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Patent # Description
2016/0304637 A PREPARATION METHOD OF A SUPPORTED METALLOCENE CATALYST
The present invention relates to a preparation method of a highly active supported metallocene catalyst which can prepare a polyolefin of high bulk density....
2016/0304636 VINYL CHLORIDE POLYMER AND PREPARATION METHOD THEREOF
The present invention relates to a vinyl chloride polymer having good thermal stability due to the restraint of dehydrochlorination by heat or ultraviolet...
2016/0304635 ELASTOMER COMPOSITIONS WITH SILANE FUNCTIONALIZED SILICA AS REINFORCING FILLERS
Certain embodiments described herein are directed to silane functionalized fillers that may be, for example, covalently coupled to a polymer. In some examples,...
2016/0304634 PHOSPHONIUM IONOMERS COMPRISING PENDANT VINYL GROUPS AND PROCESSES FOR PREPARING SAME
The present invention relates to ionomers comprising a reaction product of the reaction between a halogenated isoolefin copolymer and at least one phosphorus...
2016/0304633 AZIDE-CONTAINING FLUOROPOLYMERS AND THEIR PREPARATION
Fluoropolymers containing one or more azide group wherein the azide group is not a sulfonyl-azide group and processes of preparing them.
2016/0304632 METHOD FOR PRODUCING POLYVINYL ALCOHOL
A method for producing polyvinyl alcohols by means of catalytic reactions of alcoholic polyvinyl ester solutions in extruders, wherein the polyvinyl esters are...
2016/0304631 PROCESS FOR SEPARATING COMPONENTS OF A REACTION MIXTURE OBTAINED BY HIGH-PRESSURE POLYMERIZATION OF...
The present disclosure generally relates to a process for separating polymeric and gaseous components of a reaction mixture obtained by high-pressure...
2016/0304630 POROUS CYCLODEXTRIN POLYMERIC MATERIALS AND METHODS OF MAKING AND USING SAME
A nucleophilic substitution reaction to crosslink cyclodextrin (CD) polymer with rigid aromatic groups, providing a high surface area, mesoporous CD-containing...
2016/0304629 USE OF POLY ALPHA-1,3-GLUCAN ETHERS AS VISCOSITY MODIFIERS
A hydrocolloid or aqueous solution comprising a poly alpha-1,3-glucan ether compound is disclosed having a viscosity of at least about 10 centipoise (cPs). The...
2016/0304628 MULTIVALENT GLYCOPEPTIDES THAT TIGHTLY BIND TO TARGET PROTEINS
The invention relates to a glycopolypeptide that includes one or more modified amino acid residues having a sidechain comprising a monosaccharide or an...
2016/0304627 ACCEPTOR FRAMEWORK FOR CDR GRAFTING
The present invention relates to an antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a particularly...
2016/0304626 In Vivo Method for Generating Diversity in a Protein Scaffold
A transgenic non-human animal is provided. In certain embodiments, the animal comprises a genome comprising an immunoglobulin heavy chain locus comprising: a)...
2016/0304625 ANTIBODIES TARGETING B-CELL RECEPTOR COMPLEX MEMBRANE BOUND IGM AND USES THEREOF
The present invention relates to antibodies targeting the membrane bound IgM (mIgM) of the B-cell receptor complex found in B-cell lymphomas and leukemias and...
2016/0304624 Cell-Based Anti-Cancer Compositions With Reduced Toxicity and Methods of Making and Using the Same
Isolated pluralities of T cells which recognize at least one epitope of an intestinal cancer antigen or CNS cancer antigen and pharmaceutical compositions...
2016/0304623 METHOD FOR MANUFACTURING DIGESTIVE ENZYME ANTIBODY AND EGG HAVING SAME, AND FOR MANUFACTURING PROCESSED PRODUCT...
There are many reports of diseases caused by overeating, satiation, and an unbalanced diet, and various therapeutic methods and therapeutic drugs are proposed...
2016/0304622 HUMAN ANTIBODY AGAINST AGGRECANASE-TYPE ADAMTS SPECIES FOR THERAPEUTICS OF AGGRECANASE-RELATED DISEASES
The present invention provides an antibody that specifically binds to human aggrecanase, and inhibits enzymatic activity of the human aggrecanase. In one...
2016/0304621 ANTI-HER2 ANTIBODY AND CONJUGATE THEREOF
Disclosed are an anti-HER2 antibody and conjugate of the anti-HER2 antibody and small molecule medicine. Also disclosed are uses of the antibody and conjugate...
2016/0304620 Preparations and Methods for Treating a GD2 Positive Cancer
The present invention relates to preparations and methods for treating a GD2 positive cancer by administering a preparation comprising a chimeric or humanized...
2016/0304619 RECEPTOR TYROSINE KINASE-LIKE ORPHAN RECEPTOR 1 (ROR1) SINGLE CHAIN FV ANTIBODY FRAGMENT CONJUGATES AND METHODS...
Compositions including an antibody single-chain variable fragment (scFv) conjugate that specifically binds to ROR1 tumor-associated antigen are provided. The...
2016/0304618 ANTIBODIES FOR DIAGNOSIS OF ACUTE MYELOID LEUKEMIA
A polypeptide in particular an antibody or antibody fragment is disclosed wherein the polypeptide is corresponding to certain complementarity determining...
