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METHODS FOR PREDICTING THE PROGRESSION AND TREATING A CHRONIC KIDNEY
DISEASE IN A PATIENT
The present invention relates to a method for predicting the progression of chronic kidney disease (CKD) in a patient and also to an inhibitor of NGAL gene...
COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
The invention relates to iRNA, e.g., double-stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and methods of using...
REDUCING INTRON RETENTION
Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to...
LIPID PARTICLES WITH ASYMMETRIC CATIONIC LIPIDS FOR RNA DELIVERY
What is described is a lipid particle comprising the compound of formula I ##STR00001## wherein R.sub.1 consists of alkyl, alkenyl, alkynyl, or cholesteryl; ...
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY
MODIFIED SHORT INTERFERING NUCLEIC...
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic,...
COMPOSITIONS AND TREATMENTS BASED ON CADHERIN MODULATION
Anti-cadherin and anti-ZO-1 agents and compositions, and kits containing them for use in the promotion and/or improvement of wound healing and/or tissue...
TARGETING GLIOMA STEM CELLS BY SEQUENCE-SPECIFIC FUNCTIONAL INHIBITION OF
Methods for malignant glioma diagnosis/prognosis using miR-138 as a prognostic biomarker and methods for treating malignant glioma and inhibiting glioma stem...
COMPOSITIONS AND METHODS FOR MODULATING NEURONAL EXCITABILITY AND MOTOR
The invention is directed to compositions and methods for treating or reducing the likelihood of the development of epilepsy in an individual. The method...
NOVEL FORMATS FOR ORGANIC COMPOUNDS FOR USE IN RNA INTERFERENCE
The disclosure relates to compositions comprising a RNAi agent having a novel format including a spacer subunit. The disclosure relates to compositions...
TREATING DISEASES ASSOCIATED WITH PGC1-ALPHA BY MODULATING MICRORNAS
MIR-130A AND MIR-130B
Methods of regulating PGC1.alpha. and/or PGC1.beta., or treating diseases associated with PGC1.alpha. and/or PGC1.beta. using a miR-130a RNA, miR-130b RNA, or...
MICRORNA INHIBITION FOR THE TREATMENT OF INFLAMMATION AND
The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of...
MICRORNA COMPOUNDS AND METHODS FOR MODULATING MIR-21 ACTIVITY
Described herein are compositions and methods for the inhibition of miR-21 activity. The compositions have certain nucleoside modification patterns that yield...
SERPINA1 SIRNAS: COMPOSITIONS OF MATTER AND METHODS OF TREATMENT
The technology described herein relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the Serpina1 gene, and methods of using such dsRNA...
BIOACTIVE RENAL CELLS
The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.
The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically...
Micro-screening Apparatus, Process, and Products
Microcavity arrays and methods for quantitative biochemical and biophysical analysis of populations of biological variants. Examples include high-throughput...
SEQUENCE TAG DIRECTED SUBASSEMBLY OF SHORT SEQUENCING READS INTO LONG
The invention provides methods for preparing DNA sequencing libraries by assembling short read sequencing data into longer contiguous sequences for genome...
EVOLUTION OF BOND-FORMING ENZYMES
Strategies, systems, methods, reagents, and kits for the directed evolution of bond-forming enzymes are provided herein. Evolution products, for example,...
MUTATED INTERNAL RIBOSOMAL ENTRY SITE (IRES) FOR CONTROLLED GENE
The present invention relates to a nucleic acid molecule comprising one or multiple mutant IRES elements. Further, the present invention relates to methods of...
PROTEIN SCAFFOLDS AND METHODS OF USE
This disclosure describes non-naturally occurring protein scaffolds and methods of making and using the protein scaffolds. In one aspect, therefore, this...
Stabilized Fibronectin Domain Compositions, Methods and Uses
A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin),...
METHODS AND COMPOSITIONS FOR GENERATION OF BINDING AGENTS AGAINST CELL
Provided are methods and compositions for identifying binding polypeptides (e.g., antibodies or antigen binding fragments thereof) that specifically binds to a...
METHOD FOR CAPTURING AND ENCODING NUCLEIC ACID FROM A PLURALITY OF SINGLE
This invention relates to methods for capturing and encoding nucleic acid from a plurality of single cells. A plurality of solid supports is randomly placed...
POLYMER ENGINEERED REGENERATING BIOSCAVENGERS
Embodiments of the invention provide at least one polymer covalently conjugated to an esterase. The at least one polymer includes a plurality of oxime...
MUTANT CHONDROITINASE ABC I COMPOSITIONS AND METHODS OF THEIR USE
Disclosed are compositions comprising mutant chondroitinase ABC I and methods of their use. Compositions comprising either the nucleic acid or amino acid...
METHOD FOR PURIFYING AND QUANTIFYING THROMBIN AND ITS DEGRADATION
Provided is a method for purifying .alpha.-thrombin and for quantifying .alpha.-thrombin and its degradation polypeptides in a liquid proteinatious solution....
RECOMBINANT VITAMIN K DEPENDENT PROTEINS WITH HIGH SIALIC ACID CONTENT AND
METHODS OF PREPARING SAME
Methods of isolating highly sialylated recombinant vitamin K dependent proteins, particularly Factor IX, by chromatographic methods are described. The highly...
