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Patent # Description
2016/0251356 FLUORESCENT CARBAPENEMS
Chromogenic or fluorescent carbapenems according to formula I, wherein Ar is a mono or disubstituted carbocyclic aromatic group or an optionally mono or...
2016/0251355 PYRIDO[4,3-B]PYRAZINE-2-CARBOXAMIDES AS NEUROGENIC AGENTS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
The present invention relates to compounds of general formula I wherein R.sup.1, R.sup.2 and R.sup.3 are as defined herein which may be used for the treatment...
2016/0251354 METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION
A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: ##STR00001## comprises: (a) reacting Compound (X): ##STR00002## or a...
2016/0251353 INHIBITORS OF INFLUENZA VIRUSES REPLICATION
Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: ...
2016/0251352 HETEROCYCLIC COMPOUND
The present invention provides a compound having a superior JAK inhibitory action, which is useful as an agent for the prophylaxis or treatment of autoimmune...
2016/0251351 INHIBITORS OF HISTONE DEACETYLASE
The present invention relates to compounds of formula (I): ##STR00001## or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U,...
2016/0251350 CRYSTALLINE FORMS OF A PYRROLOPYRIDINE COMPOUND
Disclosed are crystalline forms of (R)--N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)c- yclopropanecarboxamide, and salts, solvates, and...
2016/0251349 SOLID FORM OF PYRAZOLOPYRIDINE COMPOUND
A novel crystalline form or amorphous of formula (I) and preparation method thereof are disclosed in present invention, wherein the novel crystalline form is...
2016/0251348 PYRIDO[2,3-d]PYRIMIDIN-4-ONE COMPOUNDS AS TANKYRASE INHIBITORS
Pyrido[2,3-d]pyrimidin-4-one compounds, formulations containing those compounds, and their use as tankyrase 1 and 2 inhibitors Formula (I). ##STR00001##
2016/0251347 FUSED PYRIMIDINE COMPOUNDS
Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and...
2016/0251346 3,3-DISUBSTITUTED-(8-AZA-BICYCLO[3.2.1]OCT-8-YL)-[5-(1H-PYRAZOL-4-YL)-THIO- PHEN-3-YL]-METHANONES AS INHIBITORS...
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain ...
2016/0251345 Amorphous Salt of a Macrocyclic Inhibitor of HCV
The amorphous form of the sodium salt of the macrocyclic inhibitor of HCV of formula: ##STR00001## as well as processes for manufacturing this salt.
2016/0251344 Novel crystalline form of 2-piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}-3-chloro- ...
The present invention relates to a novel crystalline form of 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-y- ...
2016/0251343 PHOTOACID COMPOSITIONS HAVING EXTENDED LIFETIME OF PROTON DISSOCIATION STATE
A photoacid includes a nucleophilic (NuH) moiety having a photodissociable proton, an electron accepting (EA) moiety, and a bridge structure (X) bonded to both...
2016/0251342 ALDEHYDE DERIVATIVE OF SUBSTITUTED OXAZOLIDINONES
The present invention concern towards the prodrug of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-morpholin-4-yl)phenyl]-1,3-oxazolidin- ...
2016/0251341 SUBSTITUTED TRIAZOLE COMPOUNDS AS SERINE PROTEASE INHIBITORS
There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin and/or kallikrein, which compounds include substituted...
2016/0251340 HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
2016/0251339 AROMATIC HETEROCYCLIC COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS
Provided herein are novel aromatic heterocyclic compounds or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a...
2016/0251338 AMORPHOUS ALLISARTAN ISOPROXIL, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION CONTAINING...
The present invention relates to an amorphous allisartan isoproxil which is an angiotensin II receptor blocker with good flowability and a large bulk density...
2016/0251337 6-(5-HYDROXY-1H-PYRAZOL-1-YL)NICOTINAMIDE INHIBITORS OF PHD
The present invention provides compounds of the formula: ##STR00001## which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for...
2016/0251336 MODIFIED AMINO ACIDS COMPRISING TETRAZINE FUNCTIONAL GROUPS, METHODS OF PREPARATION, AND METHODS OF THEIR USE
Provided herein are modified amino acids comprising a tetrazine groups according to Formula I: polypeptides, antibodies, payloads and conjugates comprising...
2016/0251335 NEW COMPOUNDS
The invention relates to compounds of the general formula (I) wherein the variable have the meanings as indicated in the claims, or a physiologically...
2016/0251334 MANUFACTURING PROCESS FOR PYRIMIDINE DERIVATIVES
The invention relates to processes for manufacturing a compound of formula 5, ##STR00001## or a stereoisomer, tautomer or a salt thereof, wherein the...
2016/0251333 PROCESSES FOR THE PREPARATION OF (S)-3-(4-((4-(MORPHOLINOMETHYL)BENZYL)OXY)-1-OXOISOINDOLIN-2-YL)PIPERIDIN- ...
Provided are processes for the preparation of enantiomerically enriched or enantiomerically pure ...
2016/0251332 Herbicidal Compounds
The invention relates to dihydro hydantoin compounds of the formula (I) wherein X, R.sup.3, R.sup.a, R.sup.b R.sup.c and R.sup.d are as defined in the...
