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Patent # Description
2016/0279256 MULTI-ARM BIODEGRADABLE POLYMERS FOR NUCLEIC ACID DELIVERY
In some embodiments, the present disclosure pertains to compositions for nucleic acid delivery into cells. In some embodiments, the composition comprises: (1)...
2016/0279255 THERAPEUTIC COMPOSITIONS INCLUDING MODULATORS OF deltaPKC AND/OR epsilonPKC, AND USES THEREOF
Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of peptide modulators of...
2016/0279254 METHODS AND MATERIALS FOR TREATMENT OF POMPE'S DISEASE
This document relates to molecular complexes having acid alpha glucosidase activity and at least one modification that results in enhanced ability of the...
2016/0279253 N-TERMINAL MODIFIED PEG-TRAIL
Disclosed herein are an N-terminal modified PEG-TRAIL conjugates and methods of making and using thereof. The PEG-TAIL conjugates have bioactivity that is...
2016/0279252 COMPOSITIONS FOR INDUCING IMMUNE TOLERANCE TO COAGULATION FACTOR PROTEINS
Provided herein are conjugates for inducing tolerance of a coagulation factor protein, wherein the conjugate comprises a coagulation factor protein or an...
2016/0279251 RANDOM COPOLYMER THERAPEUTIC AGENT CARRIERS AND ASSEMBLIES THEREOF
Provided herein are particles assemblies including a shell surrounding a core. The shell includes a particle-stabilizing random copolymer. The core includes a...
2016/0279250 METHODS FOR STRUCTURAL DETERMINATION OF SELENIUM DERIVATIZED NUCLEIC ACID COMPLEXES
Methods for crystallizing a molecule of interest, such as a polypeptide, in complex with nucleic acid, including contacting the molecule of interest with...
2016/0279249 AMINOFUCOIDAN AS A VECTOR FOR FIBRINOLYSIS IN THROMBOTIC DISEASES
The invention relates to a vector targeting thrombus, having t-PA binding property consisting of a thrombus targeting fucoidan moiety, which is covalently...
2016/0279248 EXTRACELLULAR TARGETED DRUG CONJUGATES
The present invention relates to, inter alia, extracellular drug conjugates (EDC) in which an antibody or other targeting agent (e.g. a targeting moiety) is...
2016/0279247 CYCLIC PEPTIDE
A cyclic peptide (10) includes two domains (D1,D2), each including three charged sub-domains (14, 16). The first domain (D1) includes two anionic sub-domains...
2016/0279246 METHODS AND SYSTEMS FOR CONTINUOUS HETEROGENEOUS CRYSTALLIZATION
Methods of heterogeneous crystallization and related systems are provided. In some embodiments, a method comprises crystallizing an agent in a suspension...
2016/0279245 TOPICAL FORMULATIONS, SYSTEMS, AND METHODS
The present disclosure is drawn to topical formulations, transdermal systems, and related methods. In one embodiment, a topical formulation is provided that...
2016/0279244 GENE ELECTROTRANSFER INTO SKIN CELLS
The present invention relates to methods for transferring a nucleic acid in vivo into skin cells wherein the nucleic acid is injected by intradermal (ID)...
2016/0279243 Compositions and Methods for Treating and Preventing Staphylococcus Aureus Infections
Antibodies having Fab regions that specifically bind to Staphylococcus aureus protein A are capable of mediating opsinization of Staphylococcus aureus bacteria...
2016/0279242 STABLE FORMULATIONS OF POLYPEPTIDES AND USES THEREOF
Formulations are provided that contain single variable domains with a good solubility and good stability under different storage, transportation and stress...
2016/0279241 ANTI-ANGIOGENESIS THERAPY FOR THE TREATMENT OF OVARIAN CANCER
This invention concerns in general treatment of diseases and pathological conditions with anti-VEGF antibodies. More specifically, the invention concerns the...
2016/0279240 DETECTION OF ARGININE METHYLATION OF EGFR FOR PREDICTION OF RESISTANCE TO THERAPY
This invention provides biomarkers (e.g., methylation of R198 or R200 of EGFR or the presence of an arginine at position 497 of EGFR) for the prediction of...
2016/0279239 SUBCUTANEOUS ADMINISTRATION OF ANTI-CD74 ANTIBODY FOR SYSTEMIC LUPUS ERYTHEMATOSUS AND AUTOIMMUNE DISEASE
Disclosed are methods, compositions and uses of concentrated formulations of anti-CD74 antibody, of use for treating autoimmune diseases. In a specific...
2016/0279238 MONITORING IMMUNOTHERAPY OF LEWY BODY DISEASE FROM CONSTIPATION SYMPTOMS
The invention provides methods of monitoring immunotherapy directed against alpha-synuclein by comparing a subject's constipation symptoms before treatment and...
2016/0279237 ADJUVANT COMPOSITIONS AND RELATED METHODS
The present disclosure provides for an adjuvant composition that is suited for injectable as well as transdermal administration. The adjuvant composition...
2016/0279236 USE OF RAPAMYCIN AS VACCINE ADJUVANT AND PREPARATION METHOD THEREFOR
Disclosed are an immuno-enhancer composition, a use of same as a vaccine adjuvant, and a preparation method therefor. The composition comprises rapamycin and a...
