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6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically...
PIPERAZINE DERIVATIVES AS FASN INHIBITORS
Compounds of the formula I ##STR00001## in which R, X.sup.1, X.sup.2, X.sup.3, X.sup.4, R.sup.1, R.sup.2 and q have the meanings indicated in Claim 1, are...
Solid Forms of Ivacaftor and Processes for the Preparation Thereof
Provided herein is a polymorphic form of Ivacaftor, namely APO-I, as well as processes for the preparation and pharmaceutical compositions of the same. Also,...
QUINOLINES DERIVATIVES AS NOVEL ANTICANCER AGENTS
The invention provides quinoline derivatives, their manufacture, pharmaceutical compositions containing them, and their use as medicaments. The active...
ARYLQUINOLINE AND ANALOG COMPOUNDS AND USE THEREOF TO TREAT CANCER
The subject technology relates to arylquinoline compounds and their use for treating cancer or cancer metastasis. The compounds of the subject technology...
COMPOUNDS THAT INDUCE ABA RESPONSES
The present invention provides agonist compounds that active ABA receptors, and agricultural formulations comprising the agonist compounds. The agricultural...
NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE
THEREOF IN MEDICINE AS WELL AS IN...
Benzenesulfonamide compounds having a structure of formula (I) are described. Also described, are methods for synthesizing the compounds and to the use thereof...
ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12,
IL-23 AND/OR IFNalpha RESPONSES
Compounds having the following formula (I): or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and...
CATALYTIC HYDROGENATION OF NITRILES
The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular ...
NMDA ANTAGONIST PRODRUGS
Prodrugs of an NMDA antagonist, (S)-1-phenyl-2-(pyridin-2-yl)ethanamine, useful for the treatment of depression (particularly major depressive disorder) or...
NOVEL METHOD FOR SYNTHESIZING KEY INTERMEDIATE OF APIXABAN
The invention relates to a method for synthesizing an intermediate of Apixaban comprising reacting a compound of formula I with 5-chloro-valeryl chloride in...
NOVEL 3-AZABICYCLO[3.1.0]HEXANE DERIVATIVE AND USE THEREOF FOR MEDICAL
The object of the present invention is to provide a compound having an antagonistic action against .mu.-opioid receptors, which causes less side effects and...
ARYL- AND HETEROARYL-PYRROLIDINE-2-CARBOXAMIDE COMPOUNDS
The application relates to novel compounds and their use in treating and preventing diseases and conditions mediated by modulation of voltage-gated sodium...
DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE...
Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and...
ENZYMATIC PROCESS FOR THE PREPARATION OF
(S)-5-(4-FLUORO-PHENYL)-5-HYDROXY- 1MORPHOLIN-4-YL-PENTAN-1-ONE, AN
The present invention provides an enzymatic process for the preparation of (S)-5-(4-Fluoro-phenyl)-5-hydroxy-Imorpholin-4-yl-pentan-1-one by the reduction of...
Method for refining 2-nito-4-methylsulfonyl benzoic acid and intermediate
A method for refining a 2-nitro-4-methylsulfonyl benzoic acid and an intermediate thereof are provided, wherein the method includes steps of: using a crude...
THROMBOXANE RECEPTOR ANTAGONISTS
The invention generally relates to compounds that function as TP antagonists for treating thrombosis and other cardiovascular, renal, or pulmonary diseases. In...
Antibacterial compounds of formula (I) are provided: ##STR00001## as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical...
FILTERING MATERIAL, FILTER, METHOD OF FILTRATION, METHOD OF PRODUCING
PHENYLIMINE COMPOUND, METHOD OF PRODUCING...
A filtering material including a polymerization product of a compound represented by formula (1-0) or a derivative thereof; and a method of producing a...
SUPERELASTIC MATERIAL AND ENERGY STORAGE MATERIAL, ENERGY ABSORPTION
MATERIAL, ELASTIC MATERIAL, ACTUATOR, AND...
A superelastic material is provided, which can exhibit superelasticity even with a reduced amount of energy compared with the conventional superelastic...
Crystalline Solid and Amorphous Forms of (-)-Halofenate and Methods
The present invention provides crystalline solid and amorphous forms of (-)-halofenate. The crystalline solid forms may be used in various pharmaceutical...
IMPROVED PROCESS FOR PREPARING CHLORINATED BIPHENYLANILIDES AND
The present invention relates to a process for preparing substituted biphenylanilides of the formula (I) ##STR00001##
Biological Buffers with Wide Buffering Ranges
Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be...
The present invention relates to fungicidal N-cycloalkyl-N-[(cycloalkenylphenyl)methylene]carboxamide derivatives and their thiocarbonyl derivatives, their...
GAMMA AMINO ACID BUILDING BLOCKS
The invention provides compounds and methods, for example, to carry out organocatalytic Michael additions of aldehydes to cyclically constrained nitroethylene...
ESTER COMPOUNDS INCLUDING TRIESTERS HAVING TERMINAL VICINAL ACYL GROUPS
Provided herein are certain esters, including those of the Formula I: ##STR00001## wherein z is an integer selected from 0 to 15; R.sub.1, independently for each...
