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The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R.sup.1 and...
INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS
This invention relates to indoline compounds of the structural formula: ##STR00001## or their pharmaceutically acceptable salts, wherein the variables are ...
SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having benzoic acid structure...
SELECTIVE AEROBIC OXIDATIONS USING CARBON NITRIDE NANOTUBES
The present invention discloses an improved oxidation process using carbon nitride nanotubes as metal free catalyst and molecular O2 as the oxidant to obtain...
The present invention provides new therapeutic compounds for treatment of diseases caused or influenced by microtubule stability, such as proliferative...
METHOD FOR PRODUCING 2-FURALDEHYDE
An object of the present invention is to provide a method for suppressing the corrosion of a reactor and reducing waste in the production of 2-furaldehyde from...
PRODUCTION OF FURFURAL FROM XYLOSE
Described is a method for producing furfural from one or more substances selected from the group consisting of xylose, oligosaccharides comprising xylose units...
METHOD FOR PREPARING FURAN DERIVATIVES FROM BIOMASS
The present invention relates to a method for preparing for a furan derivative from biomass, comprising step (1) of preparing 5-hydroxymethylfurfural by...
SULFONATES OF FURAN-2,5-DIMETHANOL AND
(TETRAHYDROFURAN-2,5-DIYL)DIMETHANOL AND DERIVATIVES THEREOF
A process for preparing furanic mono- and/or di-sulfonate molecules from the reduction products of HMF, in particular, from either ...
The present invention is directed to novel retinoid-related orphan receptor gamma (ROR.gamma.) modulators, processes for their preparation, pharmaceutical...
NOVEL METABOLITES OF VANOXERINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS
CONTAINING THE SAME AND METHODS OF...
Disclosed embodiments are related to pharmaceutical compositions comprising novel piperazine compounds and methods of administration of the same to a patient...
TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE AND RELATED BICYCLIC
COMPOUNDS FOR INHIBITION OF RORgamma...
The invention provides certain bicylic heterocyclic compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X.sup.1, X.sup.2,...
METHODS FOR PRODUCING VILOXAZINE SALTS AND NOVEL POLYMORPHS THEREOF
Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction...
METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES
Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture...
EXCIMER FORMING COMPOUNDS
The present application is directed to excimer forming compounds of Formula I: W--V--[Y].sub.n wherein W is an excimer forming fluorophore, V is a linker...
Hydrazide Containing Nuclear Transport Modulators and Uses Thereof
The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula...
CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
Fused Bicyclic Heteroaromatic Derivatives As Modulators of TNF Activity
A series of substituted heteroaromatic compounds containing two fused six-membered rings, tivity, are accordingly of benefit in the treatment and/or prevention...
Myeloperoxidase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, cardiovascular...
PROCESS FOR THE PREPARATION OF ROSUVASTATIN CALCIUM AND PREPARATION OF ITS
The present invention relates to process for the preparation of 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrim- ...
FIPRONIL PRODUCTION PROCESS
An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethy- lsulphinyl-pyrazole, of formula (I) is...
NOVEL COMPOUNDS AS JNK KINASE INHIBITORS
The present invention is directed to modulators, such as inhibitors, of JNK isoform 2 (JNK2) or isoform 3 (JNK3) comprising compounds of formula (I) or formula...
ALKYLPYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES
The invention provides pyrazolyl guanidine compounds that inhibit F.sub.1F.sub.o-ATPase, and methods of using pyrazolyl guanidine compounds as therapeutic...
N-SUBSTITUTED PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC
The invention provides pyrazolyl guanidine compounds that inhibit F.sub.1F.sub.0-ATPase, and methods of using pyrazolyl guanidine compounds as therapeutic...
3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN
RECEPTOR USEFUL FOR THE TREATMENT OF...
The present invention relates to certain 3-phenyl-pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of...
3-SPIRO-7-HYDROXAMIC ACID TETRALINS AS HDAC INHIBITORS
The present invention is directed to inhibitors of histone deacetylases (HDACs) such as HDAC6, and their use in the treatment of diseases such as cell...
QUINOLONE COMPOUND AND PHARMACEUTICAL COMPOSITION
The present invention provides a quinolone compound represented by General Formula (1) ##STR00001## or a salt thereof, wherein R.sub.1 represents a hydrogen...
NOVEL ANTIFUNGAL OXODIHYDROPYRIDINECARBOHYDRAZIDE DERIVATIVE
The present invention relates to novel oxodihydropyridinecarbohydrazide derivatives with excellent antifungal activities, an antifungal composition containing...
