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Patent # Description
2016/0304487 CATIONIC LIPID
The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R.sup.1 and...
2016/0304486 INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS
This invention relates to indoline compounds of the structural formula: ##STR00001## or their pharmaceutically acceptable salts, wherein the variables are ...
2016/0304485 SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having benzoic acid structure...
2016/0304484 SELECTIVE AEROBIC OXIDATIONS USING CARBON NITRIDE NANOTUBES
The present invention discloses an improved oxidation process using carbon nitride nanotubes as metal free catalyst and molecular O2 as the oxidant to obtain...
2016/0304483 Peloruside Analogs
The present invention provides new therapeutic compounds for treatment of diseases caused or influenced by microtubule stability, such as proliferative...
2016/0304482 METHOD FOR PRODUCING 2-FURALDEHYDE
An object of the present invention is to provide a method for suppressing the corrosion of a reactor and reducing waste in the production of 2-furaldehyde from...
2016/0304481 PRODUCTION OF FURFURAL FROM XYLOSE
Described is a method for producing furfural from one or more substances selected from the group consisting of xylose, oligosaccharides comprising xylose units...
2016/0304480 METHOD FOR PREPARING FURAN DERIVATIVES FROM BIOMASS
The present invention relates to a method for preparing for a furan derivative from biomass, comprising step (1) of preparing 5-hydroxymethylfurfural by...
2016/0304479 SULFONATES OF FURAN-2,5-DIMETHANOL AND (TETRAHYDROFURAN-2,5-DIYL)DIMETHANOL AND DERIVATIVES THEREOF
A process for preparing furanic mono- and/or di-sulfonate molecules from the reduction products of HMF, in particular, from either ...
2016/0304478 NOVEL COMPOUNDS
The present invention is directed to novel retinoid-related orphan receptor gamma (ROR.gamma.) modulators, processes for their preparation, pharmaceutical...
2016/0304477 NOVEL METABOLITES OF VANOXERINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS OF...
Disclosed embodiments are related to pharmaceutical compositions comprising novel piperazine compounds and methods of administration of the same to a patient...
2016/0304476 TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma...
The invention provides certain bicylic heterocyclic compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X.sup.1, X.sup.2,...
2016/0304475 METHODS FOR PRODUCING VILOXAZINE SALTS AND NOVEL POLYMORPHS THEREOF
Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction...
2016/0304474 METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES
Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture...
2016/0304473 EXCIMER FORMING COMPOUNDS
The present application is directed to excimer forming compounds of Formula I: W--V--[Y].sub.n wherein W is an excimer forming fluorophore, V is a linker...
2016/0304472 Hydrazide Containing Nuclear Transport Modulators and Uses Thereof
The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula...
2016/0304471 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
2016/0304470 Fused Bicyclic Heteroaromatic Derivatives As Modulators of TNF Activity
A series of substituted heteroaromatic compounds containing two fused six-membered rings, tivity, are accordingly of benefit in the treatment and/or prevention...
2016/0304469 2-Thiopyrimidinones
Myeloperoxidase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, cardiovascular...
2016/0304468 PROCESS FOR THE PREPARATION OF ROSUVASTATIN CALCIUM AND PREPARATION OF ITS NOVEL INTERMEDIATES
The present invention relates to process for the preparation of 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrim- ...
2016/0304467 FIPRONIL PRODUCTION PROCESS
An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethy- lsulphinyl-pyrazole, of formula (I) is...
2016/0304466 NOVEL COMPOUNDS AS JNK KINASE INHIBITORS
The present invention is directed to modulators, such as inhibitors, of JNK isoform 2 (JNK2) or isoform 3 (JNK3) comprising compounds of formula (I) or formula...
2016/0304465 ALKYLPYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF
The invention provides pyrazolyl guanidine compounds that inhibit F.sub.1F.sub.o-ATPase, and methods of using pyrazolyl guanidine compounds as therapeutic...
2016/0304464 N-SUBSTITUTED PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF
The invention provides pyrazolyl guanidine compounds that inhibit F.sub.1F.sub.0-ATPase, and methods of using pyrazolyl guanidine compounds as therapeutic...
2016/0304463 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF...
The present invention relates to certain 3-phenyl-pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of...
2016/0304462 3-SPIRO-7-HYDROXAMIC ACID TETRALINS AS HDAC INHIBITORS
The present invention is directed to inhibitors of histone deacetylases (HDACs) such as HDAC6, and their use in the treatment of diseases such as cell...
2016/0304461 QUINOLONE COMPOUND AND PHARMACEUTICAL COMPOSITION
The present invention provides a quinolone compound represented by General Formula (1) ##STR00001## or a salt thereof, wherein R.sub.1 represents a hydrogen...
2016/0304460 NOVEL ANTIFUNGAL OXODIHYDROPYRIDINECARBOHYDRAZIDE DERIVATIVE
The present invention relates to novel oxodihydropyridinecarbohydrazide derivatives with excellent antifungal activities, an antifungal composition containing...
