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Patent # Description
2016/0272621 GSK-3 INHIBITORS
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds to treat...
2016/0272620 NOVEL UNCHARGED REACTIVATORS AGAINST OP-INHIBITION OF HUMAN ACETYLCHOLINESTERASE
Novel uncharged reactivators of human acetylcholinesterase, pharmaceutical compositions including the compounds, and their use for reactivating human...
2016/0272619 Neuroprotective Compounds and Use Thereof
Provided herein are compositions and methods for reducing one or both of axonal degeneration and neuronal cell death associated with a disease or traumatic...
2016/0272618 PHOTOCLEAVABLE CHEMICAL INDUCERS OF DIMERIZATION (CID) AND METHODS OF USE
The instant invention provides photolysable compounds, and their use in reversible chemical induced dimerization and light-induced regulation of proteins.
2016/0272617 SUBSTITUTED PHENYLALANINE DERIVATIVES
The invention relates to substituted phenylalanine derivatives and to processes for preparation thereof, and to the use thereof for production of medicaments...
2016/0272616 METHODS FOR THE PREPARATION OF CHARGED CROSSLINKERS
Processes for the preparation of charged crosslinkers bearing a sulfonic acid moiety are disclosed. These procedures also optionally include methods to convert...
2016/0272615 PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS
The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
2016/0272614 CONTINUOUS ARYCYCLIC COMPOUND
This is to provide a continuous arycyclic compound having a DGAT1 inhibitory activity, and useful for prophylaxis and/or treatment of obesity or hyperlipidemia...
2016/0272613 Pyridazinone Derivatives and their use as Herbicides
Pyridazinone derivatives of the general formula (I) are described as herbicides. ##STR00001## In this formula (I), Y, R.sup.1, R.sup.2 and R.sup.3 are each...
2016/0272612 ANTHROPOD REPELLENT CHEMICALS
Compositions and methods for repelling arthropods. The compositions include a carrier and an arthropod repelling compound, which can be a compound discovered...
2016/0272611 KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, are provided herein. Also provided are pharmaceutical compositions comprising at...
2016/0272610 PROCESS FOR PREPARING CHLOROACETALDEHYDE ACETALS
The invention relates to a process for preparing chloroacetaldehyde acetals of monohydric, dihydric or higher-functionality aliphatic alcohols, in which the...
2016/0272609 ORGANOCATALYTIC PROCESS FOR ASYMMETRIC SYNTHESIS OF DECANOLIDES
The present invention discloses organocatalytic process for asymmetric synthesis of highly enantioselective decanolide compounds in high yield with >99% ee....
2016/0272608 ORGANOCATALYTIC PROCESS FOR ASYMMETRIC SYNTHESIS OF DECANOLIDES
The present invention discloses organocatalytic process for asymmetric synthesis of highly enantioselective decanolide compounds in high yield with >99% ee....
2016/0272607 CHROMENONE DERIVATIVES
The invention concerns chromenone derivatives of Formula I ##STR00001## or a pharmaceutically-acceptable salts thereof, wherein each of R.sup.1, R.sup.2,...
2016/0272606 PROCESS FOR PREPARATION OF DRONEDARONE BY OXIDATION OF A HYDROXYL GROUP
The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof ##STR00001## which comprises...
2016/0272605 Disubstituted Maleic Anhydrides with Altered Kinetics of Ring Closure
We describe anhydride compounds suitable for physiologically labile modification of amine-containing molecules. The described anhydrides form reversible...
2016/0272604 3-FURYL-2-CYANO-2-ACRYLAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Disclosed are a 3-furyl-2-cyano-2-acrylamide derivative with epidermal growth factor receptor (EGFR) inhibitory activity and pharmaceutical acceptable salt...
2016/0272603 TRAIL ENHANCERS FOR THE SELECTIVE KILLING OF CANCER CELLS
The invention is directed to methods of inducing apoptosis, arresting cell cycle, or inhibiting cellular proliferation, or any combination thereof, in a tumor...
2016/0272602 PIPERAZINE CARBAMATES AND METHODS OF MAKING AND USING SAME
Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as...
2016/0272601 Antibacterial Thiazolecarboxylic Acids
Compounds of general formula (I): ##STR00001## wherein R.sup.1, R.sup.11, Y, R.sup.2, n and A are as defined herein are useful as inhibitors or...
2016/0272600 INHIBITORS OF BETA-SECRETASE
The present invention is directed to a compound represented by the following structural formula ##STR00001## or a pharmaceutically acceptable salt thereof....
2016/0272599 AZOCANE AND AZONANE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of...
2016/0272598 PROCESS FOR THE PREPARATION OF N-IODOAMIDES
The present invention provides new stable crystalline N-iodoamides -1-iodo-3,5,5-trimethylhydantoin (1-ITMH) and 3-iodo-4,4-dimethyl-2-oxazolidinone (IDMO)....
2016/0272597 Novel Oxazolidinone Antibacterial Compound
The invention relates to novel oxazolidinone compound. More particularly, the invention relates to novel [(S)--N-[[3-[4-fluoro-3-morpholino ...
2016/0272596 TETRAHYDRO-BENZODIAZEPINONES
Disclosed are compounds of Formula I, or pharmaceutically acceptable salts thereof, wherein W, X, Y, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as...
2016/0272595 QUINAZOLINONE AND ISOQUINOLINONE DERIVATIVE
The present invention relates to quinazolinone and isoquinolinone derivatives represented by formula (I) or pharmaceutically acceptable salts thereof. ...
