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Process to Visbreak Propylene-Based Polymers with C-C Initiators
The invention provides a process to prepare a second propylene-based polymer from a first propylene-based polymer, each propylene-based polymer having a melt...
RUBBER COMPOSITION FOR TIRES AND PNEUMATIC TIRE
Provided are a rubber composition for tires that shows a balanced improvement in properties such as fuel economy, processability, heat aging resistance,...
Carboxylated Derivatives of Glucosaminoglycans and Use as Drugs
The invention relates to glucosaminoglycan derivatives, endowed with heparanase inhibitory activity and antitumor activity, bearing carboxylate groups in...
METHODS FOR MAKING SACCHARIDE-PROTEIN GLYCOCONJUGATES
The invention provides a process for the reductive amination of a carbonyl group at the reducing terminus of a polysaccharide, wherein the reductive amination...
ANTIBODY AGAINST ALOPECIA-INDUCING SUBSTANCE AS ANTIGEN, COMPOSITION AND
Causes of hair loss have not been completely clarified and still remain unknown in many points. However, it appears that hair loss is partly caused by a...
ASSAYS FOR TIMP2 HAVING IMPROVED PERFORMANCE IN BIOLOGICAL SAMPLES
The invention provides TIMP2 immunoassays with improved clinical performance, particularly when used in the evaluation of renal injuries. The immunoassays rely...
Novel Methods and Antibodies for Treating Coagulapathy
The present invention relates to pro-coagulant human Protein S inhibitors, such as antibodies or antigen-binding fragments thereof that can be administered...
METHODS USING MONOVALENT ANTIGEN BINDING CONSTRUCTS TARGETING HER2
Provided herein are methods of use and treatment using a first or a first and second monovalent antigen-binding constructs targeting HER2. The monovalent...
ANTI-TROP2 ANTIBODY-DRUG CONJUGATE
It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is...
PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PREVENTION OF CANCER
It is intended to provide a CAPRIN-1-targeting antibody superior in antitumor activity to conventional antibodies, and use thereof as a therapeutic and/or...
ANTIBODY THERAPEUTICS THAT BIND CD38
There is disclosed compositions and methods relating to or derived from anti-CD38 antibodies. More specifically, there is disclosed fully human antibodies that...
METHODS OF SYNTHESIZING HETEROMULTIMERIC POLYPEPTIDES IN YEAST USING A
HAPLOID MATING STRATEGY
Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is...
ENGINEERED IMMUNOGLOBULIN FC POLYPEPTIDES DISPLAYING IMPROVED COMPLEMENT
Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain are provided. In certain embodiments, polypeptides have an...
THERAPEUTIC ANTIBODIES AND THEIR USES
The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell...
CHIMERIC ANTIGEN RECEPTORS TARGETING B-CELL MATURATION ANTIGEN
The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells...
G-PROTEIN COUPLED RECEPTOR AGONISTS AND METHODS
Peptide-grafted antibodies having agonist activity against a Class B GPCR and their uses, and methods for identifying same. Mammalian cell lines for...
Antibody Therapeutics That Bind CD123
There is disclosed compositions and methods relating to or derived from anti-CD123 antibodies. More specifically, there is disclosed fully human antibodies...
BISPECIFIC ANTIBODIES AGAINST CD3EPSILON and ROR1
A bispecific antibody specifically binding to the two targets human CD3.epsilon. (further named also as "CD3") and the extracellular domain of human ROR1...
Reducing Systemic Regulatory T Cell Levels or Activity for Treatment of
A pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a...
Uses and Compositions for Treatment of Psoriatic Arthritis
The invention provides methods, uses and compositions for the treatment of psoriatic arthritis. The invention describes methods and uses for treating psoriatic...
Specific Binding Members for NGF
Specific binding members for Nerve Growth Factor (NGF), in particular anti-NGF antibody molecules, especially human antibody molecules, and especially those...
Pharmaceutical composition of an anti-VEGF antibody
The present invention relates to liquid pharmaceutical formulations for intravitreal injection of an anti-VEGF antibody which does not contain saccharides for...
IMMUNOLOGICAL METHODS AND COMPOSITIONS FOR THE TREATMENT OF ALZHEIMER'S
The present invention relates to immunogenic compositions and peptides comprising residues 4-10 (FRHDSGY) of the amyloid peptide Abeta.sub.42. The invention...
COMPOSITIONS AND METHODS OF TREATING THROMBOSIS
A method of inhibiting hypercoagulation and/or thrombosis in a subject having or at risk of hypercoagulation or thrombosis includes administering to the...
Secreted aP2 and Methods of Inhibiting Same
A method of reducing a symptom of a clinical disorder characterized by aberrantly elevated circulating aP2 is carried out by administering to a subject an...
