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Patent # Description
2016/0251656 MicroRNAs Modulating the Effect of Glucocorticoid Signaling
The present invention discloses microRNAs (miR) involved in the regulation of the lipid and glucose metabolism. Several conserved miR molecules were found as...
2016/0251655 COMPOSITIONS FOR MODULATING C9ORF72 EXPRESSION
Disclosed herein are compositions and methods for reducing expression of C90RF72 mRNA and protein in an animal with C90RF72 specific inhibitors. Also disclosed...
2016/0251654 Novel short hairpin RNA compositions, methods of making and applications thereof
Provided herein are novel synthetic short hairpin RNA (shRNA) molecules and compositions and kits comprising such molecules, as well as methods of making and...
2016/0251653 THERAPEUTIC COMPOUNDS
The present invention is directed to RNA interference (RNAi) molecules targeted against a Huntington's disease nucleic acid sequence, and methods of using...
2016/0251652 COMPOSITIONS FOR INHIBITING CHECKPOINT GENE EXPRESSION AND USES THEREOF
The present invention is directed to compounds, compositions, and methods useful for modulating PD1, PDL1, IDO1, LAG3, TIM3, CTLA4, IDO2, CEACAM1, OX40, and/or...
2016/0251651 CELL FREE CLONING OF NUCLEIC ACIDS
Methods and devices for cell-free sorting and cloning of nucleic acid libraries are provided herein.
2016/0251650 LINKING SEQUENCE READS USING PAIRED CODE TAGS
Artificial transposon sequences having code tags and target nucleic acids containing such sequences. Methods for making artificial transposons and for using...
2016/0251649 METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells...
2016/0251648 FUNCTIONAL GENOMICS USING CRISPR-CAS SYSTEMS, COMPOSITIONS, METHODS, SCREENS AND APPLICATIONS THEREOF
The present invention generally relates to libraries, kits, methods, applications and screens used in functional genomics that focus on gene function in a cell...
2016/0251647 CONTINUOUS FLOW NUCLEIC ACID EXTRACTION APPARATUS AND METHOD OF USE THEREOF
A continuous flow nucleic acid extraction apparatus comprising a piston column apparatus for the extraction of nucleic acids from a nucleic acid sample. The...
2016/0251646 TISSUE SCAFFOLDS FOR ELECTRICALLY EXCITABLE CELLS
Inventive concepts relate generally to nanofibrous scaffolds useful for electrophysiological assays. Scaffolds include polymeric nanofibrous components and...
2016/0251645 MUTANT POLYPEPTIDES AND USES THEREOF
The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of...
2016/0251644 NOVEL POLYPEPTIDES AND USES THEREOF
The present disclosure provides novel polypeptides with improved 3-buten-2-ol dehydratase activity, polypeptides with improved linalool dehydratase activity,...
2016/0251643 Aldolases, Nucleic Acids Encoding Them and Methods for Making and Using Them
This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity,...
2016/0251642 STABLE FUNGAL CEL6 ENZYME VARIANTS
The disclosure provides variant Ce16a enzymes having increased thermostability, methods of making and using such polypeptides.
2016/0251641 ALPHA-AMYLASE AND ALPHA-AMYLASE VARIANTS
The invention relates to a novel Termamyl-like alpha-amylase, and Termamyl-like alpha-amylases comprising mutations in two, three, four, five or six...
2016/0251640 Compositions And Methods Of Nucleic Acid-Targeting Nucleic Acids
This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof. Genome engineering can refer...
2016/0251639 METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells...
2016/0251638 THERAPEUTIC NUCLEASE-ALBUMIN FUSIONS AND METHODS
The invention provides for hybrid nuclease-albumin molecules with increased pharmacokinetic properties. The hybrid nuclease-albumin molecules of the invention...
