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Patent # Description
2016/0298098 METHOD FOR THE GENERATION OF COMPACT TALE-NUCLEASES AND USES THEREOF
The present invention relates to a method for the generation of compact Transcription Activator-Like Effector Nucleases (TALENS) that can efficiently target...
2016/0298097 Mutant Cas9 Proteins
Methods of making deletion mutants of Cas9 proteins and making chimeric Cas9 proteins are described. The Cas9 N- and C-terminal domains may play critical roles...
2016/0298096 CRISPR-CAS SYSTEM MATERIALS AND METHODS
The invention relates to Type II CRIS-PR-Cas systems of Cas9 enzymes, guide RNAs and associated specific PAMs.
2016/0298095 Nucleic acid molecules for increased protein production
The present invention relates to the improved production of proteins, preferably enzymes such as lipases. In particular, the invention relates to a mutated...
2016/0298094 METHOD OF IDENTIFYING A CELL WITH AN INTRACELLULAR CONCENTRATION OF A SPECIFIC METABOLITE, WHICH INTRACELLULAR...
A method for identifying a cell having an intracellular concentration of a particular metabolite that is increased compared to the wild type of the cell,...
2016/0298093 TGF-BETA SUPERFAMILY TYPE I AND TYPE II RECEPTOR HETEROMULTIMERS AND USES THEREOF
In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of a type I serine/threonine kinase...
2016/0298092 OMEGA-TRANSAMINASE MUTANTS WITH ACTIVITY IMPROVEMENTS TOWARD KETONES AND METHODS FOR PRODUCING OPTICALLY PURE...
Provided is an omega-transaminase mutant with improved activity using a point mutation in an active site of an omega-transaminase. Specifically, provided is a...
2016/0298091 CONSTRUCTION OF NEW VARIANTS OF DEXTRANSUCRASE DSR-S BY GENETIC ENGINEERING
The present invention relates to a recombinant process for the production of truncated or mutated dextransucrases while conserving the enzymatic activity or...
2016/0298090 MODIFIED P450 REDUCTASE WITH N-TERMINAL DELETIONS AND ENDOPLASMIC RETICULUM RETENTION TAG
The present invention provides an isolated or recombinant polypeptide comprising or consisting of a modified P450 reductase which lacks N-terminal amino acids...
2016/0298089 SYNERGISTIC GENOME-NONINTEGRATING REPROGRAMMING BY MICRORNAS AND TRANSCRIPTION FACTORS
Disclosed herein are methods of generating induced pluripotent stem cells. The method involves providing a quantity of somatic or non-embryonic cells,...
2016/0298088 COMPOSITIONS AND METHODS FOR DIFFERENTIATING STEM CELLS INTO CELL POPULATIONS COMPRISING BETA-LIKE CELLS
Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g.,...
2016/0298087 LIVER-MIMETIC DEVICE AND METHOD FOR SIMULATION OF HEPATIC FUNCTION USING SUCH DEVICE
A liver-mimetic device and method include a 3D polymer scaffold having a matrix of liver-like lobules with hepatic-functioning particles encapsulated within...
2016/0298086 METHOD FOR DETERMINING THE CARDIO-GENERATIVE POTENTIAL OF MAMMALIAN CELLS
This document is related to a method for determining the cardio-generative potential of mammalian cells which comprises the assessment of a CARdiac generation...
2016/0298085 COMPOSITIONS AND METHODS FOR PRODUCING AND ADMINISTERING BROWN ADIPOCYTES
The present disclosure provides compositions comprising a hydrogel and a cell adhesion ligand that enhances the differentiation of mesenchymal stem cells into...
2016/0298084 CO-CULTURE OF PLACENTAL CELLS AND STEM CELLS FROM A SECOND SOURCE
The present invention relates to a combination of placental stem cells and stem or progenitor cells derived from a second source, wherein the combination shows...
2016/0298083 Method of Blood Pooling and Storage
The disclosure provides methods of making a cell-containing product having a uniform amount of cells therein. The method comprises pooling red blood cells from...