(3R) EPIMER OF OCTAHYDRO-7,7-DIMETHYL-8-METHYLENE 1H-3A,
6-METHANOAZULEN-3-YL ACETATE, COMPOSITION, SYNTHESIS...
The first subject matter of the invention is the (3R) epimer of octahydro-7,7-dimethyl-8-methylene-1H-3a, 6-methanoazulen-3-yl acetate ...
HYDROGENATION METHOD OF PHTHALATE COMPOUND
There are provided a method for hydrogenation of a phthalate compound. According to the method for hydrogenation of the present invention, a hydrogenation...
PROCESS FOR PRODUCING METHYL METHACRYLATE
The present invention relates to a catalytic continuous process for producing methyl methacrylate, said process comprising the step of reacting methacrolein...
METHOD OF PRODUCING INGENOL-3-ANGELATE
The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). ##STR00001## Furthermore, the invention relates to intermediates...
ANTIDIABETIC BICYCLIC COMPOUNDS
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may...
Method for Producing Isomeric Hexanoic Acids From the Subsidiary Flows
Arising During the Production of Pentanals
A process for preparing isomeric hexanoic acids comprising 2-methylpentanoic acid from the secondary streams obtained in the preparation of pentanals,...
TERTIARY ALKYLAMINES AS METHACROLEIN SYNTHESIS CO-CATALYST
The present invention relates to a process for producing methacrolein from propionaldehyde and formalin. This novel process is notable in that the catalyst...
ASYMMETRIC CATALYTIC DECARBOXYLATIVE ALKYL ALKYLATION USING LOW CATALYST
CONCENTRATIONS AND A ROBUST PRECATALYST
This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers....
NOVEL METHOD FOR THE SYNTHESIS OF KHUSIMONE
A novel method for synthesis of khusimone, by bringing zizanal into contact with an oxidizing reagent in the presence of a base and an organic solvent.
ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, ACTINIC
RAY-SENSITIVE OR RADIATION-SENSITIVE...
The composition contains an alkali-soluble resin and a crosslinking agent that is represented by the following General Formula (I). In the formula, each of...
NOVEL ORGANOLEPTIC COMPOUNDS
The present invention relates to novel aldehyde compounds and their use as fragrance materials.
PROCESS FOR THE PREPARATION OF 4-BROMO-1-CHLORO-2-(4-ETHOXYBENZYL)BENZENE
The present invention provides a process for the preparation of 4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene of Formula III, which can be used as an intermediate...
METHOD FOR CARBON DIOXIDE HYDROGENATION OF SYNGAS AND THE INTEGRATION OF
THE PROCESS WITH SYNGAS CONVERSION...
Techniques for synthesizing methanol are provided. In an exemplary embodiment, the processes include obtaining a syngas mixture from an integrated carbon...
A method of preparing a cyclopropane ring-bearing compound of the formula I ##STR00001## in which R.sup.1 and R.sup.2 are independently selected from ...
Production of Biphenyl Compounds
In a process for producing biphenyl compounds, a C.sub.n aromatic hydrocarbon may be hydroalkylated to give C.sub.2n cycloalkylaromatic compounds and byproduct...
IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS
A process of converting a carbon-carbon multiple bond to a cyclopropane ring, comprising the addition of a N-alkyl-N-nitroso compound to a mixture of alkene...
BISMUTH-BASED ENERGETIC MATERIALS
Energetic compounds based on bismuth salts with reduced toxicity that are obtained through the reaction of soluble bismuth salts with soluble salts of organic...
FIELD APPLICATION OF SUGARS TO INCREASE CROP YIELD
Enhancement of crop yields through the application of sugars, for example, monosaccharides, and/or disaccharides and/or polysaccharides, to soil. Application...
MULTIPHASE COMPOSITIONS FOR OXIDATION PROTECTION OF COMPOSITE ARTICLES
The present disclosure includes carbon-carbon composite articles having multiphase glass oxidation protection coatings for limiting thermal and/or catalytic...
ANTICORROSION AGENT FOR REINFORCED CONCRETE AND CORROSION PREVENTING
An anticorrosion agent comprising (A) an organosilicon compound of formula (1) and (B) an amine compound of formula (2) and/or an amine compound of formula (3)...
COMPOSITIONS AND METHODS FOR DELIVERY OF CARBON DIOXIDE
Compositions and methods are provided for a system in which liquid carbon dioxide, or a mixture of liquid and gaseous carbon dioxide, is converted to solid...
A method may include positioning a first ceramic or ceramic matrix composite (CMC)part and a second ceramic or CMC part adjacent to each other to define a...
SYSTEM, METHOD AND APPARATUS FOR PLASMA ARC WELDING CERAMICS AND SAPPHIRE
Two ceramic or sapphire pieces are welded together using a plasma torch that includes a cylindrical vessel having first and second ends, a tangential inlet...
METHODS OF MANUFACTURING POLYMER DERIVED CERAMIC PARTICLES.
Methods for forming small volumetric shapes of polymer derived ceramic materials, including liquid-liquid forming methods, tower forming methods, and methods...