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NANOSTRUCTURE CONJUGATES FOR MODULATION OF LOCATION-SPECIFIC SUBTYPES OF
RECEPTORS AND ION CHANNELS
Nanostructure conjugates, methods for their preparation, and methods for their use are described. The nanostructure conjugates are useful in inhibiting,...
BIFUNCTIONAL CYTOTOXIC AGENTS CONTAINING THE CTI PHARMACOPHORE
The present invention is directed to novel bifunctional CTI-CTI and CBI-CTI dimers of the formula: F.sup.1-L.sup.1-T-L.sup.2-F.sup.2 where F.sup.1, L.sup.1, T,...
PEPTIDIC NANODELIVERY COMPOSITION TARGETING TWO RECEPTORS
A polypeptide conjugate for use in a method for binding and/or internalization of the polypeptide conjugate to a mammalian cell having a transferrin receptor...
NUCLEIC ACID NANOSTRUCTURES FOR IN VIVO AGENT DELIVERY
The present disclosure provides, in some aspects, nucleic acid nanostructures subsaturated with polyamine polymers. The present disclosure also provides, in...
ALKYNYL MULTI-ARM POLYETHYLENE GLYCOL DERIVATIVE
The present invention provides an alkynyl multi-arm polyethylene glycol derivative having a structure of a general formula I or general formula X VIII. In the...
MULTI-ARM POLYETHYLENE GLYCOL-AZIDO DERIVATIVE
Provided is a multi-arm polyethylene glycol-azido derivative of general formula I , wherein R is a central molecule,which is selected from a polyhydroxy...
INSULIN-LIKE GROWTH FACTOR MIMETICS FOR USE IN THERAPY
This relates to the use of an IGF-1 mimetic in human therapy. In particular, disclosed herein is the use of an IGF-1 precursor protein, particularly a human...
OPTICALLY-ACTIVATED SYSTEM FOR REDUCING THE APPEARANCE OF SKIN
Optically-activated systems and methods for reducing the appearance of dark under eye circles are provided. The systems comprise a complex of a fluorescent...
Acylated Glucagon Analogues
The present invention relates to novel peptide compounds which have an improved physical stability in solution and improved solubility at neutral pH, to the...
HYDROGELS FORMED FROM POLYPEPTIDE MICELLES AND METHODS OF USE THEREOF
The presently disclosed subject matter is directed to compositions, methods, and systems (e.g., platforms) comprising the same, the systems comprising,...
TRIORTHOGONAL REAGENTS FOR DUAL PROTEIN CONJUGATION
The present invention relates to triorthogonal reagents useful for site-specifically modifying a protein with two orthogonal groups that can be subsequently...
METHODS OF IMPROVING TOLERABILITY, PHARMACODYNAMICS, AND EFFICACY OF
BETA-ALANINE AND USE THEREFOR
The present invention relates in some aspects to compositions (e.g., pharmaceutical, nutritional compositions, etc.), formulations, and food or beverage...
SESAME OIL BASED INJECTION FORMULATIONS
Injectable formulations comprising ethanol, sesame oil, and an Immune Response Modifier compound are disclosed. Methods of making the formulations and methods...
Dual Peptide-Mediated Targeted Delivery System
This invention is generally related to a dual-peptide delivery system, where one peptide exhibits a receptor-targeting moiety and the other peptide exhibits an...
Low Molecular Weight Immune-Modulators As Adjuvants for Specific
The invention relates to a pharmaceutical composition for local modulation of T cell and B cell responses at the site of allergen or antigen presentation, made...
Lipid Layer Forming Composition for Administration onto a Surface of a
A lipid layer forming composition comprises a volatile silicone oil of a boiling point above 180.degree. C., a polar lipid, optionally a C.sub.2-C.sub.4...
COMPOSITIONS COMPRISING LECITHIN OILS AND NSAIDS FOR PROTECTING THE
GASTROINTESTINAL TRACT AND PROVIDING...
