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Patent # Description
2016/0264983 METHODS FOR PLASTID TRANSFORMATION
Methods and compositions for plastid transformation and regeneration or development of transplastomic plants are provided. Embryo explants may be excised from...
2016/0264982 METHOD FOR PLANT GENOME SITE-DIRECTED MODIFICATION
Provided is a method for plant genome site-directed modification. Specifically, a method for plant genome site-directed modification introduced by RNA is...
2016/0264981 METHODS AND COMPOSITIONS FOR MULTIPLEX RNA GUIDED GENOME EDITING AND OTHER RNA TECHNOLOGIES
The invention includes materials and methods to generate numerous small RNAs from one polynucleotide construct (synthetic gene) to facilitate RNA-guided...
2016/0264980 Transgenic plants with enhanced agronomic traits
This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to...
2016/0264979 Methods for Controlling Flower Development in Plants
The present invention provides a method of controlling the sexuality of a plant comprising treating the plant with a composition comprising a compound selected...
2016/0264978 MICROORGANISMS FOR PRODUCING 1,4-BUTANEDIOL AND METHODS RELATED THERETO
The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine...
2016/0264977 IMPROVED WOUND HEALING COMPOSITIONS AND TREATMENTS
This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly...
2016/0264976 DYNAMIN 2 INHIBITOR FOR THE TREATMENT OF CENTRONUCLEAR MYOPATHIES
The present disclosure relates to an inhibitor of Dynamin 2 for use in the treatment of centronuclear myopathies. The present disclosure relates to...
2016/0264975 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF
The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using thereof.
2016/0264974 USE OF MICRORNA PRECURSORS AS DRUGS FOR INDUCING CD34-POSITIVE ADULT STEM CELL EXPANSION
This invention generally relates to a composition and its production method useful for developing drugs/vaccines and/or therapies against a variety of...
2016/0264973 METHODS RELATING TO CIRCULATING TUMOR CELL CLUSTERS AND THE TREATMENT OF CANCER
Described herein are methods and assays relating to the presence and/or level of circulating tumor cells (CTCs). These CTC-Cs represent a highly metastatic...
2016/0264972 Compositions and Methods for Inhibiting Expression of a Gene from the Ebola Virus
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
2016/0264971 COMPOSITIONS AND METHODS FOR SILENCING EBOLA VIRUS GENE EXPRESSION
The present invention provides compositions comprising therapeutic nucleic acids (e.g., interfering RNA such as siRNA) that target Ebola virus (EBOV) gene...
2016/0264970 Methods and compositions for backscattering interferometry
The present invention relates to methods and compositions for enhancing backscattering interferometry (BSI) in detection of biomolecular interactions,...
2016/0264969 METHODS FOR TREATING OR PREVENTING OPHTHALMOLOGICAL DISEASES
This invention relates to methods and compositions useful for the treatment or prevention of an ophthalmological disease, comprising administration of an...
2016/0264968 MODIFIED iRNA AGENTS
The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose. The...
2016/0264967 OLIGONUCLEOTIDE COMPRISING AN INOSINE FOR TREATING DMD
The invention provides an oligonucleotide comprising an inosine, and/or a nucleotide containing a base able to form a wobble base pair or a functional...
2016/0264966 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE LECT2 GENE
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the LECT2 gene, and methods of using such dsRNA compositions to alter...
2016/0264965 RNA Targeting in Alpha-Synucleinopathies
Therapies and assays to screen for small molecules that can have therapeutic use in the control of neurodegenerative diseases such as Parkinson's and other...
2016/0264964 RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond...
2016/0264963 Compositions and Methods for Inhibiting Expression of Transthyretin
The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression...
2016/0264962 TAL-EFFECTOR ASSEMBLY PLATFORM, CUSTOMIZED SERVICES, KITS AND ASSAYS
The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized...
2016/0264961 PROTEASE-RESISTANT SYSTEMS FOR POLYPEPTIDE DISPLAY AND METHODS OF MAKING AND USING THEREOF
The present invention generally relates to bacterial polypeptide display systems, libraries using these bacterial display systems, and methods of making and...
2016/0264960 METHOD FOR PRODUCING ANTIGEN-BINDING MOLECULE USING MODIFIED HELPER PHAGE
The present invention provides a method for preparing a bacteriophage displaying an antigen-binding molecule, comprising the step of contacting a helper phage...
2016/0264959 PHAGE MICROARRAY PROFILING OF THE HUMORAL RESPONSE TO DISEASE
The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present...
2016/0264958 COMPOSITIONS AND METHODS FOR SYNTHETIC GENE ASSEMBLY
Methods and compositions are provided for assembly of large nucleic acids where the assembled large nucleic acids lack internal sequence modifications made...
2016/0264957 METHOD FOR PRODUCING PURIFIED SOYBEAN OLIGOSACCHARIDE LIQUID
A method for producing a purified soybean oligosaccharide liquid according to the present invention is a method for producing a purified soybean...
