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Patent # Description
2016/0289689 METHOD FOR TRANSFORMATION OF STRAMENOPILE
To provide a transformation method for producing a stramenopile organism having an improved unsaturated fatty acid production capability by disrupting a gene...
2016/0289688 COMPOSITIONS AND METHODS FOR USE IN TREATING SILICOSIS AND LUNG CANCER
A method for treating an inflammatory disease is provided. The method comprises administering an effective amount of a BLT1 inhibitor to a subject in need...
2016/0289687 SMALL INTERFERENCE RNAS, USES THEREOF AND METHOD FOR INHIBITING THE EXPRESSION OF PLK1 GENE
The present invention provides siRNAs for inhibiting the expression of plk1 gene, and the method for inhibiting the expression of plk1 gene in mammalian cells....
2016/0289686 METHODS FOR IDENTIFYING THERAPEUTIC TARGETS AND TREATING MONITORING CANCERS
The present invention provides methods for treating cancers having a mutation in one or more tumor suppressor genes, comprising providing to a subject in need...
2016/0289685 PARP9 AND PARP14 AS KEY REGULATORS OF MACROPHAGE ACTIVATION
The invention relates to compositions and methods for inhibiting macrophage activation via modulating PARP9 and/or PARP14 expression or activity, such as small...
2016/0289684 USE OF IKK EPSILON INHIBITORS TO ACTIVATE NFAT AND T CELL RESPONSE
Disclosed herein are compositions and methods of activating nuclear factor of activated T cells (NFAT) and T cell response by inhibiting IKK.epsilon..
2016/0289683 Mutator Activity Induced by microRNA-155 (miR-155) Links Inflammation and Cancer
Methods of reducing spontaneous mutation rate of a cell in a subject in need thereof by reducing endogenous levels of miR-155 are described.
2016/0289682 PRODUCTION AND UTILIZATION OF A NOVEL ANTI-CANCER DRUG IN THERAPY
This invention generally relates to a design and method for developing novel anti-tumor and/or anti-cancer drugs, vaccines and therapies, using microRNA and/or...
2016/0289681 RNA-BASED HIV INHIBITORS
Provided herein are, inter alia, antiviral recombinant nucleic acid compositions and methods of using the same. The recombinant nucleic acid compositions...
2016/0289680 METHOD FOR PREPARING NUCLEIC ACID APTAMER
An object of the present invention is to develop and provide a method for efficiently and conveniently producing a nucleic acid aptamer, particularly, a DNA...
2016/0289679 NUCLEIC ACID LIGANDS TO LL37
The present invention is directed to nucleic acid ligands to LL37, methods for producing said nucleic acid ligands, and methods for utilizing said nucleic acid...
2016/0289678 USE OF MICRORNA 146-A IN THE DIAGNOSIS, TREATMENT AND PREVENTION OF PICORNAVIRUS INFECTION AND MICRORNA 146-A...
The present invention found that host miRNAs might be involved in Picornavirus pathogenesis through suppression of type I IFNs induction and could act as...
2016/0289677 APOB Antisense Conjugate Compounds
The present invention relates to conjugates of antisense oligonucleotides (oligomers) that target the APOB gene at position 2265 to 2277.
2016/0289676 COMPOSITIONS AND METHODS FOR INHIBITING NF- kB AND SOD-1 TO TREAT AMYOTROPHIC LATERAL SCLEROSIS
The invention relates to pharmaceutical compositions, kits, methods, and uses for the treatment of amyotrophic lateral sclerosis. In particular, the invention...
2016/0289675 Guide RNA with chemical modifications
The present invention relates to modified guide RNAs and their use in clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated...
2016/0289674 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF MEMBRANE PROTEINS
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA...
2016/0289673 OPTIMIZED SMALL GUIDE RNAS AND METHODS OF USE
Methods, compositions, and kits are provided herein for CRISPER/Cas-mediated nucleic acid detection or modification.
2016/0289672 High Throughput Screening of Enzyme Libraries
Provided herein, among other things, is method comprising: a) placing a planar absorbent support comprising an in vitro transcription and translation (IVTT)...
2016/0289671 METHOD OF MANUFACTURING PROTEIN ARRAY OR PEPTIDE ARRAY, METHOD OF IDENTIFYING FUNCTIONAL PROTEIN OR FUNCTIONAL...
There is provided a method of manufacturing a protein array or peptide array suitable for an efficient screening of a functional protein or functional peptide....
2016/0289670 COMPOSITIONS AND METHODS FOR MOLECULAR LABELING
The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each...
2016/0289669 DEVICES AND SYSTEMS FOR MOLECULAR BARCODING OF NUCLEIC ACID TARGETS IN SINGLE CELLS
Disclosed herein are devices and systems comprising a) a substrate comprising at least 100 microwells and a plurality of beads, wherein a plurality of the at...
2016/0289668 Production Method for Charged Non-Protein Amino Acid-Containing Peptide
An object of the present invention is to provide a method of producing a peptide containing a charged non-proteinogenic amino acid in a cell-free translation...
2016/0289667 ACCELERATED DIRECTED EVOLUTION OF MICROBIAL CONSORTIA FOR THE DEVELOPMENT OF DESIRABLE PLANT PHENOTYPIC TRAITS
The disclosure relates to methods for the screening, identification, and/or application of one or more microorganisms of use in imparting one or more...
2016/0289666 METHODS AND KITS FOR CAPTURING SPERM NUCLEIC ACIDS
The invention generally relates to methods and kits for capturing sperm nucleic acids from or in a biological sample. In one embodiment the method the method...
2016/0289665 NUCLEIC ACID EXTRACTION APPARATUS
The present invention provides a nucleic acid extraction instrument including a base, an outer housing connected with the base, and an instrumental main body...