2016/0251637 COMPOSITIONS FOR INCREASING POLYPEPTIDE STABILITY AND ACTIVITY, AND RELATED METHODS
This disclosure provides peptides, polypeptides, fusion polypeptides, compositions, and methods for enhancing or increasing the stability of a polypeptide...
2016/0251636 NEW METHODS TO PRODUCE ACTIVE TERT
The present invention relates to a method to reproducibly produce large amounts of soluble and active telomerase reverse transcriptase (TERT) by expressing...
2016/0251635 RECOMBINANT PRODUCTION OF STEVIOL GLYCOSIDES
Recombinant polypeptides having UDP-glycosyltransferase activities, including a 1,2-19-O-glucose glycosylation activity and a 1,2-13-O-glucose glycosylation...
2016/0251634 MUTATED GENES FOR THE CATALYTIC PROTEIN OF OPLOPHORUS LUCIFERASE AND USE THEREOF
Secreted luciferases which are different from those known heretofore have been desired. The present invention provides a luciferase mutant comprising an amino...
2016/0251633 RECOMBINANT YEAST AND SUBSTANCE PRODUCTION METHOD USING THE SAME
Substance productivity is improved by introducing a metabolic pathway for synthesis of acetyl-CoA or acetic acid from glucose-6-phosphate into yeast. Acetic...
2016/0251632 METHOD FOR ADJUSTING EXPRESSION OF HYDROXYMETHYLGLUTARYL COA REDUCTASE USING BZIP-TYPE TRANSCRIPTION FACTOR,...
The present invention provides a method enhancing the polyisoprenoid biosynthesis pathway. Also provided are an isoprenoid-producing plant having an overall...
2016/0251631 DECREASING POTENTIAL IATROGENIC RISKS ASSOCIATED WITH INFLUENZA VACCINES
Influenza viruses for use in preparing human vaccines have traditionally been grown on embryonated hen eggs, although more modern techniques grow the virus in...
2016/0251630 METHODS AND MOLECULES FOR SUPPRESSION OF RNA SILENCING
Certain embodiments of the invention relate to mutant forms of flock house virus B2 protein characterized by having enhanced suppressor of RNA silencing...
2016/0251629 COMPOSITIONS AND METHODS FOR REPROGRAMMING EUKARYOTIC CELLS
The present invention relates to methods for changing the state of differentiation of a eukaryotic cell, the methods comprising introducing mRNA encoding one...
2016/0251628 Apparatus And Method For Filtration Of A Suspension
The present invention provides devices suitable for filtration including diafiltration of a suspension containing a species such as particles, cells or...
2016/0251627 Differentiation and Enrichment of Islet-like Cells From Human Pluripotent Stem Cells
Methods for differentiating human pluripotent stem cells into islet-like cells are provided. In certain embodiments, the methods utilize sequential culturing...
2016/0251626 THREE-DIMENSIONAL TISSUE AND PRODUCTION METHOD THEREFOR
Provided are an elastic three-dimensional tissue and a method by which the tissue can be produced. The elastic three-dimensional tissue includes smooth muscle...
2016/0251625 METHOD FOR SCALABLE SKELETAL MUSCLE LINEAGE SPECIFICATION AND CULTIVATION
The present disclosure relates to methods for enhancing cultured meat production, such as livestock-autonomous meat production. In certain aspects, the meat is...
2016/0251624 REPROGRAMMING CARDIOMYOCYTES WITH ONE TRANSCRIPTION FACTOR
Compositions and methods are described herein for chemically inducing cells that express a single pluripotency transcription factor to change their...
2016/0251623 NOVEL CHONDROCYTE INDUCTION METHOD
Provided is a method for producing chondrocytes from pluripotent stem cells, the method comprising the steps of: (i) inducing pluripotent stem cells to...
2016/0251622 POST-NATAL HEMATOPOEITIC ENDOTHELIAL CELLS AND THEIR ISOLATION AND USE
Provided herein are methods of isolation and identification of post-natal hemogenic endothelial cells. Further provided are substantially purified populations...
