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Patent # Description
2016/0271271 NANOSTRUCTURE CONJUGATES FOR MODULATION OF LOCATION-SPECIFIC SUBTYPES OF RECEPTORS AND ION CHANNELS
Nanostructure conjugates, methods for their preparation, and methods for their use are described. The nanostructure conjugates are useful in inhibiting,...
2016/0271270 BIFUNCTIONAL CYTOTOXIC AGENTS CONTAINING THE CTI PHARMACOPHORE
The present invention is directed to novel bifunctional CTI-CTI and CBI-CTI dimers of the formula: F.sup.1-L.sup.1-T-L.sup.2-F.sup.2 where F.sup.1, L.sup.1, T,...
2016/0271269 PEPTIDIC NANODELIVERY COMPOSITION TARGETING TWO RECEPTORS
A polypeptide conjugate for use in a method for binding and/or internalization of the polypeptide conjugate to a mammalian cell having a transferrin receptor...
2016/0271268 NUCLEIC ACID NANOSTRUCTURES FOR IN VIVO AGENT DELIVERY
The present disclosure provides, in some aspects, nucleic acid nanostructures subsaturated with polyamine polymers. The present disclosure also provides, in...
2016/0271267 ALKYNYL MULTI-ARM POLYETHYLENE GLYCOL DERIVATIVE
The present invention provides an alkynyl multi-arm polyethylene glycol derivative having a structure of a general formula I or general formula X VIII. In the...
2016/0271266 MULTI-ARM POLYETHYLENE GLYCOL-AZIDO DERIVATIVE
Provided is a multi-arm polyethylene glycol-azido derivative of general formula I , wherein R is a central molecule,which is selected from a polyhydroxy...
2016/0271265 INSULIN-LIKE GROWTH FACTOR MIMETICS FOR USE IN THERAPY
This relates to the use of an IGF-1 mimetic in human therapy. In particular, disclosed herein is the use of an IGF-1 precursor protein, particularly a human...
2016/0271264 OPTICALLY-ACTIVATED SYSTEM FOR REDUCING THE APPEARANCE OF SKIN IMPERFECTIONS
Optically-activated systems and methods for reducing the appearance of dark under eye circles are provided. The systems comprise a complex of a fluorescent...
2016/0271263 Acylated Glucagon Analogues
The present invention relates to novel peptide compounds which have an improved physical stability in solution and improved solubility at neutral pH, to the...
2016/0271262 HYDROGELS FORMED FROM POLYPEPTIDE MICELLES AND METHODS OF USE THEREOF
The presently disclosed subject matter is directed to compositions, methods, and systems (e.g., platforms) comprising the same, the systems comprising,...
2016/0271261 TRIORTHOGONAL REAGENTS FOR DUAL PROTEIN CONJUGATION
The present invention relates to triorthogonal reagents useful for site-specifically modifying a protein with two orthogonal groups that can be subsequently...
2016/0271260 METHODS OF IMPROVING TOLERABILITY, PHARMACODYNAMICS, AND EFFICACY OF BETA-ALANINE AND USE THEREFOR
The present invention relates in some aspects to compositions (e.g., pharmaceutical, nutritional compositions, etc.), formulations, and food or beverage...
2016/0271259 SESAME OIL BASED INJECTION FORMULATIONS
Injectable formulations comprising ethanol, sesame oil, and an Immune Response Modifier compound are disclosed. Methods of making the formulations and methods...
2016/0271258 Dual Peptide-Mediated Targeted Delivery System
This invention is generally related to a dual-peptide delivery system, where one peptide exhibits a receptor-targeting moiety and the other peptide exhibits an...
2016/0271257 Low Molecular Weight Immune-Modulators As Adjuvants for Specific Immunotherapy
The invention relates to a pharmaceutical composition for local modulation of T cell and B cell responses at the site of allergen or antigen presentation, made...
2016/0271256 Lipid Layer Forming Composition for Administration onto a Surface of a Living Organism
A lipid layer forming composition comprises a volatile silicone oil of a boiling point above 180.degree. C., a polar lipid, optionally a C.sub.2-C.sub.4...
2016/0271255 COMPOSITIONS COMPRISING LECITHIN OILS AND NSAIDS FOR PROTECTING THE GASTROINTESTINAL TRACT AND PROVIDING...
