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Patent # Description
2016/0304937 MULTIPLEX PCR TO DETECT GENE FUSIONS
Provided herein are methods and compositions for detecting gene fusions, e.g., relevant to cancer. The present methods and compositions can be used to detect...
2016/0304936 QUANTIFICATION OF MUTANT ALLELES AND COPY NUMBER VARIATION USING DIGITAL PCR WITH NONSPECIFIC DNA-BINDING DYES
Methods and reagents for performing digital PCR for detection and quantification of mutant alleles and copy number variation are disclosed. In particular, the...
2016/0304935 SYSTEMS AND METHODS FOR WHOLE GENOME AMPLIFICATION
Provided herein are systems and methods for whole genome amplification and sequencing. In particular, provided herein are systems and methods for detection of...
2016/0304934 METHOD FOR MEASURING MODIFIED NUCLEOBASE USING GUIDE PROBE, AND KIT THEREFOR
The present invention provides a method for measuring a modified nucleobase that increases detection sensitivity for the modified nucleobase in a target...
2016/0304933 METHODS AND COMPOSITIONS TO DETECT THE LEVEL OF LYSOSOMAL EXOCYTOSIS ACTIVITY AND METHODS OF USE
Methods are provided for the prognosis, diagnosis and treatment of various pathological states, including cancer, chemotherapy resistance and dementia...
2016/0304932 METHOD AND A KIT FOR THE DIAGNOSIS OF HEPATIC DISEASE UTILIZING THE SULFYDRYL-OXIDIZING PROPERTY OF SERUM
The present invention refers to a method and a kit for the diagnosis of a hepatic disease utilizing the sulfydryl-oxidizing property of serum. Sulfydryl can be...
2016/0304931 METHOD FOR DETERMINATION OF DIVERSITY AND VIABILITY THRESHOLDS USED TO ASSESS MICROORGANISMS IN PROCESS SAMPLES
The invention is directed towards methods and compositions for identifying the specific microorganisms present in a particular potion of a water process...
2016/0304930 FAD-CONJUGATED GLUCOSE DEHYDROGENASE GENE
An object of the present invention is to provide: a novel gene (polynucleotide) encoding an FAD-conjugated glucose dehydrogenase having excellent properties...
2016/0304929 BIO-ENZYME SENSOR CAPABLE OF SUPER HYDROPHOBIC SOLID-LIQUID-GAS THREE-PHASE COEXISTENCE AND METHOD FOR...
A bio-enzyme sensor capable of super-hydrophobic solid-liquid-gas three-phase coexistence and a method for preparing the same. The bio-enzyme sensor comprises,...
2016/0304928 Control of Protein Glycosylation by Culture Medium Supplementation and Cell Culture Process Parameters
The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell...
2016/0304927 PREPARATION METHOD OF NEW RECOMBINANT ANTIBACTERIAL POLYPEPTIDE MEDICINE
The invention provides a method of preparing a new recombinant antibacterial polypeptide medicine, which primarily relates to liquid culture medium formula...
2016/0304926 Synthesis of L-Nucleic Acids by Means of an Enzyme
The present invention is related to a method for adding one or more L-nucleotides to the 3'end of a first L-nucleic acid, wherein the method comprises the step...
2016/0304925 ENZYME BASED METHODS OF SEPARATING PROTEIN FROM PROTEIN-RICH MATERIAL
Improved enzyme based methods of separating protein from protein-rich material are provided. A method can include utilizing a modeling equation to more...
2016/0304924 SYNERGISTIC FOOD FERMENTATION UTILIZING FUNGAL MYCELIUM AND BACILLI
Foods that are fermented with synergistic and simultaneous use of bacilli and mycelial cultures. The foods include a cellulosic food substrate containing...
2016/0304923 COMPOSITIONS AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS
The present invention relates to host cells that produce compounds that are characterized as benzylisoquinolines, as well as select precursors and...
