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Patent # Description
2016/0304537 SOLUBLE GUANYLATE CYCLASE ACTIVATORS
A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate...
2016/0304536 SOLUBLE GUANYLATE CYCLASE ACTIVATORS
A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate...
2016/0304535 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY
The present invention is to provide a novel compound (I) shown below, having the anti-virus activity; particularly the HIV integrase inhibitory activity, and a...
2016/0304534 GAMMA SECRETASE MODULATORS
Disclosed herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein each of the substituents is given the definition as set...
2016/0304533 COMPOUNDS, COMPOSITIONS AND METHODS FOR INHIBITING CNKSR1
Compounds that inhibit CNKSR1, pharmaceutical compositions including compounds that inhibit CNKSR1 and methods of treating disease or disorders that respond to...
2016/0304532 FURO[3,4-b]PYRAN COMPOUNDS AND PHARMACEUTICAL USES
Furo[3,4-b]pyran compounds similar in chemical structure to the natural product known as TAN-2483B and their use for treating cancer, osteoporosis, Type 2...
2016/0304531 MACROCYCLIC DEAZA-PURINONES FOR THE TREATMENT OF VIRAL INFECTIONS
This invention relates to macrocyclic deaza-purinones derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating...
2016/0304530 Fused Tricyclic Imidazole Derivatives As Modulators of TNF Activity
A series of substituted fused tricyclic imidazole derivatives, in particular dihydro-1H-pyrano[4',3':4,5]imidazo[1,2-a]pyridine, ...
2016/0304529 Novel Opioid Compounds and Their Uses
The present invention relates to opioid compounds, especially to C14 esters and ethers of naltrexone and analogues thereof. The present invention also relates...
2016/0304528 PHARMACEUTICAL COMPOSITIONS COMPRISING PERILLYL ALCOHOL DERIVATIVES
A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated...
2016/0304527 SUBSTITUTED PYRAZOLOPYRIMIDINES AND METHOD OF USE
Compounds of formula (I) ##STR00001## and pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, L.sup.1 and G.sup.1 are as...
2016/0304526 INDAZOLONES AS MODULATORS OF TNF SIGNALING
The disclosure provides compounds of Formula (I) ##STR00001## pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and...
2016/0304525 Cyclopenta[d]pyrimidines And Substituted Cyclopenta[d]pyrimidines As Antitubulin and Microtubule Targeting...
The present invention provides a compound of Formula I, and salts thereof, and a pharmaceutical composition comprising a compound of Formula I: ##STR00001## ...
2016/0304524 IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN-ALPHA RESPONSES
Compounds having the following formula (I), or a stereoisomer or pharmaceutically-acceptable salt thereof, where R.sup.1, R.sup.2, R.sup.3, R.sup.4, and...
2016/0304523 Fused Tricyclic Benzimidazoles Derivatives As Modulators of TNF Activity
A series of tricyclic benzimidazole derivatives, in particular dihydro-1H-imidazo [1,2-a]benzimidazole, dihydro-1H-pyrrolo [1,2-a]benzimidazole,...
2016/0304522 Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce...
2016/0304521 NOVEL N-ACYL-(3-SUBSTITUTED)-5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRA- ZINES AS SELECTIVE NK-3 RECEPTOR...
Novel compounds of Formula I ##STR00001## and their use in therapeutic treatments.
2016/0304520 An improved process for preparing Linagliptin and its key Intermediates
The present invention relates to a process for the preparation of Linagliptin or a pharmaceutically acceptable slat thereof. Further aspects of the present...
2016/0304519 SERINE/THREONINE KINASE INHIBITORS
Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases....
2016/0304518 SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS
The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment...
2016/0304517 TRICYCLIC MODULATORS OF TNF SIGNALING
The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and...
2016/0304516 INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic...
2016/0304515 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIM CHANNEL
The present invention provides compounds of Formula (I) (Formula (I)) including pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK...
2016/0304514 Tetrahydroimidazopyridine Derivatives As Modulators of TNF Activity
A series of substituted 4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are...
2016/0304513 Imidazopyridine Derivatives As Modulators of TNF Activity
A series of substituted 3H imidazo[4,5-b]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the...
2016/0304512 Triazolopyridine Derivatives As Modulators of TNF Activity
A series of substituted [1,2,4]triazolo[4,3-a]pyridine derivatives, being potent modulators of human TNF activity, are accordingly of benefit in the treatment...
