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Patent # Description
2016/0297798 SUBSTITUTED TRIAZINE BMI-1 INHIBITORS
Amine substituted triazine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus...
2016/0297797 DIHYDROPYRAZOLE GPR40 MODULATORS
The present invention provides compounds of Formula (I): (Formula (I), or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the...
2016/0297796 PYRROLIDINYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS
Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R.sup.1, R.sup.2, R.sup.a,...
2016/0297795 Tetrahydrobenzimidazole Derivatives as Modulators of TNF Activity
A series of substituted 4,5,6,7-tetrahydrobenzimidazole derivatives, being potent modulators of human TNF.alpha. activity, are accordingly of benefit in the...
2016/0297794 PROCESS FOR MAKING REVERSE TRANSCRIPTASE INHIBITORS
The present invention is directed to a novel process for synthesizing 3-(substituted ...
2016/0297793 N-ACYLIMINO HETEROCYCLIC COMPOUNDS
The present invention relates to N-acylimino compound of formula (I): ##STR00001## wherein X is O or S, in particular O; Y is a single bond, O, S or NR.sup.5;...
2016/0297792 PIPERIDINE OR PIPERAZINE LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE...
The present invention relates to piperidine or piperazine linked imidazole and triazole derivatives, compositions comprising said compounds, alone or in...
2016/0297791 PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS
The present invention provides new processes for the preparation of unsubstituted and substituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione...
2016/0297790 CYTOTOXIN COMPOUNDS AND METHODS OF ISOLATION
The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these...
2016/0297789 INDANONE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS OR OPTICAL ISOMERS THEREOF, PREPARATION METHOD FOR...
Disclosed are novel indanone derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical...
2016/0297788 REDUCTION OF HMF ETHERS WITH METAL CATALYST
Methods of making reduced derivatives of hydroxymethyl furfural using metal catalysts are described. The derivatives may have tetrahydrofuran or furan nucleus...
2016/0297787 PROCESS FOR PRODUCING FURAN AND ITS DERIVATIVES
An efficient, hydrogen gas-free, high yielding, moderate temperature and safe-to-handle process for producing furan and its derivatives from furfural, which...
2016/0297786 METHOD FOR PRODUCING HYDRIDE USING UNSATURATED COMPOUND HAVING CARBON NUMBER OF 4 AS RAW MATERIAL
The present invention relates to a method for producing a hydride having a carbon number of 4, comprising contacting, in liquid phase, an unsaturated compound...
2016/0297785 MONO- AND DIALKYL ETHERS OF FURAN-2,5-DIMETHANOL AND (TETRA-HYDROFURAN-2,5-DIYL)DIMETHANOL AND AMPHIPHILIC...
Linear mono- and dialkyl ethers of furan-2,5-dimethanol (FDM) and/or 2,5-bis(hydroxymethyl)tetrahydrofuran (bHMTHF), methods for their preparation, and...
2016/0297784 Taxanes Compounds, Preparation Method Therefor, and Uses Thereof
The present invention provides taxanes compounds with a formula (I) or formula (II) structure, a method for preparing the compounds, as well as the use of the...
2016/0297783 PROCESS FOR FORMING PROPYLENE OXIDE FROM OXIDATION OF METHYL BENZYL ALCOHOL
The present disclosure relates to a method of preparing propylene oxide comprising the steps: (a) oxidizing alpha-methylbenzyl alcohol with air to form a...
2016/0297782 CATALYST PERFORMANCE IN PROPYLENE EPOXIDATION
The present disclosure relates to a method of epoxidizing an olefin to form an epoxide, the method comprising contacting an alkene.sub.(C.ltoreq.12) or...
2016/0297781 CATALYST FOR THE EPOXIDATION OF ALKENES
The present invention relates to a catalyst for the epoxidation of alkenes, comprising silver, rhenium, cesium, lithium, tungsten and sulfur on a support. The...
2016/0297780 Preparation of Cobicistat Intermediates
The present disclosure provides crystalline piperidine sulfamoyl intermediates of formula 8 and 9. The present disclosure also relates to an improved process...
2016/0297779 MODIFIED OXAZINE RESIN AND USE OF A COMPOSITION COMPRISING THE SAME
The present disclosure is to provide a modified oxazine compound and use of a composition comprising the same.
2016/0297778 CRYSTALLINE FORMS OF LESINURAD AND ITS SODIUM SALT
Novel crystalline forms of lesinurad and its sodium salt, processes for their preparation, pharmaceutical compositions comprising these new forms, and use of...
2016/0297777 SMALL MOLECULE INHIBITORS OF PI3-KINASE SIGNALING
Provided are certain 1,2,3-triazole and 1,2,3-triazole dimer analogs of DM-PIT-1 which are second-generation selective non-phosphoinositide small molecule...
2016/0297776 MERCAPTOTRIAZOLE DRAG REDUCER FOR TRANSMISSION PIPELINE AND PREPARATION METHOD THEREFOR
The present invention provides a mercaptotriazole-based drag-reducing agent for gas pipelines and its preparation method. The drag-reducing agent is prepared...
2016/0297775 QUINAZOLINE DERIVATIVES AS TAM FAMILY KINASE INHIBITORS
Disclosed are compounds, compositions and methods for treating diseases, syndromes, conditions and disorders that are affected by the modulation of the...
