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Patent # Description
2016/0257745 NOVEL MODULATORS AND METHODS OF USE
Novel modulators, including antibodies and derivatives thereof, and methods of such modulators to treat hyperproliferative disorders are provided.
2016/0257744 DUAL SPECIFIC ANTIBODIES
The invention provides dual specific antibodies and methods of making and using such antibodies. In general, the dual specific antibodies are generated by...
2016/0257743 MATERNAL TH17 CELLS AND PSYCHIATRIC DISORDERS
Methods are presented herein for reducing the risk of developing a psychiatric disorder (e.g., autism like disorder) in a fetus involving administering an...
2016/0257742 THERAPEUTIC ANTIBODIES AND USES THEREOF
Provided herein are methods, compositions, and uses relating to inhibitors of stem cell factor. For example, provided herein are antibodies targeting stem cell...
2016/0257741 HUMAN ANTIBODIES AGAINST EOTAXIN AND THEIR USE
Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which...
2016/0257740 Connective Tissue Growth Factor Antibodies
The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities...
2016/0257739 PROTECTING GROUP COMPRISING A PURIFICATION TAG
The present invention relates to compounds comprising a protecting group moiety-tag moiety conjugate, a method of purification and monoconjugates obtained from...
2016/0257738 ANTI-VEGF ANTIBODIES
Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit...
2016/0257737 ANTI-TRANSTHYRETIN ANTIBODIES
The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases...
2016/0257736 ANTI-TRANSTHYRETIN ANTIBODIES
The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases...
2016/0257735 REGULATION OF NPVF GENE AND ITS PRODUCTS: A METHOD FOR MODULATING ENERGY IMBALANCE
The invention relates to methods for modulating energy utilization by targeting the Npvf pathway. Inhibition of the Npvf pathway promotes energy utilization in...
2016/0257734 ANTIBODY BINDING MICROBIAL HEPARIN BINDING MOTIF TO RETARD OR PREVENT MICROBIAL BIOFILM FORMATION ON IMPLANTED...
Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of...
2016/0257733 METHODS OF TREATING S. AUREUS-ASSOCIATED DISEASES
The present invention provides for methods of preventing and/or treating S. aureus-associated bacteremia and sepsis, and methods for preventing and/or treating...
2016/0257732 NEUTRALIZING ANTI-INFLUENZA A ANTIBODIES AND USES THEREOF
The invention relates to antibodies and binding fragments thereof that are capable of binding to influenza A virus hemagglutinin and neutralizing at least one...
2016/0257731 MONOCLONAL ANTIBODIES TARGETING NEUTRALIZING EPITOPES ON H7 INFLUENZA VIRUSES
The present invention relates to the murine monoclonal antibody (mAb) 11B9 and to mAb 62 each of which target major neutralizing epitopes of influenza A H7...
2016/0257730 COLOSTRUM/MILK PROTEIN COMPOSITIONS
Provided are colostrum and milk polypeptides recombinantly expressed in photosynthetic organisms containing colostrum and milk polypeptides, compositions...
2016/0257729 GLUCAGON-GLP-1-GIP TRIPLE AGONIST COMPOUNDS
The present invention relates to compounds which have agonist activity at the glucagon, GIP and GLP-1 receptors, and to their use in the treatment of metabolic...
2016/0257728 BIOACTIVE RECOMBINANT BMP-9 PROTEIN, MB109, EXPRESSED AND ISOLATED FROM BACTERIA
The disclosure provides for the expression and purification of bioactive recombinant bone morphogenetic protein (BMP)-9 from bacteria (MB109) and the use of...
2016/0257727 IMMUNOGENIC PEPTIDES OF THE CYCLIN B1 TUMOR ANTIGEN
The present invention relates to peptides comprising at least one CD4.sup.+ T epitope, which is immunodominant in vitro, of the cyclin B1 tumor antigen, said...
2016/0257726 PROTOXIN-II VARIANTS AND METHODS OF USE
The present invention relates to Protoxin-II variants, polynucleotides encoding them, and methods of making and using the foregoing.
2016/0257725 BIFUNCTIONAL STAPLED POLYPEPTIDES AND USES THEREOF
The invention relates to bifunctional stapled or stiched peptides comprising a targeting domain, a linker moiety, and an effector domain, that can be used to...
2016/0257724 CHIMERIC GENE FOR HETEROLOGOUS EXPRESSION WHICH ENCODES FOR PEPTIDES WITH ANTIMICROBIAL ACTIVITY
The present invention relates to a chimeric nucleotide sequence encoding peptides with antimicrobial activity, to be expressed on plants as bioreactors, plant...
2016/0257723 ANTIGENIC POLYPEPTIDES OF TRICHINELLA AND USES THEREOF
The invention relates to novel polypeptides which are recognized by anti-Trichinella antibodies. Said polypeptides can be used particularly for detecting...
2016/0257722 VACCINE CARRIER
The present invention relates to a hypoallergenic protein consisting of at least one hypoallergenic molecule derived from an allergen, which is fused or...
2016/0257721 Desmoglein 2 (DSG2) Binding Proteins and Uses Therefor
The present invention provides recombinant adenoviral compositions and methods for their use in treating disorders associated with epithelial tissues.
2016/0257720 HIV-1 ANTIGENS WITH DISCRETE CONFORMATIONAL FORMS ON THE V1/V2 DOMAIN AND METHODS OF USE THEREOF
The present invention relates to a novel composition of HIV-1 Env proteins that contain structurally and immunologically distinct VI/V2 domains. Methods of...
