nonsense mediated decay pathway in the target cell. The compositions...
MIXED ALLERGEN COMPOSITIONS AND METHODS FOR USING THE SAME
Mixed allergen compositions of two or more different allergens are provided. In some instances, the mixed allergen compositions include: a nut allergen; an...
CMV IMMUNO-STIMULATORY COMPOSITION
The invention relates to a CMV strain comprising interferon bets (IFNb) useful in immuno-stimulatory compositions and vaccines
STABILIZED HUMAN IMMUNODEFICIENCY VIRUS (HIV) CLADE C ENVELOPE (ENV)
TRIMER VACCINES AND METHODS OF USING SAME
The invention features stabilized human immunodeficiency virus (H IV) clade C envelope (Env) trimers. The invention also features vaccines, nucleic acids, and...