2016/0289664 ACTIVATED PLATELET COMPOSITION WITH TUNABLE GROWTH FACTOR LEVEL
Methods and systems for generating a tunable or customizable activated product composition are related. In certain embodiments, one or more of electric pulse...
2016/0289663 NOVEL CHIMERIC GENE ATF7IP-PDGFRB OF ACUTE LYMPHOBLASTIC LEUKEMIA
To identify a mutation that can serve as an indicator for predicting the effectiveness of drug treatment in cancers such as leukemia; to provide a means for...
2016/0289662 COMPOSITION FOR DISPERSING BIOLOGICAL TISSUE
The purpose of the present invention is to acquire a highly proliferative cell at a high efficiency from a sample derived from a biological tissue. Provided is...
2016/0289661 ENDOGLUCANASE VARIANTS HAVING IMPROVED ACTIVITY, AND USES OF SAME
The present invention relates to the expression and optimisation of enzymes involved in the breakdown of lignocellulosic biomass. The present invention relates...
2016/0289660 High Fidelity Restriction Endonucleases
Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a...
2016/0289659 METHODS AND COMPOSITIONS FOR MODIFYING A SINGLE STRANDED TARGET NUCLEIC ACID
The present disclosure provides compositions and methods for binding and/or cleaving a single stranded target nucleic acid. Subject compositions include a Cas9...
2016/0289658 Polypeptides Having Phospholipase A Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having phospholipase A activity and polynucleotides encoding the polypeptides. The invention also...
2016/0289657 ACETYLCHOLINESTERASE-Fc DOMAIN FUSION PROTEIN
Fusion polypeptides are provided including modified human Acetylcholinesterase conjugated to the Fc region of an immunoglobulin. Methods of preparing these...
2016/0289656 METHODS OF PRODUCING CARBOXYLIC ACIDS
The invention relates to methods for enriching monomer content in a cycloalkane oxidation process mixed organic waste stream. In particular, the methods...
2016/0289655 Thermostable Phytase Variants
The present invention relates to a phytase which has at least 70% identity to a phytase derived from E. coli and comprises at least one modification as...
2016/0289654 Organophosphorous Hydrolase Variants
The present invention relates to organophosphorous hydrolase variants. The present invention also relates to polynucleotides encoding the variants; nucleic...
2016/0289653 Stable Enzymes by Glycation Reduction
The present teachings provide enzymes with improved stability arising from reduced glycation. Glycation reduction can be achieved by a variety of means,...
2016/0289652 STABILIZED REVERSE TRANSCRIPTASE FUSTION PROTEINS
Stabilized reverse transcriptase fusion proteins including a thermostable reverse transcriptase connected to a stabilizer protein are described. Attaching the...
2016/0289651 ULK1 COMPOSITIONS, INHIBITORS, SCREENING AND METHODS OF USE
This disclosure relates to methods and compositions useful for the treatment of cancer and diseases and disorders associated with autophagy.
2016/0289650 FLUORESCENT PROTEIN BIOSENSORS TO PROBE THE CONFORMATIONAL ACTIVATION OF CDK/CYCLIN KINASES
The present invention relates to compounds comprising a polypeptide comprising an amino acid sequence derived from the sequence of a cyclin-dependent kinase...
2016/0289649 BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS
The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host...
2016/0289648 NUCLEIC ACIDS ENCODING PLANT GLUTAMINE PHENYLPYRUVATE TRANSAMINASE (GPT) AND USES THEREOF
Glutamine phenylpyruvate transaminase (GPT) proteins, nucleic acid molecules encoding GPT proteins, and uses thereof are disclosed. Provided herein are various...
2016/0289647 PROKARYOTIC DESATURASES MODIFIED BY DIRECTED EVOLUTION TO REDUCE SATURATED AND INCREASE UNSATURATED FATTY ACIDS...
Transgenic eukaryotic (animal, plant and fungal) cells and organisms that contain decreased levels of saturated fatty acids are provided. The transgenic...
2016/0289646 MANIPULATING THE CIRCADIAN CLOCK TO INCREASE GENE EXPRESSION
A method of increasing gene expression by manipulating the circadian clock is described that includes transforming a photosynthetic organism to include an...
2016/0289645 Adenovirus Expressing Immune Cell Stimulatory Receptor Agonist(s)
Certain embodiments include the enhancement of effectiveness for an adenoviral cancer therapy.
2016/0289644 Immortalization of Epithelial Cells and Methods of Use
The present invention is directed towards methods of culturing non-keratinocyte epithelial cells, with the methods comprising culturing non-keratinocyte...
2016/0289643 Immortalization of Epithelial Cells and Methods of Use
The present invention is directed towards methods of culturing non-keratinocyte epithelial cells, with the methods comprising culturing non-keratinocyte...
2016/0289642 METHOD FOR GENERATING PANCREATIC HORMONE-PRODUCING CELLS
Provided is a method for inducing pancreatic hormone-producing cells from pancreatic progenitor cells efficiently. The method comprises a step of culturing the...
2016/0289641 METHOD FOR PROMOTING HAIR GROWTH USING COMPOSITION COMPRISING PDGF-D TREATED ADIPOSE-DERIVED STEM CELLS
Provided is a composition for promoting hair growth comprising platelet-derived growth factor-D (PDGF-D)-treated adipose-derived stem cells (ASCs) as an active...
2016/0289640 MTOR/STAT3 SIGNAL INHIBITOR-TREATED MESENCHYMAL STEM CELL HAVING IMMUNOMODULATORY ACTIVITY, AND CELL THERAPY...
The present invention relates to a mesenchymal stem cell having immunomodulatory activity and a preparation method therefor and, more specifically, to: a...
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