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Patent # Description
2016/0272671 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.
2016/0272670 STEROIDS HAVING INCREASED WATER SOLUBILITY AND RESISTANCE AGAINST METABOLISM AND METHODS FOR THEIR PRODUCTION
Steroid compounds having increased resistance against metabolism and increased water solubility are disclosed, together with methods for their production....
2016/0272669 NOVEL REAGENTS FOR UNIVERSAL SITE-SPECIFIC LABELING AND MODIFICATIONS OF NUCLEIC ACIDS
The present invention discloses a method of harnessing versatile phosphoramidation reactions to regioselectively incorporate alkynyl/azido groups into...
2016/0272668 NICOTINIC ACID RIBOSIDE OR NICOTINAMIDE RIBOSIDE COMPOSITIONS, REDUCED DERIVATIVES THEREOF, AND THE USE THEREOF...
Derivatives of nicotinic acid riboside (NAR), nicotinamide riboside (NR), and reduced NAR and NR, including ...
2016/0272667 PRODUCTION OF RHAMNOLIPID COMPOSITIONS
Provided are organic solvent free methods for obtaining compositions comprising one or more rhamnolipids as well as compositions obtainable from said methods.
2016/0272666 Partially Crystalline Glucamide Compositions And Method For Preparing Same
The invention relates to a partially crystalline N-alkyl-N-acylglucamine composition comprising at least two different acylglucamines with acyl groups selected...
2016/0272665 PRODUCTION OF RENEWABLE FINE CHEMICALS AND LIQUID FUELS
Described herein is a process for conversion and upgrading of biomass to products. The process involves converting the biomass to primary lignin-derivatives...
2016/0272664 RUTHENIUM COMPOUND, MATERIAL FOR THIN FILM FORMATION, AND PROCESS FOR THIN FILM FORMATION
Disclosed is a ruthenium compound useful as a precursor in chemical vapor growth, particularly ALD. The compound has good reactivity with a reactive gas, a...
2016/0272663 OSMIUM (II) ARENE AZO ANTI-CANCER COMPLEXES
The present invention relates to the use of certain osmium containing complexes such as cytotoxic agents particularly for the treatment of cancer. There is...
2016/0272662 GENERAL CATALYST FOR C-H FUNCTIONALIZATION
The invention provides novel manganese catalysts such as [Mn(.sup.tBuPc)], which are general for the amination of all types of C(sp.sup.3)-H bonds (aliphatic,...
2016/0272661 PURIFIED PHOSPHATIDYLCHOLINE PRODUCT MADE BY A PROCESS EMPLOYING MAGNETIC NANOPARTICLES
A process for separation and purification of phosphatides, especially phosphatidylcholine, from vegetable lecithins, comprising deoiling with acetone,...
2016/0272660 METHOD FOR THE PURIFICATION OF LECITHIN
The present invention relates to a method for the purification of lecithin, comprising the steps of (a) mixing lecithin with active carbon to form a...
2016/0272659 PREPARATION OF TITANIUM CATECHOLATE COMPLEXES IN AQUEOUS SOLUTION USING TITANIUM TETRACHLORIDE OR TITANIUM...
Titanium coordination complexes, particularly titanium catecholate complexes, can be attractive active materials for use in flow batteries. However, such...
2016/0272658 Process to Prepare Aluminoxanes by Reaction of Alkylaluminium With Allylic Alcohols
The present invention relates to a process to prepare alkylaluminoxanes by reaction of alkylaluminium with a substituted allylic alcohol of the formula wherein...
2016/0272657 HIGHLY FLUORESCENT PYRROLE-BF2 CHROMOPHORES
Fluorescent chromophores nicknamed BOPHY are provided. The chromophores may be readily synthesized in two steps from readily available reagents via the...
2016/0272656 SINGLE MOLECULE AND ORGANIC SOLAR CELL COMPRISING SAME
The present specification provides a single molecule and an organic solar cell including the same.
2016/0272655 TRICYCLIC PIPERIDINE COMPOUNDS
The present invention relates to compounds of the formula (I) ##STR00001## wherein R, R.sup.1a, R.sup.1b, R.sup.2, R.sup.3, and X are as described in the...
2016/0272654 SPIROCYCLIC DIHYDRO-THIAZINE AND DIHYDRO-OXAZINE BACE INHIBITORS, AND COMPOSITIONS AND USES THEREOF
Compounds are provided having a structure according to Formula (I): wherein A.sub.1, A.sub.2, A.sub.3, Y, R.sub.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6,...
2016/0272653 PRO-DRUGS OF NSAIAS WITH VERY HIGH SKIN AND MEMBRANES PENETRATION RATES AND THEIR NEW MEDICINAL USES
The novel positively charged pro-drugs of NSAIAs in the general formulas (1, 2a, 2b, 2c, or 2d) "Structure 1, 2a, 2b, 2c, or 2d" were designed and synthesized....
2016/0272652 BENZO-THIAZOLO-IMIDAZOLE COMPOUNDS AND USES THEREOF
The present invention relates to benzo-thiazolo-imidazole compounds and their uses. Moreover, the present invention relates to pharmaceutical compositions...
2016/0272651 DGAT1 Inhibitor and Preparation Method and Use Thereof
The present invention discloses a novel DGAT1 inhibitor, especially the compound of formula (I) or a pharmaceutically acceptable salt thereof, preparation and...
2016/0272650 PYRANOCHROMENYL PHENOL DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR TREATING METABOLIC SYNDROME OR...
Provided are a pyranochromenyl phenol derivative, a pharmaceutically acceptable salt thereof, or a solvate thereof. Also provided is a pharmaceutical...
