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Patent # Description
2016/0264633 TREATMENT OF ISCHEMIA
A system, including methods and compositions, for treatment of ischemia.
2016/0264632 NUCLEIC ACIDS AND PROTEINS FROM STREPTOCOCCUS GROUPS A AND B
The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid...
2016/0264631 COMPOSITION FOR PREVENTING MYCOPLASMA SPP. INFECTION
The present invention provides proteins that are suitable to be used as the active ingredient in subunit vaccine against Mycoplasma spp. The present invention...
2016/0264630 Cell-Permeable Peptide Inhibitors of the JNK Signal Transduction Pathway
Protein kinase inhibitors and more specifically inhibitors of the protein kinase c-Jun amino terminal kinase are herein described. Additionally, JNK inhibitor...
2016/0264629 NOVEL ADENOVIRUS ISOLATED FROM TITI MONKEYS
Provided is a Titi Monkey Adenovirus (TMAdV) that can infect both human and non-human primates. Further provided are nucleic acid sequences, proteins,...
2016/0264628 PREPARATION OF MICAFUNGIN INTERMEDIATES
The present invention relates to the preparation of compounds, in particular to the preparation of compounds of formula (I), which may be used with a compound...
2016/0264627 CYCLIC PEPTIDE BINDER AGAINST ONCOGENIC K-RAS
Cyclic peptides represented by (Formula 1) ##STR00001## selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each...
2016/0264626 METHOD FOR PRODUCING PEPTIDE HYDRAZIDE, PEPTIDE AMIDE, AND PEPTIDE THIOESTER
An object of the present invention is to provide a method for producing a peptide thioester compound, a peptide hydrazide compound, and a peptide amide...
2016/0264625 ADVANTAGEOUS MU-OPIATE RECEPTOR PEPTIDE COMPOUNDS
The subject invention provides advantageous new salts of mu-opiate receptor peptides. These salts have been found to have excellent properties in terms of...
2016/0264624 TUBULYSIN COMPOUNDS, METHODS OF MAKING AND USE
Tubulysin compounds of the formula (I) ##STR00001## where R.sup.1, R.sup.2 R.sup.3a, R.sup.3b, R.sup.4, R.sup.5, W, and n are as defined herein, are anti-mitotic...
2016/0264623 TETRAPEPTIDE COMPOUND AND METHOD FOR PRODUCING SAME
The present invention is to provide a method for the efficient production on an industrial scale of SS-31 (D-Arg-Dmt-Lys-Phe-NH.sub.2), which is an SS peptide....
2016/0264622 Compositions And Methods For Treating Ischemia And Ischemia-Reperfusion Injury
The present invention relates to compositions comprising a substantially pure compound represented by Structural Formula I: ##STR00001## and methods of using...
2016/0264621 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE
Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1 comprising administering to a subject in need thereof a...
2016/0264620 Separation And Purification Method For Vancomycin Hydrochloride Of High Purity
Provided is a separation and purification method for vancomycin hydrochloride of high purity. The method comprises the following steps: (1) obtaining a...
2016/0264619 PROCESS FOR PRODUCTION OF FIBRINOGEN
The present invention relates to a method or process for the manufacture of a virus and prion save native fibrinogen concentrate of high purity and low amounts...
2016/0264618 METHOD FOR SEPARATING ANTIBODY ISOFORMS USING CATION EXCHANGE CHROMATOGRAPHY
The present invention relates to a method for separating antibody isoforms using cation exchange chromatography and, more specifically, to a method for...
2016/0264617 Integrated Approach to the Isolation and Purification of Antibodies
Disclosed herein is an integrated approach to purification process development and execution, including processes comprising particular capture and fine...
2016/0264616 THERAPEUTIC COMPOUNDS AND METHODS
Regulator of G Protein Signaling (RGS) proteins modulate the complex signaling pathways elicited by G protein coupled receptor activation. Recent studies have...
2016/0264615 Nuclear Sulfated Oxysterol, Potent Regulator of Lipid Homeostasis, for Therapy of Hypercholesterolemia,...
The sulfated oxysterol 5-cholesten-3.beta., 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol...
2016/0264614 POLYNUCLEOTIDE MOLECULES AND USES THEREOF
The present disclosure provides alternative nucleosides, nucleotides, and polynucleotides, and methods of use thereof.
2016/0264613 COMPOUNDS FOR USE IN PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES AND PAIN
Compounds for use in prevention and treatment of neurodegenerative disease and pain are disclosed. In one embodiment of the invention, the compound is selected...
2016/0264612 MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide...
2016/0264611 4'-VINYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS RNA REPLICATION
The application discloses compounds of Formula I ##STR00001## wherein the variable substituents are as defined herein. The compounds of Formula I and...
2016/0264610 AZIDO NUCLEOSIDES AND NUCLEOTIDE ANALOGS
Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs...
2016/0264609 DISACCHARIDE INTERMEDIATE AND SYNTHESIS METHOD THEREOF
The present invention relates to a disaccharide intermediate and a synthesis method thereof, relates to the chemical pharmaceutical field, and more...
2016/0264608 Method For The Synthesis Of Ethane-1-Hydroxy-1,1-Diphosphonic Acid
The present invention is related to a method for the synthesis of ethane-1-hydroxy-1,1-diphosphonic acid or its salt which includes the steps of reacting...