A novel pharmaceutical composition is provided by which nonsteroidal anti-inflammatory drugs (NSAIDs) are added directly to phospholipid-containing oil such as...
N-ALKYL LACTAM ETHERS, AND COMPOSITIONS AND USES THEREOF
Described is a class of symmetrical and asymmetrical N-alkyl lactam ethers. One preferred ether is bis-N-ethyl pyrrolidone ether. Preferred compositions and...
Protein Formulations Containing Amino Acids
Provided are stable protein formulations that contain at least one amino acid. In certain embodiments, amino acid combinations either at least two, or three,...
STABLE CANNABINOID FORMULATIONS
The present invention is generally directed to substantially pure cannabidiol, stable cannabinoid pharmaceutical formulations, and methods of their use.
RADIOLUMINESCENT COMPOUND FOR RADIOTHERAPY AND DEEP PHOTODYNAMIC THERAPY
AND DEVICE FOR DEEP PHOTODYNAMIC THERAPY
A radioluminescent compound for radiotherapy and deep photodynamic therapy (Deep PDT), the radioluminescent compound including a molecular conjugate made up of...
ACID-SUBSTITUTED POLYANILINE-GRAFTED HYDROGEL COPOLYMER AND USE THEREOF
An (acid-substituted polyaniline)-grafted hydrogel copolymer is provided. The (acid-substituted polyaniline)-grafted hydrogel copolymer has a general formula...
COMBINATION OF AURORA KINASE INHIBITORS AND ANTI-CD20 ANTIBODIES
The present invention relates to methods for the treatment of hematological malignancies. In particular, the invention provides methods for treatment of...
CXCR4 UP- AND DOWN-REGULATION FOR TREATMENT OF DISEASES OR DISORDERS
The present invention includes a method of treating or preventing HAND in a subject in need thereof, wherein the method comprises administering to the subject...
A composition including lactoferrin and immunoglobulin, wherein the composition does not substantially include one or more of the following proteins:...
ADJUVANT COMPOSITION, VACCINE COMPOSITION CONTAINING THE SAME, AND METHOD
FOR PRODUCING BOTH OF THEM
An adjuvant composition includes a pH-sensitive carrier and a substance with stimulus to activate innate immune system. The adjuvant composition serves as a...
NUCLEIC ACIDS FOR TREATMENT OF ALLERGIES
The present invention provides DNA vaccines for the treatment of allergies. The vaccines comprise the coding sequence for one or more allergenic epitopes, and...
METHOD OF INDUCING THE PRODUCTION OF PROTECTIVE ANTI-HIV-1 ANTIBODIES
The present invention relates, in general, to an immunogen for HIV vaccination and, in particular, to a method of inducing the production of protective...
APPROACH TO PRODUCE HIV-1 GP140 ENVELOPE PROTEIN TRIMERS
Provided herein are HIV vaccines that encompasses recombinant trimers that mimic native HIV-1 envelope trimers. Also provided are methods of administering to a...
SUBUNIT VACCINE PLATFORM BASED ON MULTIMERIC RIBONUCLEOPROTEINS COMPRISING
NUCLEOPROTEINS OF A NON-SEGMENTED...
The present invention relates to a subunit vaccine platform based on multimeric ribonucleoproteins (RNPs) comprising nucleoproteins of a non- segmented...
BUNYAVIRUSES WITH SEGMENTED GLYCOPROTEIN PRECURSOR GENES AND METHODS FOR
GENERATING THESE VIRUSES
The invention relates to a bunyavirus, in which separated (NSm)Gn and Gc coding regions are functionally present on two different genome segments, preferably a...
Tetanus Toxoid and CCL3 Improve DC Vaccines
Pre-conditioning a vaccine site with a potent recall antigen such as tetanus/diphtheria (Td) toxoid can significantly improve the lymph node homing and...
Combination Therapy for Treating Cancer with a Poxvirus Expressing a Tumor
Antigen and an Antagonist and/or...