Regulated PepC Expression
The present invention relates to a recombinant fungal host cell comprising at least one first polynucleotide encoding a polypeptide of interest; and one or...
Novel Glycoside Hydrolases from Thermophlic Fungi
The present invention relates to isolated polypeptides having cellulolytic activity or hemicellulolytic activity and polynucleotides encoding the polypeptides....
PEPTIDE WITH QUORUM-SENSING INHIBITORY ACTIVITY, POLYNUCLEOTIDE THAT
ENCODES SAID PEPTIDE, AND THE USES THEREOF
The invention relates to the cloning, sequencing and characterization of the gene responsible for Quorum Quenching (QQ) activity against Quorum Sensing (QS)...
NOVEL FERULATE ESTERASE ISOLATED FROM LACTOBACCILLUS FERMENTUM
The cDNA and amino acid sequences of a ferulate esterase obtained from Lactobacillus fermentum NRRL B-1932 is determined. An expression vector for expression...
CELLS GENETICALLY MODIFIED TO COMPRISE PANCREATIC ISLET GLUCOKINASE AND
The present invention relates generally to a population of cells genetically modified to produce insulin in a glucose responsive manner and uses thereof. More...
Polypeptides Having Glucuronyl Esterase Activity and Polynucleotides
The present invention relates to isolated polypeptides having glucuronyl esterase activity, catalytic domains and polynucleotides encoding the polypeptides or...
Polypeptides Having Peroxygenase Activity and Polynucleotides Encoding
The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates...
RECOMBINANT MICROORGANISM HAVING ENHANCED ABILITY TO PRODUCE
2,3-BUTANEDIOL AND METHOD FOR PRODUCING...
The present invention relates to a gene which codes an enzyme having conversion activity between acetoin and 2,3-butanediol and has a nucleotide sequence of...
NOVEL HCV CULTURE SYSTEMS AND DIRECT-ACTING ANTIVIRAL SENSITIVITY
The present invention relates to hepatitis C virus (HCV) culture systems of genotypes 1a, 3a, 4a, 5a, and 6a that directly contribute to HCV drug and vaccine...
CULTURE METHOD FOR PLURIPOTENT STEM CELLS AND KIT AND MEDIUM FOR CULTURE
OF PLURIPOTENT STEM CELLS USED THEREIN
A culture method for pluripotent stem cells includes obtaining a polypeptide-coated culture surface by applying a polypeptide to a cell culture surface of a...
ARTIFICIAL MICROVASCULAR DEVICE AND METHODS FOR MANUFACTURING AND USING
Artificial microvascular devices may include a polymer scaffold that defines a channel with a distensible wall.
METABOLICALLY OPTIMIZED CELL CULTURE
Improved methods for large scale production of proteins and/or polypeptides in cell culture is provided. In accordance with the present invention, the method...
METABOLICALLY OPTIMIZED CELL CULTURE
An improved method for large scale production of proteins and/or polypeptides in cell culture is provided. In accordance with the present invention, the method...
DENTAL PULP MARROW SIMILAR CELLS (DPMSC) AND METHODS OF ISOLATING AND
The invention provides for isolated population of pulp marrow similar cells (DPMSCs) and methods for isolating and using these cells. The population of DPMSCs...
CARDIAC STEM CELLS AND USES OF SAME IN CARDIAC REPAIR
Method for the isolation, expansion and preservation of cardiac stem cells from human or animal tissue biopsy samples to be employed in cell transplantation...
TISSUE PROCESSING DEVICE AND ASSOCIATED SYSTEMS AND METHODS
Tissue processing devices are provided. The tissue processing devices can be used to process and transport tissue in a closed and continuous environment. The...
METHOD FOR PURIFICATION OF RETINAL PIGMENT EPITHELIAL CELLS
The present invention provides a method of purifying highly pure retinal pigment epithelial cells from a cell population obtained by induction of ...
MEDIUM FOR PREPARING A NEURAL CELL AND USAGE THEREOF
Usage of a protein kinase inhibitor in preparing a neural cell from a differentiated non-neural cell is provided.
GENERATING ARTERIAL ENDOTHELIAL CELL POPULATIONS
Methods for generating human arterial endothelial cells under defined conditions in the absence of insulin are described.
REPROGRAMMING OF PLURIPOTENT STEM CELLS FOR IMPROVED CONTROL OF THEIR
The present invention relates to a method to reprogramming pluripotent stem cells (PSCs) by epigenetic conditioning and metabolic reprogramming into p PSCs...
A three dimensional cell culture and bioreactor system is provided. The system comprises one or more cell culture chamber. Each cell culture chamber comprises...
PROTOCOL AND MEDIA FOR STORAGE AND TRANSPORT OF NK-92 CELL LINE
Described herein is a storage medium for transport of NK-92 cells comprising human serum, about 200 IU/mL and a density of non-irradiated NK-92 cells...
DEVICE FOR MANIPULATING BIOLOGICAL CELLS USING A VIBRATING SUPPORT
Device for sorting living cells, comprising at least one support including a surface having adherence properties with respect to said type of living cells,...