A novel pharmaceutical composition is provided by which nonsteroidal anti-inflammatory drugs (NSAIDs) are added directly to phospholipid-containing oil such as...
2016/0271254 N-ALKYL LACTAM ETHERS, AND COMPOSITIONS AND USES THEREOF
Described is a class of symmetrical and asymmetrical N-alkyl lactam ethers. One preferred ether is bis-N-ethyl pyrrolidone ether. Preferred compositions and...
2016/0271253 Protein Formulations Containing Amino Acids
Provided are stable protein formulations that contain at least one amino acid. In certain embodiments, amino acid combinations either at least two, or three,...
2016/0271252 STABLE CANNABINOID FORMULATIONS
The present invention is generally directed to substantially pure cannabidiol, stable cannabinoid pharmaceutical formulations, and methods of their use.
2016/0271251 RADIOLUMINESCENT COMPOUND FOR RADIOTHERAPY AND DEEP PHOTODYNAMIC THERAPY AND DEVICE FOR DEEP PHOTODYNAMIC THERAPY
A radioluminescent compound for radiotherapy and deep photodynamic therapy (Deep PDT), the radioluminescent compound including a molecular conjugate made up of...
2016/0271250 ACID-SUBSTITUTED POLYANILINE-GRAFTED HYDROGEL COPOLYMER AND USE THEREOF
An (acid-substituted polyaniline)-grafted hydrogel copolymer is provided. The (acid-substituted polyaniline)-grafted hydrogel copolymer has a general formula...
2016/0271249 COMBINATION OF AURORA KINASE INHIBITORS AND ANTI-CD20 ANTIBODIES
The present invention relates to methods for the treatment of hematological malignancies. In particular, the invention provides methods for treatment of...
2016/0271248 CXCR4 UP- AND DOWN-REGULATION FOR TREATMENT OF DISEASES OR DISORDERS
The present invention includes a method of treating or preventing HAND in a subject in need thereof, wherein the method comprises administering to the subject...
2016/0271247 Pharmaceutical Compositions
A composition including lactoferrin and immunoglobulin, wherein the composition does not substantially include one or more of the following proteins:...
2016/0271246 ADJUVANT COMPOSITION, VACCINE COMPOSITION CONTAINING THE SAME, AND METHOD FOR PRODUCING BOTH OF THEM
An adjuvant composition includes a pH-sensitive carrier and a substance with stimulus to activate innate immune system. The adjuvant composition serves as a...
2016/0271245 NUCLEIC ACIDS FOR TREATMENT OF ALLERGIES
The present invention provides DNA vaccines for the treatment of allergies. The vaccines comprise the coding sequence for one or more allergenic epitopes, and...
2016/0271244 METHOD OF INDUCING THE PRODUCTION OF PROTECTIVE ANTI-HIV-1 ANTIBODIES
The present invention relates, in general, to an immunogen for HIV vaccination and, in particular, to a method of inducing the production of protective...
2016/0271243 APPROACH TO PRODUCE HIV-1 GP140 ENVELOPE PROTEIN TRIMERS
Provided herein are HIV vaccines that encompasses recombinant trimers that mimic native HIV-1 envelope trimers. Also provided are methods of administering to a...
2016/0271242 SUBUNIT VACCINE PLATFORM BASED ON MULTIMERIC RIBONUCLEOPROTEINS COMPRISING NUCLEOPROTEINS OF A NON-SEGMENTED...
The present invention relates to a subunit vaccine platform based on multimeric ribonucleoproteins (RNPs) comprising nucleoproteins of a non- segmented...
2016/0271241 BUNYAVIRUSES WITH SEGMENTED GLYCOPROTEIN PRECURSOR GENES AND METHODS FOR GENERATING THESE VIRUSES
The invention relates to a bunyavirus, in which separated (NSm)Gn and Gc coding regions are functionally present on two different genome segments, preferably a...
2016/0271240 Tetanus Toxoid and CCL3 Improve DC Vaccines
Pre-conditioning a vaccine site with a potent recall antigen such as tetanus/diphtheria (Td) toxoid can significantly improve the lymph node homing and...
2016/0271239 Combination Therapy for Treating Cancer with a Poxvirus Expressing a Tumor Antigen and an Antagonist and/or...
The present disclosure encompasses therapies, compositions, and methods for treatment of a human cancer patient using a recombinant poxvirus encoding a...