2016/0304617 5T4-TARGETED IMMUNOFUSION MOLECULE AND METHODS
Immunofusion molecules useful for 5T4-targeted therapy. The immunofusion molecules include the 5T4 anti-gen-binding portion of an anti-5T4 antibody engineered...
2016/0304616 METHOD OF TREATMENT OF PHILADELPHIA CHROMOSOME POSITIVE LEUKEMIA
The invention provides a method for the treatment of Ph+ leukemia in a patient comprising administering to the patient (i) a BCR-ABL tyrosine kinase inhibitor,...
2016/0304615 ANTI-EGFRvIII ANTIBODIES AND USES THEREOF
The present invention provides antibodies that bind to the class III variant of EGFR (EGFRvIII) and methods of using the same. According to certain...
2016/0304614 Antigen Binding Molecules That Bind EGFR, Vectors Encoding Same, and Uses Thereof
The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal...
2016/0304613 NEUROPILIN ANTAGONISTS
Novel anti-NRP1 antibodies and variants thereof having unique structural and functional characteristics are disclosed. Also provided are uses of the antibodies...
2016/0304612 Anti-P Selectin Antibodies and Methods of Their Use and Identification
Antibodies are disclosed which bind specifically to P-selectin and which block the binding of PSGL-1 to P-selectin. These anti-P-selectin antibodies may also...
2016/0304611 COMBINATION THERAPY FOR TREATING ADULT PATIENTS WITH RELAPSED/REFRACTORY CD22+ B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
The present invention relates to use of combination therapy with an anti-CD22 antibody, such as epratuzumab or hRFB4, and another therapeutic agent for...
2016/0304610 ANTIBODIES TO ICOS
Provided herein are various embodiments relating to antibodies. Some of the embodiments include agonist antibodies that bind ICOS. Such antibodies can be used...
2016/0304609 HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODIES TO CD47
Humanized or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to and neutralize human CD47, and find use in various therapeutic...
2016/0304608 FC RECEPTOR BINDING PROTEINS
The disclosure relates to antibodies that bind FcRn and methods of using these antibodies.
2016/0304607 COMPOSITIONS COMPRISING A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND ANOTHER ANTIBODY
This provides pharmaceutical compositions that comprise a combination of an anti-cancer agent which is an first antibody and a second antibody. In some...
2016/0304606 ANTIBODIES TO HUMAN PROGRAMMED DEATH RECEPTOR PD-1
Antibodies which block binding of hPD-1 to hPD-L1 or hPD-L2 and their variable region sequences are disclosed. A method of increasing the activity (or reducing...
2016/0304605 ANTIBODIES AGAINST KIDNEY ASSOCIATED ANTIGEN 1 AND ANTIGEN BINDING FRAGMENTS THEREOF
Novel antibodies and antigen binding fragments that specifically bind to KAAG1 and which may be used in the treatment, detection and diagnosis of cancer...
2016/0304604 ANTI-PACAP ANTIBODIES AND USES THEREOF
The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies...
2016/0304603 METHODS FOR MODULATING MANNOSE CONTENT OF RECOMBINANT PROTEINS
The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.
2016/0304602 METHODS OF TREATING DISEASES
This invention generally relates to methods for the treatment of respiratory diseases, such as asthma, utilizing anti-IL-23A antibodies.
2016/0304601 Stable Aqueous Formulations of Adalimumab
The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these...
2016/0304600 Stable Aqueous Formulations of Adalimumab
The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these...
2016/0304599 Stable Aqueous Formulations of Adalimumab
The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these...
2016/0304598 PRODUCTION CELL LINE ENHANCERS
The present invention relates to discovery of the ectopic expression of EDEM2 in a production cell to improve the yield of a useful multi-subunit protein....
2016/0304597 TREATING CANCER
This document relates to methods and materials involved in treating cancer (e.g., melanoma). For example, methods and materials involved in using an...
2016/0304596 HUMAN ANTI-NGF NEUTRALIZING ANTIBODIES AS SELECTIVE NGF PATHWAY INHIBITORS
This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also...
2016/0304595 METHODS OF INCREASING STRENGTH AND FUNCTIONALITY WITH GDF8 INHIBITORS
The disclosure provides compositions, kits, and methods of using a GDF-8 inhibitor to increase lean muscle mass. In embodiments, a GDF-8 inhibitor is an...
2016/0304594 TREATMENT WITH ANTI-VEGF ANTIBODIES
This invention concerns in general treatment of diseases and pathological conditions with anti-VEGF antibodies. More specifically, the invention concerns the...
2016/0304593 Anti-PHF-tau Antibodies and Their Uses
The present invention relates to anti- PHF-tau antibodies and methods of making and using them.
2016/0304592 SPARC BINDING SCFVS
The invention provides compositions comprising SPARC binding ScFc and its use.
2016/0304591 ANTI-POLYUBIQUITIN ANTIBODIES
The invention provides anti-polyubiquitin antibodies and methods of using the same.
2016/0304590 Pharmaceutical Composition
The present invention relates to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by...
2016/0304589 OPTIMIZED Fc VARIANTS
The present invention relates to Fc variants having decreased affinity for Fc.gamma.RIIb, methods for their generation, Fc polypeptides comprising optimized Fc...
2016/0304588 PERTUSSIS ANTIBODIES AND USES THEREOF
Compositions and methods are provided that are useful to treat respiratory diseases such as whooping cough. Further, compositions and methods of immunizing are...
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