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METHOD FOR PREDICTING DEVELOPMENT OF MELANOMA BRAIN METASTASIS
The invention relates to miRNA-based methods for prognosis of melanoma brain metastasis and related methods and kits. In one embodiment, the invention provides...
KITS AND METHODS FOR DIAGNOSIS, SCREENING, TREATMENT AND DISEASE
Disclosed are methods for detecting the presence of a carcinoma or an increased likelihood that a carcinoma is present in a subject. More particularly, the...
ASSESSMENT OF THE PI3K CELLULAR SIGNALING PATHWAY ACTIVITY USING
MATHEMATICAL MODELLING OF TARGET GENE EXPRESSION
The present invention relates to a method comprising inferring activity of a PI3K cellular signaling pathway in a tissue and/or cells and/or a body fluid of a...
METHODS FOR THE DETECTION AND TREATMENT OF LEUKEMIAS THAT ARE RESPONSIVE
TO DOT1L INHIBITION
Disclosed are: (i) methods for identifying leukemia patients who (or leukemia cells that) do not exhibit an MLL-translocation, rearrangement or MLL-partial...
BIOMARKERS FOR HBV TREATMENT RESPONSE
The present invention relates to methods that are useful for predicting the response of hepatitis B virus (HBV) infected patients to pharmacological treatment.
Methods and Compositions for Measuring Beta Cell Death
Provided herein are, inter alia, nucleic acids, methods, and kits for detecting unmethylated DNA in body fluid sample of a subject. The disclosure includes...
METHODS AND KITS FOR IDENTIFYING SUSCEPTIBILITY TO
ANTIRESORPTIVE-AGENT-INDUCED OSTEONECROSIS OF THE JAW
The present invention relates, according to some embodiments, to methods and kits for identifying susceptibility to osteonecrosis of the jaw (ONJ), including,...
METHODS FOR DIAGNOSING AND TREATING DIABETES
Methods and kits for diagnosing and treating type I diabetes based upon the expression of macrophage-specific Chymotrypsin-Like Elastase Family, Member 3B,...
INFLUENCE OF GENOTYPE ON SUSCEPTIBILITY TO TREATMENT WITH FISH OIL
The present invention relates to methods for assessing an individual's susceptibility to treatment of an inflammatory disease with a dietary supplement. The...
KITS AND METHODS FOR EVALUATING, SELECTING AND CHARACTERIZING TISSUE
CULTURE MODELS USING MICRO-RNA PROFILES
A method for identifying a cluster or sub-cluster of microRNAs (miRNAs) that provides a signature profile for differentiating cells grown in one type of...
SYSTEM AND METHOD FOR CLEANING NOISY GENETIC DATA FROM TARGET INDIVIDUALS
USING GENETIC DATA FROM GENETICALLY...
A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is...
METHODS OF TAGGING PARTICLES FOR MULTIPLEXED FUNCTIONAL SCREENING
The present invention relates generally to the fields of cell biology and laboratory diagnostics, and particularly to general compositions and of uniquely...
CONFORMATIONAL PROBES AND METHODS FOR SEQUENCING NUCLEIC ACIDS
This disclosure provides a method of determining a sequence of nucleotides for a nucleic acid template. The method can include the steps of contacting the...
POLYMORPHIC GENE TYPING AND SOMATIC CHANGE DETECTION USING SEQUENCING DATA
A system and method for determining the exact pair of alleles corresponding to polymorphic genes from sequencing data and for using the polymorphic gene...
Methods for Genotyping
The present invention provides for methods for discriminating between alleles at polymorphic positions in a genome. In general the methods employ allele...
HIGH-THROUGHPUT SEQUENCING DETECTION METHOD FOR METHYLATED CPG ISLANDS
A high-throughput sequencing method for detecting methylated CpG islands includes: processing a DNA sample by using a modifier, and converting cytosine in the...
NUCLEIC ACID DETECTION AND QUANTIFICATION
The present invention relates to methods and uses for the detection or quantification of newly-synthesized double-stranded target nucleic acid molecules in a...
METHOD AND KIT FOR DETECTION OF MICROORGANISM
A kit for detecting live cells of a microorganism in a test sample by distinguishing the live cells from dead cells or injured cells by a nucleic acid...
SPATIALLY ENCODED BIOLOGICAL ASSAYS
The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an...
LUMINOPHORE-LABELED MOLECULES COUPLED WITH PARTICLES FOR MICROARRAY-BASED
A method for labeling target molecules coupled to particles for the detection of the target molecules using a microarray chip, comprises: providing a...
MONITORING DNA AMPLIFICATION
A method and kits are provided for nucleic acid quantification and discrimination using surface plasmon resonance (SPR). The method provided is able to...
BIOPROBES AND METHODS OF USE THEREOF
Disclosed are biomolecule based bioprobes that exhibit improved water solubility and mono layer-forming properties with substantially little or no aggregation...
CLOSED NUCLEIC ACID STRUCTURES
The invention provides compositions and methods for making closed nucleic acid structures in which one or both strands are continuous. The closed nucleic acid...
Bead Emulsion Nucleic Acid Amplification
Disclosed are methods for nucleic acid amplification wherein nucleic acid templates, beads, and amplification reaction solution are emulsified and the nucleic...
Mutated DNA Polymerases with High Selectivity and Activity
The present invention provides DNA polymerases and their use in various applications. The present invention also relates to uses and methods utilizing the DNA...
MULTIPLEXED, CONTINUOUS-FLOW, DROPLET-BASED PLATFORM FOR HIGH-THROUGHPUT
The present application relates to a continuous droplet flow microfluidic system, including a microfluidic chip including an optical detection section; a stage...