2016/0297774 SUBSTITUTED QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have one of the following structures (I), (II) or (III): ...
2016/0297773 PROCESSES FOR THE PREPARATION OF PYRIMIDINYLCYCLOPENTANE COMPOUNDS
The present invention relates to a process for the preparation of a compound of formula (I), wherein R.sup.1 is as defined herein, which is useful as an...
2016/0297772 PROLYL HYDROXYLASE INHIBITORS
The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I) ##STR00001## which are antagonists of HIF...
2016/0297771 SUBSTITUTED URACILS AND USE THEREOF
The present application relates to novel substituted uracil derivatives of formula (I), to a method for the production thereof, to the use thereof either alone...
2016/0297770 FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE
Fumarate compounds, pharmaceutical compositions comprising the fumarate compounds, and methods of using fumarate compounds and pharmaceutical compositions for...
2016/0297769 Benzimidazoles and Their Use in the Treatment of Tuberculosis
The present invention relates to novel 2,5,6-benzimidazole derivatives and pharmaceutically acceptable salts thereof. Another aspect of the invention relates...
2016/0297768 NOVEL IMIDAZOLE DERIVATIVES AND THERAPEUTIC USE THEREOF
The present invention relates to a novel imidazole derivative, a pharmaceutical acceptable salt thereof, and a pharmaceutical composition containing the same...
2016/0297767 ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds...
2016/0297766 FUNGICIDE PYRAZOLE CARBOXAMIDES DERIVATIVES
The present invention relates to pyrazole carboxamides derivatives of formula (1) wherein Y represents CR.sup.5 or N, T represents S or O, X1 and X2 represent...
2016/0297765 NOVEL COMPOUNDS FOR CONTROLLING ARTHROPODS
The invention relates inter alia to compounds of the general formula (I) ##STR00001## in which the A.sub.1-A.sub.4, T, n, W, Q, R.sup.1 and B.sub.1-B.sub.4 ...
2016/0297764 AMIDE COMPOUND AND PHARMACEUTICAL COMPRISING SAME
Provided is a novel compound which has an excellent A.beta. aggregation inhibitory effect and is useful as a pharmaceutical. An amide compound represented by...
2016/0297763 Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral...
The present invention relates to a compound having the general formula I, optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph,...
2016/0297762 S1P3 ANTAGONISTS
The present invention relates to antagonists of the S1P3 receptor formula (A) as herein described and pharmaceutical compositions thereof. The compounds of...
2016/0297761 NOVEL INHIBITORS OF GLUTAMINASE
The present disclosure provides compounds of formula (I) to (III) as glutaminase inhibitors, methods of preparing them, pharmaceutical compositions containing...
2016/0297760 TERT-BUTYL N-[2-ETHYL]-L-ALANINATE OR A SALT,HYDRATE OR SOLVATE THEREOF
The present invention provides a compound which is: tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-diflu- ...
2016/0297759 PROCESS FOR LARGE SCALE PRODUCTION OF ...
A process suitable for adoption to large scale manufacture of 1-[(2-bromophenyl-sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-- 1H-indole dimesylate...
2016/0297758 PYRROLIDINYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS
Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R.sup.1, R.sup.2, R.sup.a,...
2016/0297757 POLYSUBSTITUTED PYRROLES HAVING MICROTUBULE-DISRUPTING, CYTOTOXIC AND ANTITUMOR ACTIVITIES AND METHODS OF USE...
The present invention provides polysubstituted pyrrole compounds, pharmaceutically effective salts, prodrugs, solvates and hydrates thereof, having...
2016/0297756 PYRROLIDINONES AS HERBICIDES
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5,...
2016/0297755 RADICAL POLYMERIZATION INITIATOR AND METHOD FOR PRODUCING POLYMERS
The present invention involves a radical polymerization initiator comprising an organotellurium compound represented by a formula (1), wherein R.sup.1...
2016/0297754 N-SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF
The invention provides novel compounds having the general formula: ##STR00001## and pharmaceutically acceptable salts thereof, wherein the variables R.sup.A,...
2016/0297753 OXIDE CATALYST AND METHOD FOR PRODUCING SAME, AND METHOD FOR PRODUCING UNSATURATED NITRILE
There is provided a method for producing an oxide catalyst, the method including a step (a) of obtaining an aqueous mixed liquid A containing Mo, V and Sb, a...
2016/0297752 REAGENTS AND METHODS FOR ESTERIFICATION
Methods and reagents for esterification of biological molecules including proteins, polypeptides and peptides. Diazo compounds of formula I: ##STR00001## where R...
2016/0297751 NOVEL BIS-AMIDE DERIVATIVE AND USE THEREOF
The present invention relates to a novel bis-amide derivative compound or a pharmaceutically acceptable salt thereof; a method of preparation thereof; and a...
2016/0297750 METHOD FOR PRODUCING AMIDE DERIVATIVE
An amide derivative represented by Formula (3), which exhibits excellent efficacy in pest control effect, is produced by allowing a compound represented by the...
2016/0297749 ALTERNATIVE PROCESS FOR THE PURIFICATION OF AN INTERMEDIATE IN THE SYNTHESIS OF NON-IONIC X-RAY CONTRAST AGENTS
Alternative continuous downstream processes for the production of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide ("Compound A") are...
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