2016/0304922 Host Cell Modified to Produce 2-Pyrrolidone
The present invention provides for a genetically modified host cell comprising a 2-pyrrolidone synthase, or an enzymatically active fragment thereof,...
2016/0304921 LOV-D ACYLTRANSFERASE MEDIATED ACYLATION
Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii)...
2016/0304920 MICROORGANISMS FOR PRODUCTION OF O-SUCCINYL HOMOSERINE AND METHOD FOR PRODUCTION OF O-SUCCINYL HOMOSERINE USING...
The present invention relates to a polypeptide which is resistant to feedback inhibition by methionine and has an activity of homoserine O-succinyltransferase,...
2016/0304919 MICROORGANISMS FOR PRODUCTION OF O-SUCCINYLHOMOSERINE AND METHOD FOR PRODUCTION OF O-SUCCINYLHOMOSERINE USING...
The present invention relates to a polypeptide having a resistant to feedback inhibition by methionine and an activity of homoserine O-succinyltransferase, a...
2016/0304918 MICROORGANISMS FOR PRODUCTION OF O-SUCCINYLHOMOSERINE AND METHOD FOR PRODUCTION OF O-SUCCINYLHOMOSERINE USING...
The present invention relates to a polypeptide having a resistant to feedback inhibition by methionine and an activity of homoserine O-succinyltransferase, a...
2016/0304917 Modified Microorganism for Improved Production of Alanine
The present invention relates to a modified microorganism having, compared to its wildtype, an increased activity of the enzyme that is encoded by the...
2016/0304916 PICHIA CIFERRII CELLS AND USES THEREOF
The invention relates to genetically modified Pichia ciferrii cells, to the use thereof and to a method of producing sphingoid bases and sphingolipids.
2016/0304915 PROCESS FOR PRODUCING COENZYME Q10
A process for producing on an industrial scale the oxidized coenzyme Q.sub.10, includes culturing a reduced coenzyme Q.sub.10-producing microorganism selected...
2016/0304914 METHOD FOR PRODUCING SINGLE CELL OIL FROM LIGNOCELLULOSIC MATERIALS
The present disclosure relates to methods for producing microbial lipids. The present disclosure also relates to methods for producing microbial lipids using...
2016/0304913 YEAST STRAINS AND METHOD FOR THE PRODUCTION OF OMEGA-HYDROXY FATTY ACIDS AND DICARBOXYLIC ACIDS
The invention relates to various new yeast strains of the type Yarrowia lipolytica as well as relevant methods for the biocatalytic preparation of...
2016/0304912 A PROCESS FOR PREPARING SUCCINATE ESTER
This invention relates to a process for preparing succinate ester from a succinic acid salt present in a fermentation broth. In the first stage of this...
2016/0304911 Method for Producing Ambrein
Provided is a method for producing ambrein, comprising reacting tetraprenyl-.beta.-curcumene cyclase with 3-deoxyachilleol A to obtain ambrein.
2016/0304910 RECOMBINANT STRAIN OF SACCHAROMYCES CEREVISIAE OVERPRODUCING GLYCEROL
A truncated version of Saccharomyces cerevisiae IVL2 gene encoding a cytosolic form of acetolactate synthase was cloned into an expression cassette under...
2016/0304909 Increased Production of Isobutanol in Yeast with Reduced Mitochondrial Amino Acid Biosynthesis
Yeast cells with reduced activity of certain enzymes involved in branched chain amino acid biosynthesis in yeast mitochondria are described. Target enzymes...
2016/0304908 ENHANCED EFFICIENCY ETHANOL PRODUCTION AND SUGAR CONVERSION PROCESSES
Ethanol is produced at high concentration by the fermentation of sugars using a biocatalyst comprising an open, porous hydrophilic polymeric structure having...
2016/0304907 RNA-Guided Human Genome Engineering
A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of...
2016/0304906 METHOD FOR POSITIONING AND INTEGRATING TRANSGENE AND USE THEREOF
Provided in the present invention is a method for positioning and integrating transgene and a use thereof. Specifically provided is a variant loxP element. The...
