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Patent # Description
2016/0251406 HLA-A24 AGONIST EPITOPES OF MUC1-C ONCOPROTEIN AND COMPOSITIONS AND METHODS OF USE
The invention provides a human cytotoxic T lymphocyte (CTL) agonist epitope from the C-terminal subunit of mucin 1 (MUC1-C), which can be used as a peptide,...
2016/0251405 APPLICATION OF METRNL PROTEIN IN PREPARING HYPOLIPIDEMIC, HYPOGLYCEMIC MEDICINE
The present invention provides an application of Metrnl protein in preparing a hypolipidemic, hypoglycemic medicine or dietary supplement. The present...
2016/0251404 DESIGNED ANKYRIN REPEAT PROTEINS BINDING TO HEPATOCYTE GROWTH FACTOR
New designed ankyrin repeat proteins with binding specificity for HGF are described, as well as nucleic acids encoding such HGF binding proteins, ...
2016/0251403 PEPTIDE COMBINATIONS AND USES THEREOF IN TREATING DUST MITE ALLERGY
The invention relates to combinations of peptides or variants thereof derived from a portion of an amino sequence of CM a house dust mite allergen, e.g. the...
2016/0251402 MICROPEPTIDES AND USE OF SAME FOR MODULATING GENE EXPRESSION
Process for detecting and identifying micropeptides (miPEPs) encoded by a nucleotide sequence contained in the sequence of the primary transcript of a microRNA...
2016/0251401 METHOD FOR INCREASING ETEC CS6 ANTIGEN PRESENTATION ON CELL SURFACE AND PRODUCTS OBTAINABLE THEREOF
A method for increasing the presentation of ETEC CS6 antigen on cell surface, comprising the step of contacting cells expressing said antigen with an aqueous...
2016/0251400 HIGH AFFINITY ADAPTOR MOLECULES FOR REDIRECTING ANTIBODY SPECIFITY
Disclosed are methods for identifying high affinity adaptor molecules that bind to both a circulating antibody and a target molecule and redirect the...
2016/0251399 PEPTIDOMIMETIC MACROCYCLES
The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral disease.
2016/0251398 ANTIBACTERIAL ANTISENSE OLIGONUCLEOTIDE AND METHOD
A method for enhancing, by at least 10 fold, the antibacterial activity of an antisense oligonucleotide composed of morpholino subunits linked by ...
2016/0251397 AKT-SPECIFIC CAPTURE AGENTS, COMPOSITIONS, AND METHODS OF USING AND MAKING
The present application provides stable peptide-based Akt capture agents and the use thereof as detection, diagnosis, and treatment agents. The application...
2016/0251396 METHODS FOR SEPARATING AND PURIFYING ENDOGENOUS, EXOGENOUS AND RECOMBINANT PROTEINS/PEPTIDES FROM PLANTS AND...
The present invention relates to recombinant proteins/peptides from plant and animal materials, compositions comprising the proteins/peptides and methods for...
2016/0251395 READILY ISOLATED BISPECIFIC ANTIBODIES WITH NATIVE IMMUNOGLOBULIN FORMAT
A bispecific antibody format providing ease of isolation is provided, comprising immunoglobulin heavy chain variable domains that are differentially modified...
2016/0251394 PRODUCTION METHOD FOR POROUS CELLULOSE BEADS, AND ADSORBENT EMPLOYING SAME
The objective of the present invention is to provide to a method for easily producing high-performance porous cellulose beads having high mechanical strength....
2016/0251393 Highly Potent Glucocorticoids
The present invention relates to novel glucocorticoid compounds. The invention also relates to methods of using these compounds, the synthesis of these...
2016/0251392 5-Beta, 14-Beta-Androstane Derivatives Useful For The Treatment Of Proteinuria, Glomerulosclerosis And Renal...
Compound of formula (I), wherein the symbol have the meaning reported in the text; for preparing a medicament for the prevention and/or treatment of...
2016/0251391 NEUROACTIVE ENANTIOMERIC 15-, 16- AND 17-SUBSTITUTED STEROIDS AS MODULATORS FOR GABA TYPE-A RECEPTORS
The present disclosure is generally directed to neuroactive enantiomeric 15-, 16- and 17-substituted steroids with additional optional substituents at carbons...
2016/0251390 7-DEAZAPURINE MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF
Disclosed are compounds, pharmaceutical compositions containing the compounds, uses of the compounds and compositions as modulators of histone...
2016/0251389 INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES
The present invention relates to intermediates of Formula I ##STR00001## and to methods of synthesizing and purifying calicheamicin derivatives.
2016/0251388 SULFOXIDATION CATALYSTS AND METHODS FOR THEIR PREPARATION AND USE
Methods and compositions of catalysts for sulfoxidation reaction processes are disclosed. The sulfoxidation reaction process can be performed in an aqueous...
2016/0251387 SYNTHESIS OF 1-ALKYL-2-AMINO-IMIDAZOL-5-CARBOXYLIC ACID ESTER VIA CALPHA-SUBSTITUTED N-ALKYL-GLYCINE ESTER...
The invention provides an efficient and high yielding process for preparing TH-302, comprising at least one step wherein a dioxolane intermediate is generated...
2016/0251386 Lipid Co-factor Essential for Cell Density Signaling
Herein is described a cell density signaling protein and its tissue-specific lipid cofactor. Constructs, compositions and methods for isolation, purification...
