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Patent # Description
2016/0296548 METHODS FOR TREATING CANCER
The present invention relates to DOT1L inhibitors. The present invention also relates to pharmaceutical compositions containing these compounds and methods of...
2016/0296547 COMPOSITIONS COMPRISING AND METHODS OF USING INHIBITORS OF SODIUM-GLUCOSE COTRANSPORTERS 1 AND 2
Pharmaceutical dosage forms useful for improving the cardiovascular and/or metabolic health of patients, particularly those suffering from type 2 diabetes, are...
2016/0296546 SOLID FORMS COMPRISING 4-AMINO-I-B-D-RIBOFURANOSYL-1,3,5-TRIAZIN-2 (1H) -ONE AND A COFORMER, COMPOSITIONS AND...
Provided herein are solid forms comprising (a) 4-amino-1-.beta.-D-ribofuranosyl-1,3,5-triazin-2(1H)-one and (b) a coformer. Pharmaceutical compositions...
2016/0296545 METHOD FOR TREATING A CANCER
The present invention relates to a method for treating a cancer with the combination of a topoisomerase II inhibitor (TOP2 inhibitor) and a histone...
2016/0296544 METHODS FOR PREVENTING OR MITIGATING ACUTE ALLERGIC RESPONSES USING HUMAN MILK OLIGOSACCHARIDES
A method for preventing or mitigating an acute allergic response in a subject is disclosed. The method includes a step of administering a nutritional...
2016/0296543 COMPOSITIONS FOR PREVENTING OR TREATING ALLERGIES IN INFANTS FROM OR FED BY NON SECRETOR MOTHERS BY PROVIDING...
The present invention relates to a composition comprising at least one fucosylated oligosaccharide, for use in preventing allergies and/or treating allergies...
2016/0296542 COMPOSITIONS FOR USE IN THE PREVENTION OR TREATMENT OF NECROTIZING ENTEROCOLITIS IN INFANTS OR YOUNG CHILDREN...
The present invention relates to a composition comprising at least one human milk oligosaccharide and/or a precursor thereof, for use in preventing and/or...
2016/0296541 COMPOSITIONS FOR USE IN THE PREVENTION OR TREATMENT OF NECROTIZING ENTEROCOLITIS IN INFANTS AND YOUNG CHILDREN
The invention discloses a composition comprising LNT and at least another human milk oligosaccharide or precursor thereof, for use in preventing and/or...
2016/0296540 COMPOSITIONS FOR USE IN THE PREVENTION OR TREATMENT OF NECROTIZING ENTEROCOLITIS IN INFANTS AND YOUNG CHILDREN
The invention discloses a composition comprising an oligosaccharide mixture, said oligosaccharide mixture comprising from 40 to 80 wt % of fucosylated...
2016/0296539 COMPOSITIONS FOR ORAL ADMINISTRATION OF ZOLEDRONIC ACID OR RELATED COMPOUNDS FOR TREATING COMPLEX REGIONAL PAIN...
Oral dosage forms of bisphosphonate compounds, such as zoledronic acid, can be used to treat or alleviate pain or related conditions. The oral bioavailability...
2016/0296538 PREDICTIVE AND RESPONSE BIOMARKER FOR TH-302 ANTI-CANCER THERAPY
Cancer patients likely to respond to HAP treatment exhibit tumor tissues with high levels of hypoxia, which can be measured using PET imaging with [18F]-HX4.
2016/0296537 Pharmaceutical Compositions for Minocycline
The present application relates to a method of orally administering once daily tablet of minocycline to a subject in need thereof, wherein said tablet is...
2016/0296536 Administration of Glucocorticoid Steroids to Livestock
There is provided a method of treating a weaning piglet with a cortisol agonist where the method includes administering a dose of the cortisol agonist to the...
2016/0296535 TRANSDERMAL DRUG DELIVERY SYSTEMS FOR LEVONORGESTREL AND ETHINYL ESTRADIOL
Described are transdermal drug delivery systems for the transdermal administration of levonorgestrel and ethinyl estradiol, comprising an acrylic polymer...
2016/0296534 PROGESTERONE RECEPTOR ANTAGONIST DOSAGE FORM
The invention is directed to a pharmaceutical composition comprising a progesterone receptor antagonist namely ...
2016/0296533 LIBIDO-ENHANCING THERAPEUTIC AND USE
A composition for enhancing libido of a pharmaceutically effective amount of a libido-enhancing therapeutic of ...
2016/0296532 Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
The present disclosure includes compositions of a semi-crystalline or crystalline pharmaceutically active agent dispersed in a polymer matrix, in which the...
2016/0296531 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS
Disclosed are methods of synthesis and/or purification of certain 3,7-diamino-phenothiazin-5-ium compounds ("diaminophenothiazinium compounds") including...
2016/0296530 NOVEL COMPOUND USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
A novel compound able to inhibit JAK is disclosed, this compound may be prepared as a pharmaceutical composition, and may be used for the prevention and...
2016/0296529 AMINOTRIAZOLOPYRIDINE FOR USE IN THE TREATMENT OF INFLAMMATION, AND PHARMACEUTICAL COMPOSITIONS THEREOF
The present invention relates to the compound according to Formula I, and to its use in medicine, in particular in the treatment of inflammatory conditions,...
2016/0296528 MACROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS
There is provided compounds of formula I, wherein R1, R.sup.2a, R.sup.2b, R.sup.2c, X, Y, Z, R.sup.3 and ring A/B have meanings given in the description, and...
2016/0296527 HIV PROTEASE INHIBITORS
The present invention is directed to 5-heteroarylmorpholine derivatives and their use in the inhibition of HIV protease, the inhibition of HIV replication, the...
