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Patent # Description
2016/0280706 INHIBITORS OF BRUTON'S TYROSINE KINASE
This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds...
2016/0280705 NAPHTHYRIDINE DERIVATIVES USEFUL AS ALPHA-V-BETA-6 INTEGRIN ANTAGONISTS
A compound of formula (I) or a salt thereof ##STR00001## wherein R.sub.1 represents a hydrogen atom, a methyl group or a ethyl group R.sub.2 represents a...
2016/0280704 CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS
Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma,...
2016/0280703 Heteroaryloxycarbocyclyl Compounds as PDE 10 Inhibitors
Heteroaryloxycarbocyclyl compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating...
2016/0280702 THIAZOLYL AND OXAZOLYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS
Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as...
2016/0280701 INHIBITORS OF COLLAGEN PROLYL 4-HYDROXYLASE
Biheteroaryl dicarboxylates and esters, and salts thereof which are useful as modulators of CP4H activity and more particularly as inhibitors of CP4H....
2016/0280700 ANTIPARASITIC COMPOUNDS
The invention relates to 1,2,4-thiadiazole derivatives and their use to treat parasites.
2016/0280699 SUBSTITUTED PHENYLALANINE DERIVATIVES
The invention relates to substituted phenylalanine derivatives and to processes for preparation thereof, and to the use thereof for production of medicaments...
2016/0280698 SOLID STATE FORMS OF A QUINAZOLINE DERIVATIVE AND ITS USE AS A BRAF INHIBITOR
This application relates to various salts and solid state forms of Compound (I). This application also relates to pharmaceutical compositions and therapeutic...
2016/0280697 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE
Compounds and compositions comprising compounds that activate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the...
2016/0280696 Substituted 1,2,5-oxadiazole compounds and their use as herbicides
The present invention relates to a compound of formula I, wherein the variables are defined as in the specification. The invention further refers to a...
2016/0280695 PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE
The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general...
2016/0280694 5-AMINO-QUINOLINE-8-CARBOXAMIDE DERIVATIVES AS 5-HT4 RECEPTOR AGONISTS
The present invention relates to novel quinoline compounds of formula (I), and their pharmaceutically acceptable salts and process for their preparation. The...
2016/0280693 ACTIVATORS OF CLASS I HISTONE DEACETLYASES (HDACS) AND USES THEREOF
The present invention provides compounds of Formulae (A), (B), (C), and (D), pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals,...
2016/0280692 N-(MONOCYCLIC ARYL),N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS
Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as...
2016/0280691 TRIAZOLE INTERMEDIATES USEFUL IN THE SYNTHESIS OF PROTECTED N-ALKYLTRIAZOLECARBALDEHYDES
Described herein are compounds and methods of making such compounds useful in the synthesis of protected N-alkyl-triazolecarbaldehydes. ##STR00001##
2016/0280690 PYRAZOLYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS
Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as...
2016/0280689 AN IMPROVED PROCESS FOR THE PREPARATION OF PAZOPANIB OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
The present invention is relates to an improved process for the preparation of pazopanib or a pharmaceutically acceptable salts thereof. The present invention...
2016/0280688 SUBSTITUTED PHENYLALANINE DERIVATIVES
The invention relates to substituted phenylalanine derivatives and to processes for preparation thereof, and to the use thereof for production of medicaments...
2016/0280687 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or...
2016/0280686 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or...
2016/0280685 SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS
Amine substituted pyridine and pyrazine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia...
2016/0280684 TRK-INHIBITING COMPOUND
The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for...
2016/0280683 SOLID FORMS OF AN ASK1 INHIBITOR
Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-y- l)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were...
2016/0280682 N-PYRROLIDINYL,N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS
Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R.sup.1, R.sup.2, R.sup.a,...
2016/0280681 N-BICYCLIC ARYL,N'-PYRAZOLYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS
Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as...
2016/0280680 PYRROLIDINE GPR40 MODULATORS
The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as...
2016/0280679 RESIST COMPOSITION, METHOD OF FORMING RESIST PATTERN, ACID GENERATOR, PHOTOREACTIVE QUENCHER, AND COMPOUND
A resist composition which generates acid upon exposure and exhibits changed solubility in a developing solution under action of acid, and which includes a...
2016/0280678 LITHIUM SELECTIVE CROWN ETHER,LITHIUM ADSORBENT USING SAME, AND PREPARATION METHOD THEREOF.
Disclosed herein are a novel crown ether with bulky and rigid groups and a method for preparing the same. Also provided are a lithium adsorbent comprising the...
