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Patent # Description
2016/0303137 DUAL PI3K AND WNT PATHWAY INHIBITION AS A TREATMENT FOR CANCER
Disclosed is a combination therapy for cancer. Additionally, the administration of inhibitors of the phosphoinositide 3-kinase (PI3K) signaling pathway and the...
2016/0303136 COMBINATION OF PI3K-INHIBITORS
The present invention relates to combinations of at least two components, component A and component B, component A being an inhibitor of PI3K kinase, and...
2016/0303135 COMBINATION THERAPY FOR TREATING CANCER
The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents,...
2016/0303134 COMBINATION OF PI3K-INHIBITORS
The present invention relates to combinations of at least two components, component A and component B, component A being an inhibitor of PI3K kinase, and...
2016/0303133 TREATMENT OF GASTROINTESTINAL AND OTHER DISORDERS
Provided herein are methods and compositions for treating gastrointestinal disorders using beta blockers. Compositions comprising Beta blockers such as Timolol...
2016/0303132 PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS
The present invention concerns a compound of formula (I) ##STR00001## or a pharmaceutically acceptable salt or solvate thereof, where R.sup.1-R.sup.3 and Y are...
2016/0303131 METHOD FOR TREATMENT OF SOLID MALIGNANCIES INCLUDING ADVANCED OR METASTATIC SOLID MALIGNANCIES
The present invention relates to the use of Volasertib or a salt thereof or the hydrate thereof for treating patients suffering from solid malignancies...
2016/0303130 METHODS FOR TREATING B CELL PROLIFERATIVE DISORDERS
Described herein are methods for treating B cell proliferative disorders, in an individual in need thereof. The methods include administering to an individual...
2016/0303129 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES
The present invention provides compounds of Formula A: ##STR00001## or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the...
2016/0303128 PREPARATION AND METHODS OF USE FOR ORTHO-ARYL 5-MEMBERED HETEROARYL-CARBOXAMIDE CONTAINING MULTI-TARGETED...
The present disclosure relates to compounds of the Formula (I): ##STR00001## and pharmaceutically acceptable salts, as kinase modulators, compatible with the...
2016/0303127 COMBINATION THERAPY WITH C-MET AND EGFR ANTAGONISTS
The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention relates to...
2016/0303126 SERINE/THREONINE KINASE INHIBITORS
Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of...
2016/0303125 DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS
Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in...
2016/0303124 INHIBITORS OF IMMUNE CHECKPOINT MODULATORS AND RELATED METHODS
The present disclosure relates to the use MNK-specific inhibitors to inhibit immunosuppression components, such as immune checkpoint proteins PD-1, PD-L1,...
2016/0303123 CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS
Chromene compounds of formula (I), defined herein, inhibit phosphoinositide 3-kinases (PI3K) and are useful for the treatment of disorders associated with a...
2016/0303122 TREATMENT OF HEPATITIS B VIRAL
A method for treating or preventing Hepatitis B virus infection in a subject, which comprises administering to said subject in need thereof a therapeutically...
2016/0303121 HETEROARYL COMPOUNDS AND USES THEREOF
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
2016/0303120 Quinoline Derivatives as PDE10A Enzyme Inhibitors
The present invention provides quinoline derivatives of formula I that are PDE10A enzyme inhibitors, and as such are useful to treat neurodegenerative and...
2016/0303119 COMBINATION OF BRIMONIDINE AND TIMOLOL FOR TOPICAL OPHTHALMIC USE
Disclosed are pharmaceutical compositions comprising brimonidine and timolol for topical ophthalmic delivery and a method of treatment comprising administering...
2016/0303118 BENZENESULFONAMIDE DERIVATIVES OF QUINOXALINE, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN METHODS...
Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of using these chemical entities, e.g., for treatment of cancer are...
2016/0303117 CHROMONE DERIVATIVE AS A DOPAMINE D3 RECEPTOR ANTAGONIST FOR ITS USE FOR THE TREATMENT OF AUTISM SPECTRUM DISORDER
The present invention claims a chromone derivative and pharmaceutical compositions and combinations comprising a least the said derivative, which is a dopamine...
2016/0303116 TREATMENT OF MULTIPLE SCLEROSIS WITH A 1,2,4-TRIAZOLO [1,5A] PYRIDINE DERIVATIVE
The present disclosure provides methods and compositions for treating chronic autoimmune diseases, such as multiple sclerosis, using ...
2016/0303115 OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES FOR THE TREATMENT OF DEPRESSIVE AND STRESS DISORDERS
A method of treating a depressive or stress disorder in a subject afflicted therewith comprising administering to the subject an effective amount of a compound...
2016/0303114 PHARMACEUTICAL COMPOSITIONS CONTAINING VANOXERINE AND P450 INHIBITORS AND METHODS OF TERMINATING ACUTE EPISODES...
Compositions comprising vanoxerine (GBR 12909) and a P450 inhibitor, including compositions of vanoxerine and one or more P450 inhibitors, processes for their...
2016/0303113 METHODS OF SELF-ADMINISTRATION OF VANOXERINE FOR TERMINATING ACUTE EPISODES OF CARDIAC ARRHYTHMIA IN MAMMALS
Disclosed embodiments are related to methods of administration of vanoxerine wherein a patient, previously and successfully treated for cardiac arrhythmia with...
2016/0303112 METHODS OF REMOTE MONITORING OF SELF-ADMINISTRATION OF VANOXERINE FOR TERMINATING ACUTE EPISODES OF CARDIAC...