METHODS FOR FULL-LENGTH AMPLIFICATION OF DOUBLE-STRANDED LINEAR NUCLEIC
ACIDS OF UNKNOWN SEQUENCES
An adaptor for use in amplifying all linear, double-stranded nucleic acid molecules of unknown sequences in a sample is disclosed. The adaptor consists of: (1)...
CODON-OPTIMIZED GENE FOR MUTATED SHRIMP LUCIFERASE AND METHOD FOR USE
There has been a demand for a codon-optimized gene for the mutated catalytic domain of Oplophorus luciferase, which is capable of efficiently expressing a...
SYSTEMS AND METHODS FOR ARTIFICIAL TEST STRIP CONTROLS
A linearity standard includes a plurality of calibration solutions, each calibration solution having a different level of a reactant having a known response in...
COMPOUNDS AND METHODS RELATING TO LYSOSOMAL STORAGE DISORDERS
Methods are provided for detecting enzymatic activity of various lysosomal storage enzymes using substrates that include: a sugar moiety; a linker moiety...
PROTEIN STRUCTURAL BIOMARKERS TO GUIDE TARGETED CHEMOTHERAPIES
A rapid, infrared spectroscopic method has been developed to assess the efficacy of targeted chemotherapeutics against the structure of the polypeptide target,...
NAPHTHALENE DERIVED CHROMOGENIC ENZYME SUBSTRATES
Conjugates of 2,3-dihydroxynaphthalene and its derivatives with enzyme cleavable groups are chromogenic substrates that form coloured compounds when complexed...
REAGENTS AND METHODS FOR SCREENING MPS I, II, IIIA, IIIB, IVA, VI, AND VII
Reagents, methods, and kits for assaying enzymes associated with lysosomal storage diseases MPS-I, MPS-II, MPS-IIIA, MPS-IIIB, MPS-IV A, MPS-VI, and MPS VII....
METHOD OF TREATING TUBERCULOSIS
The present invention addresses a need for improved methods of treating M. tuberculosis infection using enhancers of respiration, and compositions for treating...
RAPID TEST FOR MICROBIAL RESISTANCES BY MASS SPECTROMETRY
The invention relates to methods and instruments for determining the resistances of microbes to antibiotics, in particular those microbes which produce...
METHOD FOR THE DIFFERENTIAL ENUMERATION OF LACTIC ACID BACTERIA IN A
MIXTURE IN A FOOD PRODUCT
The invention relates to a method for distinguishing between and enumerating strains of lactic acid bacteria or Bifidobacteria present in a food product. This...
METHOD FOR DETECTING VIABLE CELLS IN A CELL SAMPLE
The invention relates to a method for determining the presence and/or amount of viable cells in a cell containing sample, for example, a fluid sample, using a...
METHOD OF NONINVASIVELY DETECTING PLANT PATHOGENIC VIRUS AND ELECTRONIC
A method of noninvasively detecting plant pathogenic virus and an electronic apparatus thereof are provided. The method is adapted to the electronic apparatus...
OVER-EXPRESSION OF A FATTY ACID TRANSPORTER GENE AND OF GENES ENCODING
ENZYMES OF THE BETA-OXIDATION PATHWAY...
The present invention relates to a method of producing riboflavin in a genetically modified organism of the genus Eremothecium, wherein said genetic...
Enzymatic Method for Preparing Rebaudioside M
Provided is a method for preparing rebaudioside M by using an enzyme method. In the method, rebaudioside A or rebaudioside D is used as a substrate; and in the...
THERMOPHILIC AND THERMOACIDOPHILIC BIOPOLYMER-DEGRADING GENES AND ENZYMES
FROM ALICYCLOBACILLUS ACIDOCALDARIUS...
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are...
COMPOSITIONS COMPRISING A BETA-GLUCOSIDASE POLYPEPTIDE AND METHODS OF USE
The present compositions and methods relate to a beta-glucosidase from Melanocarpus albomyces, polynucleotides encoding the beta-glucosidase, and methods of...
ENDOGLUCANASE VARIANTS HAVING IMPROVED ACTIVITY, AND USES OF SAME
The present invention relates to the expression and optimisation of enzymes involved in the breakdown of lignocellulosic biomass. The present invention relates...
APPARATUS AND METHOD FOR REDUCTION OF PHENOL IN ENZYMATIC SOLUTIONS AND/OR
Provided are an apparatus and method for reducing the phenol concentration in a commercial enzyme solution and/or feedstock.
Processes for Increasing Enzymatic Hydrolysis of Cellulosic Material
The present invention relates to methods for increasing hydrolysis of a cellulosic material, comprising: hydrolyzing the cellulosic material with an enzyme...
Host Cells and Methods for Producing 1-Deoxyxylulose 5-phosphate (DXP)
and/or a DXP Derived Compound
The present invention provides for a genetically modified host cell capable of producing 1-deoxyxylulose 5-phosphate or 1-deoxy-D-xylulose 5-phosphate (DXP)...
ENGINEERED BETA-SUBUNIT OF TRYPTOPHAN SYNTHASE FOR PRODUCTION OF
NON-CANONICAL AMINO ACIDS
This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates...
Novel Method for the cheap, efficient, and effective production of
pharmaceutical and therapeutic api's...
The present invention is a method for the biosynthesis of hundreds of compounds, mainly found in the cannabis plant. The starting material for these compounds...
Method for Producing Acetylated Sphingoid Base
Provided is a means for producing an acetylated sphingoid base using modified microorganism in the genus Starmerella, particularly Starmerella bombicola. A...
METHOD FOR ENRICHING THE BIOMASS OF THRAUSTOCHYTRIUM GENUS MICROALGAE WITH
The present invention relates to a fermenting method for enriching biomass of Thraustochytrium genus microalgae, specifically Schizochytrium sp. or...