2016/0296526 TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS
The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of...
2016/0296525 AMINOQUINAZOLINE AND PYRIDOPYRIMIDINE DERIVATIVES
The invention provides a method of treating cancer in a patient by administering a compound of formula (I): ##STR00001## wherein R.sup.1 R.sup.2 and R.sup.3...
2016/0296524 IRAK INHIBITORS AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same.
2016/0296523 Sirtuin Modulators as Inhibitors of Cytomegalovirus
Agents and methods of inhibiting or improving the growth of viruses are provided.
2016/0296522 FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE
Fumarate compounds, pharmaceutical compositions comprising the fumarate compounds, and methods of using fumarate compounds and pharmaceutical compositions for...
2016/0296521 INHIBITORS OF HSV NUCLEOTIDYL TRANSFERASES AND USES THEREFOR
The present invention involves identification of inhibitors of herpesvirus nucleic acid metabolism. Also provided are methods of treatment using agents...
2016/0296520 COMBINATION THERAPY
Reversing resistance to a B-Raf inhibitor for the treatment of a proliferative disease by obtaining a tumor sample from the patient and testing it for genetic...
2016/0296519 PREVENTION OF HIV-INFECTION
This invention relates to the use of a parenteral formulation comprising the NNRTI TMC278 for the long term prevention of HIV infection in a subject at risk of...
2016/0296518 INDOLES
Herein are disclosed indoles of formula (I) ##STR00001## where the various groups are defined herein, and which are useful for treating cancer.
2016/0296517 AZAINDAZOLE COMPOUNDS AND METHODS OF USE
Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl...
2016/0296516 HYDROMORPHONE AND NALOXONE FOR TREATMENT OF PAIN AND OPIOID BOWEL DYSFUNCTION SYNDROME
The present invention relates to prolonged release pharmaceutical dosage forms comprising hydromorphone or a pharmaceutically acceptable salt thereof and...
2016/0296515 NOVEL DIHYDROQUINOLIZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
The invention provides novel compounds having the general formula: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as described...
2016/0296514 PHARMACOLOGICALLY ACTIVE COMPOUNDS
The present invention relates to compounds of formula II ##STR00001## wherein X, Y, R.sub.2, R.sub.3, R.sub.4 and Ar are all as defined herein. The compounds of...
2016/0296513 TREATMENT OF MULTIPLE SCLEROSIS BY ALEMTUZUMAB INDUCTION FOLLOWED BY LAQUINIMOD THERAPY
This invention provides a method of treating a subject afflicted with multiple sclerosis (MS) or presenting clinically isolated syndrome (CIS) which comprises...
2016/0296512 TREATMENT OF CROHN'S DISEASE WITH LAQUINIMOD
This application provides for a method of treating a subject suffering from Crohn's disease, the method comprising periodically administering to the subject an...
2016/0296511 LAQUINIMOD FOR REDUCING THALAMIC DAMAGE IN MULTIPLE SCLEROSIS
This invention provides methods for inhibiting or reducing thalamic damage in a subject comprising administering to the subject an amount of laquinimod,...
2016/0296510 LIQUID PHARMACEUTICAL FORMULATIONS OF PALONOSETRON
The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron....
2016/0296509 NOVEL QUINOLINE DERIVATIVES AND THEIR USE IN NEURODEGENERATIVE DISEASES
The present invention relates to quinoline compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of P2X7, and for the...
2016/0296508 CCR6 COMPUNDS
Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6: ##STR00001##
2016/0296507 IMIDAZOPYRIDINE, IMIDAZOPYRIMIDINE AND IMIDAZOPYRAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS
Disclosed is a compound of Formula I: ##STR00001## or a salt thereof, in which X, X.sup.1, X.sup.2, R.sup.1, R.sup.2, and R.sup.3 are described herein. Also...
2016/0296506 Methods and Compositions for Treating HIV Infection
Disclosed are methods of treating HIV infections comprising, in one aspect, administering compounds that are phospholipase D inhibitors. This abstract is...
2016/0296505 THERAPEUTIC DRUG FOR DISEASES RELATED TO ENDOPLASMIC RETICULUM CELL DEATH IN CORNEAL ENDOTHELIUM
The present invention provides a treatment drug or prophylactic drug for diseases, disorders, or conditions related to endoplasmic reticulum (ER) stress....
2016/0296504 METHODS AND COMPOSITIONS FOR TREATING NEPHROGENIC DIABETES INSIPIDUS
Disclosed is a treatment of diabetes insipidus. Methods of treating diabetes insipidus disorders associated with P2Y receptors using the compounds and...
2016/0296503 NOVEL QUINUCLIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME
Provided is an aerosol container comprising a powder inhalant comprising 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicy- ...
2016/0296502 ANTIBACTERIAL COMPOSITIONS
Pharmaceutical compositions comprising: (a) at least one antibacterial agent selected from cefixime, cefpodoxime, ceftibuten, cefuroxime or a pharmaceutically...
2016/0296501 P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS
The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of...
2016/0296500 TACROLIMUS FOR USE IN TREATING DISEASES CHARACTERIZED BY PROTEIN AGGREGATE DEPOSITION IN NEURONAL CELLS
This invention relates to the use of a very low dose of tacrolimus or a close structural analogue to treat a disease characterised by deposition of protein...
2016/0296499 Spiroindoline Antiparasitic Derivatives
The invention describes novel spiropiperidines of Formula (1A), (1B), and (1C) stereoisomers thereof, veterinarily acceptable salts thereof, compositions...
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