2016/0304511 Imidazopyridine Derivatives As Modulators of TNF Activity
A series of substituted 1H imidazo[4,5-b]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the...
2016/0304510 IMIDAZOLONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
This application relates to imidazolone compounds, pharmaceutically acceptable salts, solvents, polymorphs or prodrugs thereof, and further relates to...
2016/0304509 HERBICIDAL 3-(2-BENZYLOXYPHENYL)-2,4-DIHYDROXY-1,8-NAPHTHYRIDINE DERIVATIVES
The present invention relates to herbicidal benzyloxy-substituted phenyl-diones and phenyl-dioxo-thiazinones of formula (I), as well as to herbicidal...
2016/0304508 COMPOUND, AND INK, COLOR FILTER RESIST COMPOSITION, THERMAL TRANSFER RECORDING SHEET AND TONER CONTAINING THE SAME
A lightfast orange color compound is provided. The compound has a structure including a pyrazolone ring and a thiazole ring that are bound to each other.
2016/0304507 SUBSTITUTED PYRAZOLE COMPOUNDS AS CRAC MODULATORS
The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium...
2016/0304506 SUBSTITUTED PYRIDINE COMPOUNDS AS CRAC MODULATORS
The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium...
2016/0304505 2-ACYLAMIDOMETHYL AND SULFONYLAMIDOMETHYL BENZOXAZINE CARBAMATES FOR INHIBITION OF RORgamma ACTIVITY AND THE...
The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.a,...
2016/0304504 CRYSTALLINE FORMS OF N-(4-((3-(2-AMINO-4-PYRIMIDINYL)-2-PYRIDINYL)OXY)PHENYL)-4-(4-METHYL ...
The present invention relates to crystalline forms and co-crystal forms of pharmaceutically acceptable salts of the compound, ...
2016/0304503 TAZAROTENE WITH LOW DIMER IMPURITY FOR TREATING ACNE OR PSORIASIS
The present invention relates to a method of treating acne or psoriasis by topically administering Tazarotene substantially free of dimer impurity of formula ...
2016/0304502 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels....
2016/0304501 COMPOUND HAVING HIGHER INHIBITORY ACTIVITY ON PROTEIN KINASE G AND PREPARATION METHOD THEREOF
Disclosed are a compound of Formula I, ##STR00001## having higher inhibition of protein kinase G (PKG) activity and pharmaceutically acceptable salts thereof. In...
2016/0304500 Methods of Promoting Wound Healing Using CRM1 Inhibitors
The invention generally relates to the use of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by...
2016/0304499 LXR MODULATORS
The present invention provides compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as modulators of liver X receptors (LXR),...
2016/0304498 INHIBITORS OF CELLULAR NECROSIS AND RELATED METHODS
A compound having the following structure (I): ##STR00001## or a pharmaceutically acceptable salt, prodrug, stereoisomer or tautomer thereof, is provided....
2016/0304497 INHIBITORS OF BRUTON'S TYROSINE KINASE
This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds...
2016/0304496 INDAZOLONES AS MODULATORS OF TNF SIGNALING
The disclosure provides indazolone compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof...
2016/0304495 MONOCYCLIC PYRIMIDINE/PYRIDINE COMPOUNDS AS INHIBITORS OF P97 COMPLEX
Monocyclic pyrimidine and pyridine compounds having a benzyl amine substituent at the 4 position and a 5:6 bicyclic heteroaryl substituent at the 2 position of...
2016/0304494 PYRIMIDINYL TYROSINE KINASE INHIBITORS
The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable...
2016/0304493 5-(Pyridin-2-yl-Amino)-Pyrazine-2-Carbonitrile Compounds and Their Therapeutic Use
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain ...
2016/0304492 SUBSTITUTED BIPIPERIDINYL DERIVATIVES
The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of...
2016/0304491 SUBSTITUTED PIPERIDINYLTETRAHYDROQUINOLINES
The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or...
2016/0304490 2-PYRIDYLOXY-3-ESTER-4-ETHER OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to 2-pyridyloxy-3-ester-4-ether compounds which are antagonists of orexin receptors. The present invention is also directed...
2016/0304489 Particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2- ...
The present invention relates to particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2- ...
2016/0304488 INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/BETA-CATENIN SIGNALING PATHWAY INHIBITORS
Indazole-3-carboxamide compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an...
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