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Patent # Description
2016/0289339 ANTI-HUMAN mIgA ANTIBODIES CAPABLE OF LYSING mIgA-B LYMPHOCYTES AND DECREASING IgA PRODUCTION
Disclosed herein is an anti-migis-.alpha..alpha.antibody specific for the migis-.alpha. of human m.alpha. chain that can bind to mIgA on B lymphocytes, cause...
2016/0289338 ANTIBODIES ANTI MATRIPTASE FOR THE TREATMENT OF CANCER
The invention provides antibodies which bind to the extracellular domain of the Tyrosine-protein kinase transmembrane receptor Matriptase. Nucleic acid...
2016/0289337 NEW POLYPEPTIDES
The present disclosure relates to a class of engineered polypeptides having a binding affinity for carbonic anhydrase IX (CAIX), and provides a CAIX binding...
2016/0289336 CANCER BIOMARKERS AND USES THEREOF
The invention relates the use of Human Epidermal Growth Factor Receptor 2 (HER2) gene copy number and HER2 mRNA levels as biomarkers to identify cancers which...
2016/0289335 BISPECIFIC ANTIGEN-BINDING CONSTRUCTS TARGETING HER2
Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding...
2016/0289334 Compositions and Methods of Treating Tumors
Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are...
2016/0289333 Antibodies with Altered Binding to FcRn and Methods of Using Same
This invention relates to antibodies with altered binding to FcRn, and particularly antibodies having enhanced binding to FcRn and/or enhanced serum...
2016/0289332 NOVEL ANTI-CLAUDIN ANTIBODIES AND METHODS OF USE
Provided herein are novel anti-CLDN antibodies and antibody drug conjugates (ADC), including derivatives thereof, and methods of using the same to treat...
2016/0289331 IMMUNE REGULATING AGENT
The problems: It is an object of the present invention to provide an immune regulating agent capable of modulating a receptor function concerning immune...
2016/0289330 Compositions Comprising Rank/Rankl Antagonists and Related Compounds for Treating Pain
Disclosed herein are methods of treating pain using comprising RANK/RANKL antagonists.
2016/0289329 Antigen Binding Proteins that Bind CCR2
There is disclosed compositions and methods relating to or derived from anti-CCR2 antibodies. More specifically, there is disclosed fully human antibodies that...
2016/0289328 MONOVALENT ANTIGEN BINDING CONSTRUCTS TARGETING EGFR AND/OR HER2 AND USES THEREOF
Provided herein are monovalent antigen-binding constructs targeting EGFR and/or HER2. The monovalent antigen-binding constructs can include at least one...
2016/0289327 AMINO ACID SEQUENCES THAT MODULATE THE INTERACTION BETWEEN CELLS OF THE IMMUNE SYSTEM
The present invention relates to amino acid sequences that block the interaction between (a target on) an antigen presenting cell (APC) and (a target on) a...
2016/0289326 Therapeutic and Diagnostic Methods for Manipulating Phagocytosis Through Calreticulin and Low Density...
Therapeutic and diagnostic methods are provided, which methods relate to the expression of calreticulin on cancer cells and hematopoietic cells.
2016/0289325 SIGLEC-15 ANTIBODIES IN TREATING BONE LOSS-RELATED DISEASE
Novel antibodies and antigen binding fragments that specifically binds to Siglec-15 are described herein. In some embodiments, the antibodies or antigen...
2016/0289324 MATRIX METALLOPROTEASE-CLEAVABLE AND SERINE PROTEASE-CLEAVABLE SUBSTRATES AND METHODS OF USE THEREOF
The invention relates generally to polypeptides that include at least a first cleavable moiety (CM1) that is a substrate for at least one matrix ...
2016/0289323 ANTIBODY MOLECULES HAVING BINDING SPECIFICITY FOR HUMAN IL-13
The invention relates to antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and...
2016/0289322 HUMAN ANTI-IL-33 NEUTRALIZING MONOCLONAL ANTIBODY
An object of the present invention is to provide an antibody having antagonistic effect against IL-33, in particular an isolated human anti-IL-33 neutralizing...
2016/0289321 IL-17A BINDING AGENT AND USES THEREOF
Provided is an antibody capable of specially recognizing IL-17A and binding to IL-17A. The antibody can be used for treating inflammation and autoimmune...
2016/0289320 METHOD FOR MODULATING APPETITE
The present invention provides a method of modulating appetite and/or body weight in a subject, said method comprising administering to said subject an...
2016/0289319 ANTI-CCL2 ANTIBODIES FOR TREATMENT OF SCLERODERMA
The present invention provides, among other things, improved anti-CCL2 antibodies characterized with high affinity, potency, tissue selectivity and/or epitope...
2016/0289318 COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth...
2016/0289317 COMBINATION THERAPY FOR THE TREATMENT OF OVARIAN CANCER
This invention concerns methods of treating a patient diagnosed with a platinum-resistant ovarian cancer comprising administering to said patient an effective...
2016/0289316 PEPTIDES FOR TREATMENT AND DIAGNOSIS OF BONE DISEASES
The present invention is directed to isolated polypeptides and antibodies suitable for producing therapeutic preparations, methods, and kits relating to bone...
2016/0289315 Treatment of Cancer Using Inhibitors of TGF-BETA and PD-1
The present disclosure relates, in general, to combination therapy using an inhibitor of transforming growth factor beta (TGF.beta.) and an inhibitor of...
