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Patent # Description
2016/0297898 Process to Visbreak Propylene-Based Polymers with C-C Initiators
The invention provides a process to prepare a second propylene-based polymer from a first propylene-based polymer, each propylene-based polymer having a melt...
2016/0297897 RUBBER COMPOSITION FOR TIRES AND PNEUMATIC TIRE
Provided are a rubber composition for tires that shows a balanced improvement in properties such as fuel economy, processability, heat aging resistance,...
2016/0297896 Carboxylated Derivatives of Glucosaminoglycans and Use as Drugs
The invention relates to glucosaminoglycan derivatives, endowed with heparanase inhibitory activity and antitumor activity, bearing carboxylate groups in...
2016/0297895 METHODS FOR MAKING SACCHARIDE-PROTEIN GLYCOCONJUGATES
The invention provides a process for the reductive amination of a carbonyl group at the reducing terminus of a polysaccharide, wherein the reductive amination...
2016/0297894 ANTIBODY AGAINST ALOPECIA-INDUCING SUBSTANCE AS ANTIGEN, COMPOSITION AND PRODUCTION METHOD
Causes of hair loss have not been completely clarified and still remain unknown in many points. However, it appears that hair loss is partly caused by a...
2016/0297893 ASSAYS FOR TIMP2 HAVING IMPROVED PERFORMANCE IN BIOLOGICAL SAMPLES
The invention provides TIMP2 immunoassays with improved clinical performance, particularly when used in the evaluation of renal injuries. The immunoassays rely...
2016/0297892 Novel Methods and Antibodies for Treating Coagulapathy
The present invention relates to pro-coagulant human Protein S inhibitors, such as antibodies or antigen-binding fragments thereof that can be administered...
2016/0297891 METHODS USING MONOVALENT ANTIGEN BINDING CONSTRUCTS TARGETING HER2
Provided herein are methods of use and treatment using a first or a first and second monovalent antigen-binding constructs targeting HER2. The monovalent...
2016/0297890 ANTI-TROP2 ANTIBODY-DRUG CONJUGATE
It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is...
2016/0297889 PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PREVENTION OF CANCER
It is intended to provide a CAPRIN-1-targeting antibody superior in antitumor activity to conventional antibodies, and use thereof as a therapeutic and/or...
2016/0297888 ANTIBODY THERAPEUTICS THAT BIND CD38
There is disclosed compositions and methods relating to or derived from anti-CD38 antibodies. More specifically, there is disclosed fully human antibodies that...
2016/0297887 METHODS OF SYNTHESIZING HETEROMULTIMERIC POLYPEPTIDES IN YEAST USING A HAPLOID MATING STRATEGY
Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is...
2016/0297886 ENGINEERED IMMUNOGLOBULIN FC POLYPEPTIDES DISPLAYING IMPROVED COMPLEMENT ACTIVATION
Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain are provided. In certain embodiments, polypeptides have an...
2016/0297885 THERAPEUTIC ANTIBODIES AND THEIR USES
The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell...
2016/0297884 CHIMERIC ANTIGEN RECEPTORS TARGETING B-CELL MATURATION ANTIGEN
The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells...
2016/0297883 G-PROTEIN COUPLED RECEPTOR AGONISTS AND METHODS
Peptide-grafted antibodies having agonist activity against a Class B GPCR and their uses, and methods for identifying same. Mammalian cell lines for...
2016/0297882 Antibody Therapeutics That Bind CD123
There is disclosed compositions and methods relating to or derived from anti-CD123 antibodies. More specifically, there is disclosed fully human antibodies...
2016/0297881 BISPECIFIC ANTIBODIES AGAINST CD3EPSILON and ROR1
A bispecific antibody specifically binding to the two targets human CD3.epsilon. (further named also as "CD3") and the extracellular domain of human ROR1...
2016/0297880 Reducing Systemic Regulatory T Cell Levels or Activity for Treatment of Alzheimer's Disease
A pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a...
2016/0297879 Uses and Compositions for Treatment of Psoriatic Arthritis
The invention provides methods, uses and compositions for the treatment of psoriatic arthritis. The invention describes methods and uses for treating psoriatic...
2016/0297878 Specific Binding Members for NGF
Specific binding members for Nerve Growth Factor (NGF), in particular anti-NGF antibody molecules, especially human antibody molecules, and especially those...
2016/0297877 Pharmaceutical composition of an anti-VEGF antibody
The present invention relates to liquid pharmaceutical formulations for intravitreal injection of an anti-VEGF antibody which does not contain saccharides for...
2016/0297876 IMMUNOLOGICAL METHODS AND COMPOSITIONS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
The present invention relates to immunogenic compositions and peptides comprising residues 4-10 (FRHDSGY) of the amyloid peptide Abeta.sub.42. The invention...
2016/0297875 COMPOSITIONS AND METHODS OF TREATING THROMBOSIS
A method of inhibiting hypercoagulation and/or thrombosis in a subject having or at risk of hypercoagulation or thrombosis includes administering to the...
2016/0297874 Secreted aP2 and Methods of Inhibiting Same
A method of reducing a symptom of a clinical disorder characterized by aberrantly elevated circulating aP2 is carried out by administering to a subject an...