COMPOSITIONS AND METHODS FOR PROPHYLAXIS AND/OR THERAPY OF DISORDERS THAT
CORRELATE WITH DENND1A VARIANT 2
Pharmaceutical compositions and methods for the treatment of DENND1 A. V2 related disorders, such as PCOS, are provided. In particular, humanized and mouse...
ANTI-PSEUDOMONAS PSL BINDING MOLECULES AND USES THEREOF
The disclosure relates to an anti-Pseudomonas PSL binding molecule and uses thereof, in particular, in prevention and treatment of Pseudomonas infection....
Transgenic Chicken Comprising an Inactivated Immunoglobulin Gene
A transgenic chicken comprising an inactivated heavy immunoglobulin gene and/or inactivated light chain immunoglobulin gene is provided, as well as cells and...
Lyophilization of Hemoglobin Solutions
A lyophilized hemoglobin composition and a method for lyophilizing hemoglobin are described. The method of the invention produces a reconstituted hemoglobin...
INHIBITORS OF TYPE 2 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS
The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to...
Composition and Method for Therapeutic Agent Delivery During Pregnancy
A composition including an elastin-like polypeptide (ELP) coupled to a therapeutic agent is provided. The ELP comprises at least about 5 repeats of the amino...
ALK7:ACTRIIB HETEROMULTIMERS AND USES THEREOF
In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of an ALK7 receptor and an...
METHOD FOR INHIBITING CELLULAR ACTIVATION BY INSULIN-LIKE GROWTH FACTOR-1
A method of inhibiting cellular activation by Insulin-like Growth Factor-1 (IGF-1) in a subject in need thereof (e.g., a subject afflicted with cancer,...
METHODS FOR TREATING CANCER
The present invention relates to methods and materials for treating an individual with KRAS-mutated cancer or a cancer in which ROCK is inhibited independently...
Influenza-Specific T-Cell Receptor and its Uses in the Detection,
Prevention and/or Treatment of Influenza
The present invention relates to specific T-cell receptor a-chains, T-cell receptor .beta.-chains and T-cell receptors comprising said T-cell receptor a-chain...
EPHA3 AND MULTI-VALENT TARGETING OF TUMORS
Provided herein is a construct comprising, in combination: an EphA3, EphA2 and/or EphB2 binding ligand; and at least one effector molecule. In some...
METHOD FOR PREPARING CRYSTALLINE INSULIN
A method for crystallizing insulin or insulin analogs under alkaline conditions and purifying the insulin or insulin analog crystals by filtering through a...
The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted...
IDENTIFICATION OF A NOVEL B CELL CYTOKINE
Compositions and methods involving IL40, a novel cytokine produced by activated B cells, are provided. The compositions include: a) anti-IL40 antibodies, IL40...
NEUREGULIN VARIANTS AND METHODS OF SCREENING AND USING THEREOF
The present invention provides polypeptide variants of neuregulin-1.beta. (NRG-1.beta.) that have enhanced or decreased binding affinity to ErbB3 and/or ErbB4....
DPY-30 Binding Peptides
Disclosed are compositions and methods for modulating Dpy-30 binding activity. The compositions may include peptides or peptidomimetics thereof that are...
The invention relates to novel entomotoxic polypeptides of the family of albumins 1b in legumes. Said polypeptides can be especially used as insecticides.
Polypeptides Having Cellulolytic Enhancing Activity and Polynucleotides
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The...
Adeno-Associated Virus with Site-Directed Mutagenesis and Site-Directed
Modification and Preparation Method and...
The present invention relates to an adeno-associated virus with site-directed mutagenesis and site-specific modification, and a preparation method and uses...
COMPOSITIONS AND METHODS FOR LONG ACTING MOLECULES
The invention relates, in part, to compositions and methods that utilize a peptide tag that binds to hemagglutanin (HA). The HA tag can be linked to a molecule...
ELICITOR PEPTIDES HAVING DISRUPTED HYPERSENSITIVE RESPONSE BOX AND USE
Disclosed are peptides that induce an active plant response, but not a hypersensitive response, when applied to plant tissue. These peptides also preferably...
AMYLOID-BETA-BINDING PEPTIDES AND THE USE THEREOF FOR THE TREATMENT AND
DIAGNOSIS OF ALZHEIMER'S DISEASE
Amyloid beta-binding peptides and the use thereof for the treatment and the diagnosis of Alzheimer's disease.
BROAD SPECTRUM ANTIBIOTIC ARYLOMYCIN ANALOGS
Arylomycin analogs are provided, wherein the analogs can have broad spectrum bioactivity. Resistance to the antibiotic bioactivity of natural product...
The present invention relates to a method for harvesting recombinant proteins from mammalian cell culture fluid. The method makes use of cationic polymers,...
It is intended to provide a novel terpenoid derivative that exhibits anti-inflammatory action and a cytoprotective action by activating the Keap1/Nrf2/ARE...