2016/0272649 DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE
This invention is directed to compounds of formula (I): ##STR00001## where r, q, R, R.sup.2, R.sup.3, R.sup.4, R.sup.5a, R.sup.5b, R.sup.5c, R.sup.6a, R.sup.6b,...
2016/0272648 Heteroaryl Substituted Pyrrolo[2,3-B] Pyridines And Pyrrolo[2,3-B] Pyrimidines As Janus Kinase Inhibitors
The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity...
2016/0272647 PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH...
Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic...
2016/0272646 RESPIRATORY SYNCYTIAL VIRUS INHIBITORS
Compounds of Formula (I), wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n are defined herein, are useful as inhibitors of RSV. ##STR00001##
2016/0272645 Heterocyclic Compounds and Methods of Use
The present application discloses compounds that are inhibitors of Btk, compounds that are inhibitors of PI3K.delta., and compounds that are dual inhibitors of...
2016/0272644 METHOD OF STABILIZING RIBOFLAVIN
A method of stabilizing riboflavin by affixing the riboflavin to at least one substrate for the riboflavin by covalent bonding, hydrogen bonding, Van der Waals...
2016/0272643 5'-NUCLEOTIDASE INHIBITORS AND THERAPEUTIC USES THEREOF
The subject matter of the present invention is compounds which have a 6-aminopurine backbone corresponding to formula (I): in which R.sub.1, R.sub.2, R.sub.3,...
2016/0272642 PROCESS FOR THE PREPARATION OF DIPEPTIDYLPEPTIDASE INHIBITORS
The present invention provides a process for the preparation of linagliptin, a compound of Formula I, the process comprising deprotecting a compound of Formula...
2016/0272641 CRYSTALLINE FORMS OF DIAZABICYCLOOCTANE DERIVATIVE AND PRODUCTION PROCESS THEREOF
A crystalline form of a diazabicyclooctane derivative represented by the following Formula (VII), and processes for producing the same: ##STR00001##
2016/0272640 SUBSTITUTED PIPERIDIN-4-AMINO-TYPE COMPOUNDS AND USES THEREOF
The disclosure relates to Substituted Piperidin-4-amino-Type Compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof wherein...
2016/0272639 COMPOUNDS AND METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS
The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of...
2016/0272638 PESTICIDALLY ACTIVE BICYCLIC HETEROCYCLES WITH SULPHUR CONTAINING SUBSTITUENTS
Compounds of the formula (I), and the agrochemically acceptable salts and N-oxides of those compounds, including all stereoisomers and tautomeric forms, and...
2016/0272637 SUBSTITUTED OXOPYRIDINE DERIVATIVES
The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the...
2016/0272636 CRYSTAL FORM OF (R)-PRAZIQUANTEL AND PREPARATION METHOD AND APPLICATION THEREOF
The present invention relates to a crystal form of (R)-praziquantel and a preparation method and uses thereof. The X-ray diffraction pattern (CuK.alpha....
2016/0272635 SUBSTITUTED DIHYDROPYRIDO[3,4-B]PYRAZINONES AS DUAL INHIBITORS OF BET PROTEINS AND POLO-LIKE KINASES
The present invention relates to substituted dihydropyrido[3,4-b]pyrazinones as dual inhibitors of BET proteins, in particular BRD4 proteins, and Polo-like...
2016/0272634 ACYCLIC CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS
The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as...
2016/0272633 N-(2-CYANO HETEROCYCLYL) PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS
Provided are compounds of Formula I, a JAK inhibitor, and use thereof for the treatment of JAK-mediated diseases by the application. ##STR00001##
2016/0272632 GEMINALLY SUBSTITUTED CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS
The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as...
2016/0272631 KETO-IMIDAZOPYRIDINE DERIVATIVES AS RORc MODULATORS
Compounds of the formula I or II: ##STR00001## or pharmaceutically acceptable salts thereof, wherein R.sup.1 is a group of formula (a), (b), (c); (d) or (e): ...
2016/0272630 Bromodomain Inhibitors
Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided. The compounds are useful as agents in the treatment of diseases and...
2016/0272629 PROCESS FOR THE PREPARATION OF BENZOHETERO [1,3] - DIAZOLE COMPOUNDS DISUBSTITUTED WITH HETEOARYL GROUPS
Process for the preparation of a benzohetero[1,3]diazole compound disubstituted with heteroaryl groups which comprises reacting at least one...
2016/0272628 NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE
A compound of Formula I is provided: ##STR00001## or pharmaceutically acceptable enantiomers, salts or solvates thereof. The invention further relates to the use...
2016/0272627 POLYMORPHIC FORMS OF SUVOROXANT
Present invention relates to crystalline form of suvorexant, amorphous form of suvorexant, amorphous solid dispersion of suvorexant, processes for their...
2016/0272626 PYRAZINE DERIVATIVES
The present invention relates to compounds of formula ##STR00001## wherein R.sup.1/R.sup.2 are hydrogen, lower alkyl, lower alkoxy, lower alkyl substituted by...
2016/0272625 HETEROCYCLIC SULFONAMIDES, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF
The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: ...
2016/0272624 METHODS FOR PREPARING BREXPIPRAZOLE, KEY INTERMEDIATES THEREOF AND SALTS THEREOF
The present invention relates to the methods for preparing brexpiprazole, the analogs, key intermediates, and salts thereof, specifically, the present...
2016/0272623 FORMATION OF MACROMOLECULES USING ITERATIVE GROWTH AND RELATED COMPOUNDS
In some embodiments, macromolecules and related methods are provided. In some embodiments, an iterative growth process may be used to form a macromolecule...
2016/0272622 TETRAZOLINONE COMPOUND AND USE THEREOF
A tetrazolinone compound represented by formula (1) ##STR00001## wherein E represents the following group E16; ##STR00002## Y represents --O--CH.sub.2--; Q...
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