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Patent # Description
2016/0287589 SUBSTITUTED-IMIDAZOPYRIDAZINES
The present invention relates to amido-substituted imidazopyridazine compounds of general formula (I): (Ia) (Ib) (Ic) (Id) in which A, Y, R1, R2, R3, R4 and n...
2016/0287588 METHODS OF TREATING A BRUTON'S TYROSINE KINASE DISEASE OR DISORDER
The present invention provides methods of treating, stabilizing or lessening the severity or progression of a disease or disorder associated with BTK.
2016/0287587 MODIFICATION OF AMYLOID-BETA LOAD IN NON-BRAIN TISSUE
The present invention relates to methods and compositions for modulating levels of amyloid-.beta. peptide (A.beta.) exhibited by non-neuronal (i.e.,...
2016/0287586 COMPOUNDS AND METHODS FOR TREATING CANDIDIASIS AND ASPERGILLUS INFECTIONS
The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for killing or inhibiting the growth of a Candida or Aspergillus...
2016/0287585 Treatment of Lung Cancer with Inhibitors of Glutaminase
The invention relates to methods of treating lung cancer using glutaminase inhibitors. In particular, results demonstrate that lung cancers characterized by an...
2016/0287584 SUBSTITUTED PYRIDAZINES FOR THE TREATMENT OF PAIN
The invention provides compounds of formula I, ##STR00001## wherein: R.sup.1 represents a cyclic group selected from phenyl, heteroaryl.sup.1, heterocyclyl.sup.1...
2016/0287583 ORAL DISPERSIBLE COMPOSITION OF A DPP-IV INHIBITOR
The present invention relates to oral dispersible compositions comprising a DPP-IV inhibitor and processes for their preparation. It further relates to a...
2016/0287582 SUBSTITUTED PYRROLIDINES AS FACTOR XIA INHIBITORS FOR THE TREATMENT THROMBOEMBOLIC DISEASES
The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the substituents are...
2016/0287581 Pharmacological Chaperones for Treating Obesity
The invention relates to methods of enhancing normal melanocortin-4 receptor (MC4R) activity, and to enhancing activity of an MC4R having a mutation which...
2016/0287580 Sustained Release Monoeximic Formulations of Opioid and Nonopioid Analgesics
The present invention relates to monoeximic solid dosage forms for administering pharmaceutical agents, particularly Hydrocodone and acetaminophen, methods for...
2016/0287579 MORPHINAN COMPOUNDS
This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a...
2016/0287578 TOLL-LIKE RECEPTOR 4 ANTAGONISTS AND USE IN AUTOIMMUNE LIVER DISEASES
The present invention relates to new medical uses of morphinans such as naltrexone, nalmefene and their related derivatives. The present invention relates to...
2016/0287577 NEURONAL MODULATION
A method for modulating an immune response by activating or inhibiting dopaminergic neurons in the Ventral Tegmental Area (VTA) is provided. Modulation is...
2016/0287576 PHARMACEUTICAL COMPOSITIONS COMPRISING DEXTROMETHORPHAN AND QUINIDINE FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
Pharmaceutical compositions and methods for treating neurological disorders by administering same are provided. The compositions comprise dextromethorphan in...
2016/0287575 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASES INVOLVING HIPPO PATHWAY
Provided herein are interfering molecules and pharmaceutical combinations comprising such interfering molecules that modulate the Hippo signaling pathway. Also...
2016/0287574 METHODS FOR THE TREATMENT OF ABNORMAL INVOLUNTARY MOVEMENT DISORDERS
Disclosed herein are new dosage regimens for deuterium-substituted benzoquinoline compounds, and methods for the treatment of abnormal muscular activity,...
2016/0287573 COMBINATION DOSAGE FORM OF A MU OPIOID RECEPTOR ANTAGONIST AND AN OPIOID AGENT
The invention provides a solid composition of the peripheral mu opioid antagonist axelopran and a combination dosage form of the mu opioid antagonist axelopran...
2016/0287572 CRYSTALLINE FORMS OF AN 8-AZABICYCLO[3.2.1]OCTANE COMPOUND
The invention provides a crystalline sulfate salt of 3-endo-(8-{2-[cyclohexylmethyl-((S)-2,3-dihydroxy-propionyl)amino]ethyl}-- ...
2016/0287571 PHARMACEUTICAL COMPOSITIONS COMPRISING ANTIBACTERIAL AGENTS
Pharmaceutical compositions comprising sulbactam or a pharmaceutically acceptable derivative, and a compound of Formula (I) or a stereoisomer or a...
2016/0287570 PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR
The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsu- ...
2016/0287569 COMBINATION THERAPY INCLUDING AN MDM2 INHIBITOR AND ONE OR MORE ADDITIONAL PHARMACEUTICALLY ACTIVE AGENTS FOR...
The present invention provides combination therapy that includes an MDM2 inhibitor and one or more additional pharmaceutically active agents, particularly for...
2016/0287568 COMPOSITION OF A NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR
The invention encompasses a composition comprising the reverse transcriptase ("RT") inhibitor ...
2016/0287567 PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION CONTAINING PIRFENIDONE IN SUSTAINED-RELEASE TABLET...
The instant invention relates to a process for the preparation of a pharmaceutical composition in sustained-release tablet form comprising from 600 milligrams...