2016/0251385 Method For The Synthesis Of Alkane-1-Hydroxy-1,1-Diphosphonic Acid
The present invention is related to a new method for the synthesis of alkane-1-hydroxy-,1-diphosphonic acid or its salts which includes the steps of --reacting...
2016/0251384 METHOD OF SEPARATING ACIDS FROM CHEMICAL REACTION MIXTURES BY MEANS OF APOLAR AMINES
A process for the removal of acids from reaction mixtures, comprising at least one product of value which is sparingly soluble in water, by at least one...
2016/0251383 METHODS FOR PRODUCING SINGLE CRYSTAL MIXED HALIDE PEROVSKITES
An aspect of the present invention is a method that includes contacting a metal halide and a first alkylammonium halide in a solvent to form a solution and...
2016/0251382 PROCESS FOR THE RUTHENIUM CATALYZED TRANS-SELECTIVE HYDROSTANNATION OF ALKYNES
The present invention refers to a process for the ruthenium-catalyzed trans-selective hydrostannation of alkynes and the so-obtained products. The inventive...
2016/0251381 ASH-FREE CYCLIC ORGANIC POLYOL-BASED REACTIVE POROGENS AND NANOPOROUS ULTRA LOW DIELECTRIC FILM BY USING THE SAME
The present disclosure relates to a reactive porogen using cyclic organic polyol and an ultra low dielectric film prepared using the same, and more ...
2016/0251380 TRICYCLIC BENZOXABOROLE COMPOUNDS AND USES THEREOF
Compounds of Formula II, ##STR00001## wherein X is selected from chloro, fluoro, bromo and iodo, R.sup.1 and R.sup.2 are each independently selected from H,...
2016/0251379 MOLECULAR SWITCHES BASED ON CIS/TRANS ISOMERIZATION OF BF2-COORDINATED AZO COMPOUNDS
Provided herein are photochromic organic compounds of Formula I or Formula II, which are useful as molecular switches capable of being triggered via a...
2016/0251378 Transmetalation Methods for the Synthesis of PET and SPECT Imaging Agents
A process for the preparation of a radionuclide imaging agent includes providing an imaging agent including a chelated place-holder metal; loading the imaging...
2016/0251377 AZAINDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS
Azaindoles having inhibitory activity on RSV replication and having the formula I ##STR00001## compositions containing these compounds as active ingredient and ...
2016/0251376 TYK2 INHIBITORS AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated...
2016/0251375 METHODS AND INTERMEDIATES FOR PREPARING MACROLACTAMS
The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for...
2016/0251374 FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC
A compound or its pharmaceutically acceptable salt, optionally including both individual enantiomeric forms, a racemate, diastereomers and mixtures thereof,...
2016/0251373 5-HT3 RECEPTOR ANTAGONISTS
The present invention provides 5-HT3 receptor antagonists of Formula (I): ##STR00001## which are useful for the treatment of diseases treatable by inhibition of ...
2016/0251372 SWEET FLAVOR MODIFIER
The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds...
2016/0251371 PROCESS FOR PREPARING ISOSORBIDE DI(METH)ACRYLATE
A process for preparing isosorbide di(meth)acrylate by transesterifying alkyl (meth)acrylate with isosorbide, comprising the steps of: (i) reacting alkyl...
2016/0251370 PROCESS FOR PREPARING ISOSORBIDE ETHOXYLATE DI(METH)ACRYLATE
A process for preparing isosorbide ethoxylate di(meth)acrylate by transesterifying alkyl (meth)acrylate with isosorbide ethoxylate, comprising the steps of: ...
2016/0251369 Azatriangulenium Salts As Pet-Quenched Fluorescent Probes
The present invention relates to a new class of substituted aza-triangulenium fluorescent dyes having a hydroxy group attached to an aryl as quenching group....
2016/0251368 Novel 8-Oxoprotoberberine Derivative or Pharmaceutically Acceptable Salt Thereof, Preparation Method Therefor...
The preset invention relates to a novel 8-oxoprotoberberine derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a...
2016/0251367 SYNTHESIS OF TRITOQUALINE SALTS
A formulation of tritoqualine salt having the purpose of improving the solubility of these novel compounds and having the following general structure: ...
2016/0251366 DEUTERATED AMLEXANOX
Provided herein is technology relating to deuterated amlexanox and particularly, but not exclusively, to compositions comprising deuterated amlexanox, methods...
2016/0251365 PROCESS FOR PREPARING OXYCODONE COMPOSITIONS
In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
2016/0251364 PROCESS FOR PREPARING OXYCODONE COMPOSITIONS
In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
2016/0251363 PROCESS FOR PREPARING OXYCODONE COMPOSITIONS
In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
2016/0251362 NOVEL COMPOUNDS
Compounds of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for treating diseases and conditions in which...
2016/0251361 IMIDAZOPYRIMIDINE AND IMIDAZOTRIAZINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
The present disclosure provides a compound of Chemical Formula (1) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising...
2016/0251360 A STABLE POLYMORPH OF THE SALT OF (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZI- ...
A stable polymorph (Form Z1) of the salt of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro ...
2016/0251359 METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF
Compounds that modulate GluR5 activity and methods of using the same are disclosed.
2016/0251358 PYRAZOLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS
The present disclosure provides compounds of Formula (IA) and/or pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular...
2016/0251357 Method of Treatment Using Substituted Imidazo[1,2b]Pyridazine Compounds
Methods for treating a disease or disorder selected from pain, cancer, inflammation, neurodegenerative disease, Typanosoma cruzi infection and osteolytic...
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