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Patent # Description
2016/0280806 MODIFIED DIENE ELASTOMER PREDOMINANTLY COMPRISING A DIENE ELASTOMER COUPLED BY AN ALKOXYSILANE COMPOUND BEARING...
The invention relates to a modified diene elastomer comprising predominantly the entity functionalized in the middle of the chain by an alkoxysilane group,...
2016/0280805 Cyclic Carbonate Azide
Cyclic carbonate azide having a structure according to the following formula (A) wherein R.sup.1-R.sup.5 are independently selected from the group consisting...
2016/0280804 Halogenated Polysaccharides
A halogenated polysaccharide is provided having a halogen content of from about 1.0 wt. % to about 85 wt. % based on the total weight of the halogenated...
2016/0280803 RESIN COMPOSITION AND RESIN MOLDED ARTICLE
A resin composition includes a cellulose derivative, wherein a Hazen color number (APHA) of the resin composition is 50 or lower.
2016/0280802 RESIN COMPOSITION AND RESIN MOLDED ARTICLE
A resin composition includes a cellulose derivative in which at least one hydroxyl group is substituted with an acetyl group in an amount ratio of 90% by...
2016/0280801 RESIN COMPOSITION AND RESIN MOLDED ARTICLE
A resin composition includes a cellulose derivative, wherein a saturated water absorption of the resin composition is in a range of 7% or greater.
2016/0280800 RESIN COMPOSITION, METHOD OF PREPARING RESIN MOLDED ARTICLE, AND RESIN MOLDED ARTICLE
A resin composition includes a cellulose derivative, wherein a water absorption warp amount after a D2 test specimen obtained by injection-molding the resin...
2016/0280799 PULMONARY ADMINISTRATION OF IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS AND CONSTRUCTS THEREOF
In one aspect, the invention relates to a method suitable for administering protein therapeutic molecules orally, sublingually, topically, intravenously,...
2016/0280798 ALK ANTIBODIES, CONJUGATES, AND CHIMERIC ANTIGEN RECEPTORS, AND THEIR USE
Chimeric antigen receptors that specifically bind to anaplastic lymphoma kinase are disclosed. Nucleic acids, recombinant expression vectors, host cells,...
2016/0280797 MODIFIED GLYCOPROTEIN, PROTEIN-CONJUGATE AND PROCESS FOR THE PREPARATION THEREOF
The invention relates to a glycoprotein comprising an optionally fucosylated glycan according to formula (105) or (106), wherein Su(A)x is a modified sugar...
2016/0280796 ANTI-WT1/HLA BI-SPECIFIC ANTIBODY
Disclosed herein is a bi-specific form of a T cell receptor mimic (TCRm) mAb with reactivity to human immune effector cell antigen and a WT1 peptide/HLA-A...
2016/0280795 BISPECIFIC ANTIBODY WITH TWO SINGLE-DOMAIN ANTIGEN-BINDING FRAGMENTS
Provided are bivalent bispecific antibody comprising a first polypeptide comprising a first Fc fragment and a first single-domain antigen-binding (VHH)...
2016/0280794 COMPOSITIONS AND METHODS RELATING TO UNIVERSAL GLYCOFORMS FOR ENHANCED ANTIBODY EFFICACY
The present disclosure relates to compositions and methods of use comprising antibodies or binding fragments thereof further comprising universal Fc glycoforms.
2016/0280793 ANTI-LAMP1 ANTIBODIES AND ANTIBODY DRUG CONJUGATES, AND USES THEREOF
Antibodies are provided which specifically bind human and Macaca fascicularis lysosomal-associated membrane protein 1 (LAMP1) proteins and immunoconjugates...
2016/0280792 ANTIBODY TO HUMAN IL-3 RECEPTOR ALPHA CHAIN
The present invention provides an antibody to human IL-3R.alpha. chain, which does not inhibit IL-3 signaling and binds to B domain of the human IL-3R.alpha....
2016/0280791 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
Engineered multivalent and multispecific binding proteins that bind two different (e.g., nonoverlapping) epitopes of the same receptor or two different...
2016/0280790 DEPLETION OF PLASMACYTOID DENDRITIC CELLS
The present invention relates to antibodies targeted to BDCA2 that deplete plasmacytoid dendritic cells (pDC) and methods of using the antibodies to treat...
2016/0280789 METHODS FOR TREATING HEMATOLOGICAL MALIGNANCIES
Described herein are methods for treating hematological malignancies and/or solid tumors in a subject using inhibitors of integrin alpha 6. In some...
2016/0280788 USE OF ANTIBODIES AGAINST ICAM-1 IN THE TREATMENT OF PATIENTS WITH RELAPSED CANCER
There is provided antibodies or antigen-binding fragments thereof with binding specificity for ICAM-1, for use in the treatment of cancer in patients who have...
2016/0280787 ANTIGEN-BINDING MOLECULE CONTAINING MODIFIED ANTIBODY VARIABLE REGION
The present inventors have successfully prepared an antigen-binding molecule comprising an antibody variable region that has binding activity against a...
2016/0280786 AMINO ACID SEQUENCES THAT MODULATE THE INTERACTION BETWEEN CELLS OF THE IMMUNE SYSTEM
The present invention relates to amino acid sequences that block the interaction between (a target on) an antigen presenting cell (APC) and (a target on) a...