Disclosed embodiments are related to methods of remotely monitoring a patient being treated for cardiac arrhythmia wherein a patient, previously and...
2016/0303111 METHOD OF TREATING ACTINIC KERATOSIS WITH 3.75% IMIQUIMOD CREAM
Pharmaceutical formulations and methods for the topical or transdermal delivery of 1-isobutyl-1H-imidazo[4,5-c]-quinolin-4-amine or ...
2016/0303110 METHODS OF TREATING ABNORMAL MUSCULAR ACTIVITY
Methods for treating abnormal muscular activity are disclosed. The methods may be performed remotely and permit monitoring of a subject outside a healthcare...
2016/0303109 Crenolanib for Treating FLT3 Mutated Proliferative Disorders
The present invention relates to the use of crenolanib, in a pharmaceutically acceptable salt form for the treatment of FLT3 mutated proliferative disorders...
2016/0303108 NOVEL DOSAGE FORM AND FORMULATION OF ABEDITEROL
The present invention provides a pharmaceutical composition in the form of a dry powder for inhalation comprising abediterol or a pharmaceutically acceptable...
2016/0303107 NOVEL METHODS OF TREATING A NEURODEGENERATIVE DISEASE IN A MAMMAL IN NEED THEREOF
The present invention provides a method of treating or ameliorating a neurodegenerative disease in a mammal, the method comprising administering to the mammal...
2016/0303106 ORAL PRODUCT
An oral product includes a body that is wholly receivable in an oral cavity. The body includes a mouth-stable polymer matrix, cellulosic fibers embedded in the...
2016/0303105 Antiparasitic Effect of Bis[3,5-Bis(Benzylidene)-4-Oxo-1-Piperidinyl]amide Derivatives
Embodiments are directed to compositions and methods for treating parasitic infections. Compounds have been identified from a library of anti-cancer drugs that...
2016/0303104 PHARMACEUTICAL COMPOSITIONS COMPRISING ANTIBACTERIAL AGENTS
Pharmaceutical compositions comprising cefepime or a pharmaceutically acceptable derivative, and a compound of Formula (I) or a stereoisomer or a...
2016/0303103 COMPOUNDS THAT TREAT MALARIA AND PREVENT MALARIA TRANSMISSION
The invention provides methods and compounds for the treatment and prevention of malaria infection and transmission in a mammal by administering compounds of...
2016/0303102 PROCESS FOR THE PRODUCTION OF DRUG FORMULATIONS FOR ORAL ADMINISTRATION
The present invention provides a simple and mild process for the preparation of nano- and/or microparticles, which particles contain one or more therapeutic...
2016/0303101 PREDICTING RESPONSE TO ALVOCIDIB BY MITOCHONDRIAL PROFILING
The present disclosure provides diagnostic methods useful for predicting a patient's response to alvocidib and guiding a physician decision to administer...
2016/0303100 Brown Adipocyte Progenitors in Human Skeletal Muscle
Brown adipose tissue ("BAT") progenitor cells and methods for identifying BAT progenitor cells in a population of cells are provided. Methods are also provided...
2016/0303099 METHODS OF TREATMENT
This disclosure relates to use of certain aldehyde compounds for treating pulmonary fibrosis, hypoxia, and connective tissue and autoimmune disease such as...
2016/0303098 Methods of Administering Pirfenidone Therapy
The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors...
2016/0303097 METHODS FOR TREATING AN IMPAIRMENT IN GAIT AND/OR BALANCE IN PATIENTS WITH MULTIPLE SCLEROSIS USING AN...
Disclosed herein is use of one or more aminopyridines in methods and compositions for treatment of impairments in gait or balance in patients with multiple...
2016/0303096 PHARMACEUTICAL COMPOSITIONS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL) ...
A pharmaceutical composition comprising Compound 1, (3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic...
2016/0303095 METHODS OF TREATING HEPATITIS B VIRUS
The present invention relates to novel methods of treating Hepatitis B Virus by administering a KDM5 inhibitor.
2016/0303094 PHARMACEUTICAL COMPOSITIONS COMPRISING ANTIBACTERIAL AGENTS
Pharmaceutical compositions comprising imipenem or a pharmaceutically acceptable derivative, and a compound of Formula (I) or a stereoisomer or a...
2016/0303093 RAPAMYCIN FORMULATIONS AND METHODS OF THEIR USE
Described herein are liquid rapamycin formulations. Described herein are methods of treating or preventing diseases or conditions, such as choroidal...
2016/0303092 TREATMENT OF SOLID TUMORS WITH RAPAMYCIN DERIVATIVES
Rapamycin derivatives have interesting effects in the treatment of solid tumours, optionally in combination with a chemotherapeutic agent.
2016/0303091 TREATMENT OF ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH ANTI-PROLIFERATE AND ANTI-INFLAMMATORY DRUGS
Embodiments of the present invention provide a method for treatment of respiratory disorders such as asthma, chronic obstructive pulmonary disease, and chronic...
2016/0303090 COMPOSITIONS AND METHODS FOR INHIBITING TUMOR GROWTH
The present invention relates to compositions and methods for preventing and treating cell proliferation in cancer. More specifically, the present invention...
2016/0303089 COMPOUND PERTAINING TO NEUROPOIESIS AND DRUG COMPOSITION
A composition for activating neurogenesis or the growth of neurons is provided. In one or more embodiments, a composition contains as an active ingredient a...
2016/0303088 MODULATORS OF PHARMACOKINETIC PROPERTIES OF THERAPEUTICS
The present application provides for a compound of Formula I, ##STR00001## or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions...
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