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Patent # Description
2016/0280756 ENGINEERED HIGH-AFFINITY HUMAN T CELL RECEPTORS
T cell receptors (TCRs) that have specificity for the WT1 antigen are provided. The TCRs include higher affinity TCRs that were engineered through the...
2016/0280755 ENGINEERED HIGH-AFFINITY HUMAN T CELL RECEPTORS
T cell receptors (TCRs) that have higher affinity for the Survivin antigen are provided. The high affinity TCRs were engineered through the generation of...
2016/0280754 GIP-GLP-1 DUAL AGONIST COMPOUNDS AND METHODS
The present invention relates to acylated GIP analogues which have dual GIP and GLP-1 activity, and their use in the treatment of metabolic disorders.
2016/0280753 BIOLOGICALLY ACTIVE PROTEINS HAVING INCREASED IN VIVO AND/OR IN VITRO STABILITY
The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides...
2016/0280752 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2016/0280751 COMPOUNDS AND METHODS FOR TREATMENT OR PREVENTION OF A PATHOGEN INFECTION
A compound comprising a C-type lectin Carbohydrate Recognition Domain (CRD) and an immunoglobulin Fc domain for use in treating or preventing a pathogen...
2016/0280750 DIAGNOSIS AND TREATMENT OF AUTOIMMUNE DISEASES
The invention relates generally to the field of autoimmunity. More specifically, the invention relates to compositions and methods for the diagnosis,...
2016/0280749 ANALOGUES OF TEMPORIN-SHa AND USES THEREOF
The present invention relates to novel antimicrobial peptides, to pharmaceutical compositions comprising said peptides and to the uses thereof, in particular...
2016/0280748 SUPERCHARGED PROTEINS FOR CELL PENETRATION
Compositions, preparations, systems, and related methods for delivering a supercharged protein, or a complex of a supercharged protein and an agent (e.g.,...
2016/0280747 ANTICALINS
The invention relates to the production of novel proteins exhibiting bonding activity for certain ligands, the so-called anticalins. To this end, the structure...
2016/0280746 POLYPEPTIDE EXHIBITING FLUORESCENT PROPERTIES, AND UTILIZATION OF THE SAME
A mode of a polypeptide according to the present invention exhibits a fluorescence property, and has (1) an amino acid sequence represented by SEQ ID NO. 1 or...
2016/0280745 METHODS FOR ENGINEERING SUGAR TRANSPORTER PREFERENCES
Provided herein are compositions and methods useful for transporting xylose, arabinose and other monosaccharides, into a yeast cell.
2016/0280744 PROTEIN COMPRISED BY LINKING BY LINKER MULTIPLE DOMAINS HAVING AFFINTIY FOR PROTEINS HAVING Fc PART OF...
The purpose of the present invention is to provide a novel protein, which have such excellent pH responsiveness that the antibody binding property to the Fc...
2016/0280743 BACTERIAL MUTANTS AND METHODS OF USE
Mutants of Gram-negative bacteria having outer membranes comprising modified FhuA nanopores absent an N-terminal plug domain are disclosed. The modified FhuA...
2016/0280742 Compositions and Methods for Treating Alzheimer's Disease
The present disclosure provides for a hyperimmune preparation comprising human polyclonal antibodies or fragments thereof specific to a cyclic peptide having...
2016/0280741 CYCLIC CITRULLINATED PEPTIDE, RHEUMATOID ARTHRITIS DIAGNOSIS COMPOSITION INCLUDING THE SAME, RHEUMATOID...
Rheumatoid arthritis is efficiently diagnosed with improved patient's convenience using a rheumatoid arthritis diagnosis composition and a kit, each including...
2016/0280740 NATURAL IGM ANTIBODIES AND INHIBITORS THEREOF
The invention provides natural IgM antibody inhibitors that may be used to treat various inflammatory diseases or disorders.
2016/0280739 MODIFIED KISSPEPTIN PEPTIDES AND USES THEREOF
The present application provides synthetic modified peptides of five to seven natural or non-natural amino acids as well as pharmaceutical compositions...
2016/0280738 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2016/0280737 ALKOXYSILANE DERIVATIVES OF N-ACYL AMINO ACIDS, N-ACYL DIPEPTIDES, AND N-ACYL TRIPEPTIDES, AND PARTICLES AND...
Hydrophilic N-acylamino acid, N-acyl dipeptide, and N-acyl tripeptide substituted silanes are prepared which can be utilized as reactive surface treatments for...
2016/0280736 CYCLIC PEPTIDE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF
The present invention relates to a cyclic peptide compound, and a preparation method, pharmaceutical composition and use thereof. In particular, the cyclic...
2016/0280735 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS
Embodiments of the invention are to compounds, methods, and compositions for use in the treatment of viral infections. More specifically embodiments of the...
2016/0280734 AN AUTOMATED, MULTI-POT HIGH-PRESSURE RADIO-SYNTHESIZER FOR PRODUCTION OF PET TRACERS
An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for...
2016/0280733 NOVEL SOPHOROLIPID COMPOUND AND COMPOSITION COMPRISING SAME
The subject invention provides a novel SL that is widely applicable to various fields including food or beverages, cosmetics, pharmaceuticals, and...
2016/0280732 MOENOMYCIN ANALOGS, METHODS OF SYNTHESIS, AND USES THEREOF
The present invention provides compounds of Formula (I): ##STR00001## or a pharmaceutically acceptable form thereof; wherein R.sup.1, R.sup.2, R.sup.3, R .sup.6,...
2016/0280731 CRYSTALLINE FORMS B, C, and D OF CANAGLIFLOZIN
Novel crystalline Forms B, C, and D of canagliflozin, processes for their preparation, pharmaceutical compositions comprising these new Forms, and use of them...