2016/0289314 CLONING, EXPRESSION & PURIFICATION METHOD FOR THE PREPARATION OF RANIBIZUMAB
A polynucleotide sequence and a method for Ranibizumab cloning, expression and production having better yield and biologically active protein.
2016/0289313 ANTIBODIES BINDING TO CANINE VASCULAR ENDOTHELIAL GROWTH FACTOR AND USES THEREOF IN TREATING CANINE...
Disclosed herein are antibodies capable of inhibiting canine vascular endothelial growth factor and uses thereof in treating a canine angiogenesis-related...
2016/0289312 METHODS FOR REDUCING ALLERGIES CAUSED BY ENVIRONMENTAL ALLERGENS
Compositions suitable for reducing symptoms of an allergic response to environmental allergens comprising molecules that specifically inhibit the ability of...
2016/0289311 COMPOSITIONS AND METHODS FOR TREATING CANCER BY RATIONAL TARGETING OF PROTEIN TRANSLATION
The present invention is drawn to therapeutics which can target hnRNP A18, a regulator of protein translation in cancer cells. The invention provides a method...
2016/0289310 Method of Providing Disease-Specific Binding Molecules and Targets
Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes...
2016/0289309 METHODS OF TREATING A TAUOPATHY
The present disclosure provides methods for treating a tauopathy (e.g., an acute tauopathy) in an individual by administering an anti-Tau antibody to the...
2016/0289308 ASSAYS FOR IGFBP7 HAVING IMPROVED PERFORMANCE IN BIOLOGICAL SAMPLES
The invention provides IGFBP7 immunoassays with improved clinical performance, particularly when used in the evaluation of renal injuries. The immunoassays...
2016/0289307 ANTI-S100A7 ANTIBODIES FOR THE TREATMENT AND DIAGNOSIS OF CANCER
The present invention relates to the use of antibodies against S100A7 protein for the prevention and/or treatment of cancer or a disease associated to an...
2016/0289306 Fab REGION-BINDING PEPTIDE
An object of the present invention is to provide a Fab region-binding peptide having an excellent ability for binding to a Fab region of IgG, an affinity...
2016/0289305 NOVEL HIV -1 BROADLY NEUTRALIZING ANTIBODIES
The present application relates novel HIV-1 broadly neutralizing antibodies. The antibodies of the present invention are further characterized by their ability...
2016/0289304 HYBRID INFLUENZA SEED VIRUSES, COMPOSITIONS THEREOF, AND USE THEREOF IN THE DIAGNOSIS OR THERAPY OF INFLUENZA
The invention provides antibody reagents for screening for seed viruses, in particular, antibodies that bind to one or more discontinuous epitopes in...
2016/0289303 METHODS AND COMPOSITIONS FOR THE TREATMENT OF HCMV
Provided herein are compositions and methods for the treatment of HCMV infection in a subject.
2016/0289302 HUMAN CYTOMEGALOVIRUS NEUTRALISING ANTIBODIES AND USE THEREOF
The invention relates to neutralizing antibodies and antibody fragments having high potency in neutralizing hCMV, wherein said antibodies and antibody...
2016/0289301 PROCESS OF CLONING AND FURTHER PURIFICATION TO MAKE A RECOMBINANT INTRAVENOUS IMMUNOGLOBULIN
The present subject matter is directed to a process of cloning and purifying recombinant intravenous immunoglobulin (IVIG), comprising cloning a target gene of...
2016/0289300 METHOD OF MANUFACTURING INTRAVENOUS IMMUNOGLOBULIN FROM FRACTION III
The present subject matter is directed to a method of manufacturing purified IVIG from Fraction III of plasma, comprising re-constituting a Fraction III paste...
2016/0289299 THERAPY FOR TREATMENT OR PREVENTION OF CONDITIONS ASSOCIATED WITH BLEEDING OR HYPOCOAGULATION
The present application generally relates to methods to prevent or treat bleeding and/or hypocoagulation in an individual in need thereof, and compositions for...
2016/0289298 SINGLE-ARM TYPE I AND TYPE II RECEPTOR FUSION PROTEINS AND USES THEREOF
In certain aspects, the disclosure provides soluble single-arm heteromeric polypeptide complexes comprising an extracellular domain of a type I...
2016/0289297 REVERSIBLE PLATELET INHIBITION
The present invention relates, in general, to receptors and to platelet aggregation and, in particular, to a method of inhibiting platelet aggregation using an...
2016/0289296 Novel peptides and combination of peptides and scaffolds for use in immunotherapy against Renal Cell Carcinoma...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2016/0289295 REDUCTION OF INFLAMMATORY DISEASE SYMPTOMS BY SHORT PEPTIDES THAT INHIBIT SIGNALING THROUGH CD28
The present disclosure relates to a method for the treatment of a non-pathogen associated inflammatory disorders in a subject in need thereof, comprising...
2016/0289294 CELL
The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising: (i)...
2016/0289293 CELL
The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising: (i)...
2016/0289292 ALK4:ACTRIIB HETEROMULTIMERS AND USES THEREOF
In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of an ALK4 receptor and an...
2016/0289291 INSULIN PRODUCTION METHODS AND PROINSULIN CONSTRUCTS
Novel proinsulins and glargine, aspart and Lis-Pro proinsulin analogs having specific amino acid and/or nucleic acid modifications suitable for improved...
2016/0289290 N-GLYCOSYLATED INSULIN ANALOGUES
Compositions and formulations comprising N-glycosylated insulin analogues are described. In particular embodiments, the glycosylated insulin analogues are...
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