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Patent # Description
2016/0244764 METHODS FOR PREDICTING THE PROGRESSION AND TREATING A CHRONIC KIDNEY DISEASE IN A PATIENT
The present invention relates to a method for predicting the progression of chronic kidney disease (CKD) in a patient and also to an inhibitor of NGAL gene...
2016/0244763 COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
The invention relates to iRNA, e.g., double-stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and methods of using...
2016/0244762 REDUCING INTRON RETENTION
Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to...
2016/0244761 LIPID PARTICLES WITH ASYMMETRIC CATIONIC LIPIDS FOR RNA DELIVERY
What is described is a lipid particle comprising the compound of formula I ##STR00001## wherein R.sub.1 consists of alkyl, alkenyl, alkynyl, or cholesteryl; ...
2016/0244760 RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC...
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic,...
2016/0244759 COMPOSITIONS AND TREATMENTS BASED ON CADHERIN MODULATION
Anti-cadherin and anti-ZO-1 agents and compositions, and kits containing them for use in the promotion and/or improvement of wound healing and/or tissue...
2016/0244758 TARGETING GLIOMA STEM CELLS BY SEQUENCE-SPECIFIC FUNCTIONAL INHIBITION OF PRO-SURVIVAL ONCOMIR-138
Methods for malignant glioma diagnosis/prognosis using miR-138 as a prognostic biomarker and methods for treating malignant glioma and inhibiting glioma stem...
2016/0244757 COMPOSITIONS AND METHODS FOR MODULATING NEURONAL EXCITABILITY AND MOTOR BEHAVIOR
The invention is directed to compositions and methods for treating or reducing the likelihood of the development of epilepsy in an individual. The method...
2016/0244756 NOVEL FORMATS FOR ORGANIC COMPOUNDS FOR USE IN RNA INTERFERENCE
The disclosure relates to compositions comprising a RNAi agent having a novel format including a spacer subunit. The disclosure relates to compositions...
2016/0244755 TREATING DISEASES ASSOCIATED WITH PGC1-ALPHA BY MODULATING MICRORNAS MIR-130A AND MIR-130B
Methods of regulating PGC1.alpha. and/or PGC1.beta., or treating diseases associated with PGC1.alpha. and/or PGC1.beta. using a miR-130a RNA, miR-130b RNA, or...
2016/0244754 MICRORNA INHIBITION FOR THE TREATMENT OF INFLAMMATION AND MYELOPROLIFERATIVE DISORDERS
The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of...
2016/0244753 MICRORNA COMPOUNDS AND METHODS FOR MODULATING MIR-21 ACTIVITY
Described herein are compositions and methods for the inhibition of miR-21 activity. The compositions have certain nucleoside modification patterns that yield...
2016/0244752 SERPINA1 SIRNAS: COMPOSITIONS OF MATTER AND METHODS OF TREATMENT
The technology described herein relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the Serpina1 gene, and methods of using such dsRNA...
2016/0244751 BIOACTIVE RENAL CELLS
The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.
2016/0244750 ANTIBODY LIBRARIES
The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically...
2016/0244749 Micro-screening Apparatus, Process, and Products
Microcavity arrays and methods for quantitative biochemical and biophysical analysis of populations of biological variants. Examples include high-throughput...
2016/0244748 SEQUENCE TAG DIRECTED SUBASSEMBLY OF SHORT SEQUENCING READS INTO LONG SEQUENCING READS
The invention provides methods for preparing DNA sequencing libraries by assembling short read sequencing data into longer contiguous sequences for genome...
2016/0244747 EVOLUTION OF BOND-FORMING ENZYMES
Strategies, systems, methods, reagents, and kits for the directed evolution of bond-forming enzymes are provided herein. Evolution products, for example,...
2016/0244746 MUTATED INTERNAL RIBOSOMAL ENTRY SITE (IRES) FOR CONTROLLED GENE EXPRESSION
The present invention relates to a nucleic acid molecule comprising one or multiple mutant IRES elements. Further, the present invention relates to methods of...
2016/0244745 PROTEIN SCAFFOLDS AND METHODS OF USE
This disclosure describes non-naturally occurring protein scaffolds and methods of making and using the protein scaffolds. In one aspect, therefore, this...
2016/0244744 Stabilized Fibronectin Domain Compositions, Methods and Uses
A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin),...
2016/0244743 METHODS AND COMPOSITIONS FOR GENERATION OF BINDING AGENTS AGAINST CELL SURFACE ANTIGENS
Provided are methods and compositions for identifying binding polypeptides (e.g., antibodies or antigen binding fragments thereof) that specifically binds to a...
2016/0244742 METHOD FOR CAPTURING AND ENCODING NUCLEIC ACID FROM A PLURALITY OF SINGLE CELLS
This invention relates to methods for capturing and encoding nucleic acid from a plurality of single cells. A plurality of solid supports is randomly placed...
2016/0244741 POLYMER ENGINEERED REGENERATING BIOSCAVENGERS
Embodiments of the invention provide at least one polymer covalently conjugated to an esterase. The at least one polymer includes a plurality of oxime...
2016/0244740 MUTANT CHONDROITINASE ABC I COMPOSITIONS AND METHODS OF THEIR USE
Disclosed are compositions comprising mutant chondroitinase ABC I and methods of their use. Compositions comprising either the nucleic acid or amino acid...
2016/0244739 METHOD FOR PURIFYING AND QUANTIFYING THROMBIN AND ITS DEGRADATION POLYPEPTIDES
Provided is a method for purifying .alpha.-thrombin and for quantifying .alpha.-thrombin and its degradation polypeptides in a liquid proteinatious solution....