2016/0280730 CARBON FIBRE COMPOSITIONS COMPRISING LIGNIN DERIVATIVES
The present disclosure provides derivatives of native lignin suitable for production of carbon fibres wherein the derivatives of native lignin have a certain...
2016/0280729 CYCLOPENTANE AND CYCLOPENTENE NUCLEOSIDE ANALOGS FOR THE TREATMENT OF HCV
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments,...
2016/0280728 CATIONIC OLIGONUCLEOTIDES, AUTOMATED METHODS FOR PREPARING SAME AND THEIR USES
The invention relates to oligonucleotide-oligocation molecules A.sub.iB.sub.jH that can be synthetized via automated phosphoramidite chemistry having...
2016/0280727 PHARMACEUTICAL COMPOUNDS FOR USE IN THE THERAPY OF CLOSTRIDIUM DIFFICILE INFECTION
The invention relates to a compound described by a general formula (1), wherein each X independently from other X can be OPO.sub.3.sup.2-, OPSO.sub.2.sup.2- or...
2016/0280726 PROCESS FOR THE PREPARATION OF LIQUID TIN(II) ALKOXIDES
A synthetic process of producing liquid tin(II) alkoxides for use as either catalysts in the synthesis of lactide or as initiators in the polymerization of...
2016/0280725 FLUORINATED CYCLOALKENE FUNCTIONALIZED SILICAS
Fluorinated cyclopentene moieties and fluorinated cyclopentene functionalized silica materials are provided. The fluorinated cyclopentene functionalized silica...
2016/0280724 N-ALKYL SUBSTITUTED CYCLIC AND OLIGOMERIC PERHYDRIDOSILAZANES, METHODS OF PREPARATION THEREOF, AND SILICON...
Novel N-alkyl substituted perhydridocyclic silazanes, oligomeric N-alkyl perhydridosilazane compounds, and N-alkylaminodihydridohalosilanes, and a method for...
2016/0280723 CHEMICAL REAGENTS FOR ATTACHING AFFINITY MOLECULES ON SURFACES
Chemical linkage reagents, methods of making and method of using the same are provided. Chemical linkage reagents according to at least some of the embodiments...
2016/0280722 Bisphenolate Transition Metal Complexes, Production and Use Thereof
Bis phenolate transition metal complexes are disclosed for use in alkene polymerization, with optional chain transfer agent, to produce polyolefins.
2016/0280721 CROSS-COUPLING OF UNACTIVATED SECONDARY BORONIC ACIDS
Provided are methods for site- and stereo-retentive cross-couplings with unactivated secondary boronic acids, which methods are particularly useful in building...
2016/0280720 LIGATED ANIONIC-ELEMENT REAGENT COMPLEXES AS NOVEL REAGENTS FORMED WITH METAL, METALLOID, AND NON-METAL ELEMENTS
A reagent includes an element, formally in oxidation state zero, in complex with a hydride molecule and an incorporated ligand. The incorporated ligand...
2016/0280719 PYRROLOPYRROLONE DERIVATIVES AND THEIR USE AS BET INHIBITORS
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the...
2016/0280718 NOVEL ANTIBACTERIAL AGENTS
This invention relates to novel macrolides, to the preparation of novel macrolides, to the use of such novel macrolides preventing, treating, or ameliorating...
2016/0280717 COMPOUND FOR INHIBITING THE GROWTH AND PROLIFERATION OF HUMAN LIVER CANCER CELLS AND METHOD FOR SYNTHESIZING IT
The compound "2-((4-nitrophenyl)amino)-6,7,8,9-tetrahydro-3H-cyclohepta[4,5]thieno-[2,- 3-d]pyrimidin-4(5H)-one" and method of synthesizing it, wherein the ...
2016/0280716 PHARMACEUTICAL SALT FORMS OF CEPHARANTHINE AND TETRANDRINE
The present disclosure relates to the preparation of pharmaceutically acceptable salt forms of the medicinal alkaloids Cepharanthine and Tetrandrine with...
2016/0280715 ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME
The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also...
2016/0280714 POLYHEDRAL CAGE-CONTAINING METALLOPORPHYRIN FRAMEWORKS, METHODS OF MAKING, AND METHODS OF USING
Embodiments of the present disclosure provide compositions including metal-organic polyhedrons, metalloporphyrin framework structures, methods of making these,...
2016/0280713 PYRAZINE DERIVATIVES AS FGFR INHIBITORS
The present invention relates to pyrazine derivatives, and pharmaceutical compositions including the same, that are inhibitors of one or more FGFR enzymes and...
2016/0280712 SYNTHESIS OF TRANS-8-CHLORO-5-METHYL-1 ...
The present invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benz- o[e]azulenes....
2016/0280711 Protein Kinase Inhibitors
The present invention relates to a novel family of protein kinase inhibitors, more specifically the present invention is directed to inhibitors of the Tec or...
2016/0280710 PROCESS FOR CRYSTALLINE PEMETREXED DIPOTASSIUM SALT
The present invention provides process for preparing crystalline Pemetrexed dipotassium (I) Form-SP9 ##STR00001## characterized by X-ray powder diffraction...
2016/0280709 METHODS FOR THE PREPARATION OF ALCAFTADINE
The invention relates to new and improved processes for the preparation of Alcaftadine and pharmaceutically acceptable salts thereof as well as an intermediate...
2016/0280708 Spirocycles as Inhibitors of 11-beta Hydroxyl Steroid Dehydrogenase Type 1
The present invention relates to certain spirocyclic compounds that are inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type 1 (11.beta.HSD1),...
2016/0280707 ALKOXY SUBSTITUTED IMIDAZOQUINOLINES
Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates,...
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