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Patent # Description
2016/0304587 Lipopolysaccharide-Targeted Peptide Mimic Vaccine Against Q Fever
A vaccine and method of vaccination for conferring immunity to Q fever is described. The vaccine comprises a polypeptide with a sequence of SLTWHKHELHRK...
2016/0304586 PROCESS FOR PREPARING INFLUENZA VACCINES
This disclosure provides a novel process for testing an influenza virus preparation for the presence of extraneous agents. The disclosure further provides a...
2016/0304585 TRANSGENIC ANIMAL FOR PRODUCTION OF ANTIBODIES HAVING MINIMAL CDRS
A transgenic animal is provided. In certain embodiments, the transgenic animal comprises a genome comprising: an immunoglobulin light chain locus comprising:...
2016/0304584 MAFB MUTANTS AND USES THEREOF
The present invention relates to MafB mutants and uses thereof for research, screening and therapeutic purposes. In particular, the present invention relates...
2016/0304583 PURIFICATION OF CELL CULTURE DERIVED ALPHA1 PROTEASE INHIBITOR
Described herein are methods for purifying recombinant, cell culture derived alpha.sub.1-protease inhibitor and removing a colored species that co-purifies...
2016/0304582 MOLECULAR ADJUVANT
The invention relates to the use of a molecular adjuvant to generate an improved immune response in a host. Over recent years extensive research and...
2016/0304581 B7X AND ITS DERIVATIVES FOR TREATING AND PREVENTING CARDIOVASCULAR DISEASE
Methods are disclosed for preventing and/or treating cardiovascular diseases comprising administering B7x or a derivative of B7x to a patient in need thereof.
2016/0304580 CD86 VARIANTS WITH IMPROVED AFFINITY FOR CTLA-4
The invention provides a polypeptide that specifically binds to CTLA-4, particularly human CTLA-4.
2016/0304579 POLYPEPTIDES AND USES THEREOF FOR TREATMENT OF AUTOIMMUNE DISORDERS AND INFECTION
This invention relates to C1ORF32 protein and its variants and fragments and fusion proteins thereof, pharmaceutical composition comprising same and methods of...
2016/0304578 INSERTABLE VARIABLE FRAGMENTS OF ANTIBODIES AND MODIFIED A1-A2 DOMAINS OF NKG2D LIGANDS
This application relates generally to the production of polypeptides having specific antigen-binding properties of Fv domains, for example, insertable variable...
2016/0304577 GLYCOSYLATED GLYCOPHORIN PEPTIDES
The present invention pertains to glycosylated peptides of the glycophorin protein and their use in medicine. In particular, the peptides carry a carbohydrate...
2016/0304576 GLUCAGON ANALOGUES
The invention provides materials and methods for promoting weight loss or preventing weight gain without affecting glycemic control. In particular, the...
2016/0304575 METHOD FOR PURIFYING RECOMBINANT FSH
The present invention relates to a method for purifying a recombinant follicle stimulating hormone (FSH) or recombinant FSH variant. The method comprises the...
2016/0304574 COMPOSITIONS AND METHODS FOR TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES AND DISORDERS
The present application discloses a novel fusion peptide of IL-2 and IL-33 and its use. It comprises a biologically active domain of Interleukin-2 (IL-2) or a...
2016/0304573 FIBROMODULIN PEPTIDE
Disclosed herein is a method of making a fibromodulin peptide (FMOD-P), compositions thereof, and methods of using the FMOD-P and the compositions thereof for...
2016/0304572 PRODUCTION OF RECOMBINANT LUBRICIN
Disclosed are new recombinant isoforms of human-like lubricin or PRG4 glycoprotein having outstanding lubrication properties and a novel glycosylation pattern,...
2016/0304571 Synthesis of Site Specifically-Linked Ubiquitin
The invention relates to a method of modifying a specific lysine residue in a polypeptide comprising at least two lysine residues, said method comprising (a)...
2016/0304570 POTENT AND SELECTIVE INHIBITORS OF NAV1.3 AND NAV1.7
Disclosed is a composition of matter comprising an isolated polypeptide, which is a peripherally-restricted Na.sub.V1.7 inhibitor. In some disclosed...
2016/0304569 INSECTICIDAL PROTEINS
Compositions and methods for controlling plant pests are disclosed. In particular, novel engineered hybrid insecticidal proteins (eHIPs) having toxicity to at...
2016/0304568 INSECTICIDAL PROTEINS
Compositions and methods for controlling plant pests are disclosed. In particular, novel engineered hybrid insecticidal proteins (eHIPs) having toxicity to at...
2016/0304567 METHODS AND COMPOSITIONS FOR THE DISPLAY OF POLYPEPTIDES ON THE PILI OF GRAM- POSITIVE BACTERIA
Provided herein are methods and compositions for the display of polypeptides of interest on the tip of pili of Gram-positive bacteria. According to the present...
2016/0304566 STAPHYLOCOCCUS AUREUS SPA5 MUTANT, COMPOSITION COMPRISING MUTANT AND PREPARATION METHOD AND USE THEREOF
Provided is staphylococcus protein A expressed by a mutational Staphylococcus aureus and its coding sequence, as well as a vector, host bacteria, composition...
2016/0304565 RECOMBINANT RESPIRATORY SYNCYTIAL VIRUS G PROTEIN FRAGMENTS
Compositions and methods useful for producing an immune response in a subject specific for the RSV G protein are described herein. The new methods and...
