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Patent # Description
2016/0311906 MODULATION OF NKG2D
The present invention relates to methods and compositions for treating and/or preventing inflammation associated with viral infection and solid organ...
2016/0311905 Reducing Systemic Regulatory T Cell Levels or Activity for Treatment of Alzheimer's Disease
A pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a...
2016/0311904 METHODS AND COMPOSITIONS FOR INCREASING PROTECTIVE ANTIBODY LEVELS INDUCED BY PNEUMOCOCCAL POLYSACCHARIDE VACCINES
The presently disclosed subject matter provides therapeutic methods and compositions for the treatment of bacterial infections caused by Streptococcus...
2016/0311903 ANTI-PDL1 ANTIBODIES, ACTIVATABLE ANTI-PDL1 ANTIBODIES, AND METHODS OF USE THEREOF
The invention relates generally to antibodies that bind programmed death ligand 1 (PDL1), activatable antibodies that specifically bind to PDL1 and methods of...
2016/0311902 CANINIZED ANTIBODIES
The present invention discloses caninized antibodies with specific properties. The present invention also discloses caninized murine antibodies againstcanine...
2016/0311901 MULTIPARTITE SIGNALING PROTEINS AND USES THEREOF
The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally...
2016/0311900 PLEXIN D1 AS A TARGET FOR TUMOR DIAGNOSIS AND THERAPY
The present invention relates to plexin D1 for use as a targetable protein in the treatment or diagnosis of disorders that involve expression of plexin D1....
2016/0311899 Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating Same
A genetically modified non-human animal is provided, wherein the non-human animal expresses an antibody repertoire capable of pH dependent binding to antigens...
2016/0311898 IL-31 MONOCLONAL ANTIBODY FORMULATIONS
The invention provides humanized mouse anti-human IL-31 antibodies and antibody fragments that are capable of binding IL-31 and thereby neutralizing,...
2016/0311897 MONOCLONAL ANTIBODIES THAT BIND BOTH IL-17A AND IL-17F
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are...
2016/0311896 PAIN TREATMENT
The present invention relates generally to a method for the treatment and prophylaxis of pain. In accordance with the present invention, it is proposed that...
2016/0311895 ANTIBODY TO N-TERMINAL REGION OF HEMOGLOBIN BETA-CHAIN
Provided is a general-purpose technique capable of measuring the HbA1c content, which is comparable to the IFCC reference method. An antibody which reacts with...
2016/0311894 NOVEL ASSAY TO DETECT HUMAN PERIOSTIN
This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients...
2016/0311893 INHIBITORS OF COMPLEMENT FACTOR H
Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.
2016/0311892 ANTI-LPS O11 ANTIBODY
The purpose of the present invention is to provide a substance having superior antibacterial activity against Pseudomonas aeruginosa, and a pharmaceutical...
2016/0311891 DNA Antibody Constructs And Method Of Using Same
Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a...
2016/0311890 Therapeutic and Diagnostic Methods Using TIM-3
The application relates to methods of treating chronic viral infection by modulating Tim-3 activity. In addition, the present application relates to methods of...
2016/0311889 REMOVAL OF SERINE PROTEASES BY TREATMENT WITH FINELY DIVIDED SILICON DIOXIDE
The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition....
2016/0311888 COMPOSITIONS AND METHODS FOR INHIBITING ENDOGENOUS IMMUNOGLOBULIN GENES AND PRODUCING TRANSGENIC HUMAN IDIOTYPE...
The invention relates to transgenic animals lacking endogenous Ig and capable of producing transgenic antibodies, as well as methods of making the same. The...
2016/0311887 MODIFIED SERPINS FOR THE TREATMENT OF BLEEDING DISORDERS
This invention relates pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1' residues within the reactive center loop (RCL) to...
2016/0311886 Constructs Binding to Phosphatidylserine and Their Use in Disease Treatment and Imaging
Disclosed are new phosphatidylserine binding constructs with surprising combinations of properties, and a range of diagnostic and therapeutic conjugates...
2016/0311885 RECOMBINANT FACTOR VIII PROTEINS
Provided are recombinant Factor VIII proteins, e.g., human Factor VIII proteins, in which one or more amino acids in at least one permissive loops or a3 domain...
2016/0311884 EGFR-BASED INHIBITOR PEPTIDES FOR COMBINATORIAL INACTIVATION OF ERBB1, ERBB2, AND ERBB3
Inhibitor peptides for combinatorial inactivation of ErbB1, ErbB2, and ErbB3 featuring an EGFR-based peptide and a cell penetrating component such as a protein...
2016/0311883 Novel Compound for Treatment of Severe Hypoglycemia
The present invention provides a novel compound useful in the treatment of hypoglycemia.
2016/0311882 Novel Compound for Treatment of Severe Hypoglycemia
The present invention provides a novel compound useful in the treatment of hypoglycemia.
2016/0311881 Novel Compound for Treatment of Severe Hypoglycemia
The present invention provides a novel compound useful in the treatment of hypoglycemia.
2016/0311880 POLYPEPTIDES, NUCLEIC ACIDS AND USES THEREOF
We describe an ELABELA polypeptide comprising a sequence CXXXRCXXXHSRVPFP (SEQ ID NO: 1), in which X signifies an amino acid residue, such as a sequence...
