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Patent # Description
2016/0289289 IDENTIFICATION OF A NEW POLYPEPTIDE HORMONE FOR MAINTENANCE OF OPTIMAL BODY WEIGHT AND BLOOD GLUCOSE
Embodiments of the disclosure concern methods and compositions that relate to increasing or decreasing the weight (including, for example, by increasing or...
2016/0289288 TYPE I INTERFERON MIMETICS AS THERAPEUTICS FOR CANCER, VIRAL INFECTIONS, AND OTHER DISEASES
The subject invention pertains to agonist peptides of type I interferons and methods of using the peptides. These peptides are based on the amino acid sequence...
2016/0289287 SMALL CATIONIC ANTI-BIOFILM AND IDR PEPTIDES
The present invention relates generally to peptides and more specifically to anti-biofilm and immunomodulatory peptides.
2016/0289286 METHODS FOR TREATING MYELODYSPLASTIC SYNDROMES AND SIDEROBLASTIC ANEMIAS
In certain aspects, the present disclosure provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including...
2016/0289285 RECOMBINANT PROTEINS THAT SIMULTANEOUSLY BIND HGF, VEGF-A AND SERUM ALBUMIN, COMPRISING ANKYRIN REPEAT DOMAINS
New designed ankyrin repeat domains with binding specificity for serum albumin, recombinant binding proteins comprising at least two designed ankyrin repeat...
2016/0289284 ARTIFICIAL DNA-BINDING PROTEINS AND USES THEREOF
The present invention relates to proteins consisting of an artificial DNA-binding domain (DBD) and related molecules and uses thereof. In particular, the...
2016/0289283 SELECTIVE PYY COMPOUNDS AND USES THEREOF
The invention relates to PYY compounds having the amino acid in the position corresponding to position 30 of hPYY(1-36) substituted with tryptophan and...
2016/0289282 Synthesis of Hydantoin Containing Peptide Products
The present invention relates to a method of synthesizing a peptide product comprising at least one hydantoin group. The peptide product may be used as a...
2016/0289281 PEPTIDE WITH MULTIPLE EPITOPES
The present invention relates to peptides comprising multiple MHC Class II-binding T cell epitopes for tolerisation therapy.
2016/0289280 Fusion protein of recombinant ganoderma immunoregulatory protein and human serum albumin, preparation method...
The present invention relates to a field of biological pharmacy, wherein a fusion protein rLZ-8 of a ganoderma immunoregulatory protein and HSA prepared with...
2016/0289279 Polypeptides Having Cellulolytic Enhancing Activity And Nucleic Acids Encoding Same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The...
2016/0289278 GENES OF AN OTITIS MEDIA ISOLATE OF NONTYPEABLE HEAMOPHILUS INFLUENZAE
The invention relates to the polynucleotide sequence of a nontypeable strain of Haemophilus influenza (NTHi) and polypeptides encoded by the polynucleotides...
2016/0289277 COMPOSITIONS AND METHODS FOR SUPPRESSION OF INHIBITOR FORMATION AGAINST COAGULATION FACTORS IN HEMOPHILIA PATIENTS
Protein replacement therapy for patients with hemophilia or other inherited protein deficiencies is often complicated by pathogenic antibody responses,...
2016/0289276 TRANSPORT AGENTS FOR CROSSING THE BLOOD-BRAIN BARRIER AND INTO BRAIN CANCER CELLS, AND METHODS OF USE THEREOF
The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery...
2016/0289275 Adeno-Associated Vectors for Enhanced Transduction and Reduced Immunogenicity
A modified adeno-associated virus (AAV) capsid protein comprising at least one non-native amino acid that confers to the modified AAV particles new properties,...
2016/0289274 TRIAZOLE MACROCYCLE SYSTEMS
The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming...
2016/0289273 PROCOAGULANT FUSION COMPOUND
The present invention provides a fusion compound comprising a procoagulant compound and an immunoglobulin constant region or a portion thereof and methods of...
2016/0289272 ANTIMICROBIAL AGENTS AND THEIR USE IN THERAPY
The present invention provides an agent, or a composition containing an agent, for use in treating or preventing a bacterial infection in a subject, wherein...
2016/0289271 Cyclosporins Modified on the MeBmt Sidechain by Heterocyclic Rings
The present invention relates to novel cyclosporin analogs, processes for preparing them, pharmaceutical compositions containing them, and methods for using...
2016/0289270 Methods, Peptides and Antibodies for Preventing, Treating and Diagnosing an Inflammatory Condition
Provided is an isolated peptide or a peptidomimetic comprising a sequence corresponding to amino acid positions 431-616 or 411-616 of the human protein TLR4 or...
2016/0289269 NOVEL CELL-PENETRATING COMPOSITIONS AND METHODS USING SAME
The invention includes an isolated transport peptide, which crosses the cell membrane of a cell and/or binds to a target cell. The invention also includes a...
2016/0289268 METHOD FOR PURIFYING ANTIBODIES
Disclosed here includes a method for purifying a biologic composition, comprising diafiltering the biologic composition into a composition comprising phosphate...
2016/0289267 NEW METHOD TO CONCENTRATE VON WILLEBRAND FACTOR OR COMPLEXES THEREOF
The present invention relates to a method for concentrating von Willebrand Factor (VWF) from an aqueous solution comprising precipitating the VWF by providing...
2016/0289266 Method for reducing colour of a biotechnological liquid
The invention relates to a method for reducing colour of a biotechnological liquid. In the method a biotechnological liquid comprising colour forming...