2016/0304564 TRIAZOLE MACROCYCLE SYSTEMS
The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming...
2016/0304563 PEPTIDE INHIBITORS OF BACE1
The invention provides peptide inhibitors of BACE1 that bind to the active site in a noncanonical fashion, and methods of use thereof.
2016/0304562 Cell penetrating protein adaptor molecules and their application in research and medicine
Cell penetrating peptides (CPPs) are established as a strategy to move cargoes into the interior of eukaryotic cells by engaging import machinery on the cell...
2016/0304561 GLYCOPEPTIDE COMPOSITIONS AND USES THEREOF
The present disclosure provides glycosylated oligopeptides having the sequence Palmitoyl-X1-Lys-X2-X3-Lys-X4-OH, where: X1 is: absent, Ser having a...
2016/0304560 PAR4 AGONIST PEPTIDES
The present invention provides PAR4 agonist peptides. These peptides are useful for developing robust PAR4 receptor assays.
2016/0304559 PEPTIDE BASED INHIBITION OF caPCNA INTERACTION IN CANCER
Peptides derived from cancer specific isoform of proliferating cell nuclear antigen (caPCNA, also known as csPCNA) or from nmPCNA-interacting proteins...
2016/0304558 CATIONIC LIPID FORMULATIONS FOR REGRESSING ESTABLISHED TUMOR
The present invention discloses an integrin receptor targeting novel cationic CGKRK-lipopeptide. The present invention further discloses a liposomal...
2016/0304557 Method for preventing or treating heart diseases by using a composition containing an isolated peptide
This present invention discloses an isolated peptide which amino acid sequence is SEQ ID NO.:1. The isolated peptide can inhibit the expressions of signal...
2016/0304556 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a...
2016/0304555 PSMA Imaging Agents
Compounds for targeting and agents for imaging, Prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents,...
2016/0304554 PROCESS FOR THE MANUFACTURE OF CYCLIC UNDECAPEPTIDES
The present invention relates to processes and intermediates useful for the manufacture of cyclic undecapeptides, such as Alisporivir.
2016/0304553 ARAMCHOL SALTS
Provided are salts of arachidyl amido cholanoic acid (Aramchol), pharmaceutical compositions including Aramchol salts, methods for their preparation, and...
2016/0304552 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF
The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.
2016/0304551 A PROCESS FOR THE PREPARATION OF REGADENOSON
The present invention provides novel processes for the preparation of regadenoson having the formula (I). In some embodiments, the intermediates for the...
2016/0304550 Gemcitabine Derivatives, Compositions Comprising Same and Pharmaceutical Applications Thereof
The invention provides gemcitabine derivatives shown in the following formula (I) and preparation methods thereof. The invention further relates to a...
2016/0304549 CRYSTALLINE PHASES OF 5,6-DICHLORO-2-(ISOPROPYLAMINO)-(1-BETA-L-RIBOFURANOSYL)-1H-BENZIMIDAZOLE
The invention relates to novel crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-(.beta.-L-ribofuranosyl)-1H-benzimidazo- le (Maribavir), pharmaceutical...
2016/0304548 Derivatives of Amphotericin B
Disclosed are derivatives of amphotericin B (AmB) characterized by improved therapeutic index compared to AmB. The AmB derivatives include C16 ureas,...
2016/0304547 MACROLIDE COMPOUND
The present disclosure relates to a macrolide compound as shown by formula I and pharmaceutically acceptable salt thereof. The compound of the present...
2016/0304546 COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER
The present invention relates generally to the field of anti-cancer therapy. More particularly, it provides novel crystalline forms of organic arsenic...
2016/0304545 COMPOUND FOR BONE SCANNING AND USE THEREOF
The disclosure provides a compound comprising bisphosphonate functional group and chelating agent. The bisphosphonate functional group part has high affinity...
2016/0304544 Oxidized Lipids and Methods of Use Thereof
The present invention is directed to oxidized lipids and pharmaceutical compositions comprising the same. The present invention is also directed to methods of...
2016/0304543 LIGAND COMPOUND, CATALYST SYSTEM FOR OLEFIN OLIGOMERIZATION, AND METHOD FOR OLEFIN OLIGOMERIZATION USING THE...
This disclosure relates to a ligand compound, a catalyst system for olefin oligomerization, and a method for olefin oligomerization using the same. The...
2016/0304542 VANADIUM-CONTAINING FILM FORMING COMPOSITIONS AND VAPOR DEPOSITION OF VANADIUM-CONTAINING FILMS
Vanadium-containing film forming compositions are disclosed, along with methods of synthesizing the same, and methods of forming Vanadium-containing films on...
2016/0304541 Hydrolysis-Stable Mesoporous Silica Material and Method for Producing It
A hydrolysis-stable mesoporous silica material has a surface bearing functional groups of formula O.sub.xSiR.sub.4-x, where x is in a range from 1-3 and where...
2016/0304540 SYNTHESIS METHOD OF ALKOXYSILANES
The direct depolymerization of biogenic and other high surface area silica sources uses both simple and hindered diols to produce alkoxysilanes in one or two...
2016/0304539 BETA-LACTAMASE INHIBITORS
Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit...
2016/0304538 COMPOSITION OF MATTER
The method relates to the field of asymmetric allylic amination and comprises preparing a chiral N-substituted allylic amine compound from the corresponding...
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