2016/0304905 Fungal Gene Library By Double Split-Marker Integration
The present invention relates to a method for site-specific chromosomal integration of a gene library in a filamentous fungal host cell and a polynucleotide...
2016/0304904 Directed Evolution and In Vivo Panning of Virus Vectors
The present invention provides methods of achieving directed evolution of viruses by in vivo screening or "panning" to identify viruses comprising scrambled...
2016/0304903 PROMOTER-REGULATED DIFFERENTIATION-DEPENDENT SELF-DELETING CASSETTE
Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human...
2016/0304902 EXPRESSION VECTOR HAVING IMPROVED ABILITY TO EXPRESS GENE
The present invention relates to an expression vector having an improved ability to express a gene, cells transformed by the expression vector, and a method...
2016/0304901 GENE FOR INDUCTION OF PARTHENOGENESIS, A COMPONENT OF APOMICTIC REPRODUCTION
Methods and compositions disclosed herein generally relate to genes involved in plant reproduction and methods of using the same.
2016/0304900 SYNTHETIC GENES
The invention provides synthetic nucleic acid sequences encoding proteins of interest that are particularly adapted to express well in plants. The claimed...
2016/0304899 METHOD FOR PRODUCING TRANSGENIC PLANT WITH INCREASED CONTENT OF 20-HYDROXYECDYSONE USING CYP85 GENE FROM...
A method for producing a transgenic plant which has increased content of 20-hydroxyecdysone compared to a wild type plant includes transforming a plant cell...
2016/0304898 Pesticidal Genes and Methods of Use
Compositions having pesticidal activity and methods for their use are provided. Compositions include isolated and recombinant polypeptides having pesticidal...
2016/0304897 GLYPHOSATE RESISTANT PLANTS AND ASSOCIATED METHODS
The present disclosure relates to certain polypeptides derived from prokaryotic DGT enzymes, and nucleic acids useful in encoding the same.
2016/0304896 ALGAL CHLOROPLASTIC SRP54 MUTANTS
Mutant photosynthetic microorganisms having reduced chlorophyll and increased photosynthetic efficiency are provided. The mutant strains have mutated...
2016/0304895 PLANT PROMOTER FOR TRANSGENE EXPRESSION
This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a promoter from a...
2016/0304894 PLANT PROMOTER FOR TRANSGENE EXPRESSION
This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a promoter from a...
2016/0304893 CAS9 NUCLEASE PLATFORM FOR MICROALGAE GENOME ENGINEERING
The present invention relates to a method of genome engineering in microalgae using the Cas9/CRISPR system. In particular, the present invention relates to...
2016/0304892 TARGETED GENE MODIFICATION USING OLIGONUCLEOTIDE-MEDIATED GENE REPAIR
The invention provides to improved methods for the modification of genes in plant cells, and plants and seeds derived therefrom. More specifically, the...
2016/0304891 COMPOSITIONS AND METHODS FOR ALTERING FLOWERING AND PLANT ARCHITECTURE TO IMPROVE YIELD POTENTIAL
The present invention provides recombinant DNA constructs, vectors and molecules comprising a polynucleotide sequence encoding a florigenic FT protein operably...
2016/0304890 TRANSGENIC PLANTS PRODUCED WITH A K-DOMAIN, AND METHODS AND EXPRESSION CASSETTES RELATED THERETO
Methods and compositions of improving plant yield by introducing into a plant the K-domain of a MADS box gene are disclosed. The expression of the K-domain...
2016/0304889 PROCESS FOR TRANSFORMATION IN WITHANIA SOMNIFERA PLANTS TO INCREASE SECONDARY METABOLITE CONTENT
Described herein is a process of genetic transformation in W. somnifera by Agrobacterium tumefaciens mediated transformation to overexpress squalene synthase...
2016/0304888 SPECIFIC ALLELES IMPORTANT FOR ETHANOL TOLERANCE
The present disclosure relates to the identification of a QTL associated with high ethanol tolerance in Saccharomyces spp. More specifically, it relates to...
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