2016/0279235 Heterodimers of Glutamic Acid
Compounds of Formula (Ia) ##STR00001## wherein R is a C.sub.6-C.sub.12 substituted or unsubstituted aryl, a C.sub.6-C.sub.12 substituted or unsubstituted...
2016/0279234 TOLEROGENIC SYNTHETIC NANOCARRIERS FOR ALLERGY THERAPY
Disclosed are synthetic nanocarrier compositions, and related methods, comprising immunosuppressants and MHC Class II-restricted epitopes of an allergen that...
2016/0279233 EPITOPES RELATED TO COELIAC DISEASE
The invention herein disclosed is related to epitopes useful in methods of diagnosing, treating, and preventing coeliac disease. Therapeutic compositions which...
2016/0279232 Gene-Deleted Variant Strain Of Porcine Pseudorabies Virus, Vaccine Composition, Method Of Making The Same And...
The present invention provides an attenuated strain of porcine pseudorabies virus (PRV), in which said attenuated strain of PRV is a variant strain of PRV with...
2016/0279231 A Method of Attenuating Porcine Pseudorabies Virus, Attenuated Strains of Porcine Pseudorabies Virus, Vaccine...
This invention provides a method of attenuating porcine pseudorabies virus, which can effectively and reproducibly attenuate porcine pseudorabies virus. The...
2016/0279230 SOLUBLE HIV-1 ENVELOPE GLYCOPROTEIN TRIMERS
The present application relates to novel HIV-1 envelope glycoproteins which may be utilized as an HIV-1 vaccine immunogens, antigens for crystallization and...
2016/0279229 Viral Vaccine Vectors
The present invention relates to a hybrid-viral vector system, in particular, but not exclusively, to a hybrid-viral vector system that can be used as a...
2016/0279228 NOVEL PNEUMOVIRUS COMPOSITIONS AND METHODS FOR USING THE SAME
Provided are newly identified pneumoviruses that can infect mammals, including dogs cats and potentially humans. Isolated polynucleotides and proteins of the...
2016/0279227 ATTENUATED NEGATIVE STRAND VIRUSES WITH ALTERED INTERFERON ANTAGONIST ACTIVITY FOR USE AS VACCINES AND...
The present invention relates, in general, to attenuated negative-strand RNA viruses having an impaired ability to antagonize the cellular interferon (IFN)...
2016/0279226 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H5N1 AND H1N1 INFLUENZA VIRUSES
Described herein is the generation of optimized H5N1 and H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to influenza virus...
2016/0279225 METHOD OF TREATMENT
The application discloses method of immunising against Neisseria meningitidis infection comprising the steps of a) immunising a human patient at a first age of...
2016/0279224 PROTEIN AND PEPTIDE-FREE SYNTHETIC VACCINES AGAINST STREPTOCOCCUS PNEUMONIAE TYPE 3
The present invention provides a protein- and peptide-free conjugate comprising a synthetic carbohydrate and a carrier molecule, wherein the synthetic...
2016/0279223 EHRLICHIA EWINGII PROTEINS, NUCLEIC ACIDS, AND METHODS OF THEIR USE
The novel omp-1 gene cluster encoding twenty one Ehrlichia ewingii (EE) proteins was isolated and sequenced completely. This invention relates to isolated E....
2016/0279222 OUTER MEMBRANE VESICLES AND USES THEREOF
The disclosure relates to outer membrane vesicles from Francisella and Piscirickettsia, and their use in vaccine compositions. In particular, the present...
2016/0279221 AMA-1 Epitopes, Antibodies, Compositions, and Methods of Making and Using the Same
Disclosed are AMA-1 immunogenic peptides and epitopes, nucleotide sequences encoding the peptides and epitopes, compositions, and vaccines including the...
2016/0279220 Scaffolds For Cell Transplantation
A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold...
2016/0279219 Scaffolds For Cell Transplantation
A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold...
2016/0279218 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2016/0279217 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2016/0279216 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2016/0279215 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2016/0279214 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2016/0279213 Survivin-Directed Cancer Vaccine Therapy
The invention relates to a therapeutically effective truncated survivin and its therapeutic use as vaccine in a liposomal preparation, wherein the survivin...
2016/0279212 ANNEXIN II VARIANT COMPOSITIONS AND METHODS
This disclosure describes polypeptides fragments of annexin II, variants thereof, compositions that includes such fragments and/or variants, and methods of...
2016/0279211 LUTZOMYIA LONGIPALPIS POLYPEPTIDES AND METHODS OF USE
Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including...
2016/0279210 COMPOSITIONS AND METHODS FOR PROMOTING NEURONAL OUTGROWTH
Neural outgrowth in the central nervous system is achieved by administering chondroitinase AC and/or chondroitinase B to degrade chondroitin sulfate...
2016/0279209 COMPOSITIONS AND METHODS FOR ADMINISTRATION OF AN ENZYME TO A SUBJECT'S AIRWAY
Methods and composition for delivery of enzymes to a subject's airway. In some aspects, nebulized composition of enzymes, such as plasminogen activators are...
2016/0279208 MODIFIED NON-CYTOTOXIC PROTEASES
The present invention relates to a modified polypeptide comprising a non-cytotoxic protease, a translocation domain, a destructive protease cleavage site and a...
2016/0279207 TARGETING GDF6 AND BMP SIGNALING FOR ANTI-MELANOMA THERAPY
The invention features methods of treating melanoma by modulating an activity of GDF6 in melanoma cells. In one aspect, the methods involve downregulating an...
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