NOVEL COMPOUND, PRODUCTION METHOD THEREFOR, AND APPLICATION THEREFOR
[Problems] To provide a novel peptide synthesis technique that is completely different than heretofore, and to provide a novel compound that enables the...
SYNTHESIS OF AN AZASUGAR AND THE INTERMEDIATES THEREOF
Process for the preparation of intermediates useful in the synthesis of miglustat and their use in its manufacture.
METHOD FOR PREPARING STRUCTURED DIRECTING AGENT
Provided is a method for preparing a structure directing agent (SDA) for crystalline molecular sieve synthesis comprising the steps of (a) hydrolyzing analkyl...
3-SPIROCYCLIC-6-HYDROXAMIC ACID TETRALINS AS HDAC INHIBITORS
The present invention is directed to inhibitors of histone deacetylases (HDACs) such as HDAC6 and HDAC11, and their use in the treatment of diseases such as...
PROCESS FOR THE PREPARATION OF
6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE AND INTERMEDIATES
The invention relates to a novel process for the preparation of rac-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (I) in pharmaceutically acceptable...
PROCESS FOR THE PRODUCTION OF PHTHALIMIDES
The invention relates to a process to produce phthalimides by heating diammonium phthalate in the presence of aromatic solvents and to a process to produce...
ANTIBIOTIC SENSITIVITY-RESTORING AND PHOTOSENSITIVE AGENTS
The present disclosure describes a method to treat conditions, including bacterial infections and cancer, using a photosensitive compound that, upon exposure...
METHOD FOR PREPARING SILODOSIN AND INTERMEDIATE THEREOF
Provided is a method for preparing silodosin. Also provided is a method for preparing an organic acid salt of a new intermediate ...
APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases...
ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
Described herein are compounds that are estrogen receptor modulators of Formula (I): ##STR00001## and stereoisomers, tautomers, or pharmaceutically ...
METHOD FOR PRODUCING D-FORM OR L-FORM AMINO ACID DERIVATIVE HAVING THIOL
The object of the present invention is to provide a method of efficiently manufacturing an optically active D- and/or L-form amino acid possessing a thiol...
ROR GAMMA (RORy) MODULATORS
A.sub.11-14 are N or CR.sub.11-14, respectively, maximum two of the four positions A simultaneously N; R.sub.1 is C(1-6)alkyl, C(3-6)cycloalkyl, ...
A PROCESS FOR THE SYNTHESIS OF ARYL SULFONES
The present patent discloses a novel, efficient and transition-metal-free room temperature single step process for synthesis of aryl sulfones and substituted...
PROCESS FOR PREPARING ALKANESULFONIC ACIDS
The present invention relates to a process for preparing alkanesulfonic acids from dialkyl disulfides with nitric acid and oxygen.
N,N-BIS(2-AMINOALKYL)-1,2-ALKYL DIAMINE DERIVATIVES
The present invention relates to 2-N,N-(bis-2-aminoalkyl)-1,2-alkyldiamine derivatives of formula (I) as such, to a process for preparing the ...
METHOD FOR SEPARATING ISOCYANATE MONOMERS
The invention relates to a method for the separation of isocyanate monomers from isocyanate-containing mixtures by the provision of the mixture in a solvent...
HYDROXAMIC ACIDS AND USES THEREOF
Compounds of formula I are provided: ##STR00001## R.sub.1 is an alkoxy or O(CH.sub.2).sub.pX, p is an integer from 2 to 3 and X is OH, NH.sub.2, or CO.sub.2H, m...
ARYL NAPHTHYL METHANONE OXIME(S) AND PROCESS FOR PREPARATION THEREOF
The present invention relates to substituted aryl naphthyl methanone oximes of general formula (I), their process for preparation and their derivatives, salts,...
BENZAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF MUSCULAR DISORDERS AND
PAIN AND FOR CONTROLLING SPASTICITY AND...
The present invention relates to a compound of formula I, or a pharmaceutically acceptable salt thereof : (I) wherein: n is 0 or 1; R1 is selected from H,...
PURIFICATION OF X-RAY CONTRAST AGENTS
The present invention relates to a process for purification of iodinated X-ray contrast agents and in particular to purification of crude dimeric contrast...
PROCESS FOR THE PREPARATION OF ADVANTAME
A novelprocess for the preparation of N--[N-[3-(3-hydroxy-4-methoxyphenyl)-propyl]-L-.alpha.-aspartyl]-L-phenyl- alanine-1-methyl ester is described. It...
ALTERNATIVE ACETYLATION PROCESS IN THE SYNTHESIS OF NON-IONIC X-RAY
An alternative acetylation process for the synthesis of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide ("Compound A"), an intermediate...