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DIHYDROPYRIDINONE MGAT2 INHIBITORS
The present invention provides compounds of Formula (I): ##STR00001## or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the...
METHOD AND COMPOSITIONS FOR TREATMENT OR PREVENTION OF INFLAMMATORY
Pharmaceutical compositions and methods for treating or preventing an inflammatory condition in a patient are disclosed. The pharmaceutical compositions and...
METHODS OF TREATING KERATIN HYPERPROLIFERATION DISORDERS USING mTOR
A method of treating or preventing keratin hyperproliferation skin disorders is set forth. The method includes the administration of an mTOR inhibitor to a...
LONG-ACTING INJECTABLE FORMULATIONS COMPRISING AN ISOXAZOLINE ACTIVE
AGENT, METHODS AND USES THEROF
This invention relates to long-acting injectable formulations for combating parasites in animals, comprising at least one isoxazoline active agent, a...
MODULATION OF MRTF-A ACTIVITY IN PATHOLOGIC FIBROSIS AND WOUND HEALING
The present disclosure concerns uses for isoxazole compounds or salts or analogs thereof for the treatment of wounds. The present disclosure also concerns...
MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN
There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl or...
PREVENTION AND TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE
Methods for preventing, treating, and/or reducing the risk of developing non-alcoholic fatty liver disease in a subject in need thereof and pharmaceutical...
CATALYTIC SCAVENGERS OF ORGANOPHOSPHATES TO POTENTIATE
BUTYRYLCHOLINESTERASE (hBChE) AS A CATALYTIC...
Provided are N-alkyl imidazole 2-aldoximes, including cationic imidazolium and uncharged tertiary imidazole aldoximes, and compositions and methods for making...
METHODS OF TREATING ALZHEIMER'S DISEASE AND PHARMACEUTICAL COMPOSITIONS
The present invention describes methods of treating dementia comprising administering an effective daily dose of ...
USE OF EQUOL FOR TREATING ANDROGEN MEDIATED DISEASES
Equol (7-hydroxy-3(4'hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of...
Composition with Pharmacological Effect for Vaporizing and Method
A composition is provided that includes a cannabinoid capable of inducing a pharmacological effect, an ester, a condensation aerosol, and a carrier liquid...
USE OF STING AGONISTS TO TREAT HEPATITIS B VIRUS INFECTION
The invention includes methods of treating a subject having hepatitis B viral (HBV) infection. In certain embodiments, the method of the invention comprises...
Formulations Containing Amorphous Dapagliflozin
The present invention belongs to the field of pharmaceutical industry and relates to an amorphous solid dispersion comprising at least one polymer and...
COMPOSITIONS AND METHODS OF INHIBITING N-ACYLETHANOLAMINE-HYDROLYZING ACID
Compounds and pharmaceutical compositions are contemplated that inhibit N-acyl-ethanolamine-hydrolyzing acid amidase (NAAA) to so increase the concentration of...
This document provides methods and materials related to treating cancer (e.g. skin cancer). For example, methods and materials relating to the use of a...
METHOD FOR TREATING SKIN INFLAMMATORY DISEASES
The present invention is directed to a method for treating skin inflammatory diseases such as dermatitis, psoriasis, and acne, and rosacea, by administering...
COMPOUNDS AND COMPOSITIONS COMPRISING SUCH COMPOUNDS FOR THE PREVENTION OR
TREATMENT OF DYSLIPIDAEMIAS
The present invention relates to the field of medicine. It more particularly relates to the use of compounds for preventing and/or treating dyslipidemia in a...
COMPOSITION CONTAINING MONOACETYLDIACYLGLYCEROL COMPOUND AS ACTIVE
INGREDIENT FOR INHIBITING BLOOD CANCER OR...
The present invention relates to a composition containing a monoacetyldiglyceride compound as an active ingredient, for inhibiting blood cancer or metastasis,...
HALOGENATED ESTERS OF CYCLOPROPANATED UNSATURATED FATTY ACIDS FOR USE IN
THE TREATMENT OF NEURODEGENERATIVE...
The present disclosure describes novel PKC-.epsilon. activators chosen from halogenated esters of unsaturated fatty acids derivatives thereof, including...
Composition preventing necrotic enteritis in galloanserans
The present invention refers to the use of a glycerol ester composition of at least one short chain fatty acid for preventing and/or alleviating necrotic...
Prostacyclin Compounds, Compositions and Methods of use Thereof
Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked...
OPHTHALMIC COMPOSITIONS AND METHODS FOR TREATING EYES
Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye...
COMPOSITION AND METHOD FOR INCREASING THE RATE OF ALCOHOL METABOLISM AND
PREVENTING HANGOVER SYMPTOMS
Compositions for increasing the rate of metabolism of alcohol in a human and preventing the symptoms of a hangover comprising amino acids of one or both of...
MEDICAMENT FOR THERAPEUTIC TREATMENT OF NEUROPATHIC DISEASE
A medicament to be applied as an external preparation for therapeutic treatment of a local symptom of a neuropathic disease, which contains gabapentin or...
COMPOSITION CONTAINING EUGENOL AS ACTIVE INGREDIENT FOR PREVENTING OR
TREATING ATOPIC DERMATITIS
The present invention relates to a pharmaceutical composition, a functional health food composition, a quasi-drug composition, and a cosmetic composition...
Phosphate-Binding Magnesium Salts And Uses Thereof
The present invention provides, among other things, compositions and methods suitable for the treatment of hyperphosphatemia based on phosphate-binding...
APPLICATION OF FLUOXETINE TO TREATMENT OF DEPIGMENTATION DISEASES
The present disclosure provides methods and pharmaceutical compositions for treating depigmentation diseases such as vitiligo or leukoctricia. The...