2016/0251331 Metal-conjugated microporous polymers
A catalyst which can catalyze ring-addition reaction of CO.sub.2 and an alkylene oxide at 0.about.180.degree. C. under 0.1.about.8.0 MPa to produce a...
2016/0251330 CHROMENE DERIVATIVES AS INHIBITORS OF TCR-NCK INTERACTION
The present invention relates to a group of compounds of formula (I) containing a chromene nucleus: ##STR00001## and which present the ability to inhibit the...
2016/0251329 FLUOROPHORE 3-HYDROXYFLAVONE
The present invention discloses the syntheses of new 3-hydroxyflavone salts with defined structures, which are suitable for sensor applications for sensing...
2016/0251328 PROCESS FOR PRODUCING DIHYDRO-2H-PYRAN DERIVATIVES
Disclosed is a process for preparing dihydro-2H-pyran derivatives of formula I: ##STR00001## wherein R.sup.1 and R.sup.2 are defined herein. The process...
2016/0251327 PROCESS FOR REMOVING IRON IONS FROM AN ORGANIC STREAM
Embodiments of the present disclosure include a process for removing iron ions from an organic stream by contacting the organic stream with an ion exchange...
2016/0251326 SILVER CATALYSTS WITH IMPROVED SIZE AND DISTRIBUTION DENSITY OF SILVER PARTICLES
A silver-based ethylene epoxidation catalyst is provided that exhibits improved performance, i.e., selectivity and activity decline. The catalyst that exhibits...
2016/0251325 METHODS OF CHEMICAL SYNTHESIS OF DIAMINOPHENOTHIAZINIUM COMPOUNDS INCLUDING METHYLTHIONINIUM CHLORIDE (MTC)
Methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as "diaminophenothiazinium compounds") including...
2016/0251324 MACROCYCLIC UREA AND SULFAMIDE DERIVATIVES AS INHIBITORS OF TAFIA
The invention relates to compounds of the formula (I) which are inhibitors of activated thrombin-activable fibrinolysis inhibitor. The compounds of the formula...
2016/0251323 PROCESS FOR PREPARING ISOXAFLUTOLE
A process for preparing isoxaflutole of formula (I) wherein the process comprises: admixing ...
2016/0251322 Substituted N-(Tetrazol-5-yl)- and N-(Triazol-5-yl)arylcarboxamide Compounds and Their Use as Herbicides
The present invention relates to a triazole compound of formula I, an N-oxide or an agriculturally suitable salt thereof, wherein the variables are defined as...
2016/0251321 SIX-MEMBERED C-N-LINKED ARYL SULFIDE DERIVATIVES AND ARYL SULFOXIDE ERIVATVES AS PEST CONROL AGENTS
The present invention relates to novel heterocyclic compounds, to processes for preparation thereof and to the use thereof for controlling animal pests, which...
2016/0251320 Compounds
Novel phenazine derivatives, methods for their preparation and their medical use, in particular as anti-neoplastic agents and anti-infective agents, are...
2016/0251319 CARBOXYLIC ACID COMPOUNDS
The present disclosure concerns at least one entity chosen from compounds of Formula (I) and pharmaceutically acceptable salts thereof: (I) wherein the...
2016/0251318 KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more...
2016/0251317 PARASITICIDAL COMPOSITIONS COMPRISING BENZIMIDAZOLE DERIVATIVES, METHODS AND USES THEREOF
The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one benzimidazole...
2016/0251316 PROCESS FOR THE PREPARATION OF ENZALUTAMIDE
The present invention provides a process for the preparation of enzalutamide.
2016/0251315 LOW HYGROSCOPIC ARIPIPRAZOLE DRUG SUBSTANCE AND PROCE3SSES FOR THE PREPARATION THEREOF
The present invention provides low hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose...
2016/0251314 2-[[[2-[(HYDROXYACETYL)AMINO]-4-PYRIDINYL]METHYL]THIO]-N-[4-(TRIFLUOROMETH- OXY)PHENYL]-3-PYRIDINECARBOXAMIDE...
In the course of developing 2-[[[2-[(hydroxyacetyl) amino]-4-pyridinyl] methyl] thio]-N-[4-(trifluoromethoxy) phenyl]-3-pyridinecarboxamide (compound A), there...
2016/0251313 PROCESS FOR REGORAFENIB
The present invention provides processes for the preparation of i) Regorafenib (4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophen- ...
2016/0251312 Honeybee Repellents and Uses Thereof
The present specification discloses honeybee repellents exhibiting repellent properties similar to 2-heptanone, compositions comprising such repellents, uses...
2016/0251311 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED 3-AMINOPIPERIDINE
The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, and in particular of its R-enantiomer...
2016/0251310 COMPOUNDS AS MODULATORS OF RORC
The present invention encompasses compounds of the formula (I): wherein the variables are defined herein which are suitable for the modulation of RORC and the...
2016/0251309 BICYCLIC COMPOUNDS
Disclosed are compounds of Formula (I) ##STR00001## and/or a salt thereof; wherein R is --OH or --OP(O)(OH).sub.2. Also disclosed are methods of using such...
2016/0251308 Cyclohexenone Compositions and Process for Making Thereof
Provided herein are processes of preparing cyclohexenone compounds useful for cancer treatments and/or diseases.
2016/0251307 ARYL ETHERS AND USES THEREOF
The present disclosure relates to HIF-2.alpha. inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in...
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