2016/0287566 Anti-demodectic active agents and topical compositions for the treatment of demodicosis in humans and animals
The present invention is directed to topical compositions and methods for preventing and treating demodicosis and the symptoms of demodectic mites, including...
2016/0287565 COMBINATION THERAPY FOR TREATING DISORDERS ASSOCIATED WITH EXCESS CORTISOL PRODUCTION
Methods are provided for treatment of disorders associated with excess cortisol production, including, but not limited to, treatment of Cushing's syndrome....
2016/0287564 METHODS OF ADMINISTERING GLUTAMINASE INHIBITORS
In some aspects, the invention relates to a method of treating cancer, a myeloproliferative disease, an immunological disease, a neurological disease, or a...
2016/0287563 Cysteine Prodrugs
Novel cysteine prodrugs and their use in the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of the Central...
2016/0287562 METHOD FOR THE TREATMENT OF NF1- OR RAS-ASSOCIATED DISORDERS
Isoxazoloanthrones and a method for treating disorders associated or caused by Ras deregulation or dysregulation, for example, disorders associated with...
2016/0287561 Inhibitors of AKT Activity
Invented are novel heterocyclic carboxamide compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and...
2016/0287560 METHODS FOR TREATING DEGENERATIVE DISEASES/INJURIES
Invented is a method of treating degenerative diseases/injuries, in a mammal, including a human, in need thereof which comprises the administration of a...
2016/0287559 TRIFLUOROMETHYL PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF
The invention provides trifluoromethyl pyrazolyl guanidine compounds that inhibit F.sub.1F.sub.0-ATPase, and methods of using trifluoromethyl pyrazolyl...
2016/0287558 ORAL PHARMACEUTICAL FORM FOR PREVENTING VASCULAR DISEASES, TABLET AS PHARMACEUTICAL FORM AND GELATIN CAPSULE AS...
The present invention broadly relates to oral dosage forms for therapeutic use in the prevention of cardiovascular and cerebrovascular diseases in mammals,...
2016/0287557 Choline Esters
Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The...
2016/0287556 DEUTERATED BENZOPYRAN COMPOUNDS AND APPLICATION THEREOF
The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or...
2016/0287555 SUBSTITUTED CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY
Novel substituted chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic...
2016/0287554 Small Molecule Metal-Activated Protein Inhibition
A cancer treatment comprises the administration of a pro-drug compound identified by an in silico candidate identification screening. The pro-drug candidates...
2016/0287553 TRANSLATION INHIBITORS IN HIGH-DOSE CHEMO- AND/OR HIGH-DOSE RADIOTHERAPY
The present invention relates to an inhibitor of protein translation for use in high-dose chemotherapy and/or high-dose radiotherapy of disease; to an...
2016/0287552 DRUG DELIVERY SYSTEM COMPRISING GELATINE NANO-PARTICLES FOR SLOWLY RELEASING HARDLY-WATER SOLUBLE SUBSTANCES...
The present invention is about preparing gelatin nanoparticles having a size of about 200 nm are supported or not supported with a hardly-water soluble drug...
2016/0287551 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES
Since a compound represented by the general formula (I) (wherein definition of each group is as described in the specification), a salt thereof, a solvate...
2016/0287550 ARYL ISONITRILES AS A NEW CLASS OF ANTIMICROBIAL COMPOUNDS
The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present...
2016/0287549 NOVEL METHODS FOR TREATING NEURODEGENERATIVE DISEASES
The invention relates to dihydroorate dehydrogenase (DHODH) inhibitors useful for the treatment of neurodegenerative diseases, such as amyotrophic lateral...
2016/0287548 MELANOMA CHEMOPREVENTION
Disclosed herein are methods and uses for preventing melanoma, reducing progression of atypical nevi, and inducing cell cycle arrest and/or apoptosis in a...
2016/0287547 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PULMONARY FIBROSIS
The present invention relates to a pharmaceutical composition for preventing or treating pulmonary fibrosis comprising an isothiocyanate-based compound and a...
2016/0287546 COMPOSITIONS AND METHODS FOR LOWERING TRIGLYCERIDES
In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in...
2016/0287545 COMPOUND PARTICULARLY FOR TREATING DEPRESSION AND ANXIETY
A compound particularly for treating depression and anxiety, having the combination of at least 11-keto-beta-boswellic acid (KBA) and ...
2016/0287544 INGENOL DERIVATIVE COMPOUNDS AND METHODS USEFUL FOR INHIBITING CANCER CELL VIABILITY AND TREATING CANCER
The present invention relates to new ingenol derivative compounds for inhibiting cancer cell viability and treating cancer. In other aspects, the invention...
2016/0287543 Methods and Compositions for Improving Kidney Function
Provided are methods and compositions for improving kidney function and for the treatment or prophylaxis of kidney disease in dogs.
2016/0287542 COMPOUNDS, COMPOSITIONS AND CORRESPONDING USES FOR PREVENTING AND/OR TREATING OF DYSLIPIDEMIA
The present invention relates to the field of medicine. It relates more particularly to the use of compounds to prevent and/or treat lipotoxicity in a subject,...
2016/0287541 Modified Release Tranexamic Acid Formulation
A modified release dosage form for the oral administration of tranexamic acid.
2016/0287540 Increasing Cancer Patient Survival Time by Administration of Dithio-Containing Compounds
The present invention discloses and claims compositions, methods of treatment, and kits which cause an increase in the time of survival in cancer patients,...
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