2016/0289265 METHOD FOR PROTEIN PURIFICATION UNDER DENATURING CONDITIONS
The invention relates to a method for the preparation of an application buffer for the purification of proteins by means of immobilized metal ion affinity...
2016/0289264 METHOD FOR PURIFYING RECOMBINANT PROTEIN
A method is provided for purifying a recombinant protein from a mixture comprising the recombinant protein and related proteins, comprising the steps of: A....
2016/0289263 Synthesis of Cyclic Imide Containing Peptide Products
The present invention relates to a method of synthesizing a peptide product comprising at least one cyclic imide group. Further, the invention relates to a...
2016/0289262 BILE ACID DERIVATIVES AS FXR/TGR5 AGONISTS AND METHODS OF USE THEREOF
The present invention provides compounds represented by Formula I, or pharmaceutically acceptable salts, stereoisomers, solvates, hydrates or combination...
2016/0289261 GLUCOCORTICOID INHIBITORS FOR TREATMENT OF PROSTATE CANCER
The present invention encompasses the recognition that reproducible and detectable changes in the level and or activity of Glucocorticoid Receptor (GR) are...
2016/0289260 METHODS OF SYNTHESIZING SUBSTITUTED PURINE COMPOUNDS
The present invention provides an efficient process for the synthesis of (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)- ...
2016/0289259 2'-Branched Nucleosides for Treatment of Viral Infections
The present invention provides a compound of formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is defined herein, which is a...
2016/0289258 FORMALDEHYDE FREE BINDER COMPOSITIONS WITH UREA-ALDEHYDE REACTION PRODUCTS
Fiber-containing composites are described that contain woven or non-woven fibers, and a cured binder formed from a binder composition that includes (1) a...
2016/0289257 GLYCOMIMETIC COMPOUNDS AND METHODS TO INHIBIT INFECTION BY HIV
Compounds, compositions and methods are provided for use to inhibit infection by human immunodeficiency virus (HIV). More specifically, the present invention...
2016/0289256 NOVEL METHOD FOR THE DEPOLYMERISATION OF LIGNIN
A method for the depolymerization of lignin includes the steps of: providing a black liquor obtained from the treatment of delignification of the biomass,...
2016/0289255 PROCESS FOR FRACTIONATING LIGNOCELLULOSICS
A method for the isolation of lignin from a lignocellulosic biomass, comprising providing a lignocellulosic biomass; extracting sugar free lignin from the...
2016/0289254 HYDROGEN OXIDATION CATALYST
The present invention is to provide a hydrogen oxidation catalyst that does not contain platinum. Disclosed is a hydrogen oxidation catalyst that is a...
2016/0289253 CREATINE PHOSPHATE ANALOG PRODRUGS, COMPOSITIONS AND METHODS OF USE THEREOF
The invention describes membrane permeable creatine phosphate analog prodrugs, pharmaceutical compositions comprising membrane permeable creatine phosphate...
2016/0289252 MITOCHONDRIA-TARGETED DICARBONYL SEQUESTERING COMPOUNDS
The invention relates to compounds having Formula (1): A-L-B or pharmaceutically acceptable salts thereof, wherein: A is a dicarbonyl sequestering moiety...
2016/0289251 OLIGOMERIC ORGANOSILANES, THE PRODUCTION THEREOF AND THE USE THEREOF IN RUBBER MIXTURES
The present invention relates to oligomeric organosilanes containing at least two different structural units within a molecule, selected from the structural...
2016/0289250 BIS(TRIMETHYLSILYL) SIX-MEMBERED RING SYSTEMS AND RELATED COMPOUNDS AS REDUCING AGENTS FOR FORMING LAYERS ON A...
A first compound having an atom in an oxidized state is reacted with a bis(trimethylsilyl) six-membered ring system or related compound to form a second...
2016/0289249 LAMINATED ARTICLES FOR MICROBIAL REMOVAL AND LOW PRESSURE DROP FILTRATION, METHODS OF MAKING, AND METHODS OF...
Laminated articles are provided including a porous fibrous nonwoven matrix and guanidine-functionalized metal silicate particles enmeshed within the porous...
2016/0289248 ARTICLES AND METHODS COMPRISING PERSISTENT CARBENES AND RELATED COMPOSITIONS
Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated...
2016/0289247 SILYLATED CYCLIC PHOSPHONAMIDES
The invention relates to silylated cyclic phosphonamides of the general formula (1) in which R.sup.1 represents an unsubstituted or fluoro-substituted alkyl...
2016/0289246 POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): ##STR00001## ...
2016/0289245 Crystalline Beta-Lactamase Inhibitor
A crystalline compound of formula (I): ##STR00001## The compound of formula (I) is a .beta.-lactamase inhibitor and may be administered in combination with an...
2016/0289244 ANTICANCER MAYTANSINOIDS WITH TWO FUSED MACROCYCLIC RINGS
This invention provides maytansinoids having improved tumor inhibition activity, in particular, the present invention provides a method of treatment of cancer,...
2016/0289243 PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR
The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsu- ...
2016/0289242 ANILINO PODOPHYLLIN DERIVATIVE HAVING ANTITUMOR ACTIVITY, METHOD FOR PREPARATION THEREOF, AND USE THEREOF
The present invention discloses an anilino-substituted podophyllin derivative having antitumor activity, method for preparation thereof, and use thereof. By...
2016/0289241 MONO-ETHERS OF ISOHEXIDES AND PROCESS FOR MAKING THE SAME
A method of making a mono-ether of an isohexide and art assemblage of novel. Song-chain isohexide mono-ethers are described. In particular, the method involves...
2016/0289240 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
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