2016/0297873 COMPOSITIONS AND METHODS FOR PROPHYLAXIS AND/OR THERAPY OF DISORDERS THAT CORRELATE WITH DENND1A VARIANT 2
Pharmaceutical compositions and methods for the treatment of DENND1 A. V2 related disorders, such as PCOS, are provided. In particular, humanized and mouse...
2016/0297872 ANTI-PSEUDOMONAS PSL BINDING MOLECULES AND USES THEREOF
The disclosure relates to an anti-Pseudomonas PSL binding molecule and uses thereof, in particular, in prevention and treatment of Pseudomonas infection....
2016/0297871 Transgenic Chicken Comprising an Inactivated Immunoglobulin Gene
A transgenic chicken comprising an inactivated heavy immunoglobulin gene and/or inactivated light chain immunoglobulin gene is provided, as well as cells and...
2016/0297870 Lyophilization of Hemoglobin Solutions
A lyophilized hemoglobin composition and a method for lyophilizing hemoglobin are described. The method of the invention produces a reconstituted hemoglobin...
2016/0297869 INHIBITORS OF TYPE 2 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS
The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to...
2016/0297868 Composition and Method for Therapeutic Agent Delivery During Pregnancy
A composition including an elastin-like polypeptide (ELP) coupled to a therapeutic agent is provided. The ELP comprises at least about 5 repeats of the amino...
2016/0297867 ALK7:ACTRIIB HETEROMULTIMERS AND USES THEREOF
In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of an ALK7 receptor and an...
2016/0297866 METHOD FOR INHIBITING CELLULAR ACTIVATION BY INSULIN-LIKE GROWTH FACTOR-1
A method of inhibiting cellular activation by Insulin-like Growth Factor-1 (IGF-1) in a subject in need thereof (e.g., a subject afflicted with cancer,...
2016/0297865 METHODS FOR TREATING CANCER
The present invention relates to methods and materials for treating an individual with KRAS-mutated cancer or a cancer in which ROCK is inhibited independently...
2016/0297864 Influenza-Specific T-Cell Receptor and its Uses in the Detection, Prevention and/or Treatment of Influenza
The present invention relates to specific T-cell receptor a-chains, T-cell receptor .beta.-chains and T-cell receptors comprising said T-cell receptor a-chain...
2016/0297863 EPHA3 AND MULTI-VALENT TARGETING OF TUMORS
Provided herein is a construct comprising, in combination: an EphA3, EphA2 and/or EphB2 binding ligand; and at least one effector molecule. In some...
2016/0297862 METHOD FOR PREPARING CRYSTALLINE INSULIN
A method for crystallizing insulin or insulin analogs under alkaline conditions and purifying the insulin or insulin analog crystals by filtering through a...
2016/0297861 Interferon Analogs
The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted...
2016/0297860 IDENTIFICATION OF A NOVEL B CELL CYTOKINE
Compositions and methods involving IL40, a novel cytokine produced by activated B cells, are provided. The compositions include: a) anti-IL40 antibodies, IL40...
2016/0297859 NEUREGULIN VARIANTS AND METHODS OF SCREENING AND USING THEREOF
The present invention provides polypeptide variants of neuregulin-1.beta. (NRG-1.beta.) that have enhanced or decreased binding affinity to ErbB3 and/or ErbB4....
2016/0297858 DPY-30 Binding Peptides
Disclosed are compositions and methods for modulating Dpy-30 binding activity. The compositions may include peptides or peptidomimetics thereof that are...
2016/0297857 ENTOMOTOXIC POLYPEPTIDES
The invention relates to novel entomotoxic polypeptides of the family of albumins 1b in legumes. Said polypeptides can be especially used as insecticides.
2016/0297856 Polypeptides Having Cellulolytic Enhancing Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The...
2016/0297855 Adeno-Associated Virus with Site-Directed Mutagenesis and Site-Directed Modification and Preparation Method and...
The present invention relates to an adeno-associated virus with site-directed mutagenesis and site-specific modification, and a preparation method and uses...
2016/0297854 COMPOSITIONS AND METHODS FOR LONG ACTING MOLECULES
The invention relates, in part, to compositions and methods that utilize a peptide tag that binds to hemagglutanin (HA). The HA tag can be linked to a molecule...
2016/0297853 ELICITOR PEPTIDES HAVING DISRUPTED HYPERSENSITIVE RESPONSE BOX AND USE THEREOF
Disclosed are peptides that induce an active plant response, but not a hypersensitive response, when applied to plant tissue. These peptides also preferably...
2016/0297852 AMYLOID-BETA-BINDING PEPTIDES AND THE USE THEREOF FOR THE TREATMENT AND DIAGNOSIS OF ALZHEIMER'S DISEASE
Amyloid beta-binding peptides and the use thereof for the treatment and the diagnosis of Alzheimer's disease.
2016/0297851 BROAD SPECTRUM ANTIBIOTIC ARYLOMYCIN ANALOGS
Arylomycin analogs are provided, wherein the analogs can have broad spectrum bioactivity. Resistance to the antibiotic bioactivity of natural product...
2016/0297850 FLOCCULATION METHOD
The present invention relates to a method for harvesting recombinant proteins from mammalian cell culture fluid. The method makes use of cationic polymers,...
2016/0297849 TERPENOID DERIVATIVES
It is intended to provide a novel terpenoid derivative that exhibits anti-inflammatory action and a cytoprotective action by activating the Keap1/Nrf2/ARE...
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