METHODS FOR ADMINISTRATION AND FORMULATIONS FOR THE TREATMENT OF REGIONAL
Provided herein are pharmaceutical formulations, methods, and systems for treating regional fat deposits and fat-related conditions and indications. Methods...
NOVEL TREATMENTS FOR ATTENTION AND COGNITIVE DISORDERS, AND FOR DEMENTIA
ASSOCIATED WITH A NEURODEGENERATIVE...
The present invention provides a method of treating or preventing an attention and/or cognitive disorder in a subject in need thereof, comprising administering...
DOSAGE REGIMEN OF AN S1P RECEPTOR MODULATOR
S1P receptor modulators are administered following a dosage regimen providing a positive benefit-risk profile.
TRANSMUCOSAL KETAMINE DELIVERY COMPOSITION
Disclosed are preparations and formulations of high thermodynamic activity lipophilic associations (LA), in which there is pairing between an ionizable...
AMANTADINE COMPOSITIONS AND METHODS OF USE
Methods of nighttime administration of amantadine to reduce sleep disturbances in patient undergoing treatment with amantadine are described, as well as...
COMPOSITION AND METHOD FOR TREATING NEUROLOGICAL DISEASE
Disclosed are compositions comprising amantadine, or a pharmaceutically acceptable salt thereof, and one or more excipients, wherein at least one of the...
METHOD TO SOLUBILIZE CURCUMINOIDS IN WATER
A method of solubilizing curcuminoids is disclosed wherein the method uses polyvinyl pyrrolidone and sodium bis (2-ethylhexyl) sulfosuccinate and the aqueous...
TOPICAL REGIONAL NEURO-AFFECTIVE THERAPY WITH CANNABINOIDS
A method of treating a disease state or condition in humans via topical brainstem afferent stimulation therapy via the administration of a cannabinoid drug(s)...
TOPICAL REGIONAL NEURO-AFFECTIVE THERAPY IN MAMMALS WITH CANNABINOIDS
A method of treating a disease state or condition in mammals other than humans via topical brainstem afferent stimulation therapy via the administration of a...
METHOD FOR PROTECTION AND IMPROVEMENT OF LIVER HEALTH WITH MESO-ZEAXANTHIN
A method for protection, treatment and improvement of liver health includes administering a meso-zeaxanthin composition in an effective amount to a subject in...
METHOD FOR STRESS MANAGEMENT AND OVERALL HEALTH STATUS IMPROVEMENT AND
COMPOSITIONS USED THEREIN
Carotenoid compositions are described for management, treatment, and/or prevention of stress by reducing cortisol levels and/or improving distribution and/or...
A transdermal patch suitable for releasing a stimulant such as caffeine for an extended time period utilizes a pressure sensitive acrylic adhesive matrix...
OLIGOMERIC/POLYMERIC SILICONE FLUIDS FOR USE IN TRANSDERMAL DRUG DELIVERY
Described are oligomeric/polymeric silicone fluids useful in transdermal drug delivery systems. Also described are compositions for the transdermal delivery of...
STABILIZED COMPOSITIONS CONTAINING ALKALINE LABILE DRUGS
A stabilized bioadhesive composition containing an alkaline labile drug and a method for its preparation are provided. In one aspect, the composition is a...
Drugs and Gene Carrier Particles That Rapidly Move Through Mucous Barriers
The invention generally relates to polymeric particles suitable for transporting bioactive agents across mucosal barriers. The invention also relates to...
BIOCOMPATIBLE GRAPHENE QUANTUM DOTS FOR DRUG DELIVERY AND BIOIMAGING
In this work we have targeted two aspects of GQDs, Size and ROS to reduce their cytotoxicity. Small size can damage cell organelles and production of ROS...
SYNTHESIS OF HYPERBRANCHED AMPHIPHILIC POLYESTER AND THERANOSTIC
A method of making a hyperbranched amphiphilic polyester compound includes drying under vacuum a mixture of 2-(4-hydroxybutyl)-malonic acid and p-toluene...
TOLEROGENIC SYNTHETIC NANOCARRIERS TO REDUCE IMMUNE RESPONSES TO
Disclosed are synthetic nanocarrier compositions, and related methods, comprising therapeutic protein APC presentable antigens and immunosuppressants that...
CONTROLLED RELEASE COMPOSITIONS COMPRISING A COMBINATION OF ISOSORBIDE
DINITRATE AND HYDRALAZINE HYDROCHLORIDE
The invention relates to a controlled release composition comprising a combination of isosorbide dinitrate and hydralazine, such as hydralazine hydrochloride,...
METHODS AND SYSTEMS FOR IMPROVED BIOAVAILABILITY OF ACTIVE PHARMACEUTICAL
INGREDIENTS INCLUDING ESOMEPRAZOLE
The present disclosure relates to delivery systems and methods for increasing the bioavailability and increasing the absorption rate by monolithic enteric...
COMPOSITIONS OF 1-[2-(2,4-DIMETHYL-PHENYLSULFANYL)-PHENYL]PIPERAZINE
Pharmaceutical compositions of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine and pharmaceutically acceptable acid addition salts thereof adapted so that...
PHARMACEUTICAL FORMULATIONS OF A BRUTON'S TYROSINE KINASE INHIBITOR
Described herein are pharmaceutical formulations of Bruton's tyrosine kinase (Btk) inhibitor ...
Delayed Release Tablet With Defined Core Geometry
A tablet comprising a core containing an active agent, and a coating, the core being disposed within the coating such that the coating has a thickness about a...