2016/0298082 METHOD FOR OBTAINING IMMUNO-STIMULATORY DENDRITIC CELLS
The present invention relates to methods for producing immuno-stimulatory autologous dendritic cells. The present invention further relates to the use of such...
2016/0298081 ENHANCED GENERATION OF CYTOTOXIC T LYMPHOCYTES BY IL-21 MEDIATED FOXP3 SUPPRESSION
A method of carrying out adoptive immunotherapy by administering a subject an antigen-specific cytotoxic T lymphocytes (CTL) preparation in a...
2016/0298080 METHOD FOR HIGHLY EFFICIENT CONVERSION OF HUMAN STEM CELLS TO LINEAGE-SPECIFIC NEURONS
The present invention relates to the field of stem cells. More specifically, the present invention provides methods and compositions useful for the highly...
2016/0298079 CELL CULTURE MEDIA, KITS AND METHODS OF USE
Albumin-supplemented and xenogeneic product-free cell culture media, cell culture media supplements, and cell culture media kits for the support of primary...
2016/0298078 POLYPEPTIDE-BASED SHUTTLE AGENTS FOR IMPROVING THE TRANSDUCTION EFFICIENCY OF POLYPEPTIDE CARGOS TO THE CYTOSOL...
The present description relates to synthetic peptides useful for increasing the transduction efficiency of polypeptide cargos to the cytosol of target...
2016/0298077 A METHOD OF FREEZE-DRYING ENCAPSULATED CELLS, FREEZE-DRIED ENCAPSULATED CELLS, COMPOSITIONS CONTAINING...
The disclosure provides a method of freeze-drying encapsulated cells, the method comprising at least two consecutive incubation steps, wherein the encapsulated...
2016/0298076 Bone Marrow Adipose Portion Isolation Device and Methods
The embodiments disclosed herein generally relate to systems, devices and methods for the fractionation, isolation, extraction and processing of the adipose...
2016/0298075 MULTICHANNEL IN-VITRO METABOLISM REAL-TIME MONITORING APPARATUS
A multichannel in-vitro metabolism real-time monitoring apparatus includes a radiation probing apparatus and a constant flow culture apparatus. The constant...
2016/0298074 FLOW ELECTROPORATION DEVICE
The present invention discloses a flow electroporation device comprising a three-dimensional electrode device and a flow electroporation chamber, the...
2016/0298073 Pulsatile Perfusion Bioreactor for Mimicking, Controlling, and Optimizing Blood Vessel Mechanics
A pulsatile perfusion bioreactor for culturing one or more engineered blood vessels having a lumen and a wall is provided. The bioreactor includes a chamber...
2016/0298072 A BIOREACTOR SYSTEM AND METHOD FOR PRODUCING A BIOPOL YMER
Provided is a bioreactor system and a fermentation process employing continuous inline medium dilution in which concentrated medium and nutrients are blended...
2016/0298071 METHODS AND APPARATUS FOR GAS STREAM MASS TRANSFER WITH A LIQUID
A system for performing a gas-liquid mass transfer includes a container bounding a compartment and having a top wall, a bottom wall, and an encircling sidewall...
2016/0298070 TRANSFER DEVICE FOR CULTURE VESSEL, CULTURE DEVICE AND HOLDER FOR CULTURE VESSEL
A transfer device for a culture vessel for transferring a culture vessel for culturing a cell, a culture device including the transfer device for a culture...
2016/0298069 APPARATUS FOR CULTURING CELLS
An apparatus for culturing cells of the present disclosure includes: a cabinet that has a main surface and a side surface, the main surface having a window; a...
2016/0298068 SINGLE-USE BIOREACTOR PORT WITH MULTIPLE SENSORS
A bioreactor vessel is provided. The bioreactor vessel comprises a bioreactor bag wall having an interior side and an exterior side and an aperture extending...
2016/0298067 METHOD FOR PRODUCING BIOGAS FROM BIOMASS USING ANAEROBIC DIGESTION AND A CORRESPONDING REACTOR
The invention relates to a method for producing biogas from biomass using anaerobic digestion wherein biomass is fed as input to a reaction space using...