2016/0271238 YEAST-BASED IMMUNOTHERAPY FOR CHORDOMA
One embodiment of the invention relates to a method to treat chordoma in an individual who has chordoma. The method includes the step of administering to an...
2016/0271237 COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF AUTOIMMUNE CONDITIONS
The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be...
2016/0271236 RECOMBINANT T-CELL RECEPTOR LIGAND FOR THE TREATMENT OF COGNITIVE AND NEUROPSYCHIATRIC IMPAIRMENT INDUCED BY...
Methods are provided for the treatment of subjects with cognitive or neuropsychiatric impairment induced by substance addiction and for increasing cognitive...
2016/0271235 METHODS OF TREATING ALLERGIES AND AUTOIMMUNE DISEASES WITH HOMOGENATE OF AXENIC C. ELEGANS
Methods of using axenic C. elegans homogenate for treating allergies or an autoimmune disease are disclosed. Also disclosed is a composition comprising a...
2016/0271234 TISSUE INHIBITOR OF METALLOPROTEINASES (Timp) LINKED TO GLYCOSYLPHOSPHATIDYLINOSITOL (Gpi) - ANCHORS FOR...
The present invention relates to fusion constructs of glycosylphosphatidylinositol (GPI)-anchored tissue inhibitors of metalloproteinases (TIMPs) and their use...
2016/0271233 FACTOR VII COMPOSITION
A stable pharmaceutical composition in liquid form or in solid form, containing factor VII. The composition is free of mannitol, sucrose, and any antioxidant.
2016/0271232 Use of Acid Stable Proteases in Animal Feed, Preferably to Increase Performance of COCC-Vaccinated Broiler Chickens
The invention relates to the use of at least one acid stable protease in poultry feed in combination with anti-coccidial vaccination of birds for increasing...
2016/0271231 TREATING CANCER STEM CELLS USING TARGETED CARGO PROTEINS
The disclosure provides targeted cargo proteins that are useful for targeting cancer stem cells, and methods of their use in treating cancer.
2016/0271230 AGENTS DIRECTED AGAINST A CIS RGMA/NEOGENIN INTERACTION OR LIPID RAFTS AND USE OF THE SAME IN METHODS OF TREATMENT
Disclosed herein is an agent that modulates a cis interaction between Repulsive Guidance Molecule A (RGMa) and Neogenin or lipid rafts. Modulation by the agent...
2016/0271229 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING HEPATITIS C VIRUS INFECTIOUS DISEASE
The present invention relates to a pharmaceutical composition for preventing or treating hepatitis C virus (HCV) infectious disease. More particularly, the...
2016/0271228 HEMOSTATIC COMPOSITIONS
The invention discloses a hemostatic composition comprising: a) a biocompatible polymer in particulate form suitable for use in hemostasis, and b) one...
2016/0271227 CONJUGATES OF SOMATOSTATIN ANALOGUES
Conjugates of carriers and hydrogels for controlling the biological half-life of somatostatin and its analogs are disclosed.
2016/0271226 PHARMACEUTICAL COMPOSITION
The present invention discloses a composition comprising readily dissociable molecular aggregates formed by combining an insulin, insulin analogue, derivative...
2016/0271225 METHODS FOR TREATING DIABETES AND REDUCING BODY WEIGHT
Methods for reducing body weight, altering body composition, treating diabetes, reducing HbA.sub.1c and reducing average daily blood glucose by the use of...
2016/0271224 METHODS OF REDUCING CORNEAL ENDOTHELIAL CELL LOSS
Provided herein are methods of reducing corneal endothelial cell loss (e.g., nerve loss-related corneal endothelial cell loss) that include selecting a subject...
2016/0271223 USE OF RELAXIN TO RESTORE MATERNAL PHYSIOLOGY IN PREGNANCIES CONCEIVED BY ASSISTED REPRODUCTIVE TECHNOLOGIES
The subject invention relates to methods for improving a subject's vasculature to normalize maternal hemodynamics, particularly in subjects attempting to...
2016/0271222 Combination Of Dopamine Agonists Plus First Phase Insulin Secretagogues For The Treatment Of Metabolic Disorders
The present invention is directed to a method of treating a metabolic disorder or key elements of a metabolic disorder such method comprising the use of an...
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