2016/0251621 SINGLE B-CELL CULTIVATION METHOD
Herein is reported a method for obtaining a B-cell comprising the following steps a) labeling B-cells, b) depositing the labeled B-cells as single cells, c)...
2016/0251620 METHOD FOR RETRIEVAL OF STEM CELLS FROM HUMAN AND ANIMAL BLOOD USING AN OXYGEN-OZONE MIXTURE
The present invention relates to a method for retrieving more numerous, viable and efficient stem cells from the blood of a patient. The method comprises a...
2016/0251619 METHOD OF OBTAINING TERMINALLY DIFFERENTIATED NEURONAL LINEAGES AND USES THEREOF
Provided is a method of inducing transdifferentiation of mesenchymal stem cells (MSC), the method including (a) culturing MSC in a first culture medium...
2016/0251618 SUBSTANTIALLY PURE HUMAN RETINAL PROGENITOR, FOREBRAIN PROGENITOR, AND RETINAL PIGMENT EPITHELIUM CELL CULTURES...
Methods for producing substantially pure cultures of human neural retinal progenitor cells, forebrain progenitor cells, and retinal pigment epithelial cells...
2016/0251617 METHOD FOR PREPARING HETEROGENETIC CORNEAL MATERIAL
Disclosed is a method for preparing a heterogenous corneal material, wherein during the whole preparation process, different concentrations of glycerol are...
2016/0251616 METHOD FOR PRODUCING RETINAL TISSUE AND RETINA-RELATED CELLS
The present invention provides a method for producing a retinal progenitor cell, including (1) a first step of subjecting pluripotent stem cells to floating...
2016/0251615 DEFINED MEDIA FOR EXPANSION AND MAINTENANCE OF PLURIPOTENT STEM CELLS
The present invention provides methods to promote the proliferation of undifferentiated pluripotent stem cells in defined media. Specifically, the invention...
2016/0251614 CELL CULTURE MEDIUM AND BIOPROCESS OPTIMIZATION
The invention provides a chemically defined cell culture media and methods of using the media. The invention also provides an inverse screen to identify small...
2016/0251613 CULTURE METHOD FOR PLURIPOTENT STEM CELLS, CULTURE KIT, AND MEDIUM FOR PLURIPOTENT STEM CELL CULTURE
A culture method for pluripotent stem cells includes culturing pluripotent stem cells on a cell culture surface of a support by using a medium in which the...
2016/0251612 CULTURE MEDIUM FOR ESTABLISHING NEUROEPITHELIAL STEM CELLS, METHOD FOR ESTABLISHING NEUROEPITHELIAL STEM CELLS,...
The present invention discloses a culture medium for establishing neuroepithelial stem cells, a method for establishing neuroepithelial stem cells, and the...
2016/0251611 A PROCESS FOR GROWING A MICROBIAL ORGANISM
An method for growing a microbial organism, comprising the cultivation of the microbial organism in the presence of a hydrolyzed composition obtained from a...
2016/0251610 MICROBES WITH CONTROLLED ADHESIVE PROPERTIES
The present invention encompasses a phototrophic microorganism with altered and controlled adhesive properties.
2016/0251609 Reduced Genome Bacteria With Improved Genetic Stability
Reduced genome bacteria with improved genetic stability are provided. Also provided are methods of producing polypeptides using the reduced genome bacteria...
2016/0251608 SYSTEM AND METHOD FOR USING A PULSE FLOW CIRCULATION FOR ALGAE CULTIVATION
A device for generating a pulsed flow in a channel containing a circulating algal culture can include a plate that is pivotably mounted on the channel and an...
2016/0251607 SYSTEM FOR RECYCLING WATER TO FACILITATE THE PRODUCTION OF ETHANOL
A system for the production of ethanol is disclosed. The system comprises a system for recycling water in an ethanol production process. The system may...
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