2016/0280785 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING AN INFLAMMATION
A method of treating multiple sclerosis (MS) in a subject in need thereof, the method comprising administering to said subject a therapeutically effective...
2016/0280784 Antibodies Directed to GPNMB and Uses Thereof
The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino...
2016/0280783 COMPOSITIONS AND METHODS FOR ANTIBODIES TARGETING EPO
The present invention relates to compositions and methods for the inhibition of EPO. The invention provides antibodies and antigen binding fragments thereof...
2016/0280782 COMPOSITIONS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS AND METHODS OF USING SAME
The present invention provides compositions and methods of treating and improving the symptoms of rheumatoid arthritis using an antibody that specifically...
2016/0280781 IL-17 ANTIBODY FORMULATION
The present invention provides stabilized pharmaceutical formulations for anti-IL-17 antibodies, comprising e.g. citrate, sodium chloride and polysorbate-80 at...
2016/0280780 HUMAN MONOCLONAL ANTIBODIES AGAINST INTERLEUKIN 8 (IL-8)
Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or...
2016/0280779 HUMAN ANTIBODY MOLECULES FOR IL-13
Specific binding members, in particular human anti-IL-13 antibody molecules and especially those which neutralize IL-13 activity. Methods for using anti-IL-13...
2016/0280778 COMPOSITIONS AND METHODS OF USE OF INTERLEUKIN-10 PEPTIDES AND ANTI-INTERLEUKIN-10 ANTIBODIES
Disclosed herein are methods of reducing a symptom of respiratory disease in a pre-weaned milk-fed mammal by orally administering an isolated antibody that...
2016/0280777 METHODS OF ADMINISTERING ANTI-TNFALPHA ANTIBODIES
Methods of treating disorders in which TNF.alpha. activity is detrimental via biweekly, subcutaneous administration of human antibodies, preferably recombinant...
2016/0280776 Uses and Compositions for Treatment of Juvenile Rheumatoid Arthritis
The invention provides methods, uses and compositions for the treatment of juvenile rheumatoid arthritis (JRA). The invention describes methods and uses for...
2016/0280775 TREATMENT FOR DUPUYTREN'S DISEASE
Musculoskeletal fibroproliferative disorders, such as Dupuytren's disease may be treated by administering locally a TNF-.alpha. antagonist. TNF-.alpha....
2016/0280774 Method for Making Heteromultimeric Molecules
Methods for making heteromultimeric molecules, such as bispecific antibodies, and compositions comprising these molecules are disclosed. The methods include...
2016/0280773 ANTI-RICIN ANTIBODIES AND USES THEREOF
The present invention relates to anti-ricin antibodies and uses thereof. More specifically, the invention relates to anti-ricin antibodies and fragments...
2016/0280772 Polypeptides, Cells, and Methods for Biofilm Therapy and Detection
This disclosure describes a fusion polypeptide that includes an anchor domain and a binding domain that specifically binds to a target biofilm. The anchor...
2016/0280771 ANTI-HIV DUAL SPECIFICITY ANTIBODIES AND METHODS OF HIV TREATMENT
Dual variable domain immunoglobulins (DVD Igs) are provided capable of tetravalent binding to bispecific sites of the human immunodeficiency virus (HIV). The...
2016/0280770 HUMAN CYTOMEGALOVIRUS NEUTRALIZING ANTIBODIES AND USE THEREOF
The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and...
2016/0280769 HUMAN CYTOMEGALOVIRUS NEUTRALIZING ANTIBODIES AND USE THEREOF
The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and...
2016/0280768 IMMUNOGLOBULIN CONSTANT REGION FC RECEPTOR BINDING AGENTS
IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are...
2016/0280767 METHODS FOR CONTROLLING PROTEIN GLYCOSYLATION
The present disclosure provides methods for improving batch-to-batch consistency of proteins produced by eukaryotic cells, as well as proteins produced thereby.
2016/0280766 HYPER-GLYCOSYLATED ANTIBODIES WITH SELECTIVE FC RECEPTOR BINDING
Means for improving the effector functions of current immunotherapeutic antibodies through targeted hyper-glycosylation of the antibody Fc region are...
2016/0280765 HUMAN IGG1 DERIVED ANTIBODY WITH PRO-APOPTOTIC ACTIVITY
A method for increasing the therapeutic efficacy of a human immunoglobulin G class 1 (IgG1) antibody, includes: mutating the human CH1.gamma.1 domain from the...
2016/0280764 Glycation Cross-link Breakers to Increase Resistance to Enzymatic Degradation
The present invention relates to a method to treat a grafts, implant, scaffold, and constructs, including allografts, xenografts, autografts, and prosthetics...
2016/0280763 ALBUMIN VARIANTS AND USES THEREOF
The present invention relates to albumin variants with an improved affinity for the neonatal Fc receptor (FcRn) and uses thereof, and in particular to the use...
2016/0280762 GLP-1 ANALOG FUSION PROTEIN AND PREPARATION METHOD AND USE THEREOF
The present invention provides a novel GLP-1 analogue fusion protein and a method for preparing the fusion protein. The fusion protein consists of three...
2016/0280761 HUMAN LEUCINE ZIPPER/TRAIL RECOMBINANT POLYPEPTIDES
Disclosed are recombinant polypeptides that include human TRAIL sequences as well as human leucine zipper motifs as well as polynucleotides that encode the...
2016/0280760 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2016/0280759 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2016/0280758 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2016/0280757 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
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