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Patent # Description
2016/0264683 ISOLATION OF ADULT MULTIPOTENTIAL CELLS BY TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE
The present invention relates to the use of tissue non-specific alkaline phosphatase (TNAP) as a marker for identifying and/or isolating adult multipotential...
2016/0264682 Inhibitors Of Complement Activation
The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors...
2016/0264681 METHODS FOR INCREASING ADIPONECTIN
In certain aspects, the present invention provides compositions and methods for increasing adiponectin in a patient in need thereof by administering an...
2016/0264680 Human Neutralizing Anti-Kit Antibodies and Uses Thereof
The invention relates to human neutralizing anti-KIT antibodies and uses thereof. More particularly, the invention relates to an antibody comprising a heavy...
2016/0264679 ANTI-ERBB3 ANTIBODIES
Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used...
2016/0264678 DISEASE THERAPY BY INDUCING IMMUNE RESPONSE TO TROP-2 EXPRESSING CELLS
The present invention concerns compositions and methods of use of bispecific antibodies comprising at least one binding site for Trop-2 (EGP-1) and at least...
2016/0264677 ANTIBODIES FOR TREATMENT OF CANCER EXPRESSING CLAUDIN 6
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including...
2016/0264676 ANTI-CD26 ANTIBODIES AND USES THEREOF
The present invention pertains to novel antibodies capable of binding to CD26, as well as to their use as a medicament. Moreover, the present invention...
2016/0264675 SYNERGISTIC COMBINATIONS OF OX40L ANTIBODIES FOR THE TREATMENT OF GVHD
The present invention relates to anti-human OX40L antibodies, new medical uses and methods.
2016/0264674 ALTERED APRIL BINDING ANTIBODIES
The invention relates to APRIL-binding antibodies, which bind the same epitope of human APRIL as an antibody having an antigen binding site of hAPRIL.01A. The...
2016/0264673 MIC-BINDING ANTIBODIES AND METHODS OF USE THEREOF
The technology described herein relates to antibodies and/or polypeptides which bind to MIC and inhibit MIC shedding. Methods of using such antibodies and/or...
2016/0264672 Antibodies Reactive with B7-H3 and Uses Thereof
The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof,...
2016/0264671 BISPECIFIC SINGLE CHAIN ANTIBODIES WITH SPECIFICITY FOR HIGH MOLECULAR WEIGHT TARGET ANTIGENS
The present invention provides a method for the selection of bispecific single chain antibodies comprising a first binding domain capable of binding to an...
2016/0264670 IMMUNOTHERAPEUTIC DOSING REGIMENS AND COMBINATIONS THEREOF
The invention described herein relates to therapeutic dosing regimens and combinations thereof for use in enhancing the therapeutic efficacy of anti-CS1...
2016/0264669 METHODS OF REDUCING SERUM LEVELS OF FC-CONTAINING AGENTS USING FCRN ANTAGONISTS
Provided are novel methods of reducing the serum levels of Fc-containing agents (e.g., antibodies and immunoadhesins) in a subject. These methods generally...
2016/0264668 ANTIBODIES SPECIFIC TO FCRN
The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally...
2016/0264667 COSTIMULATORY B7-H1 IN RENAL CELL CARCINOMA PATIENTS: INDICATOR OF TUMOR AGGRESSIVENESS AND POTENTIAL...
The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of...
2016/0264666 Antibodies Directed Against ICOS and Uses Thereof
The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation...
2016/0264665 BINDING-TRIGGERED TRANSCRIPTIONAL SWITCHES AND METHODS OF USE THEREOF
The present disclosure provides binding-triggered transcriptional switch polypeptides, nucleic acids comprising nucleotide sequences encoding the ...
2016/0264664 METHOD FOR GENERATION OF IMMUNOGLOBULIN SEQUENCES
The present invention relates to a method for generating immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are...
2016/0264663 ANTI-PODOCALYXIN ANTIBODIES AND METHODS OF USING THE SAME
The present invention is directed to compositions of matter useful for the treatment of cancer in mammals and to methods of using those compositions of matter...
2016/0264662 TEM8 ANTIBODIES AND THEIR USE
Antibodies that specifically bind TEM8 protein, conjugates thereof, and their use, are disclosed herein. In some examples the conjugates and antibodies are...
2016/0264661 ANTI-IL-12/IL-23 ANTIBODIES
Provided herein is an antibody comprising an antigen binding domain which binds to human IL-12 and human IL-23. The antibody binds human IL-12p40 existing as a...
2016/0264660 IL-3 BLOCKADE IN SYSTEMIC LUPUS ERYTHEMATOSUS AND MULTIPLE SCLEROSIS
The present invention relates to anti-IL-3 antibodies or IL-3 binding fragments thereof for use in the treatment of an autoimmune disease selected from the...
2016/0264659 ANTI-TNF ANTIBODIES, COMPOSITIONS, METHODS AND USES
The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS:1, 2 and 3 and/or all of the light...
2016/0264658 TSLP Binding Proteins
The present disclosure relates to TSLP binding proteins, such as anti-TSLP single variable domains, polynucleotides encoding such TSLP binding proteins,...
2016/0264657 GROWTH DIFFERENTIATION FACTOR (GDF) FOR TREATMENT OF DIASTOLIC HEART FAILURE
The methods and uses described herein relate to the treatment of age-related conditions, e.g. by administering an agent that inhibits the interaction of GDF11...