2016/0280677 A PROCESS FOR THE SYNTHESIS OF OLOPATADINE
The present invention provides a process for the synthesis of olopatadine. Further, the invention discloses a process that results in improved yield of the...
2016/0280676 SULFATED AND UNSULFATED FLAVONOID OLIGOMERS AS CANCER THERAPEUTICS
Sulfated and unsulfated flavonoid oligomers as inhibitors of cancer stem cells (CSCs) are provided. In particular, sulfated flavonoid dimers are shown to...
2016/0280675 ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE...
The actinic ray-sensitive or radiation-sensitive resin composition includes a crosslinking agent having a polarity converting group and an alkali-soluble...
2016/0280674 ALKYLENE OXIDE SYNTHESIS
Direct epoxidation of propene is carried out on electrochemically tuned mixed oxide catalyst surfaces in a single chamber reactor with mixed reaction gas of...
2016/0280673 METHOD FOR PREVENTION OF PREMATURE POLYMERIZATION
The present invention relates to a method for prevention of premature polymerization during the preparation, purification, transportation and storage of a...
2016/0280672 POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, OPTICALLY ANISOTROPIC BODY, AND METHOD FOR...
A polymerizable compound has a practical low melting point, excellent solubility in a general-purpose solvent, and can produce an optical film at low cost,...
2016/0280671 COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION AND/OR FIBROSIS
The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.
2016/0280670 NOVEL COMPOUNDS FOR REGENERATION OF TERMINALLY-DIFFERENTIATED CELLS AND TISSUES
The present invention discloses novel compounds and their use in medicine. Preferably the compounds are applicable in the therapy of disorders associated with...
2016/0280669 COMPOUNDS AND METHODS
A compound of formula (I) is useful as an antiviral agent, in particular for the treatment of influenza. A method for preparing the compound of formula (I) and...
2016/0280668 NOVEL COMPOUNDS FOR COMBATING ARTHROPODS
The invention relates inter alia to novel compounds of the general formula (I) ##STR00001## in which the A.sub.1-A.sub.4, T, W, Q, R.sup.1 and B.sub.1-B.sub.4 ...
2016/0280667 P2X4 RECEPTOR ANTAGONIST
The present invention relates to a diazepine derivative represented by the following general formula (I) (in the formula, R.sup.1 and R.sup.2 represent...
2016/0280666 FLUORESCENT PYRAZINE DERIVATIVES AND METHODS OF USING THE SAME IN ASSESSING RENAL FUNCTION
The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X.sup.1 to X.sup.4 of Formulas I and II may be...
2016/0280665 FLUORESCENT PYRAZINE DERIVATIVES AND METHODS OF USING THE SAME IN ASSESSING RENAL FUNCTION
The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X.sup.1 to X.sup.4 of Formulas I and II may be...
2016/0280664 Cyclopropanecarboxamido-Substituted Aromatic Compounds as Anti-tumor Agents
The present disclosure relates to novel cyclopropanecarboxamido-substituted aromatic compounds that inhibit protein kinases and their use in anti-tumor area....
2016/0280663 5-FLUORO-4-IMINO-3-(ALKYL/SUBSTITUTED ALKYL)-1-(ARYLSULFONYL)-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE AND PROCESSES FOR ...
Provided herein are 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)3,4-dihydropyrimidin-2(1H)-one and processes for their preparation which may...
2016/0280662 5-FLUORO-4-IMINO-3-(ALKYL/SUBSTITUTED ALKYL)-1-(ARYLSULFONYL)-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE AND PROCESSES FOR ...
Provided herein are 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1H)-one and processes for their preparation which may...
2016/0280661 LXR MODULATORS
Compounds, pharmaceutically acceptable salts, isomers, or prodrugs thereof, of the invention are disclosed, which are useful as modulators of the activity of...
2016/0280660 1-ARYL-3-ALKYLPYRAZOLE INSECTICIDES
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein Q is ##STR00002## and Z,...
2016/0280659 DIHYDROPYRAZOLE GPR40 MODULATORS
The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as...
2016/0280658 PROCESSES FOR THE PREPARATION OF LORCASERIN
The present invention relates to stable crystalline Form A of lorcaserin hydrochloride of Formula (IA) and processes for its preparation. The invention also...
2016/0280657 COMPOUNDS AND METHODS FOR TREATING CANCER, NEUROLOGICAL DISORDERS, ETHANOL WITHDRAWAL, ANXIETY, DEPRESSION, AND...
Provided herein, inter alia, are compounds and methods of treating diseases including cancer, neurological disease, alcohol withdrawal, depression and anxiety,...
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