2016/0264607 PANOTHENATE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
Compounds having the following formula (E): Formula E or a pharmaceutically acceptable salt thereof, wherein R, R', R'', X and n are as defined herein are...
2016/0264606 METHOD FOR THE PURIFICATION OF LECITHIN
A method for the purification of lecithin, comprising the steps of: a. reducing the viscosity of lecithin to a viscosity of less than about 10 Pas; then b....
2016/0264605 WATER-SOLUBLE ACETAMINOPHEN ANALOGS
The present invention provides water-soluble acetaminophen prodrugs and formulations which may be suitable for parenteral administration. Methods of treating a...
2016/0264604 NOVEL PRODRUG SALTS
Provided are novel prodrug salts of selective aquaporin inhibitors, their use as pharmaceuticals, and pharmaceutical compositions comprising them, and novel...
2016/0264603 AQUEOUS REDOX FLOW BATTERIES FEATURING IMPROVED CELL DESIGN CHARACTERISTICS
Provided are compositions having the formula M.sub.nTi(L1)(L2)(L3) wherein L1 is a catecholate, and L2 and L3 are each independently selected from...
2016/0264602 MANUFACTURING METHOD OF SILATRANE WITH THIOL GROUP AND PRESERVATION METHOD THEREOF
A manufacturing method of silatrane with thiol group and a preservation method thereof are disclosed. (3-Mercaptopropyl)trimethoxysilane and triethanolamine...
2016/0264601 Vinylsilanes for Use in Functionalized Elastomeric Polymers
The present invention relates to novel vinylsilane compounds which are useful as modifying monomers in the polymerization of conjugated diene monomers,...
2016/0264600 METHOD FOR PRODUCING SILICON COMPOUND
To provide a method for producing a silicon compound, whereby a hydrosilylation reaction of a compound having a 2-propenyl group, can be conducted with high...
2016/0264599 FUNCTIONALIZED F-POSS MONOMER COMPOSITIONS AND USES THEREOF
Functionalized F-POSS compounds comprising synthetic blends of at least two feedstocks that produce a distribution of fluorinated polyhedral oligomeric...
2016/0264598 BETA-LACTAMASE INHIBITORS
Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit...
2016/0264597 FUSED DIHYDRO-4H-PYRAZOLO[5,1-C][1,4]OXAZINYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS
Disclosed are compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, wherein Ring B, A.sup.1, A.sup.2, R.sup.6, w and n1 are...
2016/0264596 SUBSTITUTED BENZAMIDES
The invention relates to compounds of formula ##STR00001## wherein R, R.sup.1, R.sup.2, X, and Y are as defined herein and to a pharmaceutically suitable acid...
2016/0264595 BLUE ELECTROCHROMIC COMPOUND, PREPARATION METHOD AND SUBASSEMBLY THEREOF
One class of blue thiophene electrochromic compounds include 3,4-(2,2-bis(2-oxo-3-phenylpropyl))propylenedioxythiophene, ...
2016/0264594 MACROCYCLIZATION REACTIONS AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF ANALOGS OF HALICHONDRIN B
The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization...
2016/0264593 PROTEIN PHOSPHATASE INHIBITORS THAT CROSS THE BLOOD BRAIN BARRIER
The present invention provides a method for in vivo delivery of endothal to a target cell in a subject, the method comprising administering to the subject a...
2016/0264592 SULFUR-SUBSTITUTED PODOPHYLLOTOXIN DERIVATIVE, SYNTHESIS METHOD THEREOF, AND USE THEREOF
The present invention discloses a sulfur-substituted podophyllotoxin derivative, synthesis method thereof, and use thereof. The present invention introduces a...
2016/0264591 CHIRAL DOPANT AND IDENTIFICATION AND AUTHENTICATION USING POLYMERIC LIQUID CRYSTAL MATERIAL MARKINGS
Disclosed are chiral dopants of general formula (I) below as well as uses thereof involving chiral liquid crystal polymers and markings comprising these...
2016/0264590 METHOD FOR THE SYNTHESIS OF IRINOTECAN
The present invention relates to a method for the synthesis of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (i.e. iriniotecan),...
2016/0264589 OPIOID KETAL COMPOUNDS AND USES THEREOF
This invention relates to opioid ketal compounds of Formula (I), Formula (II), or Formula (III): ##STR00001## or a pharmaceutically acceptable salts thereof,...
2016/0264588 PROCESS FOR PREPARING OXYCODONE COMPOSITIONS
In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
2016/0264587 Compounds Useful for Inhibiting Metastasis from Cancer and Methods Using Same
The present invention includes compositions that are useful in preventing or treating metastasis in a subject diagnosed with cancer. The present invention also...
2016/0264586 OCTAHYDRO-CYCLOBUTA [1,2-c;3,4-c']DIPYRROL-2-YL
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, Y and R.sup.2 are as described herein, compositions including...
2016/0264585 IMIDAZOLE DERIVATIVES
The present invention relates to compounds of formula (I), wherein A, B, R.sup.1 and R.sup.2 are ##STR00001## as defined herein before useful for the treatment...
2016/0264584 Method for Preparing Ibrutinib
Provided is a method for preparing Ibrutibin (I), and steps of preparing same comprise: 4-benzyloxybenzoyl chloride (II) is used as a raw material,...
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