The present disclosure encompasses therapies, compositions, and methods for treatment of a human cancer patient using a recombinant poxvirus encoding a...
YEAST-BASED IMMUNOTHERAPY FOR CHORDOMA
One embodiment of the invention relates to a method to treat chordoma in an individual who has chordoma. The method includes the step of administering to an...
COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF AUTOIMMUNE
The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be...
RECOMBINANT T-CELL RECEPTOR LIGAND FOR THE TREATMENT OF COGNITIVE AND
NEUROPSYCHIATRIC IMPAIRMENT INDUCED BY...
Methods are provided for the treatment of subjects with cognitive or neuropsychiatric impairment induced by substance addiction and for increasing cognitive...
METHODS OF TREATING ALLERGIES AND AUTOIMMUNE DISEASES WITH HOMOGENATE OF
AXENIC C. ELEGANS
Methods of using axenic C. elegans homogenate for treating allergies or an autoimmune disease are disclosed. Also disclosed is a composition comprising a...
TISSUE INHIBITOR OF METALLOPROTEINASES (Timp) LINKED TO
GLYCOSYLPHOSPHATIDYLINOSITOL (Gpi) - ANCHORS FOR...
The present invention relates to fusion constructs of glycosylphosphatidylinositol (GPI)-anchored tissue inhibitors of metalloproteinases (TIMPs) and their use...
FACTOR VII COMPOSITION
A stable pharmaceutical composition in liquid form or in solid form, containing factor VII. The composition is free of mannitol, sucrose, and any antioxidant.
Use of Acid Stable Proteases in Animal Feed, Preferably to Increase
Performance of COCC-Vaccinated Broiler Chickens
The invention relates to the use of at least one acid stable protease in poultry feed in combination with anti-coccidial vaccination of birds for increasing...
TREATING CANCER STEM CELLS USING TARGETED CARGO PROTEINS
The disclosure provides targeted cargo proteins that are useful for targeting cancer stem cells, and methods of their use in treating cancer.
AGENTS DIRECTED AGAINST A CIS RGMA/NEOGENIN INTERACTION OR LIPID RAFTS AND
USE OF THE SAME IN METHODS OF TREATMENT
Disclosed herein is an agent that modulates a cis interaction between Repulsive Guidance Molecule A (RGMa) and Neogenin or lipid rafts. Modulation by the agent...
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING HEPATITIS C VIRUS
The present invention relates to a pharmaceutical composition for preventing or treating hepatitis C virus (HCV) infectious disease. More particularly, the...
The invention discloses a hemostatic composition comprising: a) a biocompatible polymer in particulate form suitable for use in hemostasis, and b) one...
CONJUGATES OF SOMATOSTATIN ANALOGUES
Conjugates of carriers and hydrogels for controlling the biological half-life of somatostatin and its analogs are disclosed.
The present invention discloses a composition comprising readily dissociable molecular aggregates formed by combining an insulin, insulin analogue, derivative...
METHODS FOR TREATING DIABETES AND REDUCING BODY WEIGHT
Methods for reducing body weight, altering body composition, treating diabetes, reducing HbA.sub.1c and reducing average daily blood glucose by the use of...
METHODS OF REDUCING CORNEAL ENDOTHELIAL CELL LOSS
Provided herein are methods of reducing corneal endothelial cell loss (e.g., nerve loss-related corneal endothelial cell loss) that include selecting a subject...
USE OF RELAXIN TO RESTORE MATERNAL PHYSIOLOGY IN PREGNANCIES CONCEIVED BY
ASSISTED REPRODUCTIVE TECHNOLOGIES
The subject invention relates to methods for improving a subject's vasculature to normalize maternal hemodynamics, particularly in subjects attempting to...
Combination Of Dopamine Agonists Plus First Phase Insulin Secretagogues
For The Treatment Of Metabolic Disorders
The present invention is directed to a method of treating a metabolic disorder or key elements of a metabolic disorder such method comprising the use of an...