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Patent # Description
2016/0297848 A PROCESS FOR THE PRODUCTION OF 19-NORPREGN-4-EN-3,20-DIONE-17ALPHA-OL(GESTONORONE) AND INTERMEDIATES THEREFOR
The present invention relates to a new stereoselective process for the synthesis of 17(.alpha.)-17-acetyl-17-hydroxy-estr-4-en-3-one of formula (I), as well as...
2016/0297847 METHOD OF MAKING COMPLEX NANO PARTICLES AND USING THE SAME TO REDUCE CELL VIABILITY
The development of anticancer metal-based drugs was done by reacting oyelamine with selenous acid to produce a quaternary ammonium salt which consequently...
2016/0297846 SIALIC ACID ANALOGS
The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.
2016/0297845 PROCESS FOR ISOLATING C5 SUGARS FROM BIOMASS HYDROLYZATE
Provided are processes for isolating hemicellulose-based sugar from a biomass. The process includes providing a biomass hydrolyzate including a C5 sugar,...
2016/0297844 DEHYDROGENATION CATALYST, AND CARBONYL COMPOUND AND HYDROGEN PRODUCTION METHOD USING SAID CATALYST
Objects of the present invention are to provide a novel dehydrogenation reaction catalyst, to provide a method that can produce a ketone, an aldehyde, and a...
2016/0297843 METALLOCENE COMPOUNDS, CATALYST COMPOSITIONS COMPRISING THE SAME, AND METHOD FOR PREPARING OLEFIN POLYMERS...
The present invention relates to a transition metal compound that may exhibit high activity in olefin polymerization, and easily control the properties of...
2016/0297842 Process for the Preparation of Dicycloplatin
The present invention relates to a process to prepare dicycloplatin under mild reactive conditions and at fast reaction rates. The process is reproducible and...
2016/0297841 Solvent Self-Reactions with P(CN)3 to Produce Films and Particles of C3N3P
A material with the empirical formula C.sub.3N.sub.3P is made by polymerizing P(CN).sub.3 in a polar aprotic solvent such as acetonitrile, by heating,...
2016/0297840 STABLE PANTETHEINE DERIVATIVES FOR THE TREATMENT OF PANTOTHENATE KINASE ASSOCIATED NEURODEGENERATION (PKAN) AND...
The invention relates to (S)-acyl-4'-phosphopantetheine derivatives, methods of their synthesis, and related medical uses of such compounds. Preferred medical...
2016/0297839 TIN SULFIDE QUANTUM DOTS FOR IN VIVO NEAR INFRARED IMAGING
An aqueous approach to synthesize capped SnS quantum dots (QDs) followed by optional capping molecule extension by attaching one or more extending molecules to...
2016/0297838 HYDROBORATION AND BORYLATION WITH COBALT CATALYSTS
In one aspect, cobalt complexes are described herein. In some embodiments, such cobalt complexes are operable as catalysts for hydroboration and borylation...
2016/0297837 Fused Imidazole and Pyrazole Derivatives As Modulators of TNF Activity
A series of substituted benzimidazole, imidazo[1,2-a]pyridine and pyrazolo[1,5-a]pyridine derivatives, and analogues thereof, being potent modulators of human...
2016/0297836 Photochromic Spirooxazine Compounds
A photochromic dye comprising at least one compound characterized by Formula I: ##STR00001##
2016/0297835 USE OF SMALL MOLECULE INHIBITORS TARGETING THE INTERACTION BETWEEN RAC GTPASE AND P67(PHOX)
Inhibitors of p67.sup.phox protein are provided herein, as well as pharmaceutical compositions and methods relating thereto.
2016/0297834 ACC INHIBITORS AND USES THEREOF
The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
2016/0297833 THIENOPYRIMIDINES AS MKNK1 AND MKNK2 INHIBITORS
The present invention relates to substituted thienopyrimidine compounds of general formula (I) as described and defined herein, to methods of preparing said...
2016/0297832 THIENO[3,2-C]PYRIDIN-4(5H)-ONES AS BET INHIBITORS
Thienopyridone compounds of formula (I): ##STR00001## or a salt thereof, pharmaceutical compositions containing such compounds and their use in therapy, in...
2016/0297831 ANTI-CANCER AGENTS AND PREPARATION THEREOF
Embodiments of the present invention provide, among other compounds, a family of spliceosome-inhibiting compounds that can be used as therapeutic anti-cancer...
2016/0297830 NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF BACTERIAL INFECTIOUS DISEASES
Compounds are disclosed that have a formula represented by the following: ##STR00001## wherein A, B, R.sup.1, R.sup.2 and R.sup.3 are as defined herein. Novel...
2016/0297829 METHOD FOR PRODUCING AVENACIOLIDES AND USES THEREOF
Disclosed herein are novel uses of avenaciolide derivatives and the preparation method of producing the same. The avenaciolide derivatives may suppress or...
2016/0297828 SPIROCYCLIC COMPOUNDS CONTAINING SPIRO[INDOLYL-3,1'-PYRROLO[3,4-C]PYRROLE] CORE AND SULPHUR-CONTAINING AMINO...
The present invention relates to spirocyclic compounds on the basis of 2-oxindole derivatives containing a spiro[indolyl-3,1'-pyrrolo[3,4-c]-pyrrole] core and...
2016/0297827 Imidazopyrimidine Derivatives As Modulators of TNF Activity
A series of substituted imidazo[1,2-a]pyrimidine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the...
2016/0297826 TYK2 INHIBITORS AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated...
2016/0297825 EFFICIENT METHOD FOR THE PREPARATION OF TOFACITINIB CITRATE
Disclosed is a novel process for the synthesis of tofacitinib citrate on an industrial scale with high yields and purity starting with ...