2016/0264956 RECOVERY OF INSOLUBLE ENZYME FROM FERMENTATION BROTH AND FORMULATION OF INSOLUBLE ENZYME
Methods are provided for recovery and formulation of insoluble enzymes from a microbial fermentation broth, without removal of microbial cells or cell debris....
2016/0264955 COMPOSITIONS AND METHODS FOR INHIBITION OF MMP:MMP-SUBSTRATE INTERACTIONS
The present invention provides compounds for disrupting the binding of a matrix metalloprotease (MMP) protein to a substrate protein at an interaction site...
2016/0264954 METHOD OF STABILIZING THROMBIN AND COMPOSITION THEREOF
A method of stabilizing thrombin in a thrombin solution is provided. The method comprises heating the thrombin solution at a temperature of 35-85.degree. C....
2016/0264953 RECOMBINANT GLYCOPROTEINS AND USES THEREOF
Provided herein are recombinant glycoproteins (e.g., recombinant human .alpha.-galactosidase-A proteins) with an altered (e.g., improved) glycosylation...
2016/0264952 THERMOSTABLE CELLOBIOHYDROLASE
A thermostable cellobiohydrolase, having a cellobiohydrolase catalytic domain including: (A) a polypeptide including the amino acid sequence represented by SEQ...
2016/0264951 ENZYMES HAVING ALPHA AMYLASE ACTIVITY AND METHODS OF MAKING AND USING THEM
The invention relates to alpha amylases and to polynucleotides encoding the alpha amylases. In addition methods of designing new alpha amylases and methods of...
2016/0264950 REVERSIBLY INACTIVATED THERMOSTABLE REVERSE TRANSCRIPTASES, COMPOSITIONS AND METHODS FOR USE
The present invention provides reversibly inactivated reverse transcriptase enzymes, particularly those having increased thermostability and/or...
2016/0264949 HYPERACTIVE VARIANTS OF THE TRANSPOSASE PROTEIN OF THE TRANSPOSON SYSTEM SLEEPING BEAUTY
The present invention refers to hyperactive variants of a transposase of the transposon system Sleeping Beauty (SB). The invention further refers to...
2016/0264948 TRANSAMINASE BIOCATALYSTS
The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
2016/0264947 ZINC BINDING FUSION PROTEIN OF GLUTATHIONE S-TRANSFERASE AND METALLOTHIONEIN
The present invention relates to a new zinc binding fusion protein that is a fusion protein of glutathione S-transferase (GST) and metallothionein (MT), to...
2016/0264946 S-ADENOSYLMETHIONINE (SAM) SYNTHASE VARIANTS FOR THE SYNTHESIS OF ARTIFICIAL COFACTORS
The present invention relates to isolated polypeptides that are derived from wildtype Bacillus subtilis S-Adenosylmethionine (SAM) synthase or from a...
2016/0264945 BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF ARMODAFINIL
The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods...
2016/0264944 Modified Luciferases And Uses Thereof
The present invention encompasses modified luciferases, methods for making modified luciferases, and assays utilizing modified luciferases. Modified...
2016/0264943 VIRUS PURIFICATION AND FORMULATION PROCESS
Disclosed herein is provided a virus purification and formulation process for purifying a flavivirus represented by one of a a Yellow Fever Virus, Japanese...
2016/0264942 ADSORPTIVE MEMBRANES FOR TRAPPING VIRUSES
A disposable, virus-trapping membrane, and a corresponding method to remove viruses from solution are described. The membrane includes a disposable,...
2016/0264941 PHAGE THERAPY OF PSEUDOMONAS INFECTIONS
The present invention relates to bacteriophage therapy. More particularly, the present invention relates to novel bacteriophages having a high specificity...
2016/0264940 NEW MEDIUM FOR HIGH PERFORMANCE MAMMALIAN FED-BATCH CULTURES
The present invention relates to new serum- and protein-free culture media. These media are high performance culture media, which notably improve mammalian...
2016/0264939 COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF PDX1+ PANCREATIC CELLS
Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem...
2016/0264938 Reprogramming of Cells to a New Fate
The present invention generally provides methods and compositions for transdifferentiation of an animal cell from a first non-pluripotent cell fate to a second...
2016/0264937 MYELINATION OF CONGENITALLY DYSMYELINATED FOREBRAINS USING OLIGODENDROCYTE PROGENITOR CELLS
One form of the present invention is directed to a method of remyelinating demyelinated axons by treating the demyelinated axons with oligodendrocyte...
2016/0264936 METHOD FOR PRODUCING RETINAL PIGMENT EPITHELIAL CELLS
The present invention provides a method for producing a retinal pigment epithelial cell, including (1) a first step of subjecting pluripotent stem cells to...
2016/0264935 TRANSFORMED HUMAN PLURIPOTENT STEM CELLS AND ASSOCIATED METHODS
The present disclosure provides transformed human pluripotent stem cell (t-hPSC). t-hPSCs are not dependent on Oct4 for renewal and survival, however exhibit a...
2016/0264934 METHODS FOR MODULATING AND ASSAYING m6A IN STEM CELL POPULATIONS
The present invention generally relates to methods, assays and kits to maintain a human stem cell population in an undifferentiated state by inhibiting the...
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