2016/0311879 SINGLE CHAIN IL-12 NUCLEIC ACIDS, POLYPEPTIDES, AND USES THEREOF
The present invention relates to novel single chain interleukin-12 polypeptides. The invention also relates to isolated nucleic acids encoding the single chain...
2016/0311878 THREE-HELIX BUNDLE PROTEIN AND USE THEREOF
A three-helix bundle protein, a polynucleotide encoding the three-helix bundle protein, a method of preparing the three-helix bundle protein, and a method of...
2016/0311877 CRP CAPTURE/DETECTION OF GRAM POSITIVE BACTERIA
Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting...
2016/0311876 DIAGNOSIS OF A NOVEL AUTOIMMUNE DISEASE
Polypeptides including Neurochondrin and autoantibodies binding to polypeptides including Neurochondrin are provided. Methods for diagnosing or treating...
2016/0311875 NEW PEPTIDE AND APPLICATION THEREOF
Provided are a new peptide, a vector inserting a DNA that codes said peptide, a transformant obtained by transformation with that vector, and applications of...
2016/0311874 FOLLISTATIN-RELATED FUSION PROTEINS AND USES THEREOF
In certain aspects, the present disclosure provides compositions and methods for inhibiting activity of TGF.beta. superfamily ligands, particularly ligands...
2016/0311873 SEMAPHORIN 3C VARIANTS, COMPOSITIONS COMPRISING SAID VARIANTS AND METHODS OF USE THEREOF
The present invention relates, according to some embodiments, to variants of Semaphorin 3C (Sema3C) having amino acid modifications at furin-like pro-protein...
2016/0311872 NUCLEIC ACIDS ENCODING PEPTIDES FOR TREATING WOUNDS, ANTI-ANGIOGENIC COMPOUNDS AND USES THEREOF
The present disclosure relates to protein and peptide chemistry. More particularly, it relates to compounds, compositions and uses thereof for promoting and...
2016/0311871 RESISTANT MUTANT 90 kDA HEAT SHOCK PROTEIN
An object to be solved by the present invention is to identify patients resistant to known HSP90 inhibitors, and to provide a novel therapeutic agent for...
2016/0311870 STABLE POLYPEPTIDES BINDING TO HUMAN COMPLEMENT C5
The invention relates to a polypeptide capable of binding human complement component 5 (C5), said polypeptide comprising the amino acid sequence ...
2016/0311869 Polynucleotide, Polypeptide with Immunosuppressive Activity, Expression Cassette, Expression Vector, Host Cell,...
This invention refers to polynucleotides and non-hemorrhagic and non-immunogenic polypeptides of selective immunosuppressive activity on production of...
2016/0311868 METHODS AND COMPOSITIONS FOR EXPRESSING FUNCTIONAL CLASS XIV MYOSIN
The invention, in part, includes methods and compounds useful to prepare and functional class XIV myosin. Functional class XIV myosin prepared using methods of...
2016/0311867 PESTICIDAL FUSION PROTEIN IMPROVEMENTS
Methods of increasing the biological activity of toxins. Methods of increasing the biological activity of pesticide toxins through the incorporation of...
2016/0311866 DE NOVO STRUCTURAL PROTEIN DESIGN FOR MANUFACTURING HIGH STRENGTH MATERIALS
Provided is a supramolecular polypeptide comprising alternating repeats of crystallite-forming subsequences and amorphous subsequences. The crystallite-forming...
2016/0311865 AXMI477, AXMI482, AXMI486 AND AXMI525 TOXIN GENES AND METHODS FOR THEIR USE
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding...
2016/0311864 Pesticidal Genes and Methods of Use
Compositions having pesticidal activity and methods for their use are provided. Compositions include isolated and recombinant polypeptides having pesticidal...
2016/0311863 ENGINEERED ALBUMIN BINDING POLYPEPTIDE
The present disclosure relates to a class of engineered polypeptides having a binding affinity for albumin. In particular, the present invention relates to...
2016/0311862 EPITOPE AND ITS USE OF HEPATITIS B VIRUS SURFACE ANTIGEN
Disclosed are an epitope specific to hepatitis B virus (HBV) and use thereof. The disclosed epitope is a conservative position on which mutagenesis does not...
2016/0311861 Novel Promiscuous HPV16-Derived T Helper Epitopes for Immunotherapy
The present invention relates to novel amino acid sequences of peptides derived from HPV16 that are able to bind to MHC complexes of class II, and elicit an...
2016/0311860 PEPTIDE DOMAINS THAT BIND SMALL MOLECULES OF INDUSTRIAL SIGNIFICANCE
Described herein are small peptide domains and consensus sequences that bind small target molecules of industrial importance, e.g., metals such as nickel,...
2016/0311859 SELF-ASSEMBLING POLYPEPTIDE POLYHEDRA
The invention provides a polypeptide chain capable of forming a polyhedron by self-assembly, nanostructure polyhedra self-assembled from single polypeptide...
2016/0311858 PEPTIDE-COMPOUND CYCLIZATION METHOD
An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with...
2016/0311857 PTEN ANTAGONIST PEPTIDES AND METHODS OF USING THE SAME
The presently disclosed subject matter relates to antagonists of PTEN and methods of using the same. In particular, the presently disclosed subject matter...
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