2016/0297824 IMIDAZO-FUSED HETEROCYCLES AND USES THEREOF
Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of...
2016/0297823 SUBSTITUTED AMINO TRIAZOLES, AND METHODS USING SAME
Disclosed are novel substituted amino triazoles of Formula (I), and pharmaceutically acceptable salts thereof. The compounds of Formula (I) are inhibitors of...
2016/0297822 N-benzyl tryptanthrin derivative, and preparation method and application thereof
The present invention relates to an N-benzyl tryptanthrin derivative, and preparation method and use thereof. The N-benzyl tryptanthrin derivative of the...
2016/0297821 CRYSTALLINE FORMS OF PONATINIB HYDROCHLORIDE
The present disclosure relates to polymorphic forms of the hydrochloride salt of ponatinib ("compound 1") and to processes for the preparation of these...
2016/0297820 DIMERIZER COMPOUND
There is provided a compound comprising at least two ligands that are individually coupled to a linker, wherein each ligand is independently selected from the...
2016/0297819 XANTHINE-SUBSTITUTED ALKYNYL CARBAMATES/REVERSE CARBAMATES AS A2B ANTAGONISTS
The present invention provides xanthine-substituted alkynyl carbamates/reverse carbamates and derivatives thereof and pharmaceutical compositions containing...
2016/0297818 Purine Derivatives As Modulators of TNF Activity
A series of substituted purine derivatives, being potent modulators of human TNF.alpha. activity, are accordingly of benefit in the treatment and/or prevention...
2016/0297817 BICYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND BETA-LACTAMASE INHIBITORS
A compound of formula (I): ##STR00001## wherein: M is hydrogen or a pharmaceutically acceptable salt-forming cation; Y is OR.sup.1 or NR.sup.2R.sup.3, and...
2016/0297816 2-(1,3,4-OXADIAZOL-2-YL)-7-OXO-1,6-DIAZABICYCLO[3.2.1 ]OCTANE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS
Compounds of Formula (I), their preparation, and use in preventing or treating a bacterial infection are disclosed.
2016/0297815 7-AZAINDOLE OR 4,7-DIAZAINDOLE DERIVATIVES AS IKK EPSILON AND TBK1 INHIBITOR AND PHARMACEUTICAL COMPOSITION...
Provided are 7-azaindole or 4,7-diazaindole derivatives as an IKK.epsilon. (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor. The...
2016/0297814 PROCESS FOR THE PREPARATION OF 8-(4-AMINOPHENOXY)-4H-PYRIDO[2,3-B]PYRAZIN-3-ONE DERIVATIVES
The present invention pertains generally to the field of organic chemical synthesis, and in particular to certain methods for the synthesis of ...
2016/0297813 NOVEL COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES
The present invention relates to novel compounds and pharmaceutical compositions thereof which may be useful in the treatment and/or prevention of various...
2016/0297812 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole...
2016/0297811 SUBSTITUTED TRIAZOLOPYRIDINES
The present invention relates to substituted triazolopyridine compounds of general formula (I); in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are as...
2016/0297810 NOVEL VIRAL REPLICATION INHIBITORS
The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said...
2016/0297809 ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF...
The present invention relates to aryl linked imidazole and triazole derivatives, compositions comprising said compounds, alone or in combination with other...
2016/0297808 Thiophene- or furan-substituted isothiazoline Compounds as Pesticides
The present invention relates to thiophene- or furan-substituted isothiazoline compounds of formula I ##STR00001## wherein the variables are as defined in the...
2016/0297807 NOVEL 1,2,4-OXADIAZOL COMPOUNDS ACTIVE AGAINST GRAM-POSITIVE PATHOGENS
The present invention relates to new oxazolidinone compounds of general formula (I) having antibiotic activity even against multiresistant bacterial strains...
2016/0297806 INHIBITORS OF LYSINE METHYL TRANSFERASE
There are disclosed compounds that are inhibitors of EZH2, pharmaceutical compositions containing said compounds and methods of treating hyperproliferative,...
2016/0297805 INHIBITORS OF LYSINE METHYL TRANSFERASE
There are disclosed compounds that are inhibitors of EZH2, pharmaceutical compositions containing said compounds and methods of treating hyperproliferative,...
2016/0297804 9,9,10,10-TETRAFLUORO-9,10-DIHYDROPHENANTHRENE HEPATITIS C VIRUS INHIBITOR AND APPLICATION THEREOF
The present invention belongs to the field of chemical pharmaceuticals, and specifically relates to compounds represented by formula I having a ...
2016/0297803 FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES IV
The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions...
2016/0297802 CONTROL OF HYPOXIA-INDUCIBLE GENE EXPRESSION WITH OLIGOOXOPIPERAZINE NONPEPTIDIC HELIX MIMETICS
The present invention relates to oligooxopiperazines that mimic helix .alpha.B of the C-terminal transactivation domain of HIF-1.alpha.. Also disclosed are...
2016/0297801 SUBSTITUTED 1H-INDAZOL-1-OL ANALOGS AS INHIBITORS OF BETA CATENIN/TCF PROTEIN-PROTEIN INTERACTIONS
In one aspect, the invention relates to substituted 1H-benzo[d][1,2,3]triazol-1-ol analgoues, derivatives thereof, and related compound; synthetic methods for...
2016/0297800 ARYL-SUBSTITUTED IMIDAZOLES
The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding...
2016/0297799 Benzotriazole Derivatives as Modulators of TNF Activity
A series of substituted benzotriazole derivatives, being potent modulators of various human ailments, including autoimmune and inflammatory disorders;...
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