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METHOD FOR THE GENERATION OF COMPACT TALE-NUCLEASES AND USES THEREOF
The present invention relates to a method for the generation of compact Transcription Activator-Like Effector Nucleases (TALENS) that can efficiently target...
Mutant Cas9 Proteins
Methods of making deletion mutants of Cas9 proteins and making chimeric Cas9 proteins are described. The Cas9 N- and C-terminal domains may play critical roles...
CRISPR-CAS SYSTEM MATERIALS AND METHODS
The invention relates to Type II CRIS-PR-Cas systems of Cas9 enzymes, guide RNAs and associated specific PAMs.
Nucleic acid molecules for increased protein production
The present invention relates to the improved production of proteins, preferably enzymes such as lipases. In particular, the invention relates to a mutated...
METHOD OF IDENTIFYING A CELL WITH AN INTRACELLULAR CONCENTRATION OF A
SPECIFIC METABOLITE, WHICH INTRACELLULAR...
A method for identifying a cell having an intracellular concentration of a particular metabolite that is increased compared to the wild type of the cell,...
TGF-BETA SUPERFAMILY TYPE I AND TYPE II RECEPTOR HETEROMULTIMERS AND USES
In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of a type I serine/threonine kinase...
OMEGA-TRANSAMINASE MUTANTS WITH ACTIVITY IMPROVEMENTS TOWARD KETONES AND
METHODS FOR PRODUCING OPTICALLY PURE...
Provided is an omega-transaminase mutant with improved activity using a point mutation in an active site of an omega-transaminase. Specifically, provided is a...
CONSTRUCTION OF NEW VARIANTS OF DEXTRANSUCRASE DSR-S BY GENETIC
The present invention relates to a recombinant process for the production of truncated or mutated dextransucrases while conserving the enzymatic activity or...
MODIFIED P450 REDUCTASE WITH N-TERMINAL DELETIONS AND ENDOPLASMIC
RETICULUM RETENTION TAG
The present invention provides an isolated or recombinant polypeptide comprising or consisting of a modified P450 reductase which lacks N-terminal amino acids...
SYNERGISTIC GENOME-NONINTEGRATING REPROGRAMMING BY MICRORNAS AND
Disclosed herein are methods of generating induced pluripotent stem cells. The method involves providing a quantity of somatic or non-embryonic cells,...
COMPOSITIONS AND METHODS FOR DIFFERENTIATING STEM CELLS INTO CELL
POPULATIONS COMPRISING BETA-LIKE CELLS
Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g.,...
LIVER-MIMETIC DEVICE AND METHOD FOR SIMULATION OF HEPATIC FUNCTION USING
A liver-mimetic device and method include a 3D polymer scaffold having a matrix of liver-like lobules with hepatic-functioning particles encapsulated within...
METHOD FOR DETERMINING THE CARDIO-GENERATIVE POTENTIAL OF MAMMALIAN CELLS
This document is related to a method for determining the cardio-generative potential of mammalian cells which comprises the assessment of a CARdiac generation...
COMPOSITIONS AND METHODS FOR PRODUCING AND ADMINISTERING BROWN ADIPOCYTES
The present disclosure provides compositions comprising a hydrogel and a cell adhesion ligand that enhances the differentiation of mesenchymal stem cells into...
CO-CULTURE OF PLACENTAL CELLS AND STEM CELLS FROM A SECOND SOURCE
The present invention relates to a combination of placental stem cells and stem or progenitor cells derived from a second source, wherein the combination shows...
Method of Blood Pooling and Storage
The disclosure provides methods of making a cell-containing product having a uniform amount of cells therein. The method comprises pooling red blood cells from...
METHOD FOR OBTAINING IMMUNO-STIMULATORY DENDRITIC CELLS
The present invention relates to methods for producing immuno-stimulatory autologous dendritic cells. The present invention further relates to the use of such...
ENHANCED GENERATION OF CYTOTOXIC T LYMPHOCYTES BY IL-21 MEDIATED FOXP3
A method of carrying out adoptive immunotherapy by administering a subject an antigen-specific cytotoxic T lymphocytes (CTL) preparation in a...
METHOD FOR HIGHLY EFFICIENT CONVERSION OF HUMAN STEM CELLS TO
The present invention relates to the field of stem cells. More specifically, the present invention provides methods and compositions useful for the highly...
CELL CULTURE MEDIA, KITS AND METHODS OF USE
Albumin-supplemented and xenogeneic product-free cell culture media, cell culture media supplements, and cell culture media kits for the support of primary...
POLYPEPTIDE-BASED SHUTTLE AGENTS FOR IMPROVING THE TRANSDUCTION EFFICIENCY
OF POLYPEPTIDE CARGOS TO THE CYTOSOL...
The present description relates to synthetic peptides useful for increasing the transduction efficiency of polypeptide cargos to the cytosol of target...
A METHOD OF FREEZE-DRYING ENCAPSULATED CELLS, FREEZE-DRIED ENCAPSULATED
CELLS, COMPOSITIONS CONTAINING...
The disclosure provides a method of freeze-drying encapsulated cells, the method comprising at least two consecutive incubation steps, wherein the encapsulated...
Bone Marrow Adipose Portion Isolation Device and Methods
The embodiments disclosed herein generally relate to systems, devices and methods for the fractionation, isolation, extraction and processing of the adipose...
MULTICHANNEL IN-VITRO METABOLISM REAL-TIME MONITORING APPARATUS
A multichannel in-vitro metabolism real-time monitoring apparatus includes a radiation probing apparatus and a constant flow culture apparatus. The constant...
FLOW ELECTROPORATION DEVICE
The present invention discloses a flow electroporation device comprising a three-dimensional electrode device and a flow electroporation chamber, the...
Pulsatile Perfusion Bioreactor for Mimicking, Controlling, and Optimizing
Blood Vessel Mechanics
A pulsatile perfusion bioreactor for culturing one or more engineered blood vessels having a lumen and a wall is provided. The bioreactor includes a chamber...
A BIOREACTOR SYSTEM AND METHOD FOR PRODUCING A BIOPOL YMER
Provided is a bioreactor system and a fermentation process employing continuous inline medium dilution in which concentrated medium and nutrients are blended...
METHODS AND APPARATUS FOR GAS STREAM MASS TRANSFER WITH A LIQUID
A system for performing a gas-liquid mass transfer includes a container bounding a compartment and having a top wall, a bottom wall, and an encircling sidewall...
TRANSFER DEVICE FOR CULTURE VESSEL, CULTURE DEVICE AND HOLDER FOR CULTURE
A transfer device for a culture vessel for transferring a culture vessel for culturing a cell, a culture device including the transfer device for a culture...
APPARATUS FOR CULTURING CELLS
An apparatus for culturing cells of the present disclosure includes: a cabinet that has a main surface and a side surface, the main surface having a window; a...
SINGLE-USE BIOREACTOR PORT WITH MULTIPLE SENSORS
A bioreactor vessel is provided. The bioreactor vessel comprises a bioreactor bag wall having an interior side and an exterior side and an aperture extending...
METHOD FOR PRODUCING BIOGAS FROM BIOMASS USING ANAEROBIC DIGESTION AND A
The invention relates to a method for producing biogas from biomass using anaerobic digestion wherein biomass is fed as input to a reaction space using...
System of Biomimetic Energy Synthesis
An improved system of generating renewable energy is comprised of a specific configuration of mechanisms, materials, and processes that all function together...
STABILIZATION OF FERMENTED BEVERAGES
The invention discloses a separation matrix with a porous solid support and a plurality of polyvinylpyrrolidone (PVP) polymer chains covalently attached to the...
FRACTIONATION OF HOP OILS USING LIQUID AND SUPERCRITICAL CARBON DIOXIDE
This invention discloses a method for producing of hop aroma from hop oil that uses only carbon dioxide and ethanol as solvents. It also covers `green` aromas...
DISPOSABLE DISHWASHING PAD
The present invention relates to a dishwashing pad for one-time use for manually washing dishes, wherein the dishwashing pad is coated with a dishwashing...
PORTABLE PRODUCT FOR CLEANING STAIN
The portable product for cleaning stain is composed of a body and a case for receiving and keeping the body and includes: a body including a detergent member...
DETERGENT OR CLEANING AGENT COMPRISING A DRY, WATER-SOLUBLE FOAM LAYER
The invention relates to detergent or cleaning agent products comprising: a) at least one first substantially water-soluble layer; b) at least one first...
USE OF AN OXIDISING ALKALINE GEL TO REMOVE A BIOFILM ON A SURFACE OF A
The use of a gel consisting of a colloidal solution comprising, preferably consisting of: 5% to 30% by weight, preferably 5% to 25% by weight, more preferably...
CLEANING COMPOSITION WITH RAPID FOAM COLLAPSE
An aqueous cleaning composition including: a surfactant; a first compound that is immiscible with water and has Hansen solubility parameters of 10 ...
SOLID CONCENTRATED FABRIC SOFTENER COMPOSITION
A solid fabric softening composition is disclosed which includes a quaternary ammonium fabric softening compound which is stabilized to form a solid with a...
Machine Cleaning Composition
The invention relates to a dishwasher machine cleaning detergent composition that is capable of being used during a normal dishwashing cleaning cycle.
REDUCTION OF SURFACE TENSION, INTERFACIAL TENSION, AND CRITICAL MI CELLE
CONCENTRATION USING A PROTEIN-BASED...
Surfactant-containing compositions are described which include a protein component that has the effect of improving the surface-active properties of the...
Systems and Methods for Forming Wax or Wax-Like Candles or Shells
Systems and methods are described for forming wax shells for use with electric lighting devices. A template can comprise a sleeve that defines an interior...
METHOD FOR PRODUCING RESINOUS FATTY ACID SOAP, FATTY ACID SOAP COMPOSITION
AND USE THEREOF
The present invention relates to a method for manufacturing soap from fatty and resin acids, in particular from tall oil fatty acid comprising resin acids. The...
REMOVAL OF UNWANTED PROPANOL COMPONENTS
The present invention relates to the use of short-path evaporation for reducing from deodorized triglyceride oils the content of propanol components selected...
REDUCED ENGINE DEPOSITS FROM DISPERSANT TREATED WITH COPPER
The invention provides a lubricating composition containing an oil of lubricating viscosity and a dispersant treated with copper reagent. The invention further...
CARBOXYLIC PYRROLIDINONES AND METHODS OF USE THEREOF
The present invention provides a compound comprising the reaction product of a hydrcarbyl substituted amine with an itaconate, such as an N-substituted...
SLIDING MEMBER, METHOD OF MANUFACTURING SLIDING MEMBER, AND GEAR
In a method of manufacturing a sliding member including a polyamide resin and a filler, a compound having a carbodiimide bond is supplied during kneading of...
SOLID LUBRICANT FILLED STRUCTURAL MATRIX
A coating including a structural matrix having a porosity and a solid lubricant that at least partially fills the porosity.