2016/0304459 NOVEL COMPOUND, PRODUCTION METHOD THEREFOR, AND APPLICATION THEREFOR
[Problems] To provide a novel peptide synthesis technique that is completely different than heretofore, and to provide a novel compound that enables the...
2016/0304458 SYNTHESIS OF AN AZASUGAR AND THE INTERMEDIATES THEREOF
Process for the preparation of intermediates useful in the synthesis of miglustat and their use in its manufacture.
2016/0304457 METHOD FOR PREPARING STRUCTURED DIRECTING AGENT
Provided is a method for preparing a structure directing agent (SDA) for crystalline molecular sieve synthesis comprising the steps of (a) hydrolyzing analkyl...
2016/0304456 3-SPIROCYCLIC-6-HYDROXAMIC ACID TETRALINS AS HDAC INHIBITORS
The present invention is directed to inhibitors of histone deacetylases (HDACs) such as HDAC6 and HDAC11, and their use in the treatment of diseases such as...
2016/0304455 PROCESS FOR THE PREPARATION OF 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE AND INTERMEDIATES ...
The invention relates to a novel process for the preparation of rac-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (I) in pharmaceutically acceptable...
2016/0304454 PROCESS FOR THE PRODUCTION OF PHTHALIMIDES
The invention relates to a process to produce phthalimides by heating diammonium phthalate in the presence of aromatic solvents and to a process to produce...
2016/0304453 ANTIBIOTIC SENSITIVITY-RESTORING AND PHOTOSENSITIVE AGENTS
The present disclosure describes a method to treat conditions, including bacterial infections and cancer, using a photosensitive compound that, upon exposure...
2016/0304452 METHOD FOR PREPARING SILODOSIN AND INTERMEDIATE THEREOF
Provided is a method for preparing silodosin. Also provided is a method for preparing an organic acid salt of a new intermediate ...
2016/0304451 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases...
2016/0304450 ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
Described herein are compounds that are estrogen receptor modulators of Formula (I): ##STR00001## and stereoisomers, tautomers, or pharmaceutically ...
2016/0304449 METHOD FOR PRODUCING D-FORM OR L-FORM AMINO ACID DERIVATIVE HAVING THIOL GROUP
The object of the present invention is to provide a method of efficiently manufacturing an optically active D- and/or L-form amino acid possessing a thiol...
2016/0304448 ROR GAMMA (RORy) MODULATORS
A.sub.11-14 are N or CR.sub.11-14, respectively, maximum two of the four positions A simultaneously N; R.sub.1 is C(1-6)alkyl, C(3-6)cycloalkyl, ...
2016/0304447 A PROCESS FOR THE SYNTHESIS OF ARYL SULFONES
The present patent discloses a novel, efficient and transition-metal-free room temperature single step process for synthesis of aryl sulfones and substituted...
2016/0304446 PROCESS FOR PREPARING ALKANESULFONIC ACIDS
The present invention relates to a process for preparing alkanesulfonic acids from dialkyl disulfides with nitric acid and oxygen.
2016/0304445 N,N-BIS(2-AMINOALKYL)-1,2-ALKYL DIAMINE DERIVATIVES
The present invention relates to 2-N,N-(bis-2-aminoalkyl)-1,2-alkyldiamine derivatives of formula (I) as such, to a process for preparing the ...
2016/0304444 METHOD FOR SEPARATING ISOCYANATE MONOMERS
The invention relates to a method for the separation of isocyanate monomers from isocyanate-containing mixtures by the provision of the mixture in a solvent...
2016/0304443 HYDROXAMIC ACIDS AND USES THEREOF
Compounds of formula I are provided: ##STR00001## R.sub.1 is an alkoxy or O(CH.sub.2).sub.pX, p is an integer from 2 to 3 and X is OH, NH.sub.2, or CO.sub.2H, m...
2016/0304442 ARYL NAPHTHYL METHANONE OXIME(S) AND PROCESS FOR PREPARATION THEREOF
The present invention relates to substituted aryl naphthyl methanone oximes of general formula (I), their process for preparation and their derivatives, salts,...
2016/0304441 BENZAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF MUSCULAR DISORDERS AND PAIN AND FOR CONTROLLING SPASTICITY AND...
The present invention relates to a compound of formula I, or a pharmaceutically acceptable salt thereof : (I) wherein: n is 0 or 1; R1 is selected from H,...
2016/0304440 PURIFICATION OF X-RAY CONTRAST AGENTS
The present invention relates to a process for purification of iodinated X-ray contrast agents and in particular to purification of crude dimeric contrast...
2016/0304439 PROCESS FOR THE PREPARATION OF ADVANTAME
A novelprocess for the preparation of N--[N-[3-(3-hydroxy-4-methoxyphenyl)-propyl]-L-.alpha.-aspartyl]-L-phenyl- alanine-1-methyl ester is described. It...
2016/0304438 ALTERNATIVE ACETYLATION PROCESS IN THE SYNTHESIS OF NON-IONIC X-RAY CONTRAST AGENTS
An alternative acetylation process for the synthesis of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide ("Compound A"), an intermediate...
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