2016/0244738 RECOMBINANT VITAMIN K DEPENDENT PROTEINS WITH HIGH SIALIC ACID CONTENT AND METHODS OF PREPARING SAME
Methods of isolating highly sialylated recombinant vitamin K dependent proteins, particularly Factor IX, by chromatographic methods are described. The highly...
2016/0244737 Regulated PepC Expression
The present invention relates to a recombinant fungal host cell comprising at least one first polynucleotide encoding a polypeptide of interest; and one or...
2016/0244736 Novel Glycoside Hydrolases from Thermophlic Fungi
The present invention relates to isolated polypeptides having cellulolytic activity or hemicellulolytic activity and polynucleotides encoding the polypeptides....
2016/0244735 PEPTIDE WITH QUORUM-SENSING INHIBITORY ACTIVITY, POLYNUCLEOTIDE THAT ENCODES SAID PEPTIDE, AND THE USES THEREOF
The invention relates to the cloning, sequencing and characterization of the gene responsible for Quorum Quenching (QQ) activity against Quorum Sensing (QS)...
2016/0244734 NOVEL FERULATE ESTERASE ISOLATED FROM LACTOBACCILLUS FERMENTUM
The cDNA and amino acid sequences of a ferulate esterase obtained from Lactobacillus fermentum NRRL B-1932 is determined. An expression vector for expression...
2016/0244733 CELLS GENETICALLY MODIFIED TO COMPRISE PANCREATIC ISLET GLUCOKINASE AND USES THEREOF
The present invention relates generally to a population of cells genetically modified to produce insulin in a glucose responsive manner and uses thereof. More...
2016/0244732 Polypeptides Having Glucuronyl Esterase Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having glucuronyl esterase activity, catalytic domains and polynucleotides encoding the polypeptides or...
2016/0244731 Polypeptides Having Peroxygenase Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates...
2016/0244730 RECOMBINANT MICROORGANISM HAVING ENHANCED ABILITY TO PRODUCE 2,3-BUTANEDIOL AND METHOD FOR PRODUCING...
The present invention relates to a gene which codes an enzyme having conversion activity between acetoin and 2,3-butanediol and has a nucleotide sequence of...
2016/0244729 NOVEL HCV CULTURE SYSTEMS AND DIRECT-ACTING ANTIVIRAL SENSITIVITY
The present invention relates to hepatitis C virus (HCV) culture systems of genotypes 1a, 3a, 4a, 5a, and 6a that directly contribute to HCV drug and vaccine...
2016/0244728 CULTURE METHOD FOR PLURIPOTENT STEM CELLS AND KIT AND MEDIUM FOR CULTURE OF PLURIPOTENT STEM CELLS USED THEREIN
A culture method for pluripotent stem cells includes obtaining a polypeptide-coated culture surface by applying a polypeptide to a cell culture surface of a...
2016/0244727 ARTIFICIAL MICROVASCULAR DEVICE AND METHODS FOR MANUFACTURING AND USING THE SAME
Artificial microvascular devices may include a polymer scaffold that defines a channel with a distensible wall.
2016/0244726 METABOLICALLY OPTIMIZED CELL CULTURE
Improved methods for large scale production of proteins and/or polypeptides in cell culture is provided. In accordance with the present invention, the method...
2016/0244725 METABOLICALLY OPTIMIZED CELL CULTURE
An improved method for large scale production of proteins and/or polypeptides in cell culture is provided. In accordance with the present invention, the method...
2016/0244724 DENTAL PULP MARROW SIMILAR CELLS (DPMSC) AND METHODS OF ISOLATING AND USING
The invention provides for isolated population of pulp marrow similar cells (DPMSCs) and methods for isolating and using these cells. The population of DPMSCs...
2016/0244723 CARDIAC STEM CELLS AND USES OF SAME IN CARDIAC REPAIR
Method for the isolation, expansion and preservation of cardiac stem cells from human or animal tissue biopsy samples to be employed in cell transplantation...
2016/0244722 TISSUE PROCESSING DEVICE AND ASSOCIATED SYSTEMS AND METHODS
Tissue processing devices are provided. The tissue processing devices can be used to process and transport tissue in a closed and continuous environment. The...
2016/0244721 METHOD FOR PURIFICATION OF RETINAL PIGMENT EPITHELIAL CELLS
The present invention provides a method of purifying highly pure retinal pigment epithelial cells from a cell population obtained by induction of ...
2016/0244720 MEDIUM FOR PREPARING A NEURAL CELL AND USAGE THEREOF
Usage of a protein kinase inhibitor in preparing a neural cell from a differentiated non-neural cell is provided.
2016/0244719 GENERATING ARTERIAL ENDOTHELIAL CELL POPULATIONS
Methods for generating human arterial endothelial cells under defined conditions in the absence of insulin are described.
2016/0244718 REPROGRAMMING OF PLURIPOTENT STEM CELLS FOR IMPROVED CONTROL OF THEIR DIFFERENTIATION PATHWAYS
The present invention relates to a method to reprogramming pluripotent stem cells (PSCs) by epigenetic conditioning and metabolic reprogramming into p PSCs...
2016/0244717 BIOREACTOR SYSTEM
A three dimensional cell culture and bioreactor system is provided. The system comprises one or more cell culture chamber. Each cell culture chamber comprises...
2016/0244716 PROTOCOL AND MEDIA FOR STORAGE AND TRANSPORT OF NK-92 CELL LINE
Described herein is a storage medium for transport of NK-92 cells comprising human serum, about 200 IU/mL and a density of non-irradiated NK-92 cells...
2016/0244715 DEVICE FOR MANIPULATING BIOLOGICAL CELLS USING A VIBRATING SUPPORT
Device for sorting living cells, comprising at least one support including a surface having adherence properties with respect to said type of living cells,...
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