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Patent # Description
2016/0251456 1,3-DIPOLAR COMPOUND BEARING AN IMIDAZOLE FUNCTIONAL GROUP
In a 1,3-dipolar compound of formula Q-A-B, Q comprises a dipole containing at least and preferably one nitrogen atom, A, which is preferably divalent, is an...
2016/0251455 Methods of Preparation of an Olefin Oligomerization Catalyst
A method of making a catalyst for use in oligomerizing an olefin comprising a chromium-containing compound, a pyrrole-containing compound, a metal alkyl, a...
2016/0251454 FUNCTIONALIZED COPOLYMER RUBBER CONTAINING NITRILE GROUPS
The present invention relates to functionalized copolymer rubbers containing nitrile groups and to the preparation thereof, to vulcanizable mixtures comprising...
2016/0251453 PREPARATION OF POLY ALPHA-1,3-GLUCAN ESTERS AND FILMS THEREFROM
Poly alpha-1,3-glucan ester compounds are disclosed herein with a degree of substitution of about 0.05 to about 3.0. Also disclosed are methods of producing...
2016/0251452 PROCESS FOR PRODUCING CELLULOSE DERIVATIVE AND CELLULOSE DERIVATIVE
A process for producing a cellulose derivative, comprising: a first step including reacting a cellulose and a first reactant comprising a long-chain reactant...
2016/0251451 DISSOLUTION AND PROCESSING OF CELLULOSE
The invention relates to a method for dissolving the components of gel forming materials suitable for use in wound care comprising the steps of admixing said...
2016/0251450 PROTEIN-POLYMER COMPLEX, TGase SUBSTRATE-CONTAINING POLYMER, TGase SUBSTRATE-CONTAINING MONOMER, METHOD FOR...
Provided is a protein-polymer complex which is capable of detecting a target with good sensitivity. Specifically provided is a protein-polymer complex...
2016/0251449 Antibody specific to staphylococcus aureus, therapeutic method and detection method using same
We provide new monoclonal antibody inhibitors of coagulases for treatment of S. aureus. The monoclonal antibodies are useful in targeting the SC N-terminus and...
2016/0251448 METHOD OF INCREASING THE EFFECT OF AN ACTIVATED-POTENTIATED FORM OF AN ANTIBODY
The preset invention provides a method of increasing the effect of an activated-potentiated form of an antibody to an endogenous biological molecule by...
2016/0251447 ANTIBODIES THAT SPECIFICALLY BIND ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED KINASE PHOSPHORYLATED AT...
Monoclonal antibodies that specifically bind ataxia telangiectasia-mutated and RAD3-related kinase phosphorylated at position 1989 (pT1989 ATR), antigen...
2016/0251446 PIK3C2G FUSIONS
The invention provides to PIK3C2G (phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma) gene fusions and PIK3C2G fusion proteins. The...
2016/0251445 DOSAGE AND ADMINISTRATION OF ANTI-EGFR THERAPEUTICS
Methods for optimizing a therapeutic response in a patient (e.g., a cancer patient) to an anti-EGFR therapy, and methods for preventing or ameliorating...
2016/0251444 THERAPEUTIC USE OF ANTI-CD22 ANTIBODIES FOR INDUCING TROGOCYTOSIS
Disclosed are methods and compositions of anti-B cell antibodies, preferably anti-CD22 antibodies, for diagnosis, prognosis and therapy of B-cell associated...
2016/0251443 IL-17 RECEPTOR A ANTIGEN BINDING PROTEINS
The present invention relates to IL-17 Receptor A (IL-17RA or IL-17R) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said...
2016/0251442 ANTI-PRLR ANTIBODIES AND USES THEREOF
The present invention provides antibodies that bind to prolactin receptor (PRLR) and methods of using the same. According to certain embodiments, the...
2016/0251441 ANTIBODY PURIFICATION
Described herein is a method for separating antibody fragment impurities from target antibodies or desired fragments thereof.
2016/0251440 BISPECIFIC NANOBODIES
The present disclosure relates to bispecific polypeptides comprising a first and a second immunoglobulin single variable domain (ISV), wherein said first ISV...
2016/0251439 METHOD FOR PRODUCING POLYCLONAL ANTIBODIES USING AN ANTIGENIC COMPOSITION COMPRISING PROTEIN-CONTAINING...
The invention relates to a method for producing polyclonal antibodies against an antigenic target protein which comprises inducing an immune response in a host...
2016/0251438 ANTI-GARP PROTEIN AND USES THEREOF
The present invention relates to a protein binding to GARP in the presence of TGF-.beta. and uses thereof.
2016/0251437 METHODS FOR TREATING CANCER IN PATIENTS WITH ELEVATED LEVELS OF BIM
Materials and methods for treating cancer especially in patients identified as having elevated levels of Bim are disclosed. Specifically, the disclosure...
2016/0251436 Anti-PD-1 Antibodies
Antibodies that bind to programmed cell death protein 1 (PD-1), compositions comprising such antibodies, and methods of making and using such antibodies are...
2016/0251435 NON-PLATELET DEPLETING AND NON-RED BLOOD CELL DEPLETING CD47 ANTIBODIES AND METHODS OF USE THEREOF
This invention relates generally to monoclonal antibodies that recognize CD47, more specifically to CD47 antibodies that do not cause a significant level of...
2016/0251434 NOVEL RECEPTOR TREM (TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS) AND USES THEREOF
Novel activating receptors of the lg super-family expressed on human myeloid cells, called TREM(s) (triggering receptor expressed on myeloid cells) are...