2016/0272594 PREPARATION METHOD OF DEXMEDETOMIDINE INTERMEDIATE
The present invention discloses a preparation method of 2,3-dimethyl phenyl-1-trityl-imidazole-4-ketone. In accordance with this method, imidazole-4-ethyl...
2016/0272593 FLUORINATION OF ORGANIC COMPOUNDS
Methods for fluorinating organic compounds utilizing a novel organic reagent are described herein. The invention further discloses the utility of this reagent...
2016/0272592 N-(ARYLALKYL)-N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS
Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C, X, Ra, Rb, Rc,...
2016/0272591 CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF PHENYL-PYRAZOLES USEFUL AS MODULATORS OF THE 5-HT2A...
The present invention relates to processes for preparing phenyl-pyrazoles of Formula (I) and salts and pharmaceutical compositions thereof, useful as...
2016/0272590 ARYL- AND HETEROARYLCARBONYL DERIVATIVES OF HEXAHYDROINDENOPYRIDINE AND OCTAHYDROBENZOQUINOLINE
The present invention relates to compounds defined by formula I ##STR00001## wherein the variables R.sup.1, R.sup.2, R.sup.3, R.sup.4, and m are defined as in...
2016/0272589 DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE
Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further...
2016/0272588 USP7 INHIBITOR COMPOUNDS AND METHODS OF USE
2-Aminopyridine compounds of Formula I are provided, and various substituents including stereoisomers, tautomers, and pharmaceutically acceptable salts...
2016/0272587 COMPOUNDS FOR COGNITIVE ENHANCEMENT AND METHODS OF USE THEREOF
The invention provides compounds that inhibit ROCK activity. In certain embodiments the compounds of the invention enhance cognitive function. The invention is...
2016/0272586 USE OF STABLE LIPOPHILIC HYDROXYLAMINE COMPOUNDS FOR INHIBITING POLYMERIZATION OF VINYL MONOMERS
The present invention generally relates to compounds and methods for inhibiting the radical polymerization of unsaturated compounds, particularly vinyl...
2016/0272585 Phenoxyethyl Cyclic Amine Derivatives and Their Activity as EP4 Receptor Modulators
The present invention provides a compound of the Formula (I): wherein X, R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, and R.sup.9...
2016/0272584 BIPHENYLAMIDE DERIVATIVE HSP90 INHIBITORS
Compounds of the formulas are provided: wherein variables Y.sub.1-Y.sub.5, X.sub.1-X.sub.5, A.sub.1-A.sub.4, X, y, n.sub.1, n.sub.2, and R.sub.1-R.sub.15 are...
2016/0272583 METHOD AND APPARATUS FOR PREPARING FUNCTIONALIZED GRAPHENE AND FUNCTIONALIZED GRAPHENE
There are provided a method and an apparatus for preparing a functionalized graphene, and a functionalized graphene, and more specifically, a method and an...
2016/0272582 COMPOSITIONS AND METHODS FOR THE TREATMENT OF HYPERGLYCEMIA AND METABOLIC SYNDROME
The invention relates to the compounds and compositions of Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI or its pharmaceutical...
2016/0272581 PHENYLCARBAMATE DERIVATIVES AS FORMYL PEPTIDE RECEPTOR MODULATORS
The present invention relates to N-phenyl carbamate derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as...
2016/0272580 PROCESS FOR REMOVING CATIONS FROM AN ISOPHORONENITRILE PRODUCT MIXTURE
Cations are removed from a substance stream that is produced during the production of isophoronenitrile with the help of a cation exchanger.
2016/0272579 INHIBITORS OF HISTONE DEACETYLASE
The present invention relates to compounds which inhibit histone deacetylase activity and methods of synthesizing these compounds. The present invention also...
2016/0272578 NOVEL CERAMIDE DERIVATIVES HAVING AGONISTIC EFFECTS ON EPIDERMAL CANNABINOID RECEPTORS, AND PHARMACEUTICAL OR...
The present invention relates to a novel pseudoceramide derivative, a pharmaceutically acceptable salt thereof or a solvate thereof, and a pharmaceutical or...
2016/0272577 ACYLAMINO-SUBSTITUTED FUSED CYCLOPENTANECARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
The present invention relates to compounds of the formula I, ##STR00001## wherein A, Y, Z, R.sup.3 to R.sup.6, R.sup.20 to R.sup.22 and R.sup.50 have the...
2016/0272576 FOOD OR BEVERAGE CONTAINERS COATED WITH POLYMERS OF DI(AMIDO(ALKYL)PHENOL) COMPOUNDS
Di(amido(alkyl)phenol) compounds and upgraded molecular weight polymers made from such compounds have particular utility in coating compositions, especially...
2016/0272575 Functionalized Graphene Barrier Element
Described herein are functionalized graphene compositions that have gas, fluid, and/or vapor resistant properties. Also described are barrier elements based on...
2016/0272574 DMF DISTILLATION
A method of obtaining purified DMF from a mixture comprising DMF and hydrogen chloride (HCl) involving distillation is provided.
2016/0272573 NOVEL PROCESS FOR TOTAL SYNTHESIS OF VENLAFAXINE
There is a need for short, resolution free asymmetric process for synthesis of one isomer of venlafaxine, (-)-venlafaxine. The invention provides a novel,...
2016/0272572 ADENYLYL CYCLASE INHIBITORS FOR NEUROPATHIC AND INFLAMMATORY PAIN
The invention generally relates to adenylyl cyclase inhibitor compounds and methods for treating neuropathic or inflammatory pain by using those compounds.
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