2016/0264656 ANTI-NGF ANTIBODIES AND THEIR USE
The present disclosure encompasses NGF binding proteins, specifically to antibodies that are chimeric, CDR grafted and canonized antibodies, and methods of...
2016/0264655 Treating cancers with drugs targeting CREB3L1
CREB3L1 is a biomarker for identifying cancer cells sensitive to doxorubicin (daunomycin). The biomarker is used in diagnostics and screening; for example, to...
2016/0264654 NUCLEIC ACIDS ENCODNG ANTI-C5A ANTIBODIES
The present disclosure relates to, inter alia, antibodies, or antigen-binding fragments thereof, that bind to C5a and to use of the antibodies in methods for...
2016/0264653 NOVEL MODULATORS AND METHODS OF USE
Novel modulators, including antibodies and derivatives thereof, and methods of such modulators to treat hyperproliferative disorders are provided.
2016/0264652 GLYCANS AS FUNCTIONAL CANCER TARGETS AND ANTIBODIES THERETO
A glycan having the structure gal.beta.1-3GLcNac.beta.1-3Gal.beta.1-4(Fuc.alpha.1-3)GlcNAc (LecLe.sup.x) which is attached to a lipid or protein backbone, and ...
2016/0264651 ANTI-TENASCIN-C A2 ANTIBODIES AND METHODS OF USE
The invention provides antibodies against the A2 domain of tenascin-C and methods of using the same.
2016/0264650 HUMAN ANTIBODIES TO CLOSTRIDIUM DIFFICILE TOXINS
The present invention provides fully human antibodies that bind to either toxin A or toxin B of Clostridium difficile, or to both toxin A and toxin B,...
2016/0264649 BROADLY NEUTRALIZING HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) GP120-SPECIFIC MONOCLONAL ANTIBODY
The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for...
2016/0264648 ANTIBODY HAVING BROAD NEUTRALIZATION ACTIVITY AGAINST GROUP 1 INFLUENZA A VIRUSES
From PBMCs of patients infected with H1N1pdm, three human monoclonal antibodies have been obtained which are capable of binding to an epitope present at...
2016/0264647 HUMAN MONOCLONAL ANTIBODIES AGAINST THE MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS (MERS-COV) AND ENGINEERED...
The invention provides polypeptides (e.g., antibodies) and fusion proteins that target a epitope in the receptor binding domain (RBD) of the spike (S)...
2016/0264646 PRODUCTION OF HUMAN PULMONARY SURFACTANT PROTEIN B IN PLANTS
The invention is directed to a method of producing pulmonary surfactant protein-B (SP-B) isoforms fragments and analogues thereof in a plant cell, and to...
2016/0264645 Stabilized Factor VIII Variants
The present invention relates to modified coagulation factors. In particular, the present invention relates to stabilized Factor VIII molecules conjugated with...
2016/0264644 Variant Activin Receptor
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A,...
2016/0264643 NOVEL CTLA4-IG IMMUNOADHESINS
The present application relates to CTLA4-Ig immunoadhesins that target CD80 and CD86, and their use, particularly for therapeutic purposes.
2016/0264642 Method for Improving the Specific Effector Functions of Single-Chain-Antigen-Recognizing Genetic Constructs...
The present invention relates to a method for producing a cell line expressing a stabilized functional single chain-antigen-recognizing genetic construct...
2016/0264641 Consumable Cryopreserved Cells Transiently Overexpressing Gene(s) Encoding Drug Transporter Protein(s) and/or...
The present invention discloses cryopreserved recombinant cells for screening drug candidates that transiently overexpress one or more drug transporter...
2016/0264640 WATER SOLUBLE MEMBRANE PROTEINS AND METHODS FOR THE PREPARATION AND USE THEREOF
The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof.
2016/0264639 Glycoprotein Hormone Long-Acting Superagonists
This invention provides long-acting, superactive analogs of glycoprotein hormones demonstrating enhanced bioactivity both in vitro and in vivo as compared to...
2016/0264638 WT1 HLA CLASS II-BINDING PEPTIDES AND COMPOSITIONS AND METHODS COMPRISING SAME
This invention provides WT1 peptides and methods of treating, reducing the incidence of, and inducing immune responses against a WT1-expressing cancer,...
2016/0264637 CHIMERIC PROTEIN IN THE TREATMENT OF AMYLOIDOSIS
The present invention relates to a chimeric protein comprising at least one human amyloid P component and at least one fragment of an Fc region of a human...
2016/0264636 PEPTIDE INHIBITORS OF TEAD/YAP-TAZ INTERACTION
The invention relates to an isolated peptide inhibitor of the interaction between the TEAD and YAP or TAZ proteins and a derived chimeric peptide linked to a...
2016/0264635 FLUORESCENT AND COLORED PROTEINS AND METHODS FOR USING THEM
The field of this invention relates to methods for combining genetic elements such that the activity of one of the elements provides a means for identifying,...
2016/0264634 NOVEL SCORPION TOXIN ANALOGUE AND METHOD FOR TREATING AUTOIMMUNE DISEASES
A novel peptide analogue of the Heterometrus spinnifer toxin HsTX1 is disclosed along with its application as, for example, a therapeutic agent for treating an...
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