2016/0257719 Methods and Compositions for Dengue Virus Vaccines
The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein...
2016/0257718 ANTIMICROBIAL PEPTIDE WY-21 AND APPLICATION THEREOF
An antimicrobial peptide WY-21 has amino acid sequence of Val-Lys-Phe-Phe-Arg-Lys-Leu-Lys-Lys-Ser-Val-Lys-Glu-Lys-Ile-Gly-Lys-Glu-P- he-Lys-Arg. The...
2016/0257717 METHOD FOR PREVENTING NEOPLASTIC TRANSFORMATION BY INHIBITION OF RETINOBLASTOMA PROTEIN INACTIVATION
A method for preventing neoplastic transformation by inhibition of cell cycle progression into S phase by preventing the inactivation of Retinoblastoma protein...
2016/0257716 PEPTIDOMIMETIC MACROCYCLES
The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
2016/0257715 PEPTIDE INHIBITOR OF HIV REVERSE TRANSCRIPTION
Disclosed are peptides that exhibit good binding to the anticodon stem and loop (ASL) of human lysine tRNA species, tRNA.sup.Lys3. Using a search algorithm...
2016/0257714 NESTIN-INDUCING SYNTHETIC PEPTIDE AND USE THEREOF
A synthetic peptide having nestin expression inducing ability which allows induction of expression of nestin in astrocytes; an agent for inducing nestin...
2016/0257713 CELL-PENETRATING PEPTIDES
The invention relates to a cell-penetrating peptide, optionally linked to a pro-apoptotic peptide, useful as pro-apoptotic agents, for inhibition of in vitro...
2016/0257712 INTEGRIN INTERACTION INHIBITORS FOR THE TREATMENT OF CANCER
Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by...
2016/0257711 INHIBITORS OF BETA INTEGRIN-G PROTEIN ALPHA SUBUNIT BINDING INTERACTIONS
Provided herein are compounds that inhibit a binding interaction between a .beta. integrin and a G protein subunit, as well as compositions, e.g., ...
2016/0257710 SELECTIVE INHIBITORS OF PROTEINASE 3
The present invention relates to peptidyl phosphonate esters compounds and their use selective inhibitors of proteinase 3, in particular for treating or...
2016/0257709 HEMIASTERLIN DERIVATIVES FOR CONJUGATION AND THERAPY
Provided herein are hemiasterlin derivatives, conjugates thereof, compositions comprising the derivatives or conjugates thereof, methods of producing the...
2016/0257708 ACYLATED 4-AMIDINO- AND 4-GUANIDINOBENZYLAMINES FOR THE INHIBITION OF PLASMA KALLIKREIN
The invention relates to the use of acylated 4-amidino- or 4-guanidinobenzylamine in accordance with the general formula I P4-P3-P2-P1 (I) where P4 is a...
2016/0257707 TACCALONOLIDE MICROTUBULE STABILIZERS
The invention provides epoxytaccalonolide microtubule stabilizers and their use as anti-proliferative microtubule stabilizing agents.
2016/0257706 Beta-D-2'-DEOXY-2'-alpha-FLUORO-2'-beta-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTI- TUTED PURINE NUCLEOTIDES FOR HCV...
A compound of the structure: ##STR00001## or a pharmaceutically acceptable salt or composition thereof for the treatment of a host infected with or exposed to an...
2016/0257705 GENERATION OF GLUCOSAMINE FROM PLANT MATERIAL
The invention relates to an efficient and reproducible process for generating glucosamine from plants which allows high glucosamine content to be obtained...
2016/0257704 FLAME-RETARDANT CELLULOSE ESTER PREPARATIONS
Flame retardant cellulose ester preparations include phosphorus-containing propionic acid derivatives as flame-retardant plasticizers.
2016/0257703 A METALLOCENE CATALYST FOR PREPARING A HIGH MOLECULAR WEIGHT POLYOLEFIN AND A PREPARATION METHOD THEREOF
The present invention relates to a metallocene compound having novel structure which can provide various selectivity and activity to polyolefin copolymers, a...
2016/0257702 Copper Complex for Capturing Carbon Dioxide
A composition and method are disclosed for capturing CO.sub.2. A pollutant/greenhouse gas can be converted into a valuable organic compound using a nontoxic...
2016/0257701 NOVEL HETEROCYCLIC COMPOUNDS
The present invention relates to novel GPR 40 agonists of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically...
2016/0257700 RIFAXIMIN DERIVATIVE AND USES THEREOF
25-desacetyl rifaximin or a pharmaceutically acceptable salt thereof is provided. Methods of treatment of bowl related disorders using isolated and/or purified...
2016/0257699 BENZOPIPERAZINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases,...
2016/0257698 PROCESS FOR PREPARING TETRACYCLIC HETEROCYCLE COMPOUNDS
The present invention is directed to a process for preparing Tetracyclic Heterocycle Compounds of formula (I): which are useful as HCV NS5A inhibitors. The...
2016/0257697 THIOPHENE-SUBSTITUTED TETRACYCLIC COMPOUNDS AND METHODS OFUSE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
Thiophene-substituted tetracyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein A, A', R.sup.2, R.sup.3, R.sup.4 and R.sup.5...
2016/0257696 THIENO- AND PYRROLOPYRIMIDINE ANALOGUES AS ANTICANCER AGENTS AND METHODS OF USE THEREOF
The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory...
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