2016/0251433 ANTI-C5 ANTIBODIES HAVING IMPROVED PHARMACOKINETICS
The disclosure provides antibodies that are useful for, among other things, inhibiting terminal complement (e.g., the assembly and/or activity of the C5b-9...
2016/0251432 HUMAN PAC1 ANTIBODIES
Antibodies and antigen-binding fragments thereof that bind to human PAC1 are provided. Nucleic acids encoding the antibodies and antigen-binding fragments...
2016/0251431 Anti-DLL3 antibody drug conjugates
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
2016/0251430 ANTI-BAFF-ANTI-IL-17 BISPECIFIC ANTIBODIES
Bispecific antibodies are provided that specifically bind B-cell Activating Factor of the TNF Family (BAFF) and Interleukin-17A (IL-17) and are characterized...
2016/0251429 NEUTRALISING ANTIBODY MOLECULES HAVING SPECIFICITY FOR HUMAN IL-17
The invention relates to an antibody molecule having specificity for antigenic determinants of IL-17, therapeutic uses of the antibody molecule and methods for...
2016/0251428 STABLE AND SOLUBLE ANTIBODIES INHIBITING TNF ALPHA
The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF, which comprise specific light chain and...
2016/0251427 Antibodies against phosphorylcholine in combination therapy with biologic agents
Antibodies against PC, PC conjugate or bioactive components and/or fragments thereof for use in combination therapy with one or more biologic agents and/or...
2016/0251426 Antibodies against phosphorylcholine in combination therapy with biologic agents
Antibodies against PC, PC conjugate or bioactive components and/or fragments thereof for use in combination therapy with one or more biologic agents and/or...
2016/0251425 PROTEIN PURIFICATION METHODS TO REDUCE ACIDIC SPECIES
The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount...
2016/0251424 Uses and Compositions for Treatment of Ankylosing Spondylitis
The invention provides methods, uses and compositions for the treatment of ankylosing spondylitis (AS). The invention describes methods and uses for treating...
2016/0251423 STEM CELL FACTOR INHIBITOR
Provided herein are methods, compositions, and uses relating to inhibitors of stem cell factor. For example, provided herein are antibodies targeting stem cell...
2016/0251422 ANTIBODY FORMULATION
The invention provides a stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of an antibody, optionally, not subjected to...
2016/0251421 COMBINATION OF ANGIOPOIETIN-2 ANTAGONIST AND OF VEGF-A, KDR AND/OR FLT1 ANTAGONIST FOR TREATING CANCER
The invention relates to agents which possess anti-antigenic activity and are accordingly useful in methods of treatment of disease states associated with...
2016/0251420 ANTIBODIES TO TAU AND USES THEREOF
Monoclonal antibodies to human tau aggregate, compositions comprising such tau antibodies, and methods of using such tau antibodies for the treatment of...
2016/0251419 Amyloid Protofibril Antibodies and Methods of Use Thereof
The invention relates to methods for obtaining antibodies that recognize amyloid protofibrils and antibodies that recognize one or more amyloid protofibrils....
2016/0251418 ANTI-TRANSTHYRETIN ANTIBODIES
The invention provides antibodies that specifically bind transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or...
2016/0251417 ANTIBODIES RECOGNIZING MEDIN
The invention provides antibodies that specifically bind to medin. The antibodies have the capacity to bind to monomeric, misfolded, aggregated, fibril or...
2016/0251416 Humanized Antibodies That Recognize Alpha-Synuclein
The present application discloses humanized 1H7 antibodies. The antibodies bind to human alpha synuclein and can be used for treatment and diagnosis of Lewy...
2016/0251415 Mycobacterial Antigen Composition
There is provided an antigenic composition comprising (a) a first mycobacterial antigenic polypeptide or a first mycobacterial polynucleotide; and (b) a second...
2016/0251414 ANTI-LPS ENRICHED IMMUNOGLOBULIN FOR USE IN TREATMENT AND/OR PROPHYLAXIS OF FIBROSIS
This invention relates to methods and compositions for treating fibrosis, by administering compositions comprising anti-LPS immunoglobulin enriched colostrum...
2016/0251413 ANTIBODY MOLECULES TO DENGUE VIRUS AND USES THEREOF
Antibody molecules that specifically bind to dengue virus are disclosed. In certain embodiments, the antibody molecule bind to dengue virus serotypes DV-1,...
2016/0251412 RSV-SPECIFIC BINDING MOLECULE
The invention provides antibodies and functional equivalents thereof which are capable of specifically binding RSV. Nucleic acid sequences encoding said...
2016/0251411 HOST CELL PROTEIN MODIFICATION
Compositions and methods for engineered cell lines and expressions systems are provided that allow for expression of recombinant proteins in eukaryotic cells...
2016/0251410 COMPOSITIONS AND METHODS FOR EXPRESSING RECOMBINANT POLYPEPTIDES
Methods of expressing a recombinant polypeptide of interest are provided. Accordingly there is provided a method comprising providing a cell having been...
2016/0251409 Targeted Delivery of Factor VIII Proteins to Platelets
The invention described herein relates to novel molecules and polypeptides comprising at least one amino acid sequence having significant identity with...
2016/0251408 THROMBIN CLEAVABLE LINKER WITH XTEN AND ITS USES THEREOF
The present invention provides a chimeric molecule comprising a VWF protein fused to a heterologous moiety via a VWF linker. The invention provides an...
2016/0251407 GLUCOSE-RESPONSIVE INSULIN CONJUGATES
Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a...
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