2016/0298066 System of Biomimetic Energy Synthesis
An improved system of generating renewable energy is comprised of a specific configuration of mechanisms, materials, and processes that all function together...
2016/0298065 STABILIZATION OF FERMENTED BEVERAGES
The invention discloses a separation matrix with a porous solid support and a plurality of polyvinylpyrrolidone (PVP) polymer chains covalently attached to the...
2016/0298064 FRACTIONATION OF HOP OILS USING LIQUID AND SUPERCRITICAL CARBON DIOXIDE
This invention discloses a method for producing of hop aroma from hop oil that uses only carbon dioxide and ethanol as solvents. It also covers `green` aromas...
2016/0298063 DISPOSABLE DISHWASHING PAD
The present invention relates to a dishwashing pad for one-time use for manually washing dishes, wherein the dishwashing pad is coated with a dishwashing...
2016/0298062 PORTABLE PRODUCT FOR CLEANING STAIN
The portable product for cleaning stain is composed of a body and a case for receiving and keeping the body and includes: a body including a detergent member...
2016/0298061 DETERGENT OR CLEANING AGENT COMPRISING A DRY, WATER-SOLUBLE FOAM LAYER
The invention relates to detergent or cleaning agent products comprising: a) at least one first substantially water-soluble layer; b) at least one first...
2016/0298060 USE OF AN OXIDISING ALKALINE GEL TO REMOVE A BIOFILM ON A SURFACE OF A SOLID SUBSTRATE
The use of a gel consisting of a colloidal solution comprising, preferably consisting of: 5% to 30% by weight, preferably 5% to 25% by weight, more preferably...
2016/0298059 CLEANING COMPOSITION WITH RAPID FOAM COLLAPSE
An aqueous cleaning composition including: a surfactant; a first compound that is immiscible with water and has Hansen solubility parameters of 10 ...
2016/0298058 SOLID CONCENTRATED FABRIC SOFTENER COMPOSITION
A solid fabric softening composition is disclosed which includes a quaternary ammonium fabric softening compound which is stabilized to form a solid with a...
2016/0298057 Machine Cleaning Composition
The invention relates to a dishwasher machine cleaning detergent composition that is capable of being used during a normal dishwashing cleaning cycle.
2016/0298056 REDUCTION OF SURFACE TENSION, INTERFACIAL TENSION, AND CRITICAL MI CELLE CONCENTRATION USING A PROTEIN-BASED...
Surfactant-containing compositions are described which include a protein component that has the effect of improving the surface-active properties of the...
2016/0298055 Systems and Methods for Forming Wax or Wax-Like Candles or Shells
Systems and methods are described for forming wax shells for use with electric lighting devices. A template can comprise a sleeve that defines an interior...
2016/0298054 METHOD FOR PRODUCING RESINOUS FATTY ACID SOAP, FATTY ACID SOAP COMPOSITION AND USE THEREOF
The present invention relates to a method for manufacturing soap from fatty and resin acids, in particular from tall oil fatty acid comprising resin acids. The...
2016/0298053 REMOVAL OF UNWANTED PROPANOL COMPONENTS
The present invention relates to the use of short-path evaporation for reducing from deodorized triglyceride oils the content of propanol components selected...
2016/0298052 REDUCED ENGINE DEPOSITS FROM DISPERSANT TREATED WITH COPPER
The invention provides a lubricating composition containing an oil of lubricating viscosity and a dispersant treated with copper reagent. The invention further...
2016/0298051 CARBOXYLIC PYRROLIDINONES AND METHODS OF USE THEREOF
The present invention provides a compound comprising the reaction product of a hydrcarbyl substituted amine with an itaconate, such as an N-substituted...
2016/0298050 SLIDING MEMBER, METHOD OF MANUFACTURING SLIDING MEMBER, AND GEAR
In a method of manufacturing a sliding member including a polyamide resin and a filler, a compound having a carbodiimide bond is supplied during kneading of...
2016/0298049 SOLID LUBRICANT FILLED STRUCTURAL MATRIX
A coating including a structural matrix having